Ben-Quan Shen
Senior Fellow, Senior Director and Group Head, Translational PKPD, Development Sciences
Fellow
"Genentech's stimulating environment and opportunities to advance my career really attracted me here. I'm so excited to work with so many of the brightest and most innovative scientists to develop new treatments for some of the most difficult-to-treat diseases - all while positioning myself for personal success and staying competitive at the forefront of medical technology."
28
Years at Genentech
44
Publications at Genentech
2
Awards & Honors
I received a Medical Degree from Nanjing Medical Univ. China in 1983 and then conducted my postdoctoral training at UCSF before joining Genentech in 1996.
Over my tenure at Genentech, I have served as a key scientific and strategic leader, driving the investigative PKPD effort in support of discovery and development of protein therapeutics.
I also identify and investigate key scientific issues related to the ADME and PKPD of exciting and novel drug candidates in the areas of BioOncology, Immunology, and Infectious Disease areas. I am responsible for developing novel scientific tools to understand factors that affect the disposition of biologics and leverage it for the selection and development of therapeutic candidates.
Featured Publication
A novel approach to quantitate biodistribution and transduction of adeno-associated virus gene therapy using radiolabeled AAV vectors in mice.
Mol Ther Methods Clin Dev. 2024
Hongzhi Wang, Ran Li, Shraddha Sadekar, Amrita Kamath, and Ben-Quan Shen*.
Preclinical Characterization of the Distribution, Catabolism and Elimination of Polatuzumab Vedotin-piiq (POLIVY®) Antibody-Drug Conjugate in Sprague Dawley Rats.
Journal of Clinical Medicine. 2021
Victor Yip, M. Violet Lee, Sylvia Wong, Ola Saad, Shuguang Ma, S. Cyrus Khojasteh, and Ben-Quan Shen*.
Anti-Lymphocyte Antigen 6 Complex, Locus E- Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α 1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals.
Drug Metab. Dispos. 2020
Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath, and Ben-Quan Shen*.
Characterization of Tissue Distribution, Catabolism and Elimination of an Anti-Staphylococcus aureus THIOMABTM Antibody-Antibiotic Conjugate in Rats.
Drug Metab. Dispos. 2020
Hao Cai, Victor Yip, M. Violet Lee, Sylvia Wong, Ola Saad, Shuguang Ma, Nina Ljumanovic, S. Cyrus Khojasteh, Amrita V. Kamath, and Ben-Quan Shen*.
Impact of conjugation site on ADC stability and biological activity.
Nature Biotechnology. 2012 (*Received 2015 World ADC Conference Best Publication Award 2010-2015; Highlighted in Nature Biotech 20 years Special Issue due to its impact on the ADC field over the past 20 years)
Ben-Quan Shen*, Keyang Xu*, …. and Junutula. J.R.
My Focus
Accountable for all investigative pharmacokinetics/pharmacodynamics (PK/PD) and ADME efforts for all projects in the gRED large molecule portfolio across all therapeutic areas to guide the design, development and delivery of large molecule therapeutics. This includes monoclonal antibodies (mAbs), antibody fragments, bispecifics, peptides, conjugates, ASOs, vaccines, cell and gene therapies, and imaging agents across early and late-stages of discovery and development.
