Noel Dybdal
Senior Director and Distinguished Scientist, Safety Assessment Pathology, Development Sciences
"The environment at Genentech is always stimulating and the opportunity to work with some of the brightest and most innovative scientists imaginable working toward a common and urgent goal of providing new and better options for patients is continuously rewarding. The urgency of our mission drives us to bring our best selves to work every day."
32
Years at Genentech
47
Publications at Genentech
1
Awards & Honors
Following completion of residency training in Pathology and post-doctoral work in Endocrine Pathology, I joined Genentech as a Scientist-Pathologist in 1992. I was most attracted by the Genentech reputation for rigor. Happily, given my interest and training in pathology, receptor ligand biology and radioimmunoassay and immunohistochemistry techniques, I became involved early with the oncology program teams, in particular the anti-HER2 projects. My responsibilities have also included growing the Safety Assessment Pathology group to meet the needs of all Genentech programs.
Featured Publication
Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab.
Breast Cancer Res Treat. 2005 Sep; 93(1): 3-11.
Dybdal N, Leiberman G, Anderson S, McCune B, Bajamonde A, Cohen RL, Mass RD, Sanders C, Press MF.
My Focus
Providing expertise in pathology, veterinary medicine and comparative medicine to enhance the timely development of safe Genentech medicines. Working in a highly collaborative environment with colleagues from across the gRED and Product Development to design and implement programs in support of optimal drug candidate development at Genentech. Building and supporting an industry leading Safety Assessment Pathology group. Actively driving innovation in preclinical drug development approaches, supporting and participating in internal and cross-industry efforts to increase drug development efficiency and success while building data to support regulatory acceptance.
Genentech Publications
Altex, ISSN: 1868596X
Roxanne Andaya; Ruth Sullivan; Tony Pourmohamad; Matthew Hayes; Pierre Maliver; Steven T. Laing; Catrin Hasselgren; Noel Dybdal; Adedeji; Lennart T. Anger
Toxicologic Pathology, ISSN: 01926233
Adedeji; Fiona Zhong; Janice Corpuz; Fangyao Hu; Xiaofeng Zhao; Dewakar Sangaraju; Catherine F. Ruff; Noel Dybdal
Toxicologic Pathology, ISSN: 01926233
Armelle Grevot; Julie Boisclair; Magali Guffroy; Peter Hall; Gabriele Pohlmeyer-Esch; Matt Jacobsen; Ute Bach; Anna Lena Frisk; Noel Dybdal; Xavier Palazzi
Animals,
Jessica Graham; Lisa Wong; Adeyemi O. Adedeji; Aija Kusi; Becky Lee; Donna Lee; Noel Dybdal
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719
Emmanuel Boulay; Loïs S. Miraucourt; Michael K. Pugsley; Matthew Abernathy; Ray Chui; Jill Dalton; Marjorie Demers; Noel Dybdal; Elissa Gazaille; Andrea Greiter-Wilke; Peter K. Hoffmann; Hai Huang; Carrie LaDuke; Kevin Norton; Jennifer Pierson; Isabelle Reeves; Brian Roche; Eric I. Rossman; A. Eric Schultze; Hai-Ming Tang; Todd A. Wisialowski; Simon Authier
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Hsiaotzu Chien; Helen Prior; Laura Andrews; Leon van Aerts; Annick Cauvin; David Clarke; Kaushik Datta; Maggie Dempster; Noel Dybdal; Wendy Freebern; Lolke de Haan; Danuta Herzyk; Adam Hey; Thomas Kissner; Sven Kronenberg; Michael W. Leach; Donna W. Lee; Katrin Schutte; Fiona Sewell; Kevin Trouba; Peter Ulrich; Lucinda Weir; Peter van Meer
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Helen Prior; Laura Andrews; Annick Cauvin; Hsiaotzu Chien; David Clarke; Kaushik Datta; Maggie Dempster; Noel Dybdal; Wendy Freebern; Lolke de Haan; Danuta Herzyk; Adam Hey; Thomas Kissner; Sven Kronenberg; Michael W. Leach; Donna W. Lee; Kirsty Reid; Katrin Schutte; Fiona Sewell; Kevin Trouba; Peter Ulrich; Leon van Aerts; Peter van Meer; Lucinda Weir
Toxicologic Pathology, ISSN: 01926233
