Genentech: Publications

March 1, 2006

Community-based trial of a triple-combination agent for the treatment of facial melasma

Cutis, ISSN: 00114162

Pearl Grimes; A. Paul Kelly; Helen Torok; Isaac Willis

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March 1, 2006

Synapse disassembly and formation of new synapses in postnatal muscle upon conditional inactivation of MuSK

Molecular and Cellular Neuroscience, ISSN: 10447431

Boris A. Hesser; Oliver Henschel; Veit Witzemann

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March 1, 2006

Enantioselective total synthesis of batzelladine F and definition of its structure

Journal of the American Chemical Society, ISSN: 00027863

Frederick Cohen; Larry E. Overman

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March 1, 2006

Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteers

Drug Metabolism and Disposition, ISSN: 00909556

Jie Ling; Kim A. Johnson; Zhuang Miao; Ashok Rakhit; Michael P. Pantze; Marta Hamilton; Bert L. Lum; Chandra Prakash

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March 1, 2006

A rapid method for estimation of baculovirus titer based on viable cell size

Journal of Virological Methods, ISSN: 01660934

Vasantharajan Janakiraman; William F. Forrest; Bernard Chow; Somasekar Seshagiri

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March 1, 2006

Evaluation of the absolute oral bioavailability and bioequivalence of erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in a randomized, crossover study in healthy subjects

Journal of Clinical Pharmacology, ISSN: 00912700 15524604

Paul Frohna; Jian-Feng Lu; Stephen M. Eppler; Marta Hamilton; Julie Wolf; Ashok Rakhit; Jie Ling; Sara Kenkare-Mitra; Bert L. Lum

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March 1, 2006

Effect of overexpression of a soluble pyridine nucleotide transhydrogenase (UdhA) on the production of poly(3-hydroxybutyrate) in Escherichia coli

Biotechnology Progress, ISSN: 87567938

Ailen M. Sánchez; Jared Andrews; Insiya Hussein; George N. Bennett; Ka-Yiu San

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March 1, 2006

Mitochondrial localization of CNP2 is regulated by phosphorylation of the N-terminal targeting signal by PKC: Implications of a mitochondrial function for CNP2 in glial and non-glial cells

Molecular and Cellular Neuroscience, ISSN: 10447431

John Lee; Ryan C. O'Neill; Min Woo Park; Michel Gravel; Peter E. Braun

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March 1, 2006

Vascular endothelial growth factor A signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival

Journal of the American Society of Nephrology, ISSN: 10466673

Vera Eremina; Shiying Cui; Hans-Peter Gerber; Napoleone Ferrara; Jody Haigh; Andras Nagy; Masatsugu Ema; Janet Rossant; Serge Jothy; Jeffrey H. Miner; Susan E. Quaggin

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March 1, 2006

The vascular basement membrane: A niche for insulin gene expression and β cell proliferation

Developmental Cell, ISSN: 15345807

Ganka Nikolova; Normund Jabs; Irena Konstantinova; Anna Domogatskaya; Karl Tryggvason; Lydia Sorokin; Reinhard Fässler; Guoqiang Gu; Hans-Peter Gerber; Napoleone Ferrara; Douglas A. Melton; Eckhard Lammert

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March 1, 2006

Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis

International Journal of Cancer, ISSN: 00207136 10970215

Michael Scott; W. Glenn McCluggage; Kenneth J. Hillan; Peter A. Hall; S. E. Hilary Russell

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March 1, 2006

Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis

Development (Cambridge), ISSN: 09501991

Phyllis Strickland; Grace C. Shin; Andrew Plump; Marc Tessier-Lavigne; Hinck

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March 1, 2006

Compaction agent protection of nucleic acids during mechanical lysis

Biotechnology Progress, ISSN: 87567938

Jason C. Murphy; Tony Cano; George E. Fox; Richard C. Willson

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February 24, 2006

Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit: Differences in structure and function relative to unliganded UL44

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Brent A. Appleton; Justin Brooks; Arianna Loregian; David J. Filman; Donald M. Coen; James M. Hogle

