Scientists / Our Scientists

Yulei Wang

Senior Fellow, Translational Oncology, Translational Medicine

Postdoc Mentor

"Making impacts on science and making impacts on patients. Being able to do both as a scientist at Genentech is incredible rewarding."

Years at Genentech

Awards & Honors

I joined Genentech in 2011. As a Senior Principal Scientist in the Department of Oncology Biomarker, I lead the translation and reverse translation studies in liver cancer and ovarian cancer disease areas as well as global combination immunotherapy development. By integrating cancer genomics, digital pathology, ctDNA and single cell multi-omics in clinical biomarker studies, my team has gained novel insights into potential mechanisms of response and resistance to cancer immunotherapies.

Postdoctoral Mentor

Becoming a postdoc mentor has been the most exciting and rewarding experience for me. The postdoc program provides us an excellent opportunity to gain insights into disease biology and mechanism of response and resistance in drug development via cutting-edge translation and reverse translation research.

Summary of Publications: PDF

Featured Publication

Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer.

Cancer Cell. 2021 Jul 12;39(7):928-944.e6. doi: 10.1016/j.ccell.2021.04.004. Epub 2021 May 6.

Hornburg M, Desbois M, Lu S, Guan Y, Lo AA, Kaufman S, Elrod A, Lotstein A, DesRochers TM, Munoz-Rodriguez JL, Wang X, Giltnane J, Mayba O, Turley SJ, Bourgon R, Daemen A, Wang Y.

View Abstract

Cancer-associated fibroblasts: Key players in shaping the tumor immune microenvironment.

Immunol Rev. 2021 Jul;302(1):241-258. doi: 10.1111/imr.12982. Epub 2021 Jun 1.

Desbois M, Wang Y.

View Abstract

Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.

2020 Nov 5;11:598877. doi: 10.3389/fimmu.2020.598877.

Hack SP, Zhu AX, Wang Y.

View Abstract

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.

Nat Commun. 2020 Nov 4;11(1):5583. doi: 10.1038/s41467-020-19408-2.

Desbois M, Udyavar AR, Ryner L, Kozlowski C, Guan Y, Dürrbaum M, Lu S, Fortin JP, Koeppen H, Ziai J, Chang CW, Keerthivasan S, Plante M, Bourgon R, Bais C, Hegde P, Daemen A, Turley S, Wang Y.

View Abstract

Genomic Analysis of Circulating Tumor Cells at the Single-Cell Level. J Mol Diagn.

2020 Jun;22(6):770-781. doi: 10.1016/j.jmoldx.2020.02.013. Epub 2020 Apr 2.

Lu S, Chang CJ, Guan Y, Szafer-Glusman E, Punnoose E, Do A, Suttmann B, Gagnon R, Rodriguez A, Landers M, Spoerke J, Lackner MR, Xiao W, Wang Y.

View Abstract

High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing.

J Mol Diagn. 2017 Nov;19(6):921-932. doi: 10.1016/j.jmoldx.2017.08.001. Epub 2017 Sep 1.

Guan Y, Mayba O, Sandmann T, Lu S, Choi Y, Darbonne WC, Leveque V, Ryner L, Humke E, Tam NWR, Sujathasarma S, Cheung A, Bourgon R, Lackner MR, Wang Y.

View Abstract

Upregulation of Periostin and Reactive Stroma Is Associated with Primary Chemoresistance and Predicts Clinical Outcomes in Epithelial Ovarian Cancer.

Clin Cancer Res. 2015 Jul 1;21(13):2941-51. doi: 10.1158/1078-0432.CCR-14-3111. Epub 2015 Apr 2.

Ryner L, Guan Y, Firestein R, Xiao Y, Choi Y, Rabe C, Lu S, Fuentes E, Huw LY, Lackner MR, Fu L, Amler LC, Bais C, Wang Y.

View Abstract

High-throughput detection of clinically relevant mutations in archived tumor samples by multiplexed PCR and next-generation sequencing.

Clin Cancer Res. 2014 Apr 15;20(8):2080-91. doi: 10.1158/1078-0432.CCR-13-3114. Epub 2014 Feb 26.

Bourgon R, Lu S, Yan Y, Lackner MR, Wang W, Weigman V, Wang D, Guan Y, Ryner L, Koeppen H, Patel R, Hampton GM, Amler LC, Wang Y.

View Abstract

My group’s translational research focuses on understanding the heterogeneity of the disease biology, tumor immune microenvironment and stroma biology to guide the development of novel therapeutic and diagnostic strategies.

Stanford University, Stanford, CA, Postdoctoral Fellow – 2002
University of Chicago, Chicago, IL, Ph.D – 1999
Peking University, Beijing, China, B.S. – 1991

Howard Hughes research fellowship – 1999
Guanghua award for outstanding undergraduate research – 1991

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Yulei Wang

Senior Fellow, Translational Oncology, Translational Medicine

Summary of Publications: PDF

Featured Publication

Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer.

Cancer-associated fibroblasts: Key players in shaping the tumor immune microenvironment.

Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.

Genomic Analysis of Circulating Tumor Cells at the Single-Cell Level. J Mol Diagn.

High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing.

Upregulation of Periostin and Reactive Stroma Is Associated with Primary Chemoresistance and Predicts Clinical Outcomes in Epithelial Ovarian Cancer.

High-throughput detection of clinically relevant mutations in archived tumor samples by multiplexed PCR and next-generation sequencing.