Adedeji; Tony Pourmohamad; Niraj K. Tripathi; Shelly Zhong; Kenna R. Degner; Fiona Zhong; Dewakar Sangaraju; Kevin Williams; Noel Dybdal
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Gail D. Lewis Phillips; Jun Guo; James R. Kiefer; William R. Proctor; Daniela Bumbaca Yadav; Noel Dybdal; Shen
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Paul Rossman; Tanja S. Zabka; Audrey Ruple; Dietrich Tuerck; Ramos-Vara; Liling Liu; Rodrigo Mohallem; Mark Merchant; Jackeline Franco; Christopher M. Fulkerson; Ketaki P. Bhide; Matthew Breen; Uma K. Aryal; Elaine R. Murray; Noel Dybdal; Sagar M. Utturkar; Lindsey M. Fourez; Alexander W. Enstrom; Deepika Dhawan; Deborah W. Knapp
Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody
JCI insight, ISSN: 23793708
Karin Staflin; Christina L. Zuch de Zafra; Leah Schutt; Vanessa Clark; Fiona Zhong; Maria Hristopoulos; Robyn Clark; Ji Li; Mary Mathieu; Xiaocheng Chen; Jennifer A. Johnston; Justin Low; Ryan Ybarra; Dionysos S. Slaga; Yang; Meric A. Ovacik; Noel Dybdal; Klara Totpal; Melissa Junttila; Diego Ellerman; Genee Y. Lee; Dennis; Prell; Teemu T. Junttila
Toxicologic Pathology, ISSN: 15331601 01926233
Fangyao Hu; Leah Schutt; Cleopatra Kozlowski; Karen S. Regan; Noel Dybdal; Melissa Schutten
Toxicologic Pathology, ISSN: 15331601 01926233
Renee R. Hukkanen; Noel Dybdal; Niraj K. Tripathi; Patricia V. Turner; Sean P. Troth
AAPS Journal, ISSN: 15507416
Danielle Mandikian; Isabel Figueroa; Amy Oldendorp; Hanine Rafidi; Sheila Ulufatu; Michelle G. Schweiger; Jessica A. Couch; Noel Dybdal; Sean B. Joseph; Saileta Prabhu; Gregory Z. Ferl; C. Andrew Boswell
Toxicological Sciences, ISSN: 10960929 10966080
Prell; Noel Dybdal; Akihiro Arima; Yutaka Chihaya; Ihsan Nijem; Wendy Halpern
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Jinze Li; Eric Morinello; Thomas Larsen; Denzil Frost; Ivor Caro; Stephen Gould; Lisa Wong; Angela Hendricks; Noel Dybdal; Donna M. Dambach; Melissa Schutten
Toxicologic Pathology, ISSN: 15331601 01926233
James R. Hailey; Beverly E. Maleeff; Heath C. Thomas; Gail Pearse; Jan C. Klapwijk; Patrizia G. Cristofori; Brian R. Berridge; Carie L. Kimbrough; George A. Parker; Daniel Morton; Susan A. Elmore; Jerry F. Hardisty; Noel Dybdal; David A. Rehagen; James D. Fikes; Martin Lamb; Kathleen Biddle; Bernard S. Buetow; Vinicius Carreira; Abraham Nyska; Niraj K. Tripathi; Heather C. Workman; Jean-Guy Bienvenu; Ingrid Brees; James R. Turk; Rick R. Adler
Toxicologic Pathology, ISSN: 15331601 01926233
James R. Hailey; Beverly E. Maleeff; Heath C. Thomas; Gail Pearse; Jan C. Klapwijk; Patrizia G. Cristofori; Brian R. Berridge; Carie L. Kimbrough; George A. Parker; Daniel Morton; Susan A. Elmore; Jerry F. Hardisty; Noel Dybdal; David A. Rehagen; James D. Fikes; Martin Lamb; Kathleen Biddle; Bernard S. Buetow; Vinicius Carreira; Abraham Nyska; Niraj K. Tripathi; Heather C. Workman; Jean-Guy Bienvenu; Ingrid Brees; James R. Turk; Rick R. Adler
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719
Helen Prior; Anna Bottomley; Pascal Champéroux; Jason Cordes; Eric Delpy; Noel Dybdal; Nick Edmunds; Mike Engwall; Mike Foley; Michael Hoffmann; Robert Kaiser; Ken Meecham; Stéphane Milano; Aileen Milne; Rick Nelson; Brian Roche; Jean-Pierre Valentin; Gemma Ward; Kathryn Chapman
Journal of Veterinary Internal Medicine, ISSN: 19391676 08916640
Page; Baneux; Vail; Duda; Olson; Anestidou; Noel Dybdal; Golab; Shelton; Salgaller; Hardy
Cell Death and Disease, ISSN: 20414889
Christina de Zafra; Avi Ashkenazi; Darbonne; Melissa Cheu; Klara Totpal; Shirley Ortega; Heather Flores; Mark D. Walker; Bruce Kabakoff; Bert L. Lum; Barbara J. Mounho-Zamora; Scot A. Marsters; Noel Dybdal
Science Translational Medicine, ISSN: 19466242 19466234
Liping L. Sun; Diego Ellerman; Mary Mathieu; Maria Hristopoulos; Xiaocheng Chen; Yijin Li; Xiaojie Yan; Robyn Clark; Arthur Reyes; Stefanich; Elaine Mai; Judy Young; Clarissa Johnson; Mahrukh Huseni; Xinhua Wang; Chen; Peiyin Wang; Hong Wang; Noel Dybdal; Yu-Waye Chu; Nicholas Chiorazzi; Justin M. Scheer; Teemu T. Junttila; Klara Totpal; Dennis; Allen Ebens
