Mike Costa
Senior Scientific Manager, Discovery Oncology, Research Biology
"I am inspired by my daily interactions here with like-minded scientists driven by a passion for discovery and commitment to translating a deeper understanding of biologic processes into novel disease therapies."
20
Years at Genentech
25
Publications at Genentech
3
Awards & Honors
I transitioned to Genentech in 2004 to extend my research focus from invertebrate genetics of developmental pathways to signal transduction biology in mammalian cancer models. Previously I led a C. elegans genetics group at Exelixis that identified novel regulators in several signaling pathways. At Genentech, a critical mass of talented scientists and extensive resources provide for a collaborative research environment that enables discovery of novel molecular mechanisms driving human diseases and translation of these discoveries into targeted therapies. I am inspired by my daily interactions here with like-minded scientists driven by a passion for discovery and commitment to translating a deeper understanding of biological processes into novel disease therapies.
Featured Publication
A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth.
Cancer Res. 2013 May 15;73(10):3132-3144.
Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M.
My Focus
My research group is focused on developing mechanism-based therapeutics targeting Wnt/β-catenin signaling, which is aberrantly activated at different points in the pathway in colorectal and other cancer types. We aim to better understand how β-catenin activity is regulated, and how it maintains stem-like identity and self-renewal properties in tumor cells. We utilize RNAi technology, small-molecule inhibitors, and antibodies to identify novel pathway components and investigate their mechanisms of action.
Genentech Publications
Nature Communications, ISSN: 20411723
Maria Teresa Herrera-Abreu; Guan; Khalid; Ning; Michael Costa; Jocelyn Chan; Li; Jean-Philippe Fortin; Wong; Pirunthan Perampalam; Biton; Wendy N. Sandoval; Jinchu Vijay; Marc Hafner; Rosalind J. Cutts; Wilson; Frankum; Roumeliotis; Alexander; Hickman; Brough; Syed Haider; Choudhary; Lord; Swain; Ciara Metcalfe; Nicholas C. Turner
Cell Genomics, ISSN: 2666979X
Neha Rohatgi; Jean-Philippe Fortin; Ted Lau; Yi Ying; Yue Zhang; Bettina L. Lee; Michael Costa; Rohit Reja
Cell Reports,
Kamakoti P. Bhat; Jinchu Vijay; Caroline K. Vilas; Jyoti Asundi; Jun Zou; Ted Lau; Xiaoyu Cai; Musaddeque Ahmed; Michal Kabza; Julie Weng; Jean-Philippe Fortin; Aaron T. L. Lun; Durinck; Marc Hafner; Michael Costa; Xin Ye
Nature Genetics, ISSN: 10614036
Simone M. Haag; Shiqi Xie; Celine Eidenschenk; Jean-Philippe Fortin; Marinella G. Callow; Michael Costa; Aaron T. L. Lun; Christian Cox; Sunny Z. Wu; Rachana Pradhan; Jaclyn Y. Lock; Julia A. Kuhn; Loryn Holokai; Minh Thai; Emily C. Freund; Ariane Nissenbaum; Mary E. Keir; Christopher J. Bohlen; Scott E. Martin; Kathryn R. Geiger-Schuller; Hussein A. Hejase; Brian L. Yaspan; Sandra Melo Carlos; Shannon J. Turley; Aditya Murthy
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Siyu Feng; Marinella G. Callow; Jean-Philippe Fortin; Zia Khan; David Bray; Michael Costa; Shi; Weiru Wang; Marie Evangelista
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490
Siyu Feng; Marinella G. Callow; Jean-Philippe Fortin; Zia Khan; David Bray; Michael Costa; Zhen Shi; Weiru Wang; Marie Evangelista
Proceedings of the National Academy of Sciences of the United States of America,
Siyu Feng; Marinella G. Callow; Jean-Philippe Fortin; Zia Khan; David Bray; Michael Costa; Zhen Shi; Weiru Wang; Marie Evangelista
iScience, ISSN: 25890042
Line Mygland; Shoshy Alam Brinch; Martin Frank Strand; Petter Angell Olsen; Aleksandra Aizenshtadt; Kaja Lund; Nina Therese Solberg; Max Lycke; Tor Espen Thorvaldsen; Sandra Espada; Dorna Misaghian; Christian M. Page; Oleg Agafonov; Ståle Nygård; Nai-Wen Chi; Eva Lin; Jenille Tan; Yihong Yu; Michael Costa; Stefan Krauss; Jo Waaler
Cancer Research, ISSN: 15387445 00085472
Steffan Vartanian; James Lee; Christiaan N. Klijn; Florian Gnad; Maria Bagniewska; Gabriele Schaefer; Donglu Zhang; Jenille Tan; Sara A. Watson; Liling Liu; Chen; Yuxin Liang; Colin K. Watanabe; Trinna L. Cuellar; David Kan; Ryan J. Hartmaier; Ted Lau; Michael Costa; Scott E. Martin; Mark Merchant; Benjamin Haley; David Stokoe
Genome Biology, ISSN: 1474760X 14747596