Genentech Publications
Molecular Therapy - Methods and Clinical Development,
Hongzhi Wang; Ran Li; Shraddha Sadekar; Amrita Kamath; Shen
Advanced Drug Delivery Reviews, ISSN: 0169409X
Michael Z. Liao; Dan Lu; Tong Lu; Leonid Gibiansky; Rong Deng; Divya Samineni; Randall Dere; Andy Lin; Jamie Hirata; Shen; Donglu Zhang; Dongwei Li; Chunze Li; Dale Miles
Xenobiotica, ISSN: 00498254
Victor Yip; Ola M. Saad; Douglas Leipold; Chunze Li; Amrita Kamath; Shen
Journal of Pharmaceutical Sciences, ISSN: 00223549
Rajbharan Yadav; Siddharth Sukumaran; Jeff Lutman; Mayur S. Mitra; Wendy Halpern; Tianhe Sun; A F. Setiadi; Margaret Neighbors; X Rebecca Sheng; Victor Yip; Shen; Chang Liu; Lyrialle Han; Ayse Meric Ovacik; Yan Wu; Sara Glickstein; Rebecca Kunder; Joseph R. Arron; Lin Pan; Amrita Kamath; Stefanich
Chemical Science, ISSN: 20416539 20416520
Neelie Zacharias; Vladimir N. Podust; Kimberly K. Kajihara; Douglas Leipold; Geoffrey Del Rosario; Desiree Thayer; Emily Dong; Maciej Paluch; David Fischer; Kai Zheng; Corinna Lei; Jintang He; Carl Ng; Dian Su; Luna Liu; Shabkhaiz Masih; William S. Sawyer; Jeff N. Tinianow; Jan Marik; Victor Yip; Guangmin Li; Josefa Chuh; J. Hiroshi Morisaki; Summer Park; Bing Zheng; Hilda Hernandez-Barry; Kelly M. Loyet; Min Xu; Katherine R. Kozak; Gail L. Phillips; Shen; Cong Wu; Keyang Xu; Shang-Fan Yu; Amrita Kamath; Rebecca K. Rowntree; Dorothea Reilly; Thomas H. Pillow; Andrew G. Polson; Volker Schellenberger; Wouter L. W. Hazenbos; Jack D. Sadowsky
Chemical Science, ISSN: 20416539 20416520
Neelie Zacharias; Vladimir N. Podust; Kimberly K. Kajihara; Douglas Leipold; Geoffrey Del Rosario; Desiree Thayer; Emily Dong; Maciej Paluch; David Fischer; Kai Zheng; Corinna Lei; Jintang He; Carl Ng; Dian Su; Luna Liu; Shabkhaiz Masih; William S. Sawyer; Jeff N. Tinianow; Jan Marik; Victor Yip; Guangmin Li; Josefa Chuh; J. Hiroshi Morisaki; Summer Park; Bing Zheng; Hilda Hernandez-Barry; Kelly M. Loyet; Min Xu; Katherine R. Kozak; Gail Lewis Phillips; Shen; Cong Wu; Keyang Xu; Shang-Fan Yu; Amrita Kamath; Rebecca K. Rowntree; Dorothea Reilly; Thomas H. Pillow; Andrew G. Polson; Volker Schellenberger; Wouter L. W. Hazenbos; Jack D. Sadowsky
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Gail D. Lewis Phillips; Jun Guo; James R. Kiefer; William R. Proctor; Daniela Bumbaca Yadav; Noel Dybdal; Shen
Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X
Rebecca L. Best; Nichole E. LaPointe; Olga Azarenko; Herb Miller; Genualdi; Stephen Chih; Shen; Jordan; Wilson; Stuart C. Feinstein; Nicola J. Stagg
Journal of Clinical Medicine, ISSN: 20770383
Victor Yip; M. Violet Lee; Ola M. Saad; Shuguang Ma; S. Cyrus Khojasteh; Shen
Molecular Therapy, ISSN: 15250024 15250016
Colby S. Shemesh; Joy C. Hsu; Iraj Hosseini; Shen; Rotte; Patrick S. Twomey; Sandhya Girish; Benjamin Wu
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Victor Yip; Isabel Figueroa; Brandon Latifi; Shabkhaiz Masih; Carl Ng; Douglas Leipold; Amrita Kamath; Shen
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Hao Cai; Victor Yip; M. Violet Lee; Sylvia Wong; Ola M. Saad; Shuguang Ma; Nina Ljumanovic; S. Cyrus Khojasteh; Amrita Kamath; Shen
Pharmacology Research and Perspectives, ISSN: 20521707
