Genentech: Publications

June 1, 2005

Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering

Immunity, ISSN: 10747613

Sofia Z. Raptis; Steven D. Shapiro; Pamela M. Simmons; Alec M. Cheng; Christine T.N. Pham

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June 1, 2005

Immune response in silico (IRIS): Immune-specific genes identified from a compendium of microarray expression data

Genes and Immunity, ISSN: 14664879

Abbas Alexander; Daryl T. Baldwin; Yan Ma; Wenjun Ouyang; Austin L. Gurney; Flavius Martin; Sherman Fong; Menno Van Lookeren Campagne; Godowski; P. Mickey Williams; Andrew A. Chan; Hilary F. Clark

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June 1, 2005

Tumor immunity via homeostatic T cell proliferation: Mechanistic aspects and clinical perspectives

Springer Seminars in Immunopathology, ISSN: 03444325

Roberto Baccala; Rosana Gonzalez-Quintial; Wolfgang Dummer; Argyrios N. Theofilopoulos

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June 1, 2005

Estimating heterogeneity in random effects models for longitudinal data

Biometrical Journal, ISSN: 03233847

Annabelle Lemenuel-Diot; Mallet; Laveille; Rene Bruno

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June 1, 2005

Racial differences in reperfusion therapy use in patients hospitalized with myocardial infarction: A regional phenomenon

American Heart Journal, ISSN: 00028703

Saif S. Rathore; Paul D. Frederick; Nathan R. Every; Hal V. Barron; Harlan M. Krumholz

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June 1, 2005

Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib

Journal of the National Cancer Institute, ISSN: 00278874 14602105

Daphne A. Haas-Kogan; Michael D. Prados; Tarik Tihan; Eberhard; Nannette Jelluma; Nils D. Arvold; Rachel Baumber; Kathleen R. Lamborn; Ami Kapadia; Mary Malec; Mitchel S. Berger; David Stokoe

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June 1, 2005

Immune response in silico (IRIS): Immune-specific genes identified from a compendium of microarray expression data

Genes and Immunity, ISSN: 14664879

Abbas Alexander; Daryl T. Baldwin; Yan Ma; Wenjun Ouyang; Austin L. Gurney; Flavius Martin; Fong; Menno Van Lookeren Campagne; Godowski; P. Mickey Williams; Andrew A. Chan; Hilary F. Clark

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May 27, 2005

Multiplexed serum measurement of IgG, IgA, IgM, and IgE antibody responses to therapeutic biologicals

Immunological Investigations, ISSN: 08820139

Krista McCutcheon; Edward O'Hara; David T.W. Fei

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May 20, 2005

Molecular recognition by a binary code

Journal of Molecular Biology, ISSN: 00222836

Frederic A. Fellouse; Bing Li; Deanne M. Compaan; Andrew A. Peden; Sarah G. Hymowitz; Sachdev S. Sidhu

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May 20, 2005

Evaluation of different primary recovery methods for E. coli-derived recombinant human growth hormone and compatibility with further down-stream purification

Biotechnology and Bioengineering, ISSN: 00063592

Josefine Persson; Dana C. Andersen; Philip M. Lester

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May 15, 2005

An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin

Cancer Research, ISSN: 00085472

Richard W. Tothill; Adam Kowalczyk; Danny Rischin; Alex Bousioutas; Izhak Haviv; Ryan K. Van Laar; Waring; John Zalcberg; Robyn Ward; Andrew V. Biankin; Robert L. Sutherland; Susan M. Henshall; Kwun Fong; Jonathan R. Pollack; David D.L. Bowtell; Andrew J. Holloway

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May 13, 2005

Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis

Journal of Biological Chemistry, ISSN: 00219258

Darcie Sharp; David Lawrence; Avi Ashkenazi

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May 6, 2005

A structure-based database of antibody variable domain diversity

Journal of Molecular Biology, ISSN: 00222836

Christopher J. Bond; Wiesmann; James C. Marsters Jr.; Sachdev S. Sidhu

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May 1, 2005

Tenecteplase in the treatment of thrombosed hemodialysis grafts

CardioVascular and Interventional Radiology, ISSN: 01741551

Abigail Falk; Kathy Harbour

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May 1, 2005

Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene

Genetics, ISSN: 00166731

Kyle A. Edgar; Marcia Belvin; Annette L. Parks; Kellie Whittaker; Matt B. Mahoney; Monique Nicoll; Christopher C. Park; Christopher G. Winter; Feng Chen; Kim Lickteig; Ferhad Ahmad; Hanife Esengil; Matthew V. Lorenzi; Amanda Norton; Brent A. Rupnow; Laleh Shayesteh; Mariano Tabios; Lynn M. Young; Pamela M. Carroll; Casey Kopczynski; Greg D. Plowman; Lori S. Friedman; Helen L. Francis-Lang

