Scientists / Our Scientists

Hartmut Koeppen

Senior Principal Fellow, Pathology, Research Biology

26

Years at Genentech

168

Publications at Genentech

I joined Genentech in April 1998 as Senior Pathologist after completion of my training as hematopathologist at The University of Chicago. I decided on this professional route because Genentech offered a way to apply my clinical training to basic and translational disease-focused research in a world-class facility among cutting edge scientists. I spent 2008 at MD Anderson to refresh my clinical skills. For the last few years I have been involved in efforts developing cancer immunotherapy approaches for clinical use. Genentech has changed a lot since I joined, but one vital constant is a collaborative team approach to science-based drug development.

Featured Publication

Automated tumor immunophenotyping predicts clinical benefit from anti-PD-L1 immunotherapy.

J Pathol. 2024

Li X, Eastham J, Giltnane JM, Zou W, Zijlstra A, Tabatsky E, Banchereau R, Chang CW, Nabet BY, Patil NS, Molinero L, Chui S, Harryman M, Lau S, Rangell L, Waumans Y, Kockx M, Orlova D, Koeppen H.

Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer.

Cancer Cell. 2022

Patil NS, Nabet BY, Müller S, Koeppen H., Zou W, Giltnane J, Au-Yeung A, Srivats S, Cheng JH, Takahashi C, de Almeida PE, Chitre AS, Grogan JL, Rangell L, Jayakar S, Peterson M, Hsia AW, O'Gorman WE, Ballinger M, Banchereau R, Shames DS.

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.

Nature. 2014

Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H., Hegde PS, Mellman I, Chen DS, Hodi FS.

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Nature. 2018

Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE III, Koeppen H., Astarita JL, Cubas R, Jhunjhunwala S, Banchereau R, Yang Y, Guan Y, Chalouni C, Ziai J, Şenbabaoğlu Y, Santoro S, Sheinson D, Hung J, Giltnane JM, Pierce AA, Mesh K, Lianoglou S, Riegler J, Carano RAD, Eriksson P, Höglund M, Somarriba L, Halligan DL, van der Heijden MS, Loriot Y, Rosenberg JE, Fong L, Mellman I, Chen DS, Green M, Derleth C, Fine GD, Hegde PS, Bourgon R, Powles T.

My current focus is pathology support for oncology drug development projects that have entered the phase of clinical evaluation. Our team develops and validates immunohistochemical and in-situ hybridization assays used for exploratory analyses; we collaborate with our Diagnostics partners to advance such assays as companion diagnostic assays to be approved in parallel with our therapeutics. Having had the privilege of doing research in tumor immunology in the laboratory of Hans Schreiber it is particularly rewarding for me to witness the recent clinical progress in harnessing the patient’s immune system in the fight against cancer.

The current focus of my research lab is to elucidate the role of p21-activated kinase 2 (PAK2) in vascular development, a project we are pursuing in collaboration with the Hoeflich laboratory in Translational Oncology. Previous areas of interest of our lab have been the role of ascl-2 in colorectal cancer, prostate-stem cell antigen as a potential target for antibody-drug conjugates and identification of biomarkers for antiangiogenic therapy approaches.

Molecular heterogeneity in urothelial carcinoma and determinants of clinical benefit to PD-L1 blockade

Cancer Cell, ISSN: 18783686 15356108

Habib Hamidi; Yasin Senbabaoglu; Niha Beig; Juliette Roels; Cyrus Manuel; Xiangnan Guan; Koeppen; Zoe June Assaf; Barzin Y. Nabet; Adrian Waddell; Kobe Yuen; Sophia L. Maund; Ethan S. Sokol; Jennifer M. Giltnane; Amber Schedlbauer; Eloisa Fuentes; James D. Cowan; Edward E. Kadel III; Viraj Degaonkar; Alexander Andreev-Drakhlin; Patrick Williams; Corey A. Carter; Suyasha Gupta; Elizabeth E. Steinberg; Yohann Loriot; Joaquim Bellmunt; Petros Grivas; Jonathan E. Rosenberg; Michiel S Van Der Heijden; Matthew D. Galsky; Thomas Powles; Sanjeev Mariathasan; Romain Banchereau

Immune heterogeneity in small-cell lung cancer and vulnerability to immune checkpoint blockade

Cancer Cell, ISSN: 15356108

Barzin Y. Nabet; Habib Hamidi; Myung Chang Lee; Romain Banchereau; Morris; Leah Adler; Velimir Gayevskiy; Ahmed M. Elhossiny; Srivastava; Namrata S. Patil; Kiandra A. Smith; Rajiv Jesudason; Caleb Chan; Patrick S. Chang; Matthew Fernandez; Sandra Rost; Lisa M McGinnis; Koeppen; Carl M. Gay; Minna; John V. Heymach; Joseph M. Chan; Charles M. Rudin; Lauren Averett Byers; Stephen V. Liu; Martin Reck; David S. Shames

Loss of CD20 expression as a mechanism of resistance to mosunetuzumab in relapsed/refractory B-cell lymphomas

Blood, ISSN: 00064971

Stephen J. Schuster; Huw; Christopher R. Bolen; Victor Maximov; Andrew G. Polson; Katerina Hatzi; Elisabeth A. Lasater; Sarit E. Assouline; Nancy L. Bartlett; Lihua E. Budde; Matthew Matasar; Koeppen; Emily C. Piccione; Deanna Wilson; Michael C. Wei; Shen Yin; Elicia M. Penuel

Automated tumor immunophenotyping predicts clinical benefit from anti-PD-L1 immunotherapy

Journal of Pathology, ISSN: 00223417

Xiao Li; Jeffrey Eastham; Jennifer M. Giltnane; Wei Zou; Andries Zijlstra; Evgeniy Tabatsky; Romain Banchereau; Ching-Wei Chang; Barzin Y. Nabet; Namrata S. Patil; Luciana L. Molinero; Steve Chui; Maureen Harryman; Shari Lau; Linda Rangell; Yannick Waumans; Mark Kockx; Darya Y. Orlova; Koeppen

Development of a Cryo-Pre-Embedding Immunogold Labeling Protocol for the Ultrastructural Localization of PDL1 in Human Tonsils

Microscopy and Microanalysis,

Miriam Baca; Cecile Chalouni; Koeppen; Linda Rangell; Meredith Sagolla; Mike Reichelt

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Blood advances, ISSN: 24739537 24739529

Antonina V. Kurtova; Melanie Heinlein; Simon Haas; Lars Velten; Gerrit J. P. Dijkgraaf; Elaine E. Storm; Noelyn Kljavin; Soufiane Boumahdi; Patricia Himmels; Aurelie Herault; Andrew G. Mancini; Koeppen; Monique Dail; Qingxiang Yan; Jianhuan Zhang; Ute Koch; Freddy Radtke; Zora Modrusan; Ciara Metcalfe; Robert Piskol; Frederic J. De Sauvage

CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy

Cell Reports Medicine, ISSN: 26663791

Mahrukh Huseni; Lifen Wang; Joanna E. Klementowicz; Kobe Yuen; Beatrice Breart; Christine Orr; L-F Liu; Yijin Li; Vinita Gupta; Congfen Li; Deepali Rishipathak; Jing Peng; Yasin Senbabaoglu; Zora Modrusan; Shilpa Keerthivasan; Shravan Madireddi; Ying-Jiun Chen; Eleanor J. Fraser; Ning Leng; Habib Hamidi; Koeppen; James Ziai; Kenji Hashimoto; Marcella Fassò; P. Mickey Williams; David F. McDermott; Jonathan E. Rosenberg; Thomas Powles; Leisha A. Emens; Priti S. Hegde; Ira Mellman; Shannon J. Turley; Mark S. Wilson; Sanjeev Mariathasan; Luciana L. Molinero; Mark Merchant; Nathaniel West

Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors

Nature Communications, ISSN: 20411723

Kristin M. Zimmerman Savill; Brian B. Lee; Jason Oeh; Jie Lin; Eva Lin; Wei-Jen Chung; Amy Young; Wennie Chen; Monika Miś; Kathryn Mesh; Jeffrey Eastham; Florian Gnad; Zhaoshi Jiang; Eric Stawiski; Benjamin Haley; Anneleen Daemen; Xiaojing Wang; Koeppen; Zora Modrusan; Scott Martin; Deepak Sampath; Kui Lin

Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors

Nature Communications, ISSN: 20411723

Kristin M. Zimmerman Savill; Brian B. Lee; Jason Oeh; Jie Lin; Eva Lin; Wei-Jen Chung; Amy Young; Wennie Chen; Monika Miś; Kathryn Mesh; Jeffrey Eastham; Florian Gnad; Zhaoshi Jiang; Eric Stawiski; Benjamin Haley; Anneleen Daemen; Xiaojing Wang; Koeppen; Zora Modrusan; Scott E. Martin; Deepak Sampath; Kui Lin

Whole-body CD8+ T cell visualization before and during cancer immunotherapy: a phase 1/2 trial

Nature Medicine, ISSN: 1546170X 10788956

Laura Kist de Ruijter; Pim P. van de Donk; Jahlisa S. Hooiveld-Noeken; Danique Giesen; Sjoerd G. Elias; Marjolijn N. Lub-de Hooge; Sjoukje F. Oosting; Mathilde Jalving; Timens; Adrienne H. Brouwers; Thomas C. Kwee; Jourik A. Gietema; Rudolf S. N. Fehrmann; Bernard M. Fine; Sandra M. Sanabria-Bohorquez; Mahesh Yadav; Koeppen; Jing Jing; Sebastián Guelman; Mark T. Lin; Michael Mamounas; Jeffrey Eastham; Patrick K. Kimes; Simon P. Williams; Alexander Ungewickell; Derk J. A. de Groot; Elisabeth G. E. De Vries

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers

Nature Communications, ISSN: 20411723

Jennifer Cantley; Ye; Emma Rousseau; Thomas Januario; Brian D. Hamman; Christopher M. Rose; Tommy K. Cheung; Trent Hinkle; Leofal Soto; Connor Quinn; Alicia Harbin; Elizabeth Bortolon; Xin Chen; Roy Haskell; Eva Lin; Shang-Fan Yu; Geoffrey Del Rosario; Emily Chan; Debra Dunlap; Koeppen; Scott E. Martin; Mark Merchant; Matt Grimmer; Broccatelli; Jing Wang; Jennifer Pizzano; Peter Dragovich; Michael Berlin; Robert Yauch

Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma

Nature Medicine, ISSN: 1546170X 10788956

Zhu; Abbas Alexander; Marina Ruiz de Galarreta; Yinghui Guan; Shan Lu; Koeppen; Wenjun Zhang; Chih-Hung Hsu; Aiwu Ruth He; Baek-Yeol Ryoo; Thomas Yau; Ahmed Kaseb; Adam M. Burgoyne; Farshid Dayyani; Spahn; Wendy Verret; Richard S. Finn; Han Chong Toh; Amaia Lujambio; Wang

Immune contexture of paediatric cancers

European Journal of Cancer, ISSN: 18790852 09598049

Meghna Das Thakur; Carl Franz; Laura Brennan; Jurriaan Brouwer-Visser; Rachel Tam; Konstanty Korski; Koeppen; James Ziai; Galina Babitzki; Dominique Ranchere-Vince; Alexandre Vasiljevic; Frédérique Dijoud; Perrine Marec-Bérard; Isabelle Rochet; Michael A. Cannarile; Aurélien Marabelle

Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors

Nature Biotechnology, ISSN: 15461696 10870156

Christopher W. Davies; Angela Oh; Rana Mroue; Micah Steffek; John M. Bruning; Yang Xiao; Siyu Feng; Sangeeta Jayakar; Emily Chan; Vidhyalakshmi Arumugam; Sean Carlo Uribe; Jake Drummond; Alexandra Frommlet; Cheng Lu; Yvonne Franke; Mark Merchant; Koeppen; John Quinn; Sushant Malhotra; Steven Do; Lewis Gazzard; Hans E. Purkey; Joachim Rudolph; Melinda M. Mulvihill; James T. Koerber; Weiru Wang; Marie Evangelista

Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer

Cancer Cell, ISSN: 18783686 15356108

Namrata S. Patil; Barzin Y. Nabet; Sören Müller; Koeppen; Wei Zou; Jennifer M. Giltnane; Amelia Au-Yeung; Shyam Srivats; Jason H. Cheng; Chikara Takahashi; Patricia De Almeida; Avantika S. Chitre; Jane L. Grogan; Linda Rangell; Sangeeta Jayakar; Maureen Peterson; Allison W. Hsia; William E. O'Gorman; Ballinger; Romain Banchereau; David S. Shames

Comparison of SP142 and 22C3 Immunohistochemistry PD-L1 Assays for Clinical Efficacy of Atezolizumab in Non–Small Cell Lung Cancer: Results From the Randomized OAK Trial

Clinical Lung Cancer, ISSN: 19380690 15257304

Shirish M. Gadgeel; Fred R. Hirsch; Keith M. Kerr; Fabrice Barlesi; Keunchil Park; Achim Rittmeyer; Wei Zou; Namrata Bhatia; Koeppen; Sarah M. Paul; David S. Shames; Jing Yi; Christina Matheny; Ballinger; Mark L. McCleland; David R. Gandara

Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors

Nature Biotechnology, ISSN: 15461696 10870156

Christopher W. Davies; Angela Oh; Rana Mroue; Micah Steffek; John M. Bruning; Yang Xiao; Siyu Feng; Sangeeta Jayakar; Emily Chan; Vidhyalakshmi Arumugam; Sean Carlo Uribe; Jake Drummond; Alexandra Frommlet; Cheng Lu; Yvonne Franke; Mark Merchant; Koeppen; John Quinn; Sushant Malhotra; Steven Do; Lewis Gazzard; Hans E. Purkey; Joachim Rudolph; Melinda M. Mulvihill; James T. Koerber; Weiru Wang; Marie Evangelista

Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma

Nature Medicine, ISSN: 10788956

Zhu; Abbas Alexander; Marina Ruiz de Galarreta; Yinghui Guan; Shan Lu; Koeppen; Wenjun Zhang; Chih-Hung Hsu; Aiwu Ruth He; Baek-Yeol Ryoo; Thomas Yau; Ahmed Kaseb; Adam M. Burgoyne; Farshid Dayyani; Spahn; Wendy Verret; Richard S. Finn; Han Chong Toh; Amaia Lujambio; Wang

Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma

Nature Medicine, ISSN: 1546170X 10788956

Zhu; Abbas Alexander; Marina Ruiz de Galarreta; Yinghui Guan; Shan Lu; Koeppen; Wenjun Zhang; Chih-Hung Hsu; Aiwu Ruth He; Baek-Yeol Ryoo; Thomas Yau; Ahmed Kaseb; Adam M. Burgoyne; Farshid Dayyani; Spahn; Wendy Verret; Richard S. Finn; Han Chong Toh; Amaia Lujambio; Wang

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α

Nature Communications, ISSN: 20411723

Adrien Le Thomas; Elena Ferri; Scot A. Marsters; Jonathan M. Harnoss; David Lawrence; Iratxe Zuazo-Gaztelu; Zora Modrusan; Sara Chan; Margaret Solon; Cecile Chalouni; Weihan Li; Koeppen; Joachim Rudolph; Weiru Wang; Thomas D Wu; Peter Walter; Avi Ashkenazi

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α

Nature Communications, ISSN: 20411723

Adrien Le Thomas; Elena Ferri; Scot A. Marsters; Jonathan M. Harnoss; David Lawrence; Iratxe Zuazo-Gaztelu; Zora Modrusan; Sara M. Chan; Margaret Solon; Cecile Chalouni; Weihan Li; Koeppen; Joachim Rudolph; Weiru Wang; Thomas D Wu; Peter Walter; Avi Ashkenazi

Characterization of Tumor-immune Microenvironment by High-throughput Image Analysis of CD8 Immunohistochemistry Combined With Modified Masson’s Trichrome

Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554

Charles Havnar; Shari Lau; Jeffrey Hung; Jeffrey Eastham-Anderson; Carmina Espiritu; Linda Rangell; Koeppen; James Ziai; Oded Foreman

Microenvironmental regulation of tumour immunity and response to immunotherapy

Journal of Pathology, ISSN: 10969896 00223417

Mark Kockx; Mark L. McCleland; Koeppen

Recent Advances in Pathology: the 2021 Annual Review Issue of The Journal of Pathology

Journal of Pathology, ISSN: 10969896 00223417

C Simon Herrington; Richard Poulsom; Koeppen; Philip J Coates

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

Journal for ImmunoTherapy of Cancer, ISSN: 20511426

Romain Banchereau; Avantika S. Chitre; Alexis Scherl; Thomas D Wu; Namrata S. Patil; Patricia De Almeida; Edward E. Kadel III; Shravan Madireddi; Amelia Au-Yeung; Chikara Takahashi; Ying-Jiun Chen; Zora Modrusan; Jacqueline McBride; Rhea Nersesian; Ehab A. El-Gabry; Mark D. Robida; Jeffrey Hung; Marcin Kowanetz; Wei Zou; Mark L. McCleland; Patrick Caplazi; Shadi Toghi Eshgi; Koeppen; Priti Hegde; Ira Mellman; W Rodney Mathews; Thomas Powles; Sanjeev Mariathasan; Jane L. Grogan; William E. O'Gorman

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

Journal for ImmunoTherapy of Cancer, ISSN: 20511426

Romain Banchereau; Avantika S. Chitre; Alexis Scherl; Thomas D Wu; Namrata S. Patil; Patricia De Almeida; Edward E. Kadel III; Shravan Madireddi; Amelia Au-Yeung; Chikara Takahashi; Ying-Jiun Chen; Zora Modrusan; Jacqueline McBride; Rhea Nersesian; Ehab El Gabry; Mark D. Robida; Jeffrey Hung; Marcin Kowanetz; Wei Zou; Mark L. McCleland; Patrick Caplazi; Shadi Toghi Eshgi; Koeppen; Priti Hegde; Ira Mellman; W Rodney Mathews; Thomas Powles; Sanjeev Mariathasan; Jane L. Grogan; William E. O'Gorman

Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade (Nature Medicine, (2020), 26, 5, (693-698), 10.1038/s41591-020-0860-1)

Nature Medicine, ISSN: 1546170X 10788956

Kobe Yuen; L-F Liu; Vinita Gupta; Shravan Madireddi; Shilpa Keerthivasan; Congfen Li; Deepali Rishipathak; P. Mickey Williams; Edward E. Kadel III; Koeppen; Ying-Jiun Chen; Zora Modrusan; Jane L. Grogan; Romain Banchereau; Ning Leng; AnnChristine Thåström; Xiaodong Shen; Kenji Hashimoto; Darren Tayama; Michiel S Van Der Heijden; Jonathan E. Rosenberg; David McDermott; Thomas Powles; Priti Hegde; Mahrukh Huseni; Sanjeev Mariathasan

Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade

Cancer Cell, ISSN: 18783686 15356108

Robert J. Motzer; Romain Banchereau; Habib Hamidi; Thomas Powles; David McDermott; Michael B. Atkins; Bernard Escudier; L-F Liu; Ning Leng; Abbas Alexander; Jinzhen Fan; Koeppen; Jennifer Lin; Susheela Carroll; Kenji Hashimoto; Sanjeev Mariathasan; Marjorie Green; Darren Tayama; Priti Hegde; Christina Schiff; Mahrukh Huseni; Brian I Rini

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

npj Breast Cancer, ISSN: 23744677

Zuzana Kos; Elvire Roblin; Rim S. Kim; Stefan Michiels; Brandon D. Gallas; Weijie Chen; Koen Van De Vijver; Shom Goel; Sylvia Adams; Sandra Demaria; Giuseppe Viale; Torsten Nielsen; Sunil Badve; W Fraser Symmans; Christos Sotiriou; David Rimm; Stephen M. Hewitt; Carsten Denkert; Sibylle Loibl; Stephen J Luen; John M. S. Bartlett; Peter Savas; Giancarlo Pruneri; Deborah A. Dillon; Maggie Chon U. Cheang; Andrew Tutt; Jacqueline A. Hall; Kok; Hugo M. Horlings; Anant Madabhushi; Jeroen van der Laak; Francesco Ciompi; Anne-Vibeke Laenkholm; Enrique Bellolio; Tina Gruosso; Stephen B. Fox; Juan Carlos Araya; Giuseppe Floris; Jan Hudeček; Leonie Voorwerk; Andrew H Beck; Jen Kerner; Denis Larsimont; Sabine Declercq; Gert G.G.M. Van Den Eynden; Pusztai; Anna Ehinger; Wentao Yang; Khalid AbdulJabbar; Yinyin Yuan; Rajendra Singh; Crispin Hiley; Maise Al Bakir; Alexander J. Lazar; Stephen Naber; Stephan Wienert; Miluska Castillo; Giuseppe Curigliano; Maria V. Dieci; Fabrice Andre; Charles Swanton; Jorge S. Reis-Filho; Joseph Sparano; Eva Balslev; I-Chun Chen; Elisabeth Ida Specht Stovgaard; Katherine L. Pogue-Geile; Kim R. M. Blenman; Frederique Penault-Llorca; Stuart J. Schnitt; Sunil Lakhani; Anne Vincent-Salomon; Federico Rojo; Jeremy P. Braybrooke; Matthew G. Hanna; Teresa Soler; Daniel Bethmann; Carlos A Castaneda; Karen Willard-Gallo; Ashish Sharma; Huang-Chun Lien; Susan Fineberg; Jeppe Thagaard; Laura Comerma; Paula I. Gonzalez-Ericsson; Edi Brogi; Sherene Loi; Joel Saltz; Frederick Klaushen; Lee Cooper; Mohamed Amgad; David A. Moore; Roberto Salgado; Aini Hyytiäinen; Akira I. Hida; Alastair M. Thompson; Alex Lefevre; Allen Gown; Amy Lo; Anna Sapino; Andre Moreira; Andrea Richardson; Andrea Vingiani; Andrew M. Bellizzi; Angel Guerrero; Anita Grigoriadis; Ana C. Garrido-Castro; Ashley Cimino-Mathews; Ashok Srinivasan; Balazs Acs; Baljit Singh; Benjamin Calhoun; Benjamin Haibe-Kans; Benjamin Solomon; Bibhusal Thapa; Brad H. Nelson; Carmen Ballesteroes-Merino; Carmen Criscitiello; Carolien Boeckx; Cecile Colpaert; Cecily Quinn; Chakra S. Chennubhotla; Cinzia Solinas; Damien Drubay; Dhanusha Sabanathan; Dieter Peeters; Zardavas; Doris Höflmayer; Douglas B. Johnson; Thompson; Edith A. Perez; Ehab Elgabry; Elizabeth F. Blackley; Emily Reisenbichler; Ewa Chmielik; Fabien Gaire; Fang-I Lu; Farid Azmoudeh-Ardalan; Franklin V. Peale Jr.; Fred R. Hirsch; Gabriela Acosta-Haab; Gelareh Farshid; Glenn Broeckx; Koeppen; Harry R. Haynes; Heather McArthur; Heikki Joensuu; Helena Olofsson; Ian A. Cree; Iris Nederlof; Isabel Frahm; Iva Brcic; Jack Chan; James Ziai; Jane Brock; Jelle Weseling; Jennifer M. Giltnane; Jerome Lemonnier; Jiping Zha; Joana Ribeiro; Jochen K. Lennerz; Jodi M. Carter; Johan Hartman; Johannes Hainfellner; John Le Quesne; Jonathan W. Juco; Jose van den Berg; Joselyn Sanchez; Joël Cucherousset; Julien Adam; Justin M. Balko; Kai Saeger; Kalliopi Siziopikou; Karolina Sikorska; Karsten Weber; Keith E. Steele; Kenneth Emancipator; Khalid El Bairi; Kimberly H. Allison; Konstanty Korski; Laurence Buisseret; Leming Shi; Loes F. S. Kooreman; Luciana L. Molinero; Mónica V. Estrada; Maartje Van Seijen; Magali Lacroix-Triki; Manu M. Sebastian; Marcelo L. Balancin; Marie-Christine Mathieu; Mark van de Vijver; Marlon C. Rebelatto; Martine Piccart; Matthew P. Goetz; Matthias Preusser; Mehrnoush Khojasteh; Melinda E. Sanders; Meredith M. Regan; Michael Barnes; Michael Christie; Michael Misialek; Michail Ignatiadis; Michiel de Maaker; Mieke Van Bockstal; Nadia Harbeck; Nadine Tung; Nele Laudus; Nicolas Sirtaine; Nicole Burchardi; Nils Ternes; Nina Radosevic-Robin; Oleg Gluz; Oliver Grimm; Nuciforo; Paul Jank; Pawan Kirtani; Peter H. Watson; Peter Jelinic; Prudence A. Francis; Prudence A. Russell; Robert H. Pierce; Robert Hills; Roberto Leon-Ferre; Roland De Wind; Ruohong Shui; Samuel Leung; Sami Tabbarah; Sandra C. Souza; Sandra O’Toole; Sandra M. Swain; Sarah Dudgeon; Scooter Willis; Scott Ely; Shahinaz Bedri; Sheeba Irshad; Shi-Wei Liu; Shona Hendry; Simonetta Bianchi; Sofia Bragança; Soonmyung Paik; Sua Luz; Thomas Gevaert; Timothy d’Alfons; Tom John; Tomohagu Sugie; Uday Kurkure; Veerle Bossuyt; Venkata Manem; Vincente Peg Cámaea; Weida Tong; William T. Tran; Yihong Wang; Yves Allory; Zaheed Husain; Zsuzsanna Bago-Horvath

