Chong Han
Director and Sr Principal Scientist - Chemistry, Drug Discovery, Process Chemistry, Small Molecule Pharmaceutical Sciences
"I am driven by finding practical solutions to challenging chemical problems that could eventually make a difference in patient’s lives."
14
Years at Genentech
26
Publications at Genentech
4
Awards & Honors
I joined the small molecule process chemistry group in 2010 after a postdoctoral stint with Prof. Stephen Buchwald at MIT. My current role includes leading team efforts developing efficient and robust chemical processes to supply the active pharmaceutical ingredient (API) for clinical studies and building internal technology platforms in the area of high-throughput experimentation (HTE), transition-metal catalysis, and continuous flow chemistry.
Featured Publication
Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib
Org. Lett. 2017, 19, 4806–4809.
Han, C.; Savage, S.; Al-Sayah, M.; Yajiama, H.; Remarchuk, T.; Reents, R.; Wirz, B.; Iding, H.; Bachmann, S.; Fantasia, S.; Scalone, M.; Hell, A.; Hidber, P.; Gosselin, F.*
My Focus
As a process chemist, I strive to develop highly efficient and robust chemical/biochemical processes to support drug development needs on the active pharmaceutical ingredient (API), including supplies for clinical studies. In addition, I am motivated to build/develop state-of-the-art technology platforms such as high-throughput experimentation (HTE) and continuous flow chemistry to maximize our efficiency tackling challenging problems.
Genentech Publications
Organic Process Research and Development, ISSN: 10836160
Thomas M. Bass; Daniel Zell; Sean M. Kelly; Thomas C. Malig; José G. Napolitano; Lauren E. Sirois; Chong Han; Francis Gosselin
Journal of Organic Chemistry, ISSN: 00223263
Matthew M. Pompeo; Sean M. Kelly; Frederic St-Jean; Thomas M. Bass; Derek M. Dalton; Daniel Zell; Chong Han; Lauren E. Sirois; Francis Gosselin
Organic Process Research and Development, ISSN: 10836160
Johannes Burkhard; Sebastian Herold; Christian Leitner; Haiming Zhang; Remy Angelaud; Qingping Tian; Chong Han; Francis Gosselin
Organic Letters, ISSN: 15237060
Lin Deng; Julie A. Deichert; Sierra C. Nguyen; Ian S. Young; Chong Han
Organic Process Research and Development, ISSN: 10836160
Sean M. Kelly; René Lebl; Thomas C. Malig; Thomas M. Bass; Dominique Kummli; Dainis Kaldre; Ugo Orcel; Lars Tröndlin; David Linder; Joerg Sedelmeier; Stephan Bachmann; Chong Han; Haiming Zhang; Francis Gosselin
Journal of the American Chemical Society, ISSN: 15205126 00027863
Jie Xu; Samantha Grosslight; Kyle A. Mack; Sierra C. Nguyen; Kyle Clagg; Ngiap-Kie Lim; Jacob C. Timmerman; Jeff Shen; Nicholas A. White; Lauren E. Sirois; Chong Han; Haiming Zhang; Matthew S. Sigman; Francis Gosselin
Xenobiotica, ISSN: 13665928 00498254
Chenghong Zhang; Sungjoon Cho; José G. Napolitano; David Russell; Christine Gu; Alan Deese; Chong Han; Yuan Chen; Shuguang Ma
Journal of the American Chemical Society, ISSN: 15205126 00027863
Daniel Zell; Cian Kingston; Janis Jermaks; Sleight R. Smith; Natalie Seeger; Jana Wassmer; Lauren E. Sirois; Chong Han; Haiming Zhang; Matthew S. Sigman; Francis Gosselin
Analytical Chemistry, ISSN: 15206882 00032700
Alexandre Goyon; Colin Masui; Lauren E. Sirois; Chong Han; Peter M. Yehl; Francis Gosselin; Kelly Zhang
Angewandte Chemie - International Edition, ISSN: 15213773 14337851
Raphael Bigler; Kyle A. Mack; Jeff Shen; Paolo Tosatti; Chong Han; Stephan Bachmann; Haiming Zhang; Michelangelo Scalone; Andreas Pfaltz; Scott E. Denmark; Stefan Hildbrand; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Nicholas Wong; Filip Petronijević; Allen Y. Hong; Xin Linghu; Sean M. Kelly; Haiyun Hou; Theresa Cravillion; Ngiap-Kie Lim; Sarah J. Robinson; Chong Han; Carmela Molinaro; C. Gregory Sowell; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Chong Han; Lady Mae Alabanza; Sean M. Kelly; Douglas L. Orsi; Francis Gosselin; Ryan A. Altman
Tetrahedron, ISSN: 14645416 00404020
Chong Han; Sean M. Kelly; Theresa Cravillion; Scott Savage; Nguyen; Francis Gosselin
Tetrahedron, ISSN: 14645416 00404020
Chong Han; Sean M. Kelly; Theresa Cravillion; Scott Savage; Tina Nguyen; Francis Gosselin
Journal of Organic Chemistry, ISSN: 15206904 00223263
Scott Savage; Andrew McClory; Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Colin Masui; Sarah J. Robinson; Chong Han; Christoph Ochs; Pankaj D. Rege; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Qingping Tian; Danial Beaudry; Jessica L. Defreese; Alec Fettes; Philippe James; David Linder; Sushant Malhotra; Chong Han; Remy Angelaud; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Ian S. Young; Anna-Lena Glass; Theresa Cravillion; Chong Han; Haiming Zhang; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Michael E. Dalziel; Julie A. Deichert; Diane Carrera; Danial Beaudry; Chong Han; Haiming Zhang; Remy Angelaud
Organic Process Research and Development, ISSN: 1520586X 10836160
Chong Han; Keena L. Green; Kathrin Oehring; Arthur Meili; Eugen Pfeifer; Michelangelo Scalone; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Theresa Cravillion; Scott Savage; Andrew McClory; Chong Han; Haiming Zhang; Antonio G. DiPasquale; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Chong Han; Scott Savage; Mohammad Al-Sayah; Herbert M. Yajima; Travis Remarchuk; Reinhard Reents; Beat Wirz; Hans Iding; Stephan Bachmann; Serena M. Fantasia; Michelangelo Scalone; André Hell; Pirmin Hidber; Francis Gosselin
Journal of the American Chemical Society, ISSN: 15205126 00027863
Beryl X. Li; Diane N. Le; Kyle A. Mack; Andrew McClory; Ngiap-Kie Lim; Theresa Cravillion; Scott Savage; Chong Han; David B. Collum; Haiming Zhang; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Sean M. Kelly; Chong Han; Laura Tung; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Chong Han; Keena L. Green; Eugen Pfeifer; Francis Gosselin
Organic Process Research and Development, ISSN: 10836160
Chong Han; Keena L. Green; Eugen Pfeifer; Francis Gosselin
Tetrahedron Letters, ISSN: 18733581 00404039
Eugenia Pushkarskaya; Brian Wong; Chong Han; Simona S. Capomolla; Christine Gu; Brian M. Stoltz; Haiming Zhang
Education
- Massachusetts Institute of Technology, Department of Chemistry, Postdoctoral Associate – 2010
- Boston University, Ph.D. in Organic Chemistry – 2008
- Nankai University, B.S. in Chemistry – 2002
Awards & Honors
- ACS Industrial Young Investigator Award – 2020
- “Key Contributor” Award, Genentech – 2018
- Roche Environmental Awareness in Chemical Technology, (REACT) Award – 2013
- Sugata Ray Memorial Award for International Students, Boston University – 2007