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May 1, 2005

PAK4 mediates morphological changes through the regulation of GEF-H1

Journal of Cell Science, ISSN: 00219533

Marinella G. Callow; Sergey Zozulya; Mikhail L. Gishizky; Bahija Jallal; Tod Smeal

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May 1, 2005

Disulfide locked variants of factor VIIa with a restricted β-strand conformation have enhanced enzymatic activity

Protein Science, ISSN: 09618368

Henry R. Maun; Eigenbrot; Helga Raab; David Arnott; Lilian Phu; Sherron L. Bullens; Lazarus

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May 1, 2005

GMAP: A genomic mapping and alignment program for mRNA and EST sequences

Bioinformatics, ISSN: 13674803

Thomas D Wu; Colin K. Watanabe

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May 1, 2005

A monoclonal antibody that inhibits mouse tissue factor function [7]

Journal of Thrombosis and Haemostasis, ISSN: 15387933 15387836

Daniel Kirchhofer; Paul Moran; Sherron L. Bullens; Franklin V. Peale Jr.; Bunting

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May 1, 2005

A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation

Journal of Immunology, ISSN: 00221767

Haoran Zhao; Connie C. Li; Jorge Pardo; Peter C. Chu; Charlene X. Liao; Jianing Huang; John G. Dong; Xiulan Zhou; Qi Huang; Betty Huang; Mark K. Bennett; Susan M. Molineaux; Henry Lu; Sarkiz Daniel-Issakani; Donald G. Payan; Esteban S. Masuda

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May 1, 2005

Novel brain wiring functions for classical morphogens: A role as graded positional cues in axon guidance

Development (Cambridge), ISSN: 09501991

Frédéric Charron; Marc Tessier-Lavigne

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May 1, 2005

Tissue distribution and receptor-mediated clearance of anti-CD11a antibody in mice

Drug Metabolism and Disposition, ISSN: 00909556

Greg P. Coffey; Judy Fox; Susanne Pippig; Susan Palmieri; Barbara Reitz; Michelle Gonzales; Anahid Bakshi; Josette Padilla-Eagar; Fielder

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April 26, 2005

Comparison of the global structure and dynamics of native and unmodified tRNAval

Biochemistry, ISSN: 00062960

Annaleen Vermeulen; Scott A. McCallum; Arthur Pardi

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April 25, 2005

Non-enzymatic hinge region fragmentation of antibodies in solution

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232

Cordoba; Bao-Jen Shyong; Deirdre Breen; Reed J. Harris

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April 15, 2005

γδ T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors

Journal of Immunology, ISSN: 00221767

Roberto Baccala; Deborah Witherden; Rosana Gonzalez-Quintial; Wolfgang Dummer; Charles D. Surh; Wendy L. Havran; Argyrios N. Theofilopoulos

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April 15, 2005

Napoleone Ferrara discusses Avastin™ and the future of anti-angiogenesis therapy

Drug Discovery Today, ISSN: 13596446

Ulrike Knies-Bamforth; Christopher Watson; Napoleone Ferrara

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April 1, 2005

Coregulator interactions with the thyroid hormone receptor

Molecular and Cellular Proteomics, ISSN: 15359476

Jamie M. R. Moore; R. Kiplin Guy

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April 1, 2005

Multiple protein interactions involving proposed extracellular loop domains of the tight junction protein occludin

Molecular Biology of the Cell, ISSN: 10591524

Asma Nusrat; G. Thomas Brown; Jeffrey Tom; Alex Drake; Tam T.T. Bui; Quan; Mrsny

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April 1, 2005

Safety and efficacy of intravitreal injection of ranibizumab in combination with verteporfin PDT on experimental choroidal neovascularization in the monkey

Archives of Ophthalmology, ISSN: 00039950

Deeba Husain; Ivana K. Kim; Danny Gauthier; Anne Marie Lane; Miltiadis K. Tsilimbaris; Eric Ezra; Edward Connolly; Norman Michaud; Evangelos S. Gragoudas; Charles A. O'Neill; Joseph Beyer; Joan W. Miller

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April 1, 2005

Identification of a massive reserve of hematopoietic progenitors in mice

Stem Cells and Development, ISSN: 15473287

Hal E. Broxmeyer; Scott Cooper; Lasky; Frederic J. De Sauvage

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April 1, 2005

Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis

Journal of Molecular Biology, ISSN: 00222836

Gábor Pál; Ultsch; Clark; Bridget Currell; Anthony A. Kossiakoff; Sachdev S. Sidhu

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April 1, 2005

Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: A conference report

Pharmaceutical Research, ISSN: 07248741

Jean W. Lee; Russell Weiner; Jeff M. Sailstad; Ronald Bowsher; Dean W. Knuth; Peter J. O'Brien; Jean L. Fourcroy; Rakesh Dixit; Lini Pandite; Robert G. Pietrusko; Holly D. Soares; Quarmby; Ole L. Vesterqvist; David M. Potter; James L. Witliff; Herbert A. Fritche; Timothy O'Leary; Lorah Perlee; Sunil Kadam; John A. Wagner