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

npj Breast Cancer, ISSN: 23744677

Jan Hudeček; Leonie Voorwerk; Maartje Van Seijen; Iris Nederlof; Michiel de Maaker; Jose van den Berg; Koen Van De Vijver; Karolina Sikorska; Sylvia Adams; Sandra Demaria; Giuseppe Viale; Torsten Nielsen; Sunil Badve; Stefan Michiels; W Fraser Symmans; Christos Sotiriou; David Rimm; Stephen M. Hewitt; Carsten Denkert; Sibylle Loibl; Sherene Loi; John M. S. Bartlett; Giancarlo Pruneri; Deborah A. Dillon; Maggie Chon U. Cheang; Andrew Tutt; Jacqueline A. Hall; Zuzana Kos; Roberto Salgado; Kok; Hugo M. Horlings; Aini Hyytiäinen; Akira I. Hida; Alastair M. Thompson; Alex Lefevre; Alexander J. Lazar; Allen Gown; Amy Lo; Anna Sapino; Anant Madabhushi; Andre Moreira; Andrea Richardson; Andrea Vingiani; Andrew H Beck; Andrew M. Bellizzi; Angel Guerrero; Anita Grigoriadis; Anna Ehinger; Ana C. Garrido-Castro; Anne Vincent-Salomon; Anne-Vibeke Laenkholm; Ashish Sharma; Ashley Cimino-Mathews; Ashok Srinivasan; Balazs Acs; Baljit Singh; Benjamin Calhoun; Benjamin Haibe-Kans; Benjamin Solomon; Bibhusal Thapa; Brad H. Nelson; Brandon D. Gallas; Carlos A Castaneda; Carmen Ballesteros-Merino; Carmen Criscitiello; Carolien Boeckx; Cecile Colpaert; Cecily Quinn; Chakra S. Chennubhotla; Charles Swanton; Cinzia Solinas; Crispin Hiley; Damien Drubay; Daniel Bethmann; David A. Moore; Denis Larsimont; Dhanusha Sabanathan; Dieter Peeters; Zardavas; Doris Höflmayer; Douglas B. Johnson; Thompson; Edi Brogi; Edith A. Perez; Ehab Elgabry; Elisabeth Ida Specht Stovgaard; Elizabeth F. Blackley; Elvire Roblin; Emily Reisenbichler; Enrique Bellolio; Eva Balslev; Ewa Chmielik; Fabien Gaire; Fabrice Andre; Fang-I Lu; Farid Azmoudeh-Ardalan; Federico Rojo; Tina Gruosso; Francesco Ciompi; Franklin V. Peale Jr.; Fred R. Hirsch; Frederick Klauschen; Frederique Penault-Llorca; Gabriela Acosta-Haab; Gelareh Farshid; Gert G.G.M. Van Den Eynden; Giuseppe Curigliano; Giuseppe Floris; Glenn Broeckx; Gonzalez-Ericsson; Koeppen; Harry R. Haynes; Heather McArthur; Heikki Joensuu; Helena Olofsson; Huang-Chun Lien; I-Chun Chen; Ian A. Cree; Isabel Frahm; Iva Brcic; Jack Chan; James Ziai; Jane Brock; Jelle Wesseling; Jennifer M. Giltnane; Jen Kerner; Jeppe Thagaard; Jeremy P. Braybrooke; Jeroen van der Laak; Jerome Lemonnier; Jiping Zha; Joana Ribeiro; Jochen K. Lennerz; Jodi M. Carter; Joel Saltz; Johan Hartman; Johannes Hainfellner; John Le Quesne; Jonathan W. Juco; Jorge S. Reis-Filho; Joselyn Sanchez; Joseph Sparano; Joël Cucherousset; Juan Carlos Araya; Julien Adam; Justin M. Balko; Kai Saeger; Kalliopi Siziopikou; Karen Willard-Gallo; Karsten Weber; Katherine L. Pogue-Geile; Keith E. Steele; Kenneth Emancipator; Khalid AbdulJabbar; Khalid El Bairi; Kim R. M. Blenman; Kimberly H. Allison; Konstanty Korski; Pusztai; Laura Comerma; Laurence Buisseret; Lee Cooper; Leming Shi; Loes F. S. Kooreman; Luciana L. Molinero; Mónica V. Estrada; Magali Lacroix-Triki; Maise Al Bakir; Manu M. Sebastian; Mark van de Vijver; Marcelo L. Balancin; Maria V. Dieci; Marie-Christine Mathieu; Marlon C. Rebelatto; Martine Piccart; Matthew G. Hanna; Matthew P. Goetz; Matthias Preusser; Mehrnoush Khojasteh; Melinda E. Sanders; Meredith M. Regan; Michael Barnes; Michael Christie; Michael Misialek; Michail Ignatiadis; Mieke Van Bockstal; Miluska Castillo; Mohamed Amgad; Nadia Harbeck; Nadine Tung; Nele Laudus; Nicolas Sirtaine; Nicole Burchardi; Nils Ternes; Nina Radosevic-Robin; Oleg Gluz; Oliver Grimm; Nuciforo; Paul Jank; Paula I. Gonzalez-Ericsson; Pawan Kirtani; Peter Jelinic; Peter H. Watson; Peter Savas; Prudence A. Francis; Prudence A. Russell; Rajendra Singh; Rim S. Kim; Robert H. Pierce; Robert Hills; Roberto Leon-Ferre; Roland De Wind; Ruohong Shui; Sabine De Clercq; Samuel Leung; Sami Tabbarah; Sandra C. Souza; Sandra O’Toole; Sandra M. Swain; Sarah Dudgeon; Scooter Willis; Scott Ely; Seong-Rim Kim; Shahinaz Bedri; Sheeba Irshad; Shi-Wei Liu; Shom Goel; Shona Hendry; Simonetta Bianchi; Sofia Bragança; Soonmyung Paik; Stephan Wienert; Stephen B. Fox; Stephen J Luen; Stephen Naber; Stuart J. Schnitt; Luz F. Sua; Sunil Lakhani; Susan Fineberg; Teresa Soler; Thomas Gevaert; Timothy D’Alfonso; Tom John; Tomohagu Sugie; Uday Kurkure; Veerle Bossuyt; Venkata Manem; Vincente Peg Cámara; Weida Tong; Weijie Chen; Wentao Yang; William T. Tran; Yihong Wang; Yinyin Yuan; Yves Allory; Zaheed Husain; Zsuzsanna Bago-Horvath

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer

Nature Communications, ISSN: 20411723

Mélanie Desbois; Akshata R. Udyavar; Lisa Ryner; Cleopatra Kozlowski; Yinghui Guan; Milena Dürrbaum; Shan Lu; Jean-Philippe Fortin; Koeppen; James Ziai; Ching-Wei Chang; Shilpa Keerthivasan; Marie Plante; Richard Bourgon; Carlos Bais; Priti Hegde; Anneleen Daemen; Shannon J. Turley; Wang

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

npj Breast Cancer, ISSN: 23744677

Zuzana Kos; Elvire Roblin; Rim S. Kim; Stefan Michiels; Brandon D. Gallas; Weijie Chen; Koen Van De Vijver; Shom Goel; Sylvia Adams; Sandra Demaria; Giuseppe Viale; Torsten Nielsen; Sunil Badve; W Fraser Symmans; Christos Sotiriou; David Rimm; Stephen M. Hewitt; Carsten Denkert; Sibylle Loibl; Stephen J Luen; John M. S. Bartlett; Peter Savas; Giancarlo Pruneri; Deborah A. Dillon; Maggie Chon U. Cheang; Andrew Tutt; Jacqueline A. Hall; Kok; Hugo M. Horlings; Anant Madabhushi; Jeroen van der Laak; Francesco Ciompi; Anne-Vibeke Laenkholm; Enrique Bellolio; Tina Gruosso; Stephen B. Fox; Juan Carlos Araya; Giuseppe Floris; Jan Hudeček; Leonie Voorwerk; Andrew H. Beck; Jen Kerner; Denis Larsimont; Sabine Declercq; Gert G.G.M. Van Den Eynden; Pusztai; Anna Ehinger; Wentao Yang; Khalid AbdulJabbar; Yinyin Yuan; Rajendra Singh; Crispin Hiley; Maise Al Bakir; Alexander J. Lazar; Stephen Naber; Stephan Wienert; Miluska Castillo; Giuseppe Curigliano; Maria V. Dieci; Fabrice Andre; Charles Swanton; Jorge S. Reis-Filho; Joseph Sparano; Eva Balslev; I-Chun Chen; Elisabeth Ida Specht Stovgaard; Katherine L. Pogue-Geile; Kim R. M. Blenman; Frederique Penault-Llorca; Stuart J. Schnitt; Sunil Lakhani; Anne Vincent-Salomon; Federico Rojo; Jeremy P. Braybrooke; Matthew G. Hanna; Teresa Soler; Daniel Bethmann; Carlos A Castaneda; Karen Willard-Gallo; Ashish Sharma; Huang-Chun Lien; Susan Fineberg; Jeppe Thagaard; Laura Comerma; Paula I. Gonzalez-Ericsson; Edi Brogi; Sherene Loi; Joel Saltz; Frederick Klaushen; Lee Cooper; Mohamed Amgad; David A. Moore; Roberto Salgado; Aini Hyytiäinen; Akira I. Hida; Alastair M. Thompson; Alex Lefevre; Allen Gown; Amy Lo; Anna Sapino; Andre Moreira; Andrea Richardson; Andrea Vingiani; Andrew M. Bellizzi; Angel Guerrero; Anita Grigoriadis; Ana C. Garrido-Castro; Ashley Cimino-Mathews; Ashok Srinivasan; Balazs Acs; Baljit Singh; Benjamin Calhoun; Benjamin Haibe-Kans; Benjamin Solomon; Bibhusal Thapa; Brad H. Nelson; Carmen Ballesteroes-Merino; Carmen Criscitiello; Carolien Boeckx; Cecile Colpaert; Cecily Quinn; Chakra S. Chennubhotla; Cinzia Solinas; Damien Drubay; Dhanusha Sabanathan; Dieter Peeters; Zardavas; Doris Höflmayer; Douglas B. Johnson; Thompson; Edith A. Perez; Ehab Elgabry; Elizabeth F. Blackley; Emily Reisenbichler; Ewa Chmielik; Fabien Gaire; Fang-I Lu; Farid Azmoudeh-Ardalan; Franklin V. Peale Jr.; Fred R. Hirsch; Gabriela Acosta-Haab; Gelareh Farshid; Glenn Broeckx; Koeppen; Harry R. Haynes; Heather McArthur; Heikki Joensuu; Helena Olofsson; Ian A. Cree; Iris Nederlof; Isabel Frahm; Iva Brcic; Jack Chan; James Ziai; Jane Brock; Jelle Weseling; Jennifer M. Giltnane; Jerome Lemonnier; Jiping Zha; Joana Ribeiro; Jochen K. Lennerz; Jodi M. Carter; Johan Hartman; Johannes Hainfellner; John Le Quesne; Jonathan W. Juco; Jose van den Berg; Joselyn Sanchez; Joël Cucherousset; Julien Adam; Justin M. Balko; Kai Saeger; Kalliopi Siziopikou; Karolina Sikorska; Karsten Weber; Keith E. Steele; Kenneth Emancipator; Khalid El Bairi; Kimberly H. Allison; Konstanty Korski; Laurence Buisseret; Leming Shi; Loes F. S. Kooreman; Luciana L. Molinero; Mónica V. Estrada; Maartje Van Seijen; Magali Lacroix-Triki; Manu M. Sebastian; Marcelo L. Balancin; Marie-Christine Mathieu; Mark van de Vijver; Marlon C. Rebelatto; Martine Piccart; Matthew P. Goetz; Matthias Preusser; Mehrnoush Khojasteh; Melinda E. Sanders; Meredith M. Regan; Michael Barnes; Michael Christie; Michael Misialek; Michail Ignatiadis; Michiel de Maaker; Mieke Van Bockstal; Nadia Harbeck; Nadine Tung; Nele Laudus; Nicolas Sirtaine; Nicole Burchardi; Nils Ternes; Nina Radosevic-Robin; Oleg Gluz; Oliver Grimm; Nuciforo; Paul Jank; Pawan Kirtani; Peter H. Watson; Peter Jelinic; Prudence A. Francis; Prudence A. Russell; Robert H. Pierce; Robert Hills; Roberto Leon-Ferre; Roland De Wind; Ruohong Shui; Samuel Leung; Sami Tabbarah; Sandra C. Souza; Sandra O’Toole; Sandra M. Swain; Sarah Dudgeon; Scooter Willis; Scott Ely; Shahinaz Bedri; Sheeba Irshad; Shi-Wei Liu; Shona Hendry; Simonetta Bianchi; Sofia Bragança; Soonmyung Paik; Sua Luz; Thomas Gevaert; Timothy d’Alfons; Tom John; Tomohagu Sugie; Uday Kurkure; Veerle Bossuyt; Venkata Manem; Vincente Peg Cámaea; Weida Tong; William T. Tran; Yihong Wang; Yves Allory; Zaheed Husain; Zsuzsanna Bago-Horvath

