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Zemin Zhang

Zemin Zhang
Zemin Zhang Senior Scientist: Bioinformatics

Profile | Education/Background | Top Scientific Papers | Awards & Honors

Top Scientific Papers

  • Haverty PM, Fridlyand J, Li L, Getz G, Beroukhim R, Lohr S, Wu TD, Cavet G, Zhang Z, Chant J. High-resolution genomic and expression analyses of copy number alterations in breast tumors. Genes Chromosomes Cancer 2008 Jun; 47(6): 530-42. View Abstract on PubMed

  • Liu J, Zhang Y, Lei X, Zhang Z. Natural selection of protein structural and functional properties: a SNP perspective. Genome Biol 2008 Apr 8; 9(4): R69 [Epub ahead of print]. View Abstract on PubMed

  • Hon LS, Zhang Y, Kaminker JS, Zhang Z. Computational prediction of the functional effects of amino acid substitutions in signal peptides using a model-based approach. Human Mutation In press 2008.

  • Jin H, Yang R, Zheng Z, Romero M, Ross J, Bou-Reslan H, Carano RAD, Kasman I, Mai E, Young J, Zha J, Zhang Z, Ross S, Schwall R, Colbern G, Merchant M. MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res In press 2008.

  • Hon LS, Kaminker JS, Zhang Z. Computational approaches for predicting causal missense mutations in cancer genome projects. Current Bioinformatics 2007 3 (1): 46-55.

  • Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM. DUBA: a deubiquitinase that regulates type I interferon production. Science 2007 Dec 7; 318(5856): 1628-32. Epub 2007 Nov 8. View Abstract on PubMed

  • Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B. The genomic landscapes of human breast and colorectal cancers. Science 2007 Nov 16; 318(5853): 1108-13. Epub 2007 Oct 11. View Abstract on PubMed

  • Hon LS, Zhang Z. The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression. Genome Biol 2007 Aug 14; 8: R166.

  • Zhang Y, Luoh SM, Hon LS, Baertsch R, Wood WI, Zhang Z. GeneHub-GEPIS: digital expression profiling for normal and cancer tissues based on an integrated gene database. Nucleic Acids Res 2007 Jul 1; 35(Web Server issue): W152-8. View Abstract on PubMed

  • Kaminker JS, Zhang Y, Watanabe C, Zhang Z. CanPredict: a computational tool for predicting cancer-associated missense mutations. Nucleic Acids Res 2007 Jul 1; 35(Web Server issue): W595-8. View Abstract on PubMed

  • Wang XD, Wang BE, Soriano R, Zha J, Zhang Z, Modrusan Z, Cunha GR, Gao WQ. Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis. Differentiation 2007 Mar; 75(3): 219-34. View Abstract on PubMed

  • Kaminker JS, Zhang Y, Waugh A, Haverty PM, Peters B, Sebisanovic D, Stinson J, Forrest WF, Bazan JF, Seshagiri S, Zhang Z. Distinguishing cancer-associated missense mutations from common polymorphisms. Cancer Res 2007 Jan 15; 67(2): 465-73. View Abstract on PubMed

  • Gray D, Jubb AM, Hogue D, Dowd P, Kljavin N, Yi S, Bai W, Frantz G, Zhang Z, Koeppen H, de Sauvage FJ, Davis DP. Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers. Cancer Res 2005 Nov 1; 65(21): 9751-61. View Abstract on PubMed

  • Zhang Z, Henzel WJ. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci 2004 Oct;13(10):2819-24. View Abstract on PubMed

  • Zhang Y, Eberhard DA, Frantz GD, Dowd P, Wu TD, Zhou Y, Watanabe C, Luoh SM, Polakis P, Hillan KJ, Wood WI, Zhang Z. GEPIS--quantitative gene expression profiling in normal and cancer tissues. Bioinformatics 2004 Oct 12; 20(15): 2390-8. View Abstract on PubMed

  • Desany B, Zhang Z. Bioinformatics and cancer target discovery. Drug Discov Today 2004 Sep 15; 9(18): 795-802. View Abstract on PubMed

  • Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 2004 Feb 27; 303(5662): 1371-4. View Abstract on PubMed

  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res 2003 Oct; 13(10): 2265-70. View Abstract on PubMed

  • Zhou Y, Luoh SM, Zhang Y, Watanabe C, Wu TD, Ostland M, Wood WI, Zhang Z. Genome-wide identification of chromosomal regions of increased tumor expression by transcriptome analysis. Cancer Res 2003 Sep 15; 63(18): 5781-4. View Abstract on PubMed

  • LeCouter J, Lin R, Frantz G, Zhang Z, Hillan K, Ferrara N. Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis. Endocrinology 2003 Jun; 144(6): 2606-16. View Abstract on PubMed

  • Gaensler KM, Zhang Z, Lin C, Yang S, Hardt K, Flebbe-Rehwaldt L. Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus. Proc Natl Acad Sci U S A 2003 Mar 18; 100(6): 3374-9. View Abstract on PubMed

  • Zhang Z, Wood WI. A profile hidden Markov model for signal peptides generated by HMMER. Bioinformatics 2003 Jan 22; 19(2): 307-8. View Abstract on PubMed

  • Yan M, Zhang Z, Brady JR, Schilbach S, Fairbrother WJ, Dixit VM. Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice. Curr Biol 2002 Mar 5; 12(5): 409-13. View Abstract on PubMed

  • LeCouter J, Kowalski J, Foster J, Hass P, Zhang Z, Dillard-Telm L, Frantz G, Rangell L, DeGuzman L, Keller GA, Peale F, Gurney A, Hillan KJ, Ferrara N. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature 2001 Aug 30; 412(6850): 877-84. View Abstract on PubMed

  • Kishiyama A, Zhang Z, Henzel WJ. Cleavage and identification of proteins: a modified aspartyl-prolyl cleavage. Anal Chem 2000 Nov 1;72(21):5431-6. View Abstract on PubMed

  • Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, Wood WI, Goddard AD, Gurney AL. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem 2000 Oct 6; 275(40): 31335-9. View Abstract on PubMed

  • Porcu S, Kitamura M, Witkowska E, Zhang Z, Mutero A, Lin C, Chang J, Gaensler KM. The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice. Blood 1997 Dec 1; 90(11): 4602-9. View Abstract on PubMed

  • Zhang Z, Buchman AR. Identification of a member of a DNA-dependent ATPase family that causes interference with silencing. Mol Cell Biol 1997 Sep; 17(9): 5461-72. View Abstract on PubMed