Jean-Philippe Fortin; Jenille Tan; Karen Gascoigne; Peter M. Haverty; William F. Forrest; Michael Costa; Scott E. Martin
Cell Death and Disease, ISSN: 20414889
Marinella G. Callow; Colin K. Watanabe; Katherine E. Wickliffe; Russell Bainer; Sarah Kummerfield; Julie Weng; Trinna L. Cuellar; Vasantharajan Janakiraman; Chen; Ben Chih; Yuxin Liang; Benjamin Haley; Kim Newton; Michael Costa
Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery,
Trinna L. Cuellar; Marinella G. Callow; Ted Lau; Colin Watanabe; Russell Bainer; Michael Costa; Benjamin Haley
Nature Chemical Biology, ISSN: 15524469 15524450
Maia Vinogradova; Victor S Gehling; Amy Gustafson; Shilpi Arora; Charles Tindell; Catherine Wilson; Kaylyn E Williamson; Gulfem D. Guler; Pranoti Gangurde; Wanda Manieri; Jennifer Busby; E. Megan Flynn; Fei Lan; Hyo-Jin Kim; Shobu Odate; Andrea G Cochran; Yichin Liu; Matthew Wongchenko; Yibin Yang; Tommy K. Cheung; Tobias Maile; Ted Lau; Michael Costa; Ganapati V. Hegde; Erica L. Jackson; Pitti; David Arnott; Christopher Bailey; Steve Bellon; Richard T Cummings; Brian K Albrecht; Jean-Christophe Harmange; James R. Kiefer; Patrick Trojer; Marie Classon
Toxicologic Pathology, ISSN: 15331601 01926233
Yu Zhong; Paula Katavolos; Trung Nguyen; Ted Lau; Jason Boggs; Amy Sambrone; David Kan; Mark Merchant; Eric Harstad; Dolores Diaz; Michael Costa; Melissa Schutten
Cell Reports, ISSN: 22111247
Hua Tian; Brian Biehs; Cecilia Chiu; Christian W. Siebel; Yan Wu; Michael Costa; Frederic J. De Sauvage; Ophir D. Klein
PLoS ONE, ISSN: 19326203
Travis W. Bainbridge; Venita I. DeAlmeida; Anita Izrael-Tomasevic; Cecile Chalouni; Borlan Pan; Joshua Goldsmith; Alia P. Schoen; Gabriel Quinones; Ryan Kelly; Jennie R. Lill; Wendy N. Sandoval; Michael Costa; Paul G. Polakis; David Arnott; Bonnee Rubinfeld; James A. Ernst
Science China Life Sciences, ISSN: 16747305
LiLi Qian; ChangZu Cai; PengFei Yuan; Sun-Young Jeong; XiaoZhou Yang; Venita I. DeAlmeida; James A. Ernst; Michael Costa; Stanley N. Cohen; WenSheng Wei
Cancer Research, ISSN: 00085472 15387445
Ted Lau; Emily Chan; Marinella G. Callow; Jo Waaler; Jason Boggs; Robert A. Blake; Steven Magnuson; Amy Sambrone; Melissa Schutten; Ron Firestein; Ondrej Machon; Vladimir Korinek; Edna F. Choo; Dolores Diaz; Mark Merchant; Paul G. Polakis; Daniel D. Holsworth; Stefan Krauss; Michael Costa
Structure, ISSN: 09692126 18784186
Eric Bourhis; Weiru Wang; Christine Tam; Jiyoung Hwang; Yingnan Zhang; Didier Spittler; Oscar W Huang; Yan Gong; Alberto Estevez; Inna Zilberleyb; Lionel Rouge; Cecilia Chiu; Yan Wu; Michael Costa; Rami N. Hannoush; Yvonne Franke; Andrea G Cochran
PLoS ONE, ISSN: 19326203
Marinella G. Callow; Hoanh Tran; Lilian Phu; Ted Lau; James Lee; Wendy N. Sandoval; Peter S. Liu; Sheila Bheddah; Janet Tao; Jennie R. Lill; Hongo; David P. Davis; Donald S. Kirkpatrick; Paul G. Polakis; Michael Costa
PLoS ONE, ISSN: 19326203
Yan Gong; Eric Bourhis; Cecilia Chiu; Scott Stawicki; Venita I. DeAlmeida; Bob Y. Liu; Khanhky Phamluong; Tim C. Cao; Richard A. D. Carano; James A. Ernst; Mark J. Solloway; Bonnee Rubinfeld; Rami N. Hannoush; Yan Wu; Paul G. Polakis; Michael Costa
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eric Bourhis; Christine Tam; Yvonne Franke; J.Fernando Bazan; James A. Ernst; Jiyoung Hwang; Michael Costa; Andrea G Cochran; Rami N. Hannoush
Cell, ISSN: 00928674
Harald Junge; Stacey Yang; Jeremy B. Burton; Kim Paes; Xiao Shu; French; Michael Costa; Dennis S. Rice; Weilan Ye
Nature Chemical Biology, ISSN: 15524469 15524450
Yingnan Zhang; Brent A. Appleton; Wiesmann; Ted Lau; Michael Costa; Rami N. Hannoush; Sachdev S. Sidhu
PLoS ONE, ISSN: 19326203
Nathan T. Morrell; Philipp Leucht; Ludan Zhao; Jae-Beom Kim; Derk ten Berge; Karthik Ponnusamy; A. Lyonel Carre; Henryk Dudek; Marie Zachlederova; Michael McElhaney; Shirley A. Brunton; Janet Gunzner; Marinella G. Callow; Paul G. Polakis; Michael Costa; Xiaoyan M. Zhang; Jill A. Helms; Roel Nusse
Education
- Fred Hutchinson Cancer Research Center, Postdoctoral Fellow – 1997
- Princeton University, Department of Molecular Biology, Ph.D. – 1994
- Cornell University, Department Biological Sciences, B.S. – 1986
Awards & Honors
- Founders’ Research Seminar invited speaker, Exelixis, Inc. – 2002
- Damon Runyon-Walter Winchell Foundation Postdoctoral Fellowship – 1994-1997
- Card Family Fund Dissertation Travel Research Award – 1992