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

npj Breast Cancer, ISSN: 23744677

Jan Hudeček; Leonie Voorwerk; Maartje Van Seijen; Iris Nederlof; Michiel de Maaker; Jose van den Berg; Koen Van De Vijver; Karolina Sikorska; Sylvia Adams; Sandra Demaria; Giuseppe Viale; Torsten Nielsen; Sunil Badve; Stefan Michiels; W Fraser Symmans; Christos Sotiriou; David Rimm; Stephen M. Hewitt; Carsten Denkert; Sibylle Loibl; Sherene Loi; John M. S. Bartlett; Giancarlo Pruneri; Deborah A. Dillon; Maggie Chon U. Cheang; Andrew Tutt; Jacqueline A. Hall; Zuzana Kos; Roberto Salgado; Kok; Hugo M. Horlings; Aini Hyytiäinen; Akira I. Hida; Alastair M. Thompson; Alex Lefevre; Alexander J. Lazar; Allen Gown; Amy Lo; Anna Sapino; Anant Madabhushi; Andre Moreira; Andrea Richardson; Andrea Vingiani; Andrew H. Beck; Andrew M. Bellizzi; Angel Guerrero; Anita Grigoriadis; Anna Ehinger; Ana C. Garrido-Castro; Anne Vincent-Salomon; Anne-Vibeke Laenkholm; Ashish Sharma; Ashley Cimino-Mathews; Ashok Srinivasan; Balazs Acs; Baljit Singh; Benjamin Calhoun; Benjamin Haibe-Kans; Benjamin Solomon; Bibhusal Thapa; Brad H. Nelson; Brandon D. Gallas; Carlos A Castaneda; Carmen Ballesteros-Merino; Carmen Criscitiello; Carolien Boeckx; Cecile Colpaert; Cecily Quinn; Chakra S. Chennubhotla; Charles Swanton; Cinzia Solinas; Crispin Hiley; Damien Drubay; Daniel Bethmann; David A. Moore; Denis Larsimont; Dhanusha Sabanathan; Dieter Peeters; Zardavas; Doris Höflmayer; Douglas B. Johnson; Thompson; Edi Brogi; Edith A. Perez; Ehab Elgabry; Elisabeth Ida Specht Stovgaard; Elizabeth F. Blackley; Elvire Roblin; Emily Reisenbichler; Enrique Bellolio; Eva Balslev; Ewa Chmielik; Fabien Gaire; Fabrice Andre; Fang-I Lu; Farid Azmoudeh-Ardalan; Federico Rojo; Tina Gruosso; Francesco Ciompi; Franklin V. Peale Jr.; Fred R. Hirsch; Frederick Klauschen; Frederique Penault-Llorca; Gabriela Acosta-Haab; Gelareh Farshid; Gert G.G.M. Van Den Eynden; Giuseppe Curigliano; Giuseppe Floris; Glenn Broeckx; Gonzalez-Ericsson; Koeppen; Harry R. Haynes; Heather McArthur; Heikki Joensuu; Helena Olofsson; Huang-Chun Lien; I-Chun Chen; Ian A. Cree; Isabel Frahm; Iva Brcic; Jack Chan; James Ziai; Jane Brock; Jelle Wesseling; Jennifer M. Giltnane; Jen Kerner; Jeppe Thagaard; Jeremy P. Braybrooke; Jeroen van der Laak; Jerome Lemonnier; Jiping Zha; Joana Ribeiro; Jochen K. Lennerz; Jodi M. Carter; Joel Saltz; Johan Hartman; Johannes Hainfellner; John Le Quesne; Jonathan W. Juco; Jorge S. Reis-Filho; Joselyn Sanchez; Joseph Sparano; Joël Cucherousset; Juan Carlos Araya; Julien Adam; Justin M. Balko; Kai Saeger; Kalliopi Siziopikou; Karen Willard-Gallo; Karsten Weber; Katherine L. Pogue-Geile; Keith E. Steele; Kenneth Emancipator; Khalid AbdulJabbar; Khalid El Bairi; Kim R. M. Blenman; Kimberly H. Allison; Konstanty Korski; Pusztai; Laura Comerma; Laurence Buisseret; Lee Cooper; Leming Shi; Loes F. S. Kooreman; Luciana L. Molinero; Mónica V. Estrada; Magali Lacroix-Triki; Maise Al Bakir; Manu M. Sebastian; Mark van de Vijver; Marcelo L. Balancin; Maria V. Dieci; Marie-Christine Mathieu; Marlon C. Rebelatto; Martine Piccart; Matthew G. Hanna; Matthew P. Goetz; Matthias Preusser; Mehrnoush Khojasteh; Melinda E. Sanders; Meredith M. Regan; Michael Barnes; Michael Christie; Michael Misialek; Michail Ignatiadis; Mieke Van Bockstal; Miluska Castillo; Mohamed Amgad; Nadia Harbeck; Nadine Tung; Nele Laudus; Nicolas Sirtaine; Nicole Burchardi; Nils Ternes; Nina Radosevic-Robin; Oleg Gluz; Oliver Grimm; Nuciforo; Paul Jank; Paula I. Gonzalez-Ericsson; Pawan Kirtani; Peter Jelinic; Peter H. Watson; Peter Savas; Prudence A. Francis; Prudence A. Russell; Rajendra Singh; Rim S. Kim; Robert H. Pierce; Robert Hills; Roberto Leon-Ferre; Roland De Wind; Ruohong Shui; Sabine De Clercq; Samuel Leung; Sami Tabbarah; Sandra C. Souza; Sandra O’Toole; Sandra M. Swain; Sarah Dudgeon; Scooter Willis; Scott Ely; Seong-Rim Kim; Shahinaz Bedri; Sheeba Irshad; Shi-Wei Liu; Shom Goel; Shona Hendry; Simonetta Bianchi; Sofia Bragança; Soonmyung Paik; Stephan Wienert; Stephen B. Fox; Stephen J Luen; Stephen Naber; Stuart J. Schnitt; Luz F. Sua; Sunil Lakhani; Susan Fineberg; Teresa Soler; Thomas Gevaert; Timothy D’Alfonso; Tom John; Tomohagu Sugie; Uday Kurkure; Veerle Bossuyt; Venkata Manem; Vincente Peg Cámara; Weida Tong; Weijie Chen; Wentao Yang; William T. Tran; Yihong Wang; Yinyin Yuan; Yves Allory; Zaheed Husain; Zsuzsanna Bago-Horvath

Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

npj Breast Cancer,

Mohamed Amgad; Elisabeth Ida Specht Stovgaard; Eva Balslev; Jeppe Thagaard; Weijie Chen; Sarah Dudgeon; Ashish Sharma; Jen Kerner; Carsten Denkert; Yinyin Yuan; Khalid AbdulJabbar; Stephan Wienert; Peter Savas; Leonie Voorwerk; Andrew H. Beck; Anant Madabhushi; Johan Hartman; Manu M. Sebastian; Hugo M. Horlings; Jan Hudeček; Francesco Ciompi; David A. Moore; Rajendra Singh; Elvire Roblin; Marcelo L. Balancin; Marie-Christine Mathieu; Jochen K. Lennerz; Pawan Kirtani; I-Chun Chen; Jeremy P. Braybrooke; Giancarlo Pruneri; Sandra Demaria; Sylvia Adams; Stuart J. Schnitt; Sunil R. Lakhani; Federico Rojo; Laura Comerma; Sunil Badve; Mehrnoush Khojasteh; Cynthia Mayte Villarreal Garza; Christos Sotiriou; Paula I. Gonzalez-Ericsson; Katherine L. Pogue-Geile; Rim S. Kim; David Rimm; Giuseppe Viale; Stephen M. Hewitt; John M. S. Bartlett; Frederique Penault-Llorca; Shom Goel; Huang-Chun Lien; Sibylle Loibl; Zuzana Kos; Sherene Loi; Matthew G. Hanna; Stefan Michiels; Kok; Torsten Nielsen; Alexander J. Lazar; Zsuzsanna Bago-Horvath; Loes F. S. Kooreman; Jeroen van der Laak; Joel Saltz; Brandon D. Gallas; Uday Kurkure; Michael R. Barnes; Roberto Salgado; Lee Cooper; Aini Hyytiäinen; Akira I. Hida; Alastair M. Thompson; Alex Lefevre; Allen Gown; Amy Lo; Anna Sapino; Andre Moreira; Andrea Richardson; Andrea Vingiani; Andrew M. Bellizzi; Andrew Tutt; Angel Guerrero; Anita Grigoriadis; Anna Ehinger; Ana C. Garrido-Castro; Anne Vincent-Salomon; Anne-Vibeke Laenkholm; Ashley Cimino-Mathews; Ashok Srinivasan; Balazs Acs; Baljit Singh; Benjamin Calhoun; Benjamin Haibe-Kans; Benjamin Solomon; Bibhusal Thapa; Brad H. Nelson; Carlos A Castaneda; Carmen Ballesteroes-Merino; Carmen Criscitiello; Carolien Boeckx; Cecile Colpaert; Cecily Quinn; Chakra S. Chennubhotla; Swanton; Cinzia Solinas; Crispin Hiley; Damien Drubay; Daniel Bethmann; Deborah A. Dillon; Denis Larsimont; Dhanusha Sabanathan; Dieter Peeters; Zardavas; Doris Höflmayer; Douglas B. Johnson; Thompson; Edi Brogi; Edith A. Perez; Ehab Elgabry; Elizabeth F. Blackley; Edi Brogi; Enrique Bellolio; Ewa Chmielik; Fabien Gaire; Fabrice Andre; Fang-I Lu; Farid Azmoudeh-Ardalan; Forbius Tina Gruosso; Franklin V. Peale Jr.; Fred R. Hirsch; Frederick Klaushen; Gabriela Acosta-Haab; Gelareh Farshid; Gert G.G.M. Van Den Eynden; Giuseppe Curigliano; Giuseppe Floris; Glenn Broeckx; Koeppen; Harry R. Haynes; Heather McArthur; Heikki Joensuu; Helena Olofsson; Ian A. Cree; Francesco Ciompi; Isabel Frahm; Iva Brcic; Jack Chan; Jacqueline A. Hall; James Ziai; Jane Brock; Jelle Wesseling; Jennifer M. Giltnane; Jerome Lemonnier; Jiping Zha; Joana M. Ribeiro; Jodi M. Carter; Johannes Hainfellner; John Le Quesne; Jonathan W. Juco; Jorge S. Reis-Filho; Jose van den Berg; Joselyn Sanchez; Joseph Sparano; Joël Cucherousset; Juan Carlos Araya; Julien Adam; Justin M. Balko; Kai Saeger; Kalliopi Siziopikou; Karen Willard-Gallo; Karolina Sikorska; Karsten Weber; Keith E. Steele; Kenneth Emancipator; Khalid El Bairi; Kim R. M. Blenman; Kimberly H. Allison; Koen Van De Vijver; Konstanty Korski; Pusztai; Laurence Buisseret; Leming Shi; Liu Shi-wei; Luciana L. Molinero; Mónica V. Estrada; Maartje Van Seijen; Magali Lacroix-Triki; Maggie Chon U. Cheang; Maise al Bakir; Mark Van De Vijver; Maria V. Dieci; Marlon C. Rebelatto; Martine Piccart; Matthew P. Goetz; Matthias Preusser; Melinda E. Sanders; Meredith M. Regan; Michael Christie; Michael Misialek; Michail Ignatiadis; Michiel de Maaker; Mieke Van Bockstal; Miluska Castillo; Nadia Harbeck; Nadine Tung; Nele Laudus; Nicolas Sirtaine; Nicole Burchardi; Nils Ternes; Nina Radosevic-Robin; Oleg Gluz; Oliver Grimm; Nuciforo; Paul Jank; Peter Jelinic; Peter H. Watson; Prudence A. Francis; Prudence A. Russell; Robert H. Pierce; Robert Hills; Roberto Leon-Ferre; Roland De Wind; Ruohong Shui; Sabine Declercq; Samuel Leung; Sami Tabbarah; Sandra C. Souza; Sandra O’Toole; Sandra M. Swain; Scooter Willis; Scott Ely; Seong-Rim Kim; Shahinaz Bedri; Sheeba Irshad; Shi-Wei Liu; Shona Hendry; Simonetta Bianchi; Sofia Bragança; Soonmyung Paik; Stephen B. Fox; Stephen J Luen; Stephen Naber; Sua Luz; Susan Fineberg; Teresa Soler; Thomas Gevaert; Timothy d’Alfons; Tom John; Tomohagu Sugie; Veerle Bossuyt; Venkata Manem; Vincente Peg Cámaea; Weida Tong; Wentao Yang; William T. Tran; Yihong Wang; Yves Allory; Zaheed Husain

IRE1α disruption in triple-negative breast cancer cooperates with antiangiogenic therapy by reversing ER stress adaptation and remodeling the tumor microenvironment

Cancer Research, ISSN: 15387445 00085472

Jonathan M. Harnoss; Adrien Le Thomas; Mike Reichelt; Ofer Guttman; Thomas D Wu; Scot A. Marsters; Anna Shemorry; David Lawrence; David Kan; Ehud Segal; Mark Merchant; Klara Totpal; Lisa Crocker; Kathryn Mesh; Monika Dohse; Margaret Solon; Zora Modrusan; Joachim Rudolph; Koeppen; Peter Walter; Avi Ashkenazi

High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

Nature Medicine, ISSN: 1546170X 10788956

Kobe Yuen; L-F Liu; Vinita Gupta; Shravan Madireddi; Shilpa Keerthivasan; Congfen Li; Deepali Rishipathak; P. Mickey Williams; Edward E. Kadel III; Koeppen; Ying-Jiun Chen; Zora Modrusan; Jane L. Grogan; Romain Banchereau; Ning Leng; AnnChristine Thåström; Xiaodong Shen; Kenji Hashimoto; Darren Tayama; Michiel S Van Der Heijden; Jonathan E. Rosenberg; David McDermott; Thomas Powles; Priti Hegde; Mahrukh Huseni; Sanjeev Mariathasan

Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy

Cancer Discovery, ISSN: 21598290 21598274

Claudia X. Dominguez; Sören Müller; Shilpa Keerthivasan; Koeppen; Jeffrey Hung; Sarah Gierke; Beatrice Breart; Oded Foreman; Travis W. Bainbridge; Alessandra Castiglioni; Yasin Senbabaoglu; Zora Modrusan; Yuxin Liang; Melissa Junttila; Christiaan N. Klijn; Richard Bourgon; Shannon J. Turley

Immune profiles in primary squamous cell carcinoma of the head and neck

Oral Oncology, ISSN: 18790593 13688375

Vassiliki Saloura; Evgeny Izumchenko; Zhixiang Zuo; Bao; Michael Korzinkin; Ivan Ozerov; Alex Zhavoronkov; Sidransky; Atul Bedi; Mohammad O. Hoque; Koeppen; Michaela K. Keck; Arun Khattri; London; Nikita Kotlov; Fatima; Theodore Vougiouklakis; Yusuke Nakamura; Mark Lingen; Nishant Agrawal; Peter A. Savage; Stephen Kron; Justin Kline; Marcin Kowanetz; Tanguy Y. Seiwert

Genomic features of exceptional response in vemurafenib cobimetinib–treated patients with BRAFV600-mutated metastatic melanoma

Clinical Cancer Research, ISSN: 15573265 10780432

Yibing Yan; Matthew Wongchenko; Caroline Robert; James Larkin; Paolo A. Ascierto; Brigitte Dréno; Michele Maio; Claus Garbe; Paul B. Chapman; Jeffrey A. Sosman; Zhen Shi; Koeppen; Jessie Hsu; Ilsung Chang; Ivor Caro; Isabelle Rooney; McArthur; Antoni Ribas

Genomic features of exceptional response in vemurafenib cobimetinib–treated patients with BRAFV600-mutated metastatic melanoma

Clinical Cancer Research, ISSN: 15573265 10780432

Yibing Yan; Matthew Wongchenko; Caroline Robert; James Larkin; Paolo A. Ascierto; Brigitte Dréno; Michele Maio; Claus Garbe; Paul B. Chapman; Jeffrey A. Sosman; Shi; Koeppen; Jessie Hsu; Ilsung Chang; Ivor Caro; Isabelle Rooney; McArthur; Antoni Ribas

PD-L1 and tumor-associated macrophages in de novo DLBCL

Blood advances, ISSN: 24739537 24739529

Mccord; Christopher R. Bolen; Koeppen; Edward E. Kadel III; Mikkel Z. Oestergaard; Tina Nielsen; Laurie H. Sehn; Jeffrey M. Venstrom

Development of a PD-L1 Complementary Diagnostic Immunohistochemistry Assay (SP142) for Atezolizumab