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February 15, 2006

Cutting edge: Novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods

Journal of Immunology, ISSN: 00221767

Pisabarro; Beatrice Leung; Mandy Kwong; Corpuz; Gretchen D. Frantz; Nancy Y. Chiang; Richard L. Vandlen; Laurie Diehl; Nicholas J. Skelton; Hok Seon Kim; Dan L. Eaton; Kerstin N. Schmidt

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February 9, 2006

Dr. Mastrianni's letter was referred to Genentech, the manufacturer of trastuzumab, which offers the following reply [9]

New England Journal of Medicine, ISSN: 00284793 15334406

Hal V. Barron

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February 3, 2006

New neurons follow the flow of cerebrospinal fluid in the adult brain

Science, ISSN: 00368075 10959203

Kazunobu Sawamoto; Hynek Wichterle; Oscar Gonzalez-Perez; Jeremy A. Cholfin; Masayuki Yamada; Nathalie Spassky; Noel S. Murcia; Jose Manuel Garcia-Verdugo; Oscar Marín; John L. R. Rubenstein; Marc Tessier-Lavigne; Hideyuki Okano; Arturo Alvarez-Buylla

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February 1, 2006

Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma

Cancer, ISSN: 0008543X 10970142

Brian I. Rini; Vivian Weinberg; Sarah Dunlap; Alexandra Elchinoff; Nancy Yu; Robert Bok; Jeffery Simko; Small

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February 1, 2006

Identification and immunotherapeutic targeting of antigens induced by chemotherapy

Nature Biotechnology, ISSN: 10870156 15461696

Bonnee Rubinfeld; Archana Upadhyay; Suzanna Clark; Fong; Victoria Smith; Koeppen; Ross; Paul G. Polakis

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February 1, 2006

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the αl subunit of lymphocyte function-associated antigen-1

Protein Science, ISSN: 09618368 1469896X

Keating; Clark; Lisa D. Stefanich; Arellano; Caroline P. Edwards; Bodary; Steven A. Spencer; Thomas Gadek; James C. Marsters Jr.; Beresini

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February 1, 2006

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

Developmental Biology, ISSN: 00121606

Xi-De Wang; Ching Ching Leow; Jiping Zha; Zhijun Tang; Zora Modrusan; Freddy Radtke; Michel Aguet; Frederic J. De Sauvage; Gao

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February 1, 2006

Ocular versus extraocular neovascularization: Mirror images or vague resemblances

Investigative Ophthalmology and Visual Science, ISSN: 01460404

Peter A. Campochiaro; Rhoda Alani; Kari Alitalo; Peter Brooks; Ruth Caldwell; Peter Carmeliet; Pier Paolo Claudio; Robert D'Amato; Arup Das; Rainer De Martin; Michael Detmar; Napoleone Ferrara; Robert N. Frank; Marcus Fruttiger; Antonio Giordano; Maria Grant; Hans-Peter Hammes; Mats Hellstrom; David Hinton; Eli Keshet; Alisa Koch; Richard Lang; Donald M. McDonald; Jeremy Nathans; Dario Neri; Gera Neufeld; Jean Plouet; Gregg Semenza; Nader Sheibani; David T. Shima; Philip Thorpe; Rubin Tuder; Olga Volpert; Elizabeth Wagner; Bernhard Weber; Stanley Wiegand

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January 20, 2006

In reply [2]

Journal of Clinical Oncology, ISSN: 0732183X

Fairooz F. Kabbinavar; Julie Hambleton; Robert Mass; Somnath Sarkar

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January 15, 2006

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

Cancer Research, ISSN: 00085472

Klaus P. Hoeflich; Daniel C. Gray; Mike Eby; Janet Y. Tien; Leo Wong; Janeko Bower; Alvin Gogineni; Jiping Zha; Mary J. Cole; Howard M. Stern; Lesley J. Murray; David P. Davis; Somasekar Seshagiri

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January 15, 2006

Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in mice

Blood, ISSN: 00064971 00064971

Ajay K. Malik; Megan E. Baldwin; Franklin V. Peale Jr.; Fuh; Wei-Ching Liang; Henry B. Lowman; Meng; Napoleone Ferrara; Hans-Peter Gerber