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April 1, 2005

Defining molecular targets for drug design: Synergism between academia and industry

Journal of Pediatric Gastroenterology and Nutrition, ISSN: 02772116

Andrew A. Chan

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April 1, 2005

Population pharmacokinetics or efalizumab (humanized monoclonal anti-CD11a antibody) following long-term subcutaneous weekly dosing in psoriasis subjects

Journal of Clinical Pharmacology, ISSN: 00912700

Sun; Jian-Feng Lu; Amita Joshi; Peter Compton; Paul Kwon; Rene Bruno

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April 1, 2005

Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats

Toxicological Sciences, ISSN: 10966080

Harvey Wong; Lois D. Lehman-McKeeman; Mary F. Grubb; Grossman; Vasanthi M. Bhaskaran; Eric G. Solon; Helen S. Shen; Ronald J. Gerson; Bruce D. Car; Bitao Zhao; Brian Gemzik

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April 1, 2005

Design, optimisation, and evaluation of a sheath flow interface for automated capillary electrophoresis-electrospray-mass spectrometry

Electrophoresis, ISSN: 01730835

Charles C. Liu; Jean-Francois Alary; Pauline Vollmerhaus; Miryam Kadkhodayan

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April 1, 2005

Comparative evaluation of three active air samplers: For the monitoring of airborne microorganisms

Pharmaceutical Technology, ISSN: 15432521

Evelyn F. Der; Joe P. Stablein; Daniel A. Coleman

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March 28, 2005

Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2

FEBS Letters, ISSN: 00145793

Daniel Kirchhofer; Peek; Michael T. Lipari; Karen L Billeci; Bin Fan; Paul Moran

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March 25, 2005

Impact of multiple re-use of anion-exchange chromatography media on virus removal

Journal of Chromatography A, ISSN: 00219673

Lenore A Norling; Scott Lute; Rachel Emery; Wynn Khuu; Mark Voisard; Yuan Xu; Qi Chen; Gregory S. Blank; Kurt Brorson

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March 15, 2005

IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes

Journal of Immunology, ISSN: 00221767

Katia Boniface; François-Xavier Bernard; Martine Garcia; Austin L. Gurney; Jean-Claude Lecron; Franck Morel

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March 15, 2005

Cutting edge: Recent immune status determines the source of antigens that drive homeostatic T cell expansion

Journal of Immunology, ISSN: 00221767

William C. Kieper; Amy Troy; J. Theodore Burghardt; Chris Ramsey; Joon Youb Lee; Han-Qing Jiang; Wolfgang Dummer; Hao Shen; John J. Cebra; Charles D. Surh

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March 11, 2005

Conformational lability in serine protease active sites: Structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

Journal of Molecular Biology, ISSN: 00222836

Steven Shia; Jennifer Stamos; Daniel Kirchhofer; Bin Fan; Judy Wu; Corpuz; Santell; Lazarus; Eigenbrot

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March 11, 2005

A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Alan G. Olivero; Eigenbrot; Richard Goldsmith; Kirk D. Robarge; Dean R. Artis; Flygare; Thomas E. Rawson; Daniel P. Sutherlin; Saloumeh Kadkhodayan; Beresini; Linda O. Elliott; Geralyn G. Deguzman; David W. Banner; Ultsch; Ulla Marzec; Stephen R. Hanson; Refino; Bunting; Daniel Kirchhofer

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March 7, 2005

T cells that cannot respond to TGF-β escape control by CD4+ CD25+ regulatory T cells

Journal of Experimental Medicine, ISSN: 00221007

Linda Fahlén; Simon Read; Leonid Gorelik; Stephen D. Hurst; Coffman; Richard A. Flavell; Fiona Powrie

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March 1, 2005

Proteomic profiling of surface proteins on Th1 and Th2 Cells

Journal of Proteome Research, ISSN: 15353893

Kelly M. Loyet; Wenjun Ouyang; Dan L. Eaton; Stults

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March 1, 2005

Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback

Development (Cambridge), ISSN: 09501991

Yoh-Suke Mukouyama; Hans-Peter Gerber; Napoleone Ferrara; Chenghua Gu; David J. Anderson

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March 1, 2005

Vascular endothelial growth factor D is dispensable for development of the lymphatic system

Molecular and Cellular Biology, ISSN: 02707306

Megan E. Baldwin; Michael M. Halford; Sally Roufail; Richard A. Williams; Margaret L. Hibbs; Dianne Grail; Hajime Kubo; Steven A. Stacker; Marc G. Achen

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March 1, 2005

Mass spectrometric contributions to the practice of phosphorylation site mapping through 2003

Molecular and Cellular Proteomics, ISSN: 15359476

Kelly M. Loyet; Stults; David Arnott

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March 1, 2005

Efficacy of trastuzumab

Cancer Research, ISSN: 00085472

Charles L. Vogel; Josina C. Reddy; Leonard M. Reyno

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March 1, 2005