Applied Immunohistochemistry and Molecular Morphology, ISSN: 15334058 15412016

Bharathi Vennapusa; Brian Baker; Marcin Kowanetz; Jennifer Boone; Ina Menzl; Jean-Marie Bruey; Gregg D. Fine; Sanjeev Mariathasan; Ian McCaffery; Mocci; Sandra Rost; Dustin Smith; Eslie Dennis; Szu-Yu Tang; Bita Damadzadeh; Espen Walker; Priti Hegde; Williams; Koeppen; Zachary Boyd

A clinically applicable gene-expression classifier reveals intrinsic and extrinsic contributions to consensus molecular subtypes in primary and metastatic colon cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Robert Piskol; Huw; Ismail Sergin; Christiaan Kljin; Zora Modrusan; Doris Kim; Noelyn Kljavin; Rachel Tam; Rajesh Patel; Jeremy B. Burton; Elicia M. Penuel; Xueping Qu; Koeppen; Teiko Sumiyoshi; Frederic J. De Sauvage; Lackner; Felipe de Sousa e Melo; Omar Kabbarah

Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology

npj Precision Oncology, ISSN: 2397768X

Kwame Okrah; Somayeh S. Tarighat; Bonnie Liu; Koeppen; Marie-Claire Wagle; Cheng; Sun; Anwesha Dey; Chang; Sumiyoshi; Zineb Mounir; Cummings; Garret M. Hampton; Lukas Amler; Jane Fridlyand; Priti Hegde; Shannon J. Turley; Lackner; Shih-Min A. Huang

Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology

npj Precision Oncology, ISSN: 2397768X

Kwame Okrah; Somayeh S. Tarighat; Bonnie Liu; Koeppen; Marie-Claire Wagle; Cheng; Sun; Anwesha Dey; Chang; Teiko Sumiyoshi; Zineb Mounir; Cummings; Garret M. Hampton; Lukas Amler; Jane Fridlyand; Priti Hegde; Shannon J. Turley; Lackner; Shih-Min A. Huang

Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology

npj Precision Oncology, ISSN: 2397768X

Kwame Okrah; Somayeh S. Tarighat; Bonnie Liu; Koeppen; Marie-Claire Wagle; Cheng; Sun; Anwesha Dey; Matthew T. Chang; Teiko Sumiyoshi; Zineb Mounir; Cummings; Garret M. Hampton; Lukas Amler; Jane Fridlyand; Priti Hegde; Shannon J. Turley; Lackner; Shih-Min A. Huang

Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1)

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Marcin Kowanetz; Wei Zou; Scott Gettinger; Koeppen; Mark Kockx; Schmid; Edward E. Kadel III; Ignacio I. Wistuba; Jamie E. Chaft; Naiyer A. Rizvi; David Spigel; Alexander Spira; Fred R. Hirsch; Victor Cohen; Dustin Smith; Zachary Boyd; Natasha Miley; Susan Flynn; Vincent Leveque; David S. Shames; Ballinger; Mocci; Geetha Shankar; Roel Funke; Garret M. Hampton; Alan Sandler; Lukas Amler; Ira Mellman; Daniel S. Chen; Priti Hegde

Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib

Pigment Cell and Melanoma Research, ISSN: 1755148X 17551471

Matthew Wongchenko; Antoni Ribas; Brigitte Dréno; Paolo A. Ascierto; McArthur; Jorge D. Gallo; Isabelle Rooney; Jessie Hsu; Koeppen; Yibing Yan; James Larkin

Characterization of PD-L1 expression in Chinese non-small cell lung cancer patients with PTEN expression as a means for tissue quality screening

Cancer Immunology, Immunotherapy, ISSN: 14320851 03407004

Xu-chao Zhang; Xu Cao; Chun Sun; Zhi Xie; Jian-jun Guo; Jin-ji Yang; Xue-ning Yang; Hang-jun Dai; Su-chun Li; Xin-ran Xu; Yun-xia Zuo; Meng Chen; Koeppen; Jing He; Astrid Kiermaier; David S. Shames; Gang Cheng; Yi-Long Wu

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Nature, ISSN: 14764687 00280836

Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Kobe Yuen; Wang; Edward E. Kadel III; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Romain Banchereau; Yagai Yang; Yinghui Guan; Cecile Chalouni; James Ziai; Yasin Senbabaoglu; Stephen Santoro; Daniel Sheinson; Jeffrey Hung; Jennifer M. Giltnane; Andrew A Pierce; Kathryn Mesh; Steve Lianoglou; Johannes Riegler; Richard A. D. Carano; Pontus Eriksson; Mattias Höglund; Loan Somarriba; Daniel L Halligan; Michiel S Van Der Heijden; Yohann Loriot; Jonathan E. Rosenberg; Lawrence Fong; Ira Mellman; Daniel S. Chen; Marjorie Green; Christina L. Derleth; Gregg D. Fine; Priti Hegde; Richard Bourgon; Thomas Powles

SUV420H2 is an epigenetic regulator of epithelial/ mesenchymal states in pancreatic cancer

Journal of Cell Biology, ISSN: 15408140 00219525

Manuel Viotti; Catherine Wilson; Mark L. McCleland; Koeppen; Benjamin Haley; Suchit Jhunjhunwala; Christiaan N. Klijn; Zora Modrusan; David Arnott; Marie Classon; Jean-Philippe Stephan; Ira Mellman

Molecular and Histopathological Characterization of the Tumor Immune Microenvironment in Advanced Stage of Malignant Pleural Mesothelioma

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Namrata S. Patil; Luisella Righi; Koeppen; Wei Zou; Stefania Izzo; Federica Grosso; Roberta Libener; Marco Loiacono; Valentina Monica; Consuelo Buttigliero; Silvia Novello; Priti Hegde; Mauro Papotti; Marcin Kowanetz; Giorgio Scagliotti

Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial–mesenchymal transition

EMBO Reports, ISSN: 14693178 1469221X

Dan Du; Yoko Katsuno; Dominique Meyer; Erine H Budi; Si-Han Chen; Koeppen; Hongjun Wang; Rosemary J Akhurst; Rik Derynck

Effects of molecular heterogeneity on survival of patients with BRAFV600-mutated melanoma treated with vemurafenib with or without cobimetinib in the coBRIM study

JCO Precision Oncology, ISSN: 24734284

Matthew Wongchenko; Antoni Ribas; Paolo A. Ascierto; Brigitte Dréno; Anna Maria Di Giacomo; Claus Garbe; Ilsung Chang; Jessie Hsu; Isabelle Rooney; William Lu; Koeppen; James Larkin; Yibing Yan; McArthur

Predictive Biomarkers and Targeted Therapies in Immuno-oncology

Predictive Biomarkers in Oncology: Applications in Precision Medicine,

Koeppen; Mark L. McCleland; Marcin Kowanetz

Immune Signaling in Carcinogenesis

Predictive Biomarkers in Oncology: Applications in Precision Medicine,

Mahesh Yadav; Marcin Kowanetz; Koeppen

TGF-β signalling attenuates tumour response to PD-L1 checkpoint blockade by contributing to retention of T cells in the peritumoural stroma

Annals of Oncology, ISSN: 15698041 09237534

Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Yuen; Wang; Edward E; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Yang; Yasin Senbabaoglu; Michiel S Van Der Heijden; Yohann Loriot; Ira Mellman; Daniel S. Chen; Priti Hegde; Richard Bourgon; Thomas Powles

TGF-β signalling attenuates tumour response to PD-L1 checkpoint blockade by contributing to retention of T cells in the peritumoural stroma

Annals of Oncology, ISSN: 15698041 09237534

Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Kobe Yuen; Wang; Edward E; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Yagai Yang; Yasin Senbabaoglu; Michiel S Van Der Heijden; Yohann Loriot; Ira Mellman; Daniel S. Chen; Priti Hegde; Richard Bourgon; Thomas Powles

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

PLoS ONE, ISSN: 19326203

Mark Merchant; John Moffat; Gabriele Schaefer; Jocelyn Chan; Xi Wang; Christine Orr; Jason H. Cheng; Thomas Hunsaker; Lily Shao; Stephanie J. Wang; Marie-Claire Wagle; Eva Lin; Matthias Peter; Sheerin Shahidi-Latham; Hai Ngu; Margaret Solon; Jeffrey Eastham-Anderson; Koeppen; Shih-Min A. Huang; Jacob B. Schwarz; Marcia Belvin; Kirouac; Melissa Junttila

Cotargeting of MEK and PDGFR/STAT3 pathways to treat pancreatic ductal adenocarcinoma

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Nisebita Sahu; Emily Chan; Felix Chu; Thinh Q. Pham; Koeppen; William F. Forrest; Mark Merchant; Jeffrey Settleman

Multiplexed ion beam imaging analysis for quantitation of protein expresssion in cancer tissue sections

Laboratory Investigation, ISSN: 15300307 00236837

Sandra Rost; Jennifer M. Giltnane; Jennifer M. Bordeaux; Chuck Hitzman; Koeppen; Scot D. Liu

Stem cell plasticity enables hair regeneration following Lgr5 + cell loss

Nature Cell Biology, ISSN: 14764679 14657392

Joerg D. Hoeck; Brian Biehs; Antonina V. Kurtova; Noelyn Kljavin; Felipe de Sousa e Melo; Bruno Alicke; Koeppen; Zora Modrusan; Robert Piskol; Frederic J. De Sauvage

Characterization of PD-L1 expression and immune cell infiltration in nasopharyngeal cancer

Oral Oncology, ISSN: 18790593 13688375

Oscar Siu Hong Chan; Marcin Kowanetz; Wai Tong Ng; Koeppen; Lai Kwan Chan; Rebecca Mei Wan Yeung; Haiyan Wu; Lukas Amler; Christoph Mancao

A distinct role for Lgr5 + stem cells in primary and metastatic colon cancer

Nature, ISSN: 14764687 00280836

Felipe de Sousa e Melo; Antonina V. Kurtova; Jonathan M. Harnoss; Noelyn Kljavin; Joerg D. Hoeck; Jeffrey Hung; Jeffrey Eastham-Anderson; Elaine E. Storm; Zora Modrusan; Koeppen; Gerrit J. P. Dijkgraaf; Robert Piskol; Frederic J. De Sauvage

A phase II randomized trial (GO27827) of first-line FOLFOX plus bevacizumab with or without the MET inhibitor onartuzumab in patients with metastatic colorectal cancer

Oncologist, ISSN: 1549490X 10837159

Bendell; Hochster; Lowell Hart; Irfan Firdaus; Joseph R. Mace; Joshua J. McFarlane; Kozloff; Daniel V.T. Catenacci; Jessie Hsu; Stephen P. Hack; David S. Shames; See Phan; Koeppen; Cohn

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

Nature Communications, ISSN: 20411723

Janet Lau; Jeanne Cheung; Armando Navarro; Steve Lianoglou; Benjamin Haley; Klara Totpal; Laura A. Strickland; Koeppen; Patrick Caplazi; Jacqueline McBride; Chiu; Rebecca Hong; Jane L. Grogan; Vincent Javinal; Robert Yauch; Bryan Irving; Marcia Belvin; Ira Mellman; Kim; Maike Schmidt

Randomized, double-blind, placebo-controlled, multicenter phase II study of onartuzumab plus bevacizumab versus placebo plus bevacizumab in patients with recurrent glioblastoma: Efficacy, safety, and hepatocyte growth factor and O6-methylguanine-DNA methyltransferase biomarker analyses

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Timothy Cloughesy; Gaetano Finocchiaro; Cristóbal Belda-Iniesta; Lawrence Recht; Alba A. Brandes; Estela Pineda; Tom Mikkelsen; Olivier L. Chinot; Carmen Balana; David R. Macdonald; Manfred Westphal; Kirsten Hopkins; Michael Weller; Carlos Bais; Thomas Sandmann; Jean-Marie Bruey; Koeppen; Bo Liu; Wendy Verret; See Phan; David S. Shames

Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research

Advances in Anatomic Pathology, ISSN: 15334031 10724109

Shona Hendry; Roberto Salgado; Thomas Gevaert; Prudence A. Russell; Tom John; Bibhusal Thapa; Michael Christie; Koen Van De Vijver; Mónica V. Estrada; Paula I. Gonzalez-Ericsson; Melinda E. Sanders; Benjamin Solomon; Cinzia Solinas; Gert G.G.M. Van Den Eynden; Yves Allory; Matthias Preusser; Johannes Hainfellner; Giancarlo Pruneri; Andrea Vingiani; Sandra Demaria; W Fraser Symmans; Nuciforo; Laura Comerma; Thompson; Sunil Lakhani; Seong-Rim Kim; Stuart J. Schnitt; Cecile Colpaert; Christos Sotiriou; Stefan J. Scherer; Michail Ignatiadis; Sunil Badve; Robert H. Pierce; Giuseppe Viale; Nicolas Sirtaine; Frederique Penault-Llorca; Tomohagu Sugie; Susan Fineberg; Soonmyung Paik; Ashok Srinivasan; Andrea Richardson; Yihong Wang; Ewa Chmielik; Jane Brock; Douglas B. Johnson; Justin M. Balko; Stephan Wienert; Veerle Bossuyt; Stefan Michiels; Nils Ternes; Nicole Burchardi; Stephen J Luen; Peter Savas; Frederick Klauschen; Peter H. Watson; Brad H. Nelson; Carmen Criscitiello; Sandra O'Toole; Denis Larsimont; Roland De Wind; Giuseppe Curigliano; Fabrice Andre; Magali Lacroix-Triki; Mark Van De Vijver; Federico Rojo; Giuseppe Floris; Shahinaz Bedri; Joseph Sparano; David Rimm; Torsten Nielsen; Zuzana Kos; Stephen M. Hewitt; Baljit Singh; Gelareh Farshid; Sibylle Loibl; Kimberly H. Allison; Nadine Tung; Sylvia Adams; Karen Willard-Gallo; Hugo M. Horlings; Leena Gandhi; Andre Moreira; Fred R. Hirsch; Maria V. Dieci; Maria Urbanowicz; Iva Brcic; Konstanty Korski; Fabien Gaire; Koeppen; Amy Lo; Jennifer M. Giltnane; Marlon C. Rebelatto; Keith E. Steele; Jiping Zha; Kenneth Emancipator; Jonathan W. Juco; Carsten Denkert; Jorge S. Reis-Filho; Sherene Loi; Stephen B. Fox

