Wenxian Fu
Senior Principal Scientist, Cancer Immunology, Research Biology
"Life is a journey filled with inspirations. I feel myself inspired every day at Genentech."
I joined Genentech in the summer of 2020. Prior to that, I was a faculty member at UCSD, starting as an Assistant Professor and promoted to Associate Professor with tenure. I made this career shift because I believe that Genentech is a very unique place that fosters both cutting-edge scientific research and ground-breaking therapies for patients. My role at Genentech is to lead a group focusing on dissecting tissue and tumor immune microenvironment, striving to identify novel therapeutic targets and the underlying mechanisms.
Postdoctoral Mentor
I have been very fortunate to have highly talented postdocs in my lab since I started my career as an independent investigator. Genentech offers a world-class postdoc program providing an exceptional environment for postdocs to reach their full potential. I feel privileged to be part of this program. It is a very rewarding experience.
Featured Publication
Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer.
Immunity 54:903-15, 2021.
The role of macrophages in obesity-associated islet inflammation and beta-cell abnormalities.
Nat Rev Endocrinol. 2020 Feb;16(2):81-90
Macrophages Lead to Islet Inflammation by Local Proliferation to Affect β Cell Proliferation and Function in Obesity.
Cell Metabolism 2019. 39: 457-474.
TCF1 and LEF1 control Treg competitive survival and Tfr differentiation to prevent autoimmune diseases.
Cell Reports 2019. 27:3629-3645.