Toxicology and Applied Pharmacology, ISSN: 0041008X 10960333
Kirsten Achilles Poon; Kelly Flagella; Joseph Beyer; Jay Tibbitts; Surinder Kaur; Ola M. Saad; Joo-Hee Yi; Sandhya Girish; Noel Dybdal; Theresa Reynolds
Toxicological Sciences, ISSN: 10966080 10960929
Rebecca Erickson; Jacqueline M. Tarrant; Cain; Sock-Cheng Lewin-Koh; Noel Dybdal; Harvey Wong; Elizabeth M. Blackwood; Kristina West; Ronald Steigerwalt; Michael Mamounas; Flygare; Kenjie Amemiya; Donna M. Dambach; Wayne J. Fairbrother; Dolores Diaz
Journal of Pharmacological and Toxicological Methods, ISSN: 10568719 1873488X
Leishman; Beck; Noel Dybdal; Gallacher; Guth; Holbrook; Brian Roche; Wallis
Journal of Equine Veterinary Science, ISSN: 07370806
Christiana M. Glover; Lisa M. Miller; Noel Dybdal; Alfonso Lopez; Wendy M. Duckett; Dianne McFarlane
Toxicologic Pathology, ISSN: 01926233
Darrell L. Tuomari; Ramon K. Kemp; Rani Sellers; John T. Yarrington; Frank J. Geoly; Xavier L. M. Fouillet; Noel Dybdal; Rick Perry
Cancer Immunology, Immunotherapy, ISSN: 03407004
Adams; David E. Allison; Kelly Flagella; Presta; Janet Clarke; Noel Dybdal; Kathleen McKeever; Mark X. Sliwkowski
American Journal of Veterinary Research, ISSN: 00029645
Dianne McFarlane; Lisa M. Miller; Linden E. Craig; Noel Dybdal; Perry L. Habecker; Margaret A. Miller; Jon S. Patterson; Alastair E. Cribb
Breast Cancer Research and Treatment, ISSN: 01676806
Noel Dybdal; Grazyna Leiberman; Steven M. Anderson; Bryan McCune; Alex Bajamonde; Robert L. Cohen; Robert Mass; Corsee Sanders; Michael F. Press
Journal of Neuroendocrinology, ISSN: 09538194
Dianne McFarlane; Noel Dybdal; Donaldson; Lisa M. Miller; Alastair E. Cribb
Clinical Breast Cancer, ISSN: 15268209
Robert Mass; Michael F. Press; Steven M. Anderson; Melody A. Cobleigh; Charles L. Vogel; Noel Dybdal; Grazyna Leiberman; Dennis J. Slamon; Virginia Paton
Drug Metabolism and Disposition, ISSN: 00909556
Hong Xiang; Cindy B. Nguyen; Kelley; Noel Dybdal; Escandon
Seminars in Oncology, ISSN: 00937754
Pam Klein; Noel Dybdal
Biomaterials, ISSN: 01429612
Okumu; Dao; Fielder; Noel Dybdal; Brooks; Samir Sane; Cleland
Histopathology, ISSN: 03090167
Koeppen; Wright; Burt; Philip Quirke; McNicol; Noel Dybdal; Mark X. Sliwkowski; Kenneth J. Hillan
Drug Metabolism and Disposition, ISSN: 00909556
Cindy B. Nguyen; Louise A. Harris; Szonyi; Sharon A. Baughman; Victoria Hale; Noel Dybdal; Michael D Sadick; Escandon
Compendium on Continuing Education for the Practicing Veterinarian, ISSN: 01931903
Michel Levy; Janice E. Sojka; Noel Dybdal
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642
Renhui Yang; Powell-Braxton; Annie Ko Ogaoawara; Noel Dybdal; Bunting; Osamu Ohneda; Hongkui Jin
Nature Medicine, ISSN: 10788956
Powell-Braxton; Murielle Véniant; Richard D. Latvala; Ken-Ichi Hirano; Wesley B. Won; Ross; Noel Dybdal; Constance Zlot; Stephen G. Young; Nicholas O. Davidson
Lupus, ISSN: 09612033
Verthelyi; Noel Dybdal; Kathleen A. Elias; Klinman
Annals of the New York Academy of Sciences, ISSN: 00778923
Sharma; Kelly E. Hagler; Noel Dybdal; Chronwall
Diabetes, ISSN: 00121797
Hultgren; Huang; Noel Dybdal; Stewart
Current Biology, ISSN: 09609822
David Hoke; Mebius; Noel Dybdal; Dowbenko; Gribling; Carrie Kyle; Baumhueter; Susan R. Watson
Annals of Neurology, ISSN: 15318249 03645134
Gao; Noel Dybdal; Natasha Shinsky; Amy Murnane; Charles H. Schmelzer; Mark Siegel; Gilbert-Andre Keller; Franz Hefti; Phillips; Winslow
Blood, ISSN: 00064971
Baumhueter; Noel Dybdal; Carrie Kyle; Lasky
Immunity, ISSN: 10747613
Huang; Hultgren; Noel Dybdal; Stewart
Education
- University of California, Davis, Ph.D. in Comparative Pathology – 1989
- University of California, Davis, D.V.M. – 1981
- University of California, Davis, M.A. in Endocrinology – 1977
- University of California, Davis, B.S. in Animal Physiology – 1973
Awards & Honors
- Diplomate, American College of Veterinary Pathology –