Daniela Bumbaca Yadav; Arthur Reyes; Priyanka Gupta; Jean-Michel Vernes; Y. Gloria Meng; Michelle G. Schweiger; Shannon Stainton; Fuh; Fielder; Amrita Kamath; Shen
mAbs, ISSN: 19420870 19420862
Douglas Leipold; Isabel Figueroa; Shabkhaiz Masih; Brandon Latifi; Victor Yip; Shen; Randall Dere; Montserrat Carrasco-Triguero; M. Violet Lee; Ola M. Saad; Luna Liu; Jintang He; Dian Su; Keyang Xu; Brian R. Vuillemenot; Steven T. Laing; Melissa Schutten; Katherine R. Kozak; Bing Zheng; Andrew G. Polson; Amrita Kamath
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Guangmin Li; Jun Guo; Shen; Daniela Bumbaca; Mark X. Sliwkowski; Lisa Crocker; Jennifer A. Lacap; Gail L. Phillips
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Nicola J. Stagg; Shen; Flavia Brunstein; Chunze Li; Amrita Kamath; Fiona Zhong; Melissa Schutten; Bernard M. Fine
Drug Metabolism Letters, ISSN: 18723128
Shen; Daniela Bumbaca; Qin Yue; Ola M. Saad; Jay Tibbitts; S. Cyrus Khojasteh; Sandhya Girish
Bioanalysis, ISSN: 17576199 17576180
Ola M. Saad; Shen; Keyang Xu; S. Cyrus Khojasteh; Sandhya Girish; Surinder Kaur
Clinical Cancer Research, ISSN: 15573265 10780432
Hirdesh Uppal; Estelle Doudement; Kaushiki Mahapatra; Darbonne; Daniela Bumbaca; Shen; Xiaoyan Du; Ola M. Saad; Kristin Harden; Steve Olsen; Gail L. Phillips; Dylan P. Hartley; Mark X. Sliwkowski; Sandhya Girish; Donna M. Dambach; Vanitha Ramakrishnan
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Yuan Chen; Divya Samineni; Sophie Mukadam; Harvey Wong; Shen; Dan Lu; Sandhya Girish; Cornelis E. Hop; Jin Y. Jin; Chunze Li
mAbs, ISSN: 19420870 19420862
Amrita Kamath; Victor Yip; Priyanka Gupta; C. Andrew Boswell; Daniela Bumbaca; Peter Haughney; Joni Castro; Siao Ping Tsai; Glenn Pacheco; Ross; Minhong Yan; Lisa A. Damico; Leslie A. Khawli; Shen
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Thomas H. Pillow; Janet Y. Tien; Kathryn Parsons; Sunil Bhakta; Hao Li; Leanna Staben; Guangmin Li; Josefa Chuh; Aimee Fourie-O'Donohue; Martine Darwish; Victor Yip; Luna Liu; Douglas Leipold; Dian Su; Elmer Wu; Spencer; Shen; Keyang Xu; Katherine R. Kozak; Helga Raab; Richard L. Vandlen; Gail L. Phillips; Richard H. Scheller; Paul G. Polakis; Mark X. Sliwkowski; Flygare; Jagath R. Junutula
AAPS Journal, ISSN: 15507416
Brendan C. Bender; Douglas Leipold; Keyang Xu; Shen; Jay Tibbitts; Lena E. Friberg
mAbs, ISSN: 19420870 19420862
Victor Yip; Enzo Palma; Devin B. Tesar; Eduardo E. Mundo; Daniela Bumbaca; Elizabeth K. Torres; Noe A. Reyes; Shen; Fielder; Saileta Prabhu; Leslie A. Khawli; C. Andrew Boswell
Methods in Molecular Biology, ISSN: 10643745
Kedan Lin; Jay Tibbitts; Shen
Analytical Biochemistry, ISSN: 10960309 00032697
Martha Tan; Jean-Michel Vernes; Joyce Chan; Trinna L. Cuellar; Aarati Asundi; Nelson; Victor Yip; Shen; Richard L. Vandlen; Christian W. Siebel; Meng
Current Drug Metabolism, ISSN: 13892002 18755453
Shen; Daniela Bumbaca; Ola M. Saad; Qin Yue; Cinthia V Pastuskovas; S. Cyrus Khojasteh; Jay Tibbitts; Surinder Kaur; Wang; Yu-Waye Chu; Patricia M. LoRusso; Sandhya Girish
British Journal of Pharmacology, ISSN: 00071188 14765381
Daniela Bumbaca; Hong Xiang; C. Andrew Boswell; Ruediger E. Port; Shannon Stainton; Eduardo E. Mundo; Sheila Ulufatu; Anil Bagri; Frank-Peter Theil; Fielder; Leslie A. Khawli; Shen
