Genentech: Akshay Krishnamurty | Principal Scientist, Cancer Immunology, Research Biology

Scientists / Our Scientists

"My favorite part of working at Genentech is getting to do collaborative, team-oriented science with highly skilled and driven scientists, all with a collective goal of improving human health."

Years at Genentech

Awards & Honors

My career at Genentech began in 2017 as a postdoctoral fellow in the Cancer Immunology department studying the cellular complexity of tumors. I quickly became interested in studying the role activated fibroblasts play in modulating the tumor microenvironment. In 2018 I transitioned to be a Principal Scientific Researcher as I was increasingly drawn toward learning how to leverage our basic science discoveries into potential therapeutic approaches and being part of the drug development pipeline. In 2021, I started my own research program as a Senior Scientist in the Cancer Immunology department to further our understanding of the interplay between stromal cells and immune cells in the context of cancer. Our hope is to leverage our findings to uncover novel biologies and develop innovative therapies for patients.

Featured Publication

A bird’s eye view of fibroblast heterogeneity:a pan-disease, pan-cancer perspective.

mmunological Review, 00, 1-22

Pradhan RN*, Krishnamurty AT*, Fletcher A, Turley SJ, Muller S (2021)

*co-first authors

View Abstract

Cross-tissue organization of the fibroblast lineage.

Nature, 593, 575-579

Buechler MB*, Pradhan RN*, Krishnamurty AT, Cox C, Calviello AK, Yang YA, Tam L, Caothien R, Roose-Girma M, Modrusan Z, Arron J, Bourgon R, Muller S, Turley SJ (2021)

*co-first authors

View Abstract

Lymph node stromal cells: cartographers of the immune system.

Nature Immunology, 4, 369-380

Krishnamurty AT*, Turley SJ*. (2020)

*co-corresponding author

View Abstract

My group’s research efforts are focused on further understanding the cellular and molecular mechanisms that regulate anti-tumor immunity and response to immunotherapy. We aim to integrate single cell multiomic technologies, in vivo pre-clinical models, genetic tools, imaging techniques, and clinical data to better understand these cellular interactions

Current areas of research include:

Understanding the signals that drive the formation of heterogeneous populations of cancer-associated fibroblasts (CAFs) and their influence on anti-tumor immunity
Elucidating pathways in tumor-associated stromal cells that regulate recruitment and distribution of immune cells in tumors

University of Washington, Ph.D. in Immunology – 2016
Georgetown University, M.S. in Microbiology – 2011
University of Washington, B.S. in Biochemistry – 2008

Genentech Research and Early Development Key Researcher Award – 2021
Young Investigator Outstanding Oral Presentation Award, Midwinter Conference of Immunologists – 2016
American Association of Immunologists Trainee Award – 2014
HHMI/UW Molecular Medicine Scholar Award – 2013

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Akshay Krishnamurty

Principal Scientist, Cancer Immunology, Research Biology

Featured Publication

A bird’s eye view of fibroblast heterogeneity:a pan-disease, pan-cancer perspective.

Cross-tissue organization of the fibroblast lineage.

Lymph node stromal cells: cartographers of the immune system.