Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 11551 - 11600 OF 15583 RESULTS

September 19, 2001

Application of the TIMI risk score for ST-