Bioanalysis, ISSN: 17576180 17576199
Daniela Bumbaca; Raymond K. Tong; Alexander W. Koch; Hong Xiang; Laura DeForge; Shen; Yanmei Lu
Nature Biotechnology, ISSN: 15461696 10870156
Shen; Keyang Xu; Luna Liu; Helga Raab; Sunil Bhakta; Margaret Kenrick; Kathryn Parsons; Janet Y. Tien; Shang-Fan Yu; Elaine Mai; Dongwei Li; Jay Tibbitts; Jakub Baudys; Ola M. Saad; Suzie J. Scales; Paul McDonald; Hass; Eigenbrot; Trung Nguyen; Willy A. Solis; Reina N. Fuji; Kelly Flagella; Darshana Patel; Spencer; Leslie A. Khawli; Allen Ebens; Wai Lee T. Wong; Richard L. Vandlen; Surinder Kaur; Mark X. Sliwkowski; Richard H. Scheller; Paul G. Polakis; Jagath R. Junutula
Bioconjugate Chemistry, ISSN: 15204812 10431802
C. Andrew Boswell; Eduardo E. Mundo; Crystal Zhang; Daniela Bumbaca; Nicole R. Valle; Katherine R. Kozak; Aimee Fourie-O'Donohue; Josefa Chuh; Neelima Koppada; Ola M. Saad; Herman S. Gill; Shen; Bonnee Rubinfeld; Jay Tibbitts; Surinder Kaur; Frank-Peter Theil; Fielder; Leslie A. Khawli; Kedan Lin
Analytical Biochemistry, ISSN: 10960309 00032697
Keyang Xu; Luna Liu; Ola M. Saad; Jakub Baudys; Lara Williams; Douglas Leipold; Shen; Helga Raab; Jagath R. Junutula; Amy H. Kim; Surinder Kaur
mAbs, ISSN: 19420870 19420862
Daniela Bumbaca; Anne Wong; Elizabeth Drake; Arthur Reyes; Benjamin C. Lin; Jean-Philippe Stephan; Luc Desnoyers; Shen; Dennis
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Cinthia V Pastuskovas; William Mallet; Suzanna Clark; Margaret Kenrick; Nicholas Majidy; Michelle G. Schweiger; Marjie Van Hoy; Siao Ping Tsai; Bennett; Shen; Ross; Fielder; Leslie A. Khawli; Jay Tibbitts
Molecular Cancer Therapeutics, ISSN: 15357163
Kenneth Kolinsky; Shen; Yu-E. Zhang; Joseph Kohles; Ute Dugan; Zioncheck; David Heimbrook; Kathryn Packman; Higgins
Hypertension, ISSN: 0194911X
Renhui Yang; Annie Ogasawara; Zioncheck; Zhen Ren; Guo-Wei He; Geralyn G. Deguzman; Nicolas Pelletier; Shen; Bunting; Hongkui Jin
Journal of Biological Chemistry, ISSN: 00219258
Shen; David Y. Lee; Karen M. Cortopassi; Lisa A. Damico; Zioncheck
International Journal of Cancer, ISSN: 00207136
Jun Itakura; Toshiyuki Ishiwata; Shen; Marko Kornmann; Murray Korc
Journal of Biological Chemistry, ISSN: 00219258
Shen; David Y. Lee; Zioncheck
Pulmonary Pharmacology and Therapeutics, ISSN: 10945539
Shen; Widdicombe; Mrsny
Journal of Biological Chemistry, ISSN: 00219258
Shen; David Y. Lee; Hans-Peter Gerber; Keyt; Napoleone Ferrara; Zioncheck
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN: 10400605
Shen; Ralph J. Panos; Kim Hansen-Guzmán; Widdicombe; Mrsny
Journal of Biological Chemistry, ISSN: 00219258
Shen; Widdicombe; Mrsny
Journal of Biological Chemistry, ISSN: 00219258
Shen; Roger A. Barthelson; William Skach; Dieter C. Gruenert; Elliott Sigal; Mrsny; Widdicombe
Education
- UCSF, Postdoc, Pulmonary Lung Disease focused on Cystic Fibrosis – 1993
- Chinese Academy of Medical Sciences, China, MS in Occupational Lung Disease – 1987
- Nanjing Medical College, China, MD, Medical Sciences and Public Health – 1983
Awards & Honors
- Article was highlighted in Nature Biotech “20 year of Nature Biotechnology biomedical research" – 2016
- Received a World ADC Award for Best Publication from “2015 World ADC Conference" – 2015