Chun-Wan Yen

Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X-ray Scattering

ACS Nano 2023, 17, 11454-11465.

Hammel, M.; Fan, Y.; Sarode, A.; Byrnes, A.E.; Zang, N.; Kou, P.; Nagapudi, K.; Leung, D.; Hoogenraad, C.C.; Chen, T.; Yen, C.W.^*(co-corresponding author); Hura, G.L.^*

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Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticles formulations

Int J Pharm 2023, 637, 122874

Pratisinis, A.; Fan, Y.; Portmann, M.; Hammel, M.; Kou, P.; Sarode, A.; Ringler, P.; Kovacik, L. Lauer, M.E; Lamerz, J.; Hura, G.L.; Yen, C.W.^*(co-corresponding author); Keller, M.^*

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Lipid nanoparticle delivery alters antisense oligonucleotide activity and cellular distribution in the brain

Molecular Therapy Nucleic Acids, 2023, 32, 773-793

Byrnes, A.; Dominguez, S.; Yen, C.W.; Laufer, B.; Foreman, O.; Reichelt, M.; Lin, H.; Sagolla, M.; Hotzel, K.; Ngu, H.; Sondergaard, C.; Estevez, A.; Lin, H.C.; Goyon, A.; Bian, J.; Lin, J.; Hinz, F.; Friedman, B.; Easton, A.; Hoogenraad, C.

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Intraocular delivery considerations of ocular biologic products and key preclinical determinations

Expert Opinion on Drug Delivery, 2023, 16, 118

Huges, P^*.; Rivers, H.; Bantseev, V.; Yen, C. W.; Mahler, H.-C.; Gupta, S.

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Injectable polymer-nanoparticle hydrogel for the sustained intravitreal delivery of bimatopros

Adv. Therapeutics;, 2022, 2200207

Meany, E.; Andaya, R.; Tang, S.; Kasse, C.; Fuji, R.; Grosskopf, A.; d’Aquino, A.; Bartoe, J.; Ybarra, R.; Shelton, A.; Pederson, Z.; Hu, C.; Leung, D.; Nagapudi, K.; Ubhayakar, S.; Wright, M.; Yen, C.W.^*(co-corresponding author); Appel, E.^*

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High-throughput screening and characterization of lipid nanoparticle formulations for nucleic acid delivery

American Pharmaceutical Review, Oct 2022

Fan, Y.; Yen, C.W.; Shi, Z.; Chen, T.

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An integrated strategy for assessing the metabolic stability and biotransformation of macrocyclic peptides in drug discovery toward oral delivery

Anal. Chem.,  2022, 94, 2032

Guo, Y.; Ji, S.; Wang, W.; Wang, S.; Yen, C.W.; Hu, C.; Leung, D.H.; Plise, E.; Zhang, S.; Zhang, C.; Anene, U.; Zhang, D.^*; Cunningham C.; Khojasteh, S.C.; Su, D.^*

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Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded LNPs for neuronal gene silencing

Nanoscale Adv.,  2022, 4, 2107

Sarode, L.; Fan, Y.; Byrnes, A.; Hammel, M.; Hura, G.; Fu, Y.; Kou, P.; Hu, C.; Hinz, F.; Roberts, J.; Koenig, S.G.; Nagapudi, K.; Hoogenraad, C.; Chen, T.; Leung, D. Yen, C.W.^*

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Optimization of spray-drying parameters for formulation development at preclinical scale

AAPS PharmSciTech,  2022, 23, 28

Nespi, M.; Kuhn, R.; Yen, C.W.^*; Lubach, J.W.; Leung, D.

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Sustained delivery of ocular protein therapeutics

Chapter 4 of Implantable Technologies: Drug Delivery for Peptides, Biologics and Small Molecules by Royal Society of Chemistry, 2021

Rajapopal, K.; Yen, C.W.; Ranade, S.; Barteselli, G.; Hannoush R.N.

A systematic approach for liposome and lipodisk preclinical formulation development by microfluidic technology

The AAPS Journal 2021, 23(6), 111

Levy, E.S.; Yu, J.; Estevez, A.; Mao, J.; Liu, L.; Torres, E.; Leung, D.^*; Yen, C.W.^*

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Impact of surfactant selection and incorporation on in situ nanoparticle formulation from amorphous solid dispersion

 Int J Pharm 2021, 607, 120980

Yen, C.W.; Kuhn, R.; Hu, C.; Zhang, W.; Chiang, P.-C.; Chen, J. Z.; Hau, J.; Estevez, A.; Nagapudi, K.; Leung, D. H.

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Automated high-throughput preparation and characterization of oligonucleotide-loaded lipid nanoparticles

Int J Pharm 2021, 599, 120392

Fan, Y.; Yen, C.W. (co-first author); Lin, H.-C.; Hou, W.; Estevez, A; Sarode, A.; Goyon, A.; Bian, J.; Lin, J.; Koenig, S.G.; Leung, D.; Nagapudi, K.; Zhang. K.

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Discovery of a Dual Pathway Aggregation Mechanism for a Therapeutic Constrained Peptide

J. Pharm Sci 2021, 110(6), 2362

Chen, T. et al., including Yen, C.W.

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