Ishan Deshpande - Principal Scientist, Physiological Chemistry, Structural Biology (Joint Appointment)

Ishan Deshpande

Principal Scientist, Physiological Chemistry, Structural Biology (Joint Appointment)

Postdoc Mentor
"Solving complex biological puzzles to overcome disease is exciting and motivating."
2
Years at Genentech
4
Awards & Honors

I joined Genentech in 2022 to bring my passion for protein science to bear on the study of inflammatory cell death and signaling. I was drawn to the role because it offers the opportunity to perform cutting-edge science and translate novel discoveries into impactful therapies. It is incredibly humbling and inspiring to work alongside talented colleagues for the benefit of human health.

I developed a passion for mechanistic biology during my PhD in the labs of Susan Gasser and Heinz Gut at the Friedrich Miescher Institute in Switzerland. As a postdoc in Aashish Manglik’s lab at UCSF, I delved into the fascinating biology of G protein-coupled receptors using an array of structural, biophysical and biochemical methods.

Postdoctoral Mentor

The Genentech postdoc program offers early career scientists a wonderful opportunity to perform fundamental research in an industry setting. It is a privilege to work with postdocs and share their excitement and energy for high-risk, high-reward research projects. Not only is it wonderful to see scientists grow and flourish over time, but it is also deeply satisfying and motivating.

Featured Publication

Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture.

Nature.

Pourmal S*, Truong ME*, Johnson MC*, Yang Y*, Lijuan Z, Alegre K, Stowe IB, Gupta S, Chen PA, Zhang Y, Rohou A, Newton K, Kayagaki N, Dixit VM#, Deshpande I#. (2024)