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

Advances in Anatomic Pathology, ISSN: 15334031 10724109

Shona Hendry; Roberto Salgado; Thomas Gevaert; Prudence A. Russell; Tom John; Bibhusal Thapa; Michael Christie; Koen Van De Vijver; Mónica V. Estrada; Paula I. Gonzalez-Ericsson; Melinda E. Sanders; Benjamin Solomon; Cinzia Solinas; Gert G.G.M. Van Den Eynden; Yves Allory; Matthias Preusser; Johannes Hainfellner; Giancarlo Pruneri; Andrea Vingiani; Sandra Demaria; W Fraser Symmans; Nuciforo; Laura Comerma; Thompson; Sunil Lakhani; Seong-Rim Kim; Stuart J. Schnitt; Cecile Colpaert; Christos Sotiriou; Stefan J. Scherer; Michail Ignatiadis; Sunil Badve; Robert H. Pierce; Giuseppe Viale; Nicolas Sirtaine; Frederique Penault-Llorca; Tomohagu Sugie; Susan Fineberg; Soonmyung Paik; Ashok Srinivasan; Andrea Richardson; Yihong Wang; Ewa Chmielik; Jane Brock; Douglas B. Johnson; Justin M. Balko; Stephan Wienert; Veerle Bossuyt; Stefan Michiels; Nils Ternes; Nicole Burchardi; Stephen J Luen; Peter Savas; Frederick Klauschen; Peter H. Watson; Brad H. Nelson; Carmen Criscitiello; Sandra O'Toole; Denis Larsimont; Roland De Wind; Giuseppe Curigliano; Fabrice Andre; Magali Lacroix-Triki; Mark Van De Vijver; Federico Rojo; Giuseppe Floris; Shahinaz Bedri; Joseph Sparano; David Rimm; Torsten Nielsen; Zuzana Kos; Stephen M. Hewitt; Baljit Singh; Gelareh Farshid; Sibylle Loibl; Kimberly H. Allison; Nadine Tung; Sylvia Adams; Karen Willard-Gallo; Hugo M. Horlings; Leena Gandhi; Andre Moreira; Fred R. Hirsch; Maria V. Dieci; Maria Urbanowicz; Iva Brcic; Konstanty Korski; Fabien Gaire; Koeppen; Amy Lo; Jennifer M. Giltnane; Marlon C. Rebelatto; Keith E. Steele; Jiping Zha; Kenneth Emancipator; Jonathan W. Juco; Carsten Denkert; Jorge S. Reis-Filho; Sherene Loi; Stephen B. Fox

The molecular landscape of high-risk early breast cancer: Comprehensive biomarker analysis of a phase III adjuvant population

npj Breast Cancer, ISSN: 23744677

Wilson; Yu; Xuyang Lu; Jill M. Spoerke; Yuanyuan Xiao; Carol O’brien; Heidi Savage; Huw; Wei Zou; Koeppen; William F. Forrest; Jane Fridlyand; Ling Fu; Rachel Tam; Erica Schleifman; Teiko Sumiyoshi; Luciana L. Molinero; Garret M. Hampton; O'Shaughnessy; Lackner

Brain distribution and efficacy of the brain penetrant PI3K inhibitor GDC-0084 in orthotopic mouse models of human glioblastoma

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Laurent Salphati; Bruno Alicke; Timothy P. Heffron; Sheerin Shahidi-Latham; Merry C. Nishimura; Tim C. Cao; Richard A. D. Carano; Jonathan Cheong; Joan M. Greve; Koeppen; Shari Lau; Leslie Lee; Michelle Nannini; Jodie Pang; Emile G. Plise; Cristine Quiason; Linda Rangell; Xiaolin Zhang; Stephen Gould; Phillips; Alan G. Olivero

A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study)

Cancer, ISSN: 10970142 0008543X

Vicky Makker; Fernando O. Recio; Ling Ma; Ursula A. Matulonis; Jennifer O. Lauchle; Hema Parmar; Houston N. Gilbert; Joseph A. Ware; Rui Zhu; Shan Lu; Huw; Wang; Koeppen; Jill M. Spoerke; Lackner; Carol Aghajanian

The SP142 PD-L1 IHC assay for atezolizumab (atezo) reflects pre-existing immune status in NSCLC and correlates with PD-L1 mRNA

Annals of Oncology, ISSN: 15698041 09237534

Williams; Marcin Kowanetz; Koeppen; Zachary Boyd; Edward E. Kadel III; Dustin Smith; Mark L. McCleland; Wei Zou; Priti Hegde

The SP142 PD-L1 IHC assay for atezolizumab (atezo) reflects pre-existing immune status in NSCLC and correlates with PD-L1 mRNA

Annals of Oncology, ISSN: 15698041 09237534

Williams; Marcin Kowanetz; Koeppen; Zachary Boyd; Edward E. Kadel III; Dustin Smith; Mark L. McCleland; Wei Zou; Priti Hegde

High cell-surface density of HER2 deforms cell membranes

Nature Communications, ISSN: 20411723

Inhee Chung; Mike Reichelt; Lily Shao; Robert W. Akita; Koeppen; Linda Rangell; Gabriele Schaefer; Ira Mellman; Mark X. Sliwkowski

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma

Nature Communications, ISSN: 20411723

Jeffery J. Wallin; Bendell; Roel Funke; Mario Sznol; Konstanty Korski; Suzanne Jones; Genevive Hernandez; James Mier; Xian He; F. Stephen Hodi; Mitchell Denker; Vincent Leveque; Marta Cañamero; Galina Babitski; Koeppen; James Ziai; Neeraj Sharma; Fabien Gaire; Daniel S. Chen; Waterkamp; Priti Hegde; David McDermott

Phase I study of apitolisib (GDC-0980), dual phosphatidylinositol-3-kinase and mammalian target of rapamycin kinase inhibitor, in patients with advanced solid tumors

Clinical Cancer Research, ISSN: 15573265 10780432

Saoirse O. Dolly; Andrew Wagner; Bendell; Hedy L. Kindler; Lee M. Krug; Tanguy Y. Seiwert; Marjorie G. Zauderer; Martijn P. Lolkema; Doris Apt; Ru-Fang Yeh; Jill Fredrickson; Jill M. Spoerke; Koeppen; Joseph A. Ware; Jennifer O. Lauchle; Howard A. Burris; De Bono

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor

mAbs, ISSN: 19420870 19420862

Rong Deng; Daniela Bumbaca; Cinthia V Pastuskovas; C. Andrew Boswell; David West; Kyra J. Cowan; Chiu; Jacqueline McBride; Clarissa Johnson; Yan Xin; Koeppen; Maya Leabman; Suhasini Iyer

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

Breast Cancer Research, ISSN: 1465542X 14655411

Christy C. Ong; Sarah Gierke; Cameron Pitt; Meredith Sagolla; Christine K. Cheng; Wei Zhou; Adrian M. Jubb; Laura A. Strickland; Maike Schmidt; Sergio G. Duron; David Campbell; Wei Zheng; Seameen Dehdashti; Min Shen; Nora Yang; Mark L. Behnke; Wenwei Huang; John C. McKew; Jonathan Chernoff; William F. Forrest; Matthias Peter; Suet-Feung Chin; Emad A. Rakha; Andrew R. Green; Ian O. Ellis; Carlos Caldas; Thomas O'Brien; Lori S. Friedman; Koeppen; Joachim Rudolph; Klaus P. Hoeflich

Patients with slowly proliferative early breast cancer have low five-year recurrence rates in a phase III adjuvant trial of capecitabine

Clinical Cancer Research, ISSN: 15573265 10780432

O'Shaughnessy; Koeppen; Yuanyuan Xiao; Lackner; Devchand Paul; Christopher Stokoe; John Pippen; Lea Krekow; Frankie Ann Holmes; Svetislava Vukelja; Deborah Lindquist; Scot Sedlacek; Ragene Rivera; Robert Brooks; Kristi McIntyre; Carrie Brownstein; Silke Hoersch; Blum; Stephen Jones

Randomized, phase II, placebo-controlled trial of onartuzumab and/or bevacizumab in combination with weekly paclitaxel in patients with metastatic triple-negative breast cancer

Annals of Oncology, ISSN: 15698041 09237534

Diéras; Mario Campone; Denise A. Yardley; Romieu; Vicente Valero; Isakoff; Koeppen; Wilson; Yuanyuan Xiao; David S. Shames; Mocci; Meng Chen; Schmid

Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes

Leukemia, ISSN: 14765551 08876924

Pfeifer; Bing Zheng; Erdmann; Koeppen; Mccord; Grau; Staiger; Akiko Chai; Thomas Sandmann; Madle; Dörken; Yu-Waye Chu; Chen; Lebovic; Gilles Salles; Myron S. Czuczman; Palanca-Wessels; Oliver W. Press; Ranjana H. Advani; Morschhauser; Bruce D. Cheson; Lenz; Ott; Andrew G. Polson; Kirsten E. Mundt; Lenz

MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation

EBioMedicine, ISSN: 23523964

Tom T. Chen; Ellen H. Filvaroff; Jing Peng; Scot A. Marsters; Adrian M. Jubb; Koeppen; Mark Merchant; Avi Ashkenazi

MET gene copy number alterations and expression of MET and hepatocyte growth factor are potential biomarkers in angiosarcomas and undifferentiated pleomorphic sarcomas

PLoS ONE, ISSN: 19326203

Katja Schmitz; Koeppen; Elke Binot; Jana Fassunke; Helen Künstlinger; Michaela A. Ihle; Carina Heydt; Eva Wardelmann; Reinhard Büttner; Sabine Merkelbach-Bruse; Josef Rüschoff; Hans-Ulrich Schildhaus

p21-activated kinase 2 regulates endothelial development and function through the Bmk1/Erk5 pathway

Molecular and Cellular Biology, ISSN: 10985549 02707306

Maria Radu; Karen Lyle; Klaus P. Hoeflich; Olga Villamar-Cruz; Koeppen; Jonathan Chernoff

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

Journal of Pathology, ISSN: 10969896 00223417

Wei Zhou; Adrian M. Jubb; Karen Lyle; Qian Xiao; Christy C. Ong; Rupal Desai; Ling Fu; Florian Gnad; Qinghua Song; Matthias Peter; Daniela Aust; Robert Grützmann; Mally Romero; Klara Totpal; Richard M. Neve; Yibing Yan; William F. Forrest; Wang; Rajiv Raja; Christian Pilarsky; Ana De Jesus-Acosta; Marcia Belvin; Lori S. Friedman; Mark Merchant; Elizabeth M. Jaffee; Lei Zheng; Koeppen; Klaus P. Hoeflich

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

Nature, ISSN: 14764687 00280836

Roy S. Herbst; Jean-Charles Soria; Marcin Kowanetz; Gregg D. Fine; Omid Hamid; Michael S. Gordon; Jeffrey A. Sosman; David McDermott; John D. Powderly; Scott Gettinger; Holbrook E. K. Kohrt; Leora Horn; Donald Lawrence; Sandra Rost; Maya Leabman; Yuanyuan Xiao; Ahmad Mokatrin; Koeppen; Priti Hegde; Ira Mellman; Daniel S. Chen; F. Stephen Hodi

Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Wilson; Yuanyuan Xiao; Jill M. Spoerke; Jane Fridlyand; Koeppen; Eloisa Fuentes; Huw; Ilma Abbas; Arjan Gower; Erica Schleifman; Rupal Desai; Ling Fu; Teiko Sumiyoshi; Joyce A. O’Shaughnessy; Garret M. Hampton; Lackner

An antimesothelin-monomethyl auristatin E conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Suzie J. Scales; Nidhi Gupta; Glenn Pacheco; Ron Firestein; French; Koeppen; Linda Rangell; Vivian Barry-Hamilton; Luis; Josefa Chuh; Yin Zhang; Gladys S. Ingle; Aimee Fourie-O'Donohue; Katherine R. Kozak; Ross; Dennis; Spencer

AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs

Cancer Research, ISSN: 15387445 00085472

Catherine Wilson; Ye; Thinh Q. Pham; Eva Lin; Sara M. Chan; Eric Cheng; Richard M. Neve; Lisa D. Belmont; Koeppen; Robert Yauch; Avi Ashkenazi; Jeffrey Settleman

Biomarker analyses from a placebo-controlled phase II study evaluating erlotinib±onartuzumab in advanced non-small cell lung cancer: MET expression levels are predictive of patient benefit

Clinical Cancer Research, ISSN: 10780432

Koeppen; Wei Yu; Jiping Zha; Ajay Pandita; Elicia M. Penuel; Linda Rangell; Rajiv Raja; Sankar Mohan; Rajesh Patel; Rupal Desai; Ling Fu; An Do; Vaishali Parab; Xiaoling Xia; Thomas Januario; Sharianne G. Louie; Ellen H. Filvaroff; David S. Shames; Ignacio I. Wistuba; Marina Lipkind; Jenny Huang; Mirella Lazarov; Vanitha Ramakrishnan; Lukas Amler; See Phan; Premal Patel; Amy Peterson; Robert Yauch

High-throughput detection of clinically relevant mutations in archived tumor samples by multiplexed PCR and next-generation sequencing

Clinical Cancer Research, ISSN: 15573265 10780432

Richard Bourgon; Shan Lu; Yibing Yan; Lackner; Weiru Wang; Victor Weigman; David Wang; Yinghui Guan; Lisa Ryner; Koeppen; Rajesh Patel; Garret M. Hampton; Lukas Amler; Wang

Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type i 1/2 kinase inhibitors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Steven T. Staben; Jianwen A. Feng; Karen Lyle; Marcia Belvin; Jason Boggs; Jason D. Burch; Ching-Ching Chua; Haifeng Cui; Antonio G. DiPasquale; Lori S. Friedman; Christopher E. Heise; Koeppen; Adrian Kotey; Robert Mintzer; Angela Oh; David Allen Roberts; Lionel Rouge; Joachim Rudolph; Christine Tam; Weiru Wang; Yisong Xiao; Amy Young; Yamin Zhang; Klaus P. Hoeflich

Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers

PLoS ONE, ISSN: 19326203

Erica Schleifman; Rupal Desai; Jill M. Spoerke; Yuanyuan Xiao; Cheryl Wong; Ilma Abbas; Carol O'Brien; Rajesh Patel; Teiko Sumiyoshi; Ling Fu; Rachel Tam; Koeppen; Wilson; Rajiv Raja; Garret M. Hampton; Lackner

Pathology in drug discovery and development

Journal of Pathology, ISSN: 00223417 10969896

Adrian M. Jubb; Koeppen; Jorge S. Reis-Filho

Profiling cancer genemutations in clinical formalin-fixed, paraffin-embedded colorectal tumor specimens using targeted next-generation sequencing

Oncologist, ISSN: 1549490X 10837159

Liangxuan Zhang; Liangjing Chen; Sachin Sah; Gary J. Latham; Rajesh Patel; Qinghua Song; Koeppen; Rachel Tam; Erica Schleifman; Haider Mashhedi; Sreedevi Chalasani; Ling Fu; Teiko Sumiyoshi; Rajiv Raja; William F. Forrest; Garret M. Hampton; Lackner; Priti Hegde; Shidong Jia

Developing biomarkers to predict benefit from HGF/MET pathway inhibitors

Journal of Pathology, ISSN: 00223417 10969896

Koeppen; Sandra Rost; Robert Yauch

HGF/MET-directed therapeutics in gastroesophageal cancer: A review of clinical and biomarker development

Oncotarget, ISSN: 19492553

Stephen P. Hack; Jean-Marie Bruey; Koeppen

Loss of NAPRT1 expression by tumor-specific promoter methylation provides a novel predictive biomarker for NAMPT inhibitors

Clinical Cancer Research, ISSN: 10780432 15573265

David S. Shames; Kristi Elkins; Kimberly Walter; Thomas Holcomb; Pan Du; Dane Mohl; Yang Xiao; Thinh Q. Pham; Matthias Peter; Bianca M. Liederer; Xiaorong Liang; Robert Yauch; Thomas O'Brien; Richard Bourgon; Koeppen; Lisa D. Belmont

Impact of MET expression on outcome in BRAFV600E/K advanced melanoma

Histopathology, ISSN: 03090167 13652559

Adrian M. Jubb; Antoni Ribas; Jeffrey A. Sosman; McArthur; Yibing Yan; Sandra Rost; Sherry Zhao; Koeppen

Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics

Molecular and Cellular Proteomics, ISSN: 15359476 15359484

Florian Gnad; Amy Young; Wei Zhou; Karen Lyle; Christy C. Ong; Matthew P. Stokes; Jeffrey C. Silva; Marcia Belvin; Lori S. Friedman; Koeppen; Audrey Minden; Klaus P. Hoeflich

In situ validation of an intestinal stem cell signature in colorectal cancer

Gut, ISSN: 00175749 14683288

Jennifer L. Ziskin; Debra Dunlap; Murat Yaylaoglu; Imola K. Fodor; William F. Forrest; Rajesh Patel; Nianfeng Ge; Gordon G. Hutchins; James K. Pine; Philip Quirke; Koeppen; Adrian M. Jubb

Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies

Clinical Cancer Research, ISSN: 10780432 15573265

Matthew J. Brauer; Guanglei Zhuang; Maike Schmidt; Jenny Yao; Xiumin Wu; Joshua S. Kaminker; Stefanie S. Jurinka; Ganesh Kolumam; Alicia S Chung; Adrian M. Jubb; Zora Modrusan; Tomoko Ozawa; C. David James; Phillips; Benjamin Haley; Rachel Tam; Anne C. Clermont; Jason H. Cheng; Sherry X. Yang; Sandra M. Swain; Daniel S. Chen; Stefan J. Scherer; Koeppen; Ru-Fang Yeh; Peng Yue; Jean-Philippe Stephan; Priti Hegde; Napoleone Ferrara; Mallika Singh; Carlos Bais

P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma

Journal of the National Cancer Institute, ISSN: 00278874 14602105

Christy C. Ong; Adrian M. Jubb; Diana Jakubiak; Wei Zhou; Joachim Rudolph; Matthias Peter; Marcin Kowanetz; Yibing Yan; Jarrod Tremayne; Richard Lisle; Adrian L. Harris; Lori S. Friedman; Marcia Belvin; Mark R. Middleton; Elizabeth M. Blackwood; Koeppen; Klaus P. Hoeflich

Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models

Clinical Cancer Research, ISSN: 10780432 15573265

Jie Lin; Deepak Sampath; Michelle Nannini; Brian Lee; Michael Degtyarev; Jason Oeh; Heidi Savage; Zhengyu Guan; Rebecca Hong; Robert Kassees; Leslie Lee; Tyler Risom; Stefan Gross; Bianca M. Liederer; Koeppen; Nicholas J. Skelton; Jeffery J. Wallin; Marcia Belvin; Elizabeth A. Punnoose; Lori S. Friedman; Kui Lin

Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models

Clinical Cancer Research, ISSN: 10780432 15573265

Jie Lin; Deepak Sampath; Michelle Nannini; Brian B. Lee; Michael Degtyarev; Jason Oeh; Heidi Savage; Zhengyu Guan; Rebecca Hong; Robert Kassees; Leslie Lee; Tyler Risom; Stefan Gross; Bianca M. Liederer; Koeppen; Nicholas J. Skelton; Jeffery J. Wallin; Marcia Belvin; Elizabeth A. Punnoose; Lori S. Friedman; Kui Lin

Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response

Neoplasia (United States), ISSN: 14765586 15228002

Deepak Sampath; Jason Oeh; Shelby K. Wyatt; Tim C. Cao; Koeppen; Jeffrey Eastham-Anderson; Liliane Robillard; Calvin Ho; Ross; Guanglei Zhuang; Hani Bou-Reslan; Philip Vitorino; Kai H. Barck; Sharon E. Ungersma; Jean-Michel Vernes; Maresa Caunt; Nicholas Van Bruggen; Weilan Ye; Ulka Vijapurkar; Yu-Ju Gloria Meng; Napoleone Ferrara; Lori S. Friedman; Richard A. D. Carano

Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models

Clinical Cancer Research, ISSN: 10780432 15573265

Jill M. Spoerke; Carol O'Brien; Huw; Koeppen; Jane Fridlyand; Rainer Brachmann; Matthias Peter; Ajay Pandita; Sankar Mohan; Deepak Sampath; Lori S. Friedman; Berry; Garret M. Hampton; Lukas Amler; David S. Shames; Lackner

Targeting the PI3K pathway in the brain - Efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier

Clinical Cancer Research, ISSN: 10780432 15573265

Laurent Salphati; Timothy P. Heffron; Bruno Alicke; Merry C. Nishimura; Kai H. Barck; Richard A. D. Carano; Jonathan Cheong; Kyle A. Edgar; Joan M. Greve; Samir Kharbanda; Koeppen; Shari Lau; Leslie Lee; Jodie Pang; Emile G. Plise; Jenny L. Pokorny; Hani Bou-Reslan; Jann N. Sarkaria; Jeffery J. Wallin; Xiaolin Zhang; Stephen Gould; Alan G. Olivero; Phillips

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

Nature Genetics, ISSN: 10614036 15461718

Charles M. Rudin; Durinck; Eric Stawiski; John T. Poirier; Zora Modrusan; David S. Shames; Emily A. Bergbower; Yinghui Guan; James Shin; Joseph Guillory; Rivers; Catherine K. Foo; Deepali Bhatt; Stinson; Florian Gnad; Matthias Peter; Robert Gentleman; Subhra Chaudhuri; Vasantharajan Janakiraman; Bijay S. Jaiswal; Chaitali Parikh; Yuan; Zemin Zhang; Koeppen; Thomas D Wu; Howard M. Stern; Robert Yauch; Kenneth E. Huffman; Diego D. Paskulin; Peter B. Illei; Marileila Varella-Garcia; Adi Gazdar; Frederic J. De Sauvage; Richard Bourgon; Minna; Malcolm V. Brock; Somasekar Seshagiri

Neuropilin-2 expression in cancer

Histopathology, ISSN: 03090167 13652559

Adrian M. Jubb; Susan Sa; Navneet Ratti; Laura A. Strickland; Maike Schmidt; Christopher Callahan; Koeppen

Recurrent R-spondin fusions in colon cancer

Nature, ISSN: 00280836 14764687

Somasekar Seshagiri; Eric Stawiski; Durinck; Zora Modrusan; Elaine E. Storm; Caitlin B. Conboy; Subhra Chaudhuri; Yinghui Guan; Vasantharajan Janakiraman; Bijay S. Jaiswal; Joseph Guillory; Connie Ha; Gerrit J. P. Dijkgraaf; Stinson; Florian Gnad; Melanie A. Huntley; Jeremiah D. Degenhardt; Matthias Peter; Richard Bourgon; Weiru Wang; Koeppen; Robert Gentleman; Timothy Starr; Zemin Zhang; David A. Largaespada; Thomas D Wu; Frederic J. De Sauvage

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

Nature, ISSN: 00280836 14764687

Wilson; Jane Fridlyand; Yibing Yan; Elicia M. Penuel; Luciana Burton; Emily Chan; Jing Peng; Eva Lin; Wang; Jeffrey A. Sosman; Antoni Ribas; Jiang Li; John Moffat; Daniel P. Sutherlin; Koeppen; Mark Merchant; Richard M. Neve; Jeffrey Settleman

GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death In Vitro and In Vivo

Clinical Cancer Research, ISSN: 10780432 15573265

Jeffery J. Wallin; Zhengyu Guan; Wei Wei Prior; Leslie Lee; Berry; Lisa D. Belmont; Koeppen; Marcia Belvin; Lori S. Friedman; Deepak Sampath

Intermittent administration of MEK inhibitor GDC-0973 plus pi3k inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition

Cancer Research, ISSN: 00085472 15387445

Klaus P. Hoeflich; Mark Merchant; Christine Orr; Jocelyn Chan; Doug Den Otter; Berry; Ian Kasman; Koeppen; Ken Rice; Nai-Ying Yang; Stefan Engst; Stuart H. Johnston; Lori S. Friedman; Marcia Belvin

Neuropilin-1 expression in cancer and development

Journal of Pathology, ISSN: 00223417 10969896

Adrian M. Jubb; Laura A. Strickland; Scot D. Liu; Judy Mak; Maike Schmidt; Koeppen

Ascl2 and 11p15.5 amplification in colorectal cancer

Gut, ISSN: 00175749 14683288

Adrian M. Jubb; Klaus P. Hoeflich; Matthias Peter; Yajun Jennifer Wang; Koeppen

Notch3 signalling promotes tumour growth in colorectal cancer

Journal of Pathology, ISSN: 00223417 10969896

Valentina Serafin; Luca Persano; Lidia Moserle; Giovanni Esposito; Margherita Ghisi; Matteo Curtarello; Laura Bonanno; Massimo Masiero; Domenico Ribatti; Michael Stürzl; Elisabeth Naschberger; Roland S Croner; Adrian M. Jubb; Adrian L. Harris; Koeppen; Alberto Amadori; Stefano Indraccolo

TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma

PLoS ONE, ISSN: 19326203

Kui Lin; James R. Taylor Jr.; Thomas D Wu; Johnny Gutierrez; J. Michael Elliott; Jean-Michel Vernes; Koeppen; Phillips; Frederic J. De Sauvage; Meng

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Christy C. Ong; Adrian M. Jubb; Matthias Peter; Wei Zhou; Victoria Tran; Tom Truong; Helen Turley; Thomas O'Brien; Domagoj Vucic; Adrian L. Harris; Marcia Belvin; Lori S. Friedman; Elizabeth M. Blackwood; Koeppen; Klaus P. Hoeflich

CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma

Science Translational Medicine, ISSN: 19466234 19466242

Bart Burington; Peng Yue; Xiaoyan Shi; Ranjana H. Advani; Jeffrey Lau; Jenille Tan; Susanna Y. Stinson; Stinson; Thomas Januario; Sven De Vos; Stephen Ansell; Andres Forero; Grazyna Fedorowicz; Teddy T. C. Yang; Kristi Elkins; Du; Sankar Mohan; Nancy Yu; Zora Modrusan; Somasekar Seshagiri; Shang-Fan Yu; Ajay Pandita; Koeppen; French; Andrew G. Polson; Rienk Offringa; Nancy Whiting; Allen Ebens; David Dornan

Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer

Clinical Cancer Research, ISSN: 10780432 15573265

Adrian M. Jubb; Kathy Miller; Hope S. Rugo; Adrian L. Harris; Dafeng Chen; Reimann; Melody A. Cobleigh; Maike Schmidt; Virginia K. Langmuir; Kenneth J. Hillan; Daniel S. Chen; Koeppen

Traditional Diagnostic Approaches

Leukemias: Principles and Practice of Therapy,

Koeppen; Carlos Bueso-Ramos; Sergej N. Konoplev

P21-activated kinase 1: PAK'ed with potential

Oncotarget, ISSN: 19492553

Christy C. Ong; Adrian M. Jubb; Wei Zhou; Matthias Peter; Adrian L. Harris; Marcia Belvin; Lori S. Friedman; Koeppen; Klaus P. Hoeflich

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

Nature Biotechnology, ISSN: 10870156 15461696

Mallika Singh; Anthony Lima; Rafael Molina; Patricia Hamilton; Anne C. Clermont; Vidusha Devasthali; Jennifer D. Thompson; Jason H. Cheng; Hani Bou-Reslan; Calvin Ho; Tim C. Cao; Chingwei V. Lee; Michelle Nannini; Fuh; Richard A. D. Carano; Koeppen; Ron Yu; William F. Forrest; Greg D. Plowman; Leisa Johnson

