Scientists / Our Scientists

Alessandro Ori

Senior Principal Scientist, Microchemistry, Proteomics and Lipidomics (MPL), Drug Discovery

Postdoc Mentor

"I am really excited by the opportunity to use the most advanced technologies to understand mechanisms of disease and target them for the benefit of our patients"

Awards & Honors

I hold a PhD in Biochemistry and I trained as a postdoctoral fellow at the European Molecular Biology Laboratory in Heidelberg (Germany). During my postdoc, I developed mass spectrometry-based proteomic approaches to answer fundamental questions in the fields of structural and systems biology. Before joining Genentech, I ran an academic lab for eight years studying molecular mechanisms of brain and stem cell aging. I am excited to contribute my expertise in studying complex biological processes towards Genentech’s goal of understanding and treating age-related and other diseases.

Postdoctoral Mentor

Throughout my career, I had the opportunity to collaborate with exceptional trainees and postdoctoral fellows that shaped and inspired our research program. I deeply enjoy the energy, diversity and innovative ideas that young scientists bring to research teams. Genentech offers a unique opportunity for postdoctoral fellow to train in cutting edge science, while experiencing what it takes to develop impactful medicines. The collaborative spirit and multidisciplinary nature of projects together with a dedicated mentoring program represent a unique environment to foster the next generation of science leaders.

Featured Publication

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.

Mol. Syst. Biol. 16, 1–22.

Kelmer Sacramento, E.^*, Kirkpatrick, J.M.^*, Mazzetto, M.^*, Baumgart, M., Bartolome, A., Di Sanzo, S., Caterino, C., Sanguanini, M., Papaevgeniou, N., Lefaki, M., Childs, D., Bagnoli, S., Terzibasi Tozzini, E., Di Fraia, D., Romanov, N., Sudmant, P.H., Huber, W., Chondrogianni, N., Vendruscolo, M., Cellerino, A.^#, and Ori, A.^# (2020).

View Abstract

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction.

Cell Reports. 31.

Gebert, N., Cheng, C.W., Kirkpatrick, J.M., Di Fraia, D., Yun, J., Schädel, P., Pace, S., Garside, G.B., Werz, O., Rudolph, K.L., Jasper, H., Yilmaz, Ö.H., and Ori, A. (2020).