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January 13, 2006

When proteomes collide

Science, ISSN: 00368075 10959203

Joel S. Bader; John Chant

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January 13, 2006

Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Wei-Ching Liang; Xiumin Wu; Franklin V. Peale Jr.; Chingwei V. Lee; Meng; Johnny Gutierrez; Ling Fu; Ajay K. Malik; Hans-Peter Gerber; Napoleone Ferrara; Fuh

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January 10, 2006

Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer

Journal of Clinical Oncology, ISSN: 0732183X

Adrian M. Jubb; Herbert Hurwitz; Wei Bai; Holmgren; Tobin; A. Steven Guerrero; Fairooz F. Kabbinavar; Scott N. Holden; Novotny; Gretchen D. Frantz; Kenneth J. Hillan; Koeppen

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January 3, 2006

Hospital improvement in time to reperfusion in patients with acute myocardial infarction, 1999 to 2002

Journal of the American College of Cardiology, ISSN: 07351097

Robert L. McNamara; Jeph Herrin; Elizabeth H. Bradley; Edward L. Portnay; Jeptha P. Curtis; Yongfei Wang; David J. Magid; Martha Blaney; Harlan M. Krumholz

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January 1, 2006

Counterpoint: Why biogenerics are a strawman

Nature Biotechnology, ISSN: 15461696 10870156

Robert L. Garnick

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January 1, 2006

Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology

American Journal of Pathology, ISSN: 00029440

Lucia E. Rosas; Anjali A. Satoskar; Kimberly M. Roth; Tracy L. Keiser; Joseph Barbi; Christopher A. Hunter; Frederic J. De Sauvage; Abhay R. Satoskar

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January 1, 2006

Discovery of thrombin activatable fibrinolysis inhibitor (TAFI)

Journal of Thrombosis and Haemostasis, ISSN: 15387836 15387933

Bertina; Van Tilburg; Haverkate; Bouma; Von Dem Borne; Meijers; William Campbell; Dan L. Eaton; Dirk F. Hendriks; Willemse

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January 1, 2006

IL-27 limits IL-2 production during Th1 differentiation

Journal of Immunology, ISSN: 00221767

Alejandro V. Villarino; Jason S. Stumhofer; Christiaan J. M. Saris; Robert A. Kastelein; Frederic J. De Sauvage; Christopher A. Hunter

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January 1, 2006

Cytokines, NF-kappaB, microenvironment, intestinal inflammation and cancer.

Cancer treatment and research, ISSN: 09273042

Arndt J Schottelius; Harald Dinter

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January 1, 2006

The crystal structure of murine coronin-1: A regulator of actin cytoskeletal dynamics in lymphocytes

Structure, ISSN: 09692126

Brent A. Appleton; Ping Wu; Wiesmann

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January 1, 2006

Proteomic studies support the use of multi-product immunoassays to monitor host cell protein impurities

Proteomics, ISSN: 16159853 16159861

Denise C. Krawitz; William F. Forrest; G. Tony Moreno; Joshua Kittleson; Kathleen M. Champion

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January 1, 2006

Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma

AIDS Research and Human Retroviruses, ISSN: 08892229

Seth Rakoff-Nahoum; Peter Kuebler; Jonas J. Heymann; Megan E. Sheehy; Gabriel M. Ortiz; Graham S. Ogg; Jason D. Barbour; Jack Lenz; Alan D. Steinfeld; Douglas F. Nixon

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January 1, 2006

Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei

International Journal of Infectious Diseases, ISSN: 12019712

Steven P. LaRosa; Steven M. Opal; Barbara Utterback; Sau Chi Betty Yan; Jeffrey D. Helterbrand; Andrew J.H. Simpson; Wipada Chaowagul; Nicholas J. White; Charles J. Fisher Jr.

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January 1, 2006

Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers

Pharmaceutical Research, ISSN: 07248741

Chee Ng; Stefanich; Banmeet S. Anand; Fielder; Louis Vaickus

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January 1, 2006

Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Thomas B. Casale; William W. Busse; Joel N. Kline; Zuhair K. Ballas; Mark H. Moss; Robert G. Townley; Masoud Mokhtarani; Vicki Seyfert-Margolis; Adam Asare; Kirk Bateman; Yamo Deniz

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January 1, 2006

Mayo Clinic consensus statement for the use of bisphosphonates in multiple myeloma

Mayo Clinic Proceedings, ISSN: 00256196

Martha Lacy; Angela Dispenzieri; Morie A. Gertz; Philip R. Greipp; Kimberly L. Gollbach; Suzanne R. Hayman; Shaji Kumar; John A. Lust; S. Vincent Rajkumar; Stephen J. Russell; Witzig; Steven R. Zeldenrust; David Dingli; P. Lief Bergsagel; Rafael Fonseca; Craig B. Reeder; A. Keith Stewart; Vivek Roy; Robert J. Dalton; Alan B. Carr; Deepak Kademani; Eugene E. Keller; Christopher F. Viozzi; Robert A. Kyle

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January 1, 2006

Erratum: Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution (Journal of Pharmaceutical Sciences [2005] 94 [1928-1940] DOI: 10.1002/jps.20347)

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Jun Liu; Mary D. H. Nguyen; Andya; Steven J. Shire

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January 1, 2006

Somatic mutations lead to an oncogenic deletion of Met in lung cancer

Cancer Research, ISSN: 00085472

Monica Kong-Beltran; Somasekar Seshagiri; Jiping Zha; Wenjing Zhu; Kaumudi Bhawe; Nerissa Mendoza; Thomas Holcomb; Kanan Pujara; Stinson; Ling Fu; Christophe Severin; Linda Rangell; Ralph H. Schwall; Lukas Amier; Dineli Wickramasinghe; Robert Yauch

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January 1, 2006

Concordance between central and local laboratory HER2 testing from a community-based clinical study

Clinical Breast Cancer, ISSN: 15268209

Josina C. Reddy; Reimann; Steven M. Anderson; Pam Klein

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January 1, 2006

Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma

Neuro-Oncology, ISSN: 15228517

Michael D. Prados; Kathleen R. Lamborn; Susan Chang; Eric Burton; Nicholas Butowski; Mary Malec; Ami Kapadia; Jane Rabbit; Margaretta S. Page; Ann Fedoroff; Dong Xie; Kelley

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January 1, 2006

Self-association of therapeutic proteins: Implications for product development

Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability,

Cromwell; Chantal Felten; Heather Flores; Jun Liu; Steven J. Shire

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January 1, 2006

An overview of the pharmacokinetics and pharmacodynamics of efalizumab: A monoclonal antibody approved for use in psoriasis

Journal of Clinical Pharmacology, ISSN: 00912700 15524604

Amita Joshi; Bauer; Peter Kuebler; Mark White; Cecilia Leddy; Peter Compton; Marvin Garovoy; Paul Kwon; Patricia Walicke; Russell L Dedrick

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January 1, 2006

Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid

Investigative Ophthalmology and Visual Science, ISSN: 01460404

Ivana K. Kim; Deeba Husain; Norman Michaud; Edward Connolly; Anne Marie Lane; Khayyam Durrani; Ali Hafezi-Moghadam; Evangelos S. Gragoudas; Charles A. O'Neill; Joseph Beyer; Joan W. Miller

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January 1, 2006

A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys

American Journal of Pathology, ISSN: 00029440

Yulia Vugmeyster; Dhaya Seshasayee; Wesley S. Chang; Anahid Storn; Howell; Susan Sa; Tenea Nelson; Flavius Martin; Iqbal S. Grewal; Ellen Gilkerson; Ben Wu; Jeffrey S. Thompson; Barbara N. Ehrenfels; Song Ren; An Song; Thomas R. Gelzleichter; Dimitry Danilenko

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January 1, 2006

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

Cancer Cell, ISSN: 15356108

Phillips; Samir Kharbanda; Ruihuan Chen; William F. Forrest; Robert Soriano; Thomas D Wu; Anjan Misra; Janice M. Nigro; Howard Colman; Liliana Soroceanu; P. Mickey Williams; Zora Modrusan; Burt G. Feuerstein; Kenneth D. Aldape

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