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Nature, ISSN: 00280836 14764687

Georgia Hatzivassiliou; Kyung Song; Ivana Yen; Barbara J. Brandhuber; Daniel J Anderson; Ryan Alvarado; Mary J. C. Ludlam; David Stokoe; Susan L. Gloor; Guy Vigers; Tony Morales; Ignacio Aliagas; Bonnie Liu; Steve Sideris; Klaus P. Hoeflich; Bijay S. Jaiswal; Somasekar Seshagiri; Koeppen; Marcia Belvin; Lori S. Friedman; Shiva Malek

Pegylated Kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis

Cancer Research, ISSN: 00085472 15387445

Wei Li; Bu-Er Wang; Paul Moran; Michael T. Lipari; Rajkumar Ganesan; Corpuz; Mary J. C. Ludlam; Alvin Gogineni; Koeppen; Bunting; Gao; Daniel Kirchhofer

Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma

Journal of Pathology, ISSN: 00223417 10969896

Laura A. Strickland; Ross; Simon P. Williams; Ross; Maria Romero; Spencer; Erickson; Julie Sutcliffe; Caroline Verbeke; Paul G. Polakis; Nicholas Van Bruggen; Koeppen

Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: Target and linker-drug selection

Cancer Research, ISSN: 00085472 15387445

Andrew G. Polson; Jill Calemine-Fenaux; Pamela Chan; Wesley S. Chang; Erin Christensen; Suzanna Clark; Frederic J. De Sauvage; Dan L. Eaton; Kristi Elkins; J. Michael Elliott; Gretchen D. Frantz; Reina N. Fuji; Gray; Kristin Harden; Gladys S. Ingle; Noelyn Kljavin; Koeppen; Nelson; Saileta Prabhu; Helga Raab; Ross; Jean-Philippe Stephan; Suzie J. Scales; Spencer; Richard L. Vandlen; Bernd Wranik; Shang-Fan Yu; Bing Zheng; Allen Ebens

Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma

Blood, ISSN: 15280020 00064971

David Dornan; Bennett; Chen; Dennis; Dan L. Eaton; Kristi Elkins; French; MaryAnn Go; Andrew S. Jack; Jagath R. Junutula; Koeppen; Jeffrey Lau; Jacqueline McBride; Andy Rawstron; Xiaoyan Shi; Nancy Yu; Shang-Fan Yu; Peng Yue; Bing Zheng; Allen Ebens; Andrew G. Polson

Cooperation of the agonistic DR5 antibody apomab with chemotherapy to inhibit orthotopic lung tumor growth and improve survival

Clinical Cancer Research, ISSN: 10780432

Hongkui Jin; Renhui Yang; Ross; Fong; Richard A. D. Carano; Klara Totpal; David Lawrence; Zhong Zheng; Koeppen; Howard M. Stern; Ralph H. Schwall; Avi Ashkenazi

Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate

Cancer Research, ISSN: 00085472 15387445

Gail L. Phillips; Guangmin Li; Dugger; Lisa Crocker; Kathryn Parsons; Elaine Mai; Walter A. Blättler; John M. Lambert; Ravi Chari; Robert J. Lutz; Wai Lee T. Wong; Fred Jacobson; Koeppen; Ralph H. Schwall; Sara Kenkare-Mitra; Spencer; Mark X. Sliwkowski

Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5

Cell Death and Differentiation, ISSN: 13509047 14765403

Cam Adams; Klara Totpal; David Lawrence; Scot A. Marsters; Pitti; Sharon Fong Yee; Ross; Laura DeForge; Koeppen; Meredith Sagolla; Deanne M. Compaan; Henry B. Lowman; Sarah G. Hymowitz; Avi Ashkenazi

High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate

British Journal of Haematology, ISSN: 00071048 13652141

Gladys S. Ingle; Pamela Chan; J. Michael Elliott; Wesley S. Chang; Koeppen; Jean-Philippe Stephan; Suzie J. Scales

Epidermal growth factor receptor in osteosarcoma: expression and mutational analysis

Human Pathology, ISSN: 00468177

Yong Hannah Wen; Koeppen; Roberto Garcia; Luis Chiriboga; Branden D. Tarlow; Brock A. Peters; Eigenbrot; Herman Yee; German Steiner; M. Alba Greco

Erratum: Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models (Cancer Research (2007) 67, (4924-4932))

Cancer Research, ISSN: 00085472

Youjun Chen; Suzanna Clark; Wong; Yongmei Chen; Chen; Dennis; Luis; Fiona Zhong; Sheila Bheddah; Koeppen; Alvin Gogineni; Paul G. Polakis; William Mallet

The soluble Wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo

Cancer Research, ISSN: 00085472

Venita I. DeAlmeida; Li Miao; James A. Ernst; Koeppen; Paul G. Polakis; Bonnee Rubinfeld

Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models

Cancer Research, ISSN: 00085472

Youjun Chen; Suzanna Clark; Wong; Yongmei Chen; Chen; Dennis; Luis; Fiona Zhong; Sheila Bheddah; Koeppen; Alvin Gogineni; Paul G. Polakis; William Mallet

Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia

International Immunology, ISSN: 09538178 14602377

Andrew G. Polson; Bing Zheng; Kristi Elkins; Wesley S. Chang; Du; Patrick Dowd; Lulu Yen; Christine Tan; Hongo; Koeppen; Allen Ebens

Predicting benefit from anti-angiogenic agents in malignancy

Nature Reviews Cancer, ISSN: 1474175X

Adrian M. Jubb; Adam J. Oates; Scott N. Holden; Koeppen

Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer

Oncogene, ISSN: 09509232 14765594

Shulewitz; Soloviev; Thomas D Wu; Koeppen; Paul G. Polakis; Sakanaka

Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia

Oncogene, ISSN: 09509232 14765594

Adrian M. Jubb; Sreedevi Chalasani; Gretchen D. Frantz; Ron Smits; Grabsch; Kavi; Maughan; Kenneth J. Hillan; Philip Quirke; Koeppen

Comments on plasmalemmal vesicle associated protein-1 as a novel marker implicated in brain tumor angiogenesis [3]

Clinical Cancer Research, ISSN: 10780432

Laura A. Strickland; Koeppen

Identification and immunotherapeutic targeting of antigens induced by chemotherapy

Nature Biotechnology, ISSN: 10870156 15461696

Bonnee Rubinfeld; Archana Upadhyay; Suzanna Clark; Fong; Victoria Smith; Koeppen; Ross; Paul G. Polakis

Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer

Journal of Clinical Oncology, ISSN: 0732183X

Adrian M. Jubb; Herbert Hurwitz; Wei Bai; Holmgren; Tobin; A. Steven Guerrero; Fairooz F. Kabbinavar; Scott N. Holden; Novotny; Gretchen D. Frantz; Kenneth J. Hillan; Koeppen

Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers

Cancer Research, ISSN: 00085472

Daniel C. Gray; Adrian M. Jubb; Deborah A. Hogue; Patrick Dowd; Noelyn Kljavin; Sothy Yi; Wei Bai; Gretchen D. Frantz; Zemin Zhang; Koeppen; Frederic J. De Sauvage; David P. Davis

Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)

Journal of Pathology, ISSN: 00223417

Laura A. Strickland; Adrian M. Jubb; Hongo; Fiona Zhong; Jennifer Burwick; Ling Fu; Gretchen D. Frantz; Koeppen

EphB2 is a prognostic factor in colorectal cancer

Clinical Cancer Research, ISSN: 10780432

Adrian M. Jubb; Fiona Zhong; Sheila Bheddah; Grabsch; Gretchen D. Frantz; Wolfram Mueller; Kavi; Philip Quirke; Paul G. Polakis; Koeppen

Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab

Journal of the National Cancer Institute, ISSN: 00278874 14602105

William L. Ince; Adrian M. Jubb; Scott N. Holden; Holmgren; Tobin; Meera Sridhar; Herbert Hurwitz; Fairooz F. Kabbinavar; Novotny; Kenneth J. Hillan; Koeppen

Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab

Journal of the National Cancer Institute, ISSN: 00278874 14602105

William Ince; Adrian M. Jubb; Scott N. Holden; Holmgren; Tobin; Meera Sridhar; Herbert Hurwitz; Fairooz F. Kabbinavar; Novotny; Kenneth J. Hillan; Koeppen

COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas

Cancer Research, ISSN: 00085472

David Dornan; Sheila Bheddah; Kim Newton; William Inice; Gretchen D. Frantz; Patrick Dowd; Koeppen; Vishva M. Dixit; French

Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand cooperates with chemotherapy to inhibit orthotopic lung tumor growth and improve survival

Cancer Research, ISSN: 00085472

Hongkui Jin; Renhui Yang; Fong; Klara Totpal; David Lawrence; Zhong Zheng; Ross; Koeppen; Ralph H. Schwall; Avi Ashkenazi

The ubiquitin ligase COP1 is a critical negative regulator of p53

Nature, ISSN: 00280836

David Dornan; Ingrid E. Wertz; Harumi Shimizu; David Arnott; Gretchen D. Frantz; Patrick Dowd; Karen M. O'Rourke; Koeppen; Vishva M. Dixit

Expression of vascular endothelial growth factor, hypoxia inducible factor 1α, and carbonic anhydrase IX in human tumours

Journal of Clinical Pathology, ISSN: 00219746

Adrian M. Jubb; Thinh Q. Pham; Hanby; Gretchen D. Frantz; Franklin V. Peale Jr.; Thomas D Wu; Koeppen; Kenneth J. Hillan

HER2-Targeted Therapy Reduces Incidence and Progression of Midlife Mammary Tumors in Female Murine Mammary Tumor Virus huHER2-Transgenic Mice

Clinical Cancer Research, ISSN: 10780432

David Finkle; Zhi Ricky Quan; Vida Asghari; Jessica Kloss; Nazli Ghaboosi; Elaine Mai; Wai Lee T. Wong; Hollingshead; Ralph H. Schwall; Koeppen; Sharon Erickson

EphB2 as a Therapeutic Antibody Drug Target for the Treatment of Colorectal Cancer

Cancer Research, ISSN: 00085472

Mao; Luis; Ross; Johnny Silva; Christine Tan; Crowley; Clarissa Chui; Gretchen Franz; Peter Senter; Koeppen; Paul G. Polakis

Quantification of Tumor Tissue Populations by Multispectral Analysis

Magnetic Resonance in Medicine, ISSN: 07403194

Richard A. D. Carano; Adrienne L. Ross; Ross; Simon P. Williams; Koeppen; Ralph H. Schwall; Nicholas Van Bruggen

Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells

Journal of Biological Chemistry, ISSN: 00219258

Bu-Er Wang; Shou; Ross; Koeppen; Frederic J. De Sauvage; Gao

Selective cyclin-dependent kinase 2/cyclin A antagonists that differ from ATP site inhibitors block tumor growth

Cancer Research, ISSN: 00085472

Nerissa Mendoza; Fong; James C. Marsters Jr.; Koeppen; Ralph H. Schwall; Dineli Wickramasinghe

Prostate stem cell antigen as therapy target: Tissue expression and in vivo efficacy of an immunoconjugate

Cancer Research, ISSN: 00085472

Ross; Spencer; Ilona N. Holcomb; Christine Tan; Hongo; Devaux; Linda Rangell; Gilbert-Andre Keller; Peter Schow; Rita M. Steeves; Robert J. Lutz; Gretchen D. Frantz; Kenneth J. Hillan; Franklin V. Peale Jr.; Tobin; Eberhard; Mark A. Rubin; Lasky; Koeppen

MAGI-1: A widely expressed, alternatively spliced tight junction protein

Experimental Cell Research, ISSN: 00144827

Richard Laura; Ross; Koeppen; Lasky

Dynamics of Notch expression during murine prostate development and tumorigenesis

Cancer Research, ISSN: 00085472

Shou; Ross; Koeppen; Frederic J. De Sauvage; Gao

PTEN 2, a Golgi-associated Testis-specific Homologue of the PTEN Tumor Suppressor Lipid Phosphatase

Journal of Biological Chemistry, ISSN: 00219258

Yan Wu; Dowbenko; Pisabarro; Lisa Dillard-Telm; Koeppen; Lasky

Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4

Journal of Immunology, ISSN: 00221767

Anan Chuntharapai; Dodge; Grimmer; Kurt A. Schroeder; Scot A. Marsters; Koeppen; Avi Ashkenazi; K.Jin Kim

Overexpression of HER2/neu in solid tumours: An immunohistochemical survey

Histopathology, ISSN: 03090167

Koeppen; Wright; Burt; Philip Quirke; McNicol; Noel Dybdal; Mark X. Sliwkowski; Kenneth J. Hillan

Selective expression of murine prostate stem cell antigen in fetal and adult tissues and the transgenic adenocarcinoma of the mouse prostate model of prostate carcinogenesis

American Journal of Pathology, ISSN: 00029440

Ross; Spencer; Lasky; Koeppen

Safety and antitumor activity of recombinant soluble Apo2 ligand

Journal of Clinical Investigation, ISSN: 00219738

Avi Ashkenazi; Roger Pai; Fong; Susan Leung; David Lawrence; Scot A. Marsters; Christine Blackie; Ling Chang; Amy E. McMurtrey; Andrea Hebert; Laura DeForge; Iphigenia Koumenis; Lewis; Louise A. Harris; Bussiere; Koeppen; Shahrokh; Ralph H. Schwall

Long-term inhibition of tumor growth by tumor necrosis factor in the absence of cachexia or T-cell immunity

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Teng; Ben H. Park; Koeppen; Kevin J. Tracey; Brian M. Fendly; Hans Schreiber

University of Chicago, Ph.D.- Immunology – 1990
University of Freiburg, Germany, M.D. – 1981
University of Freiburg, Germany, D.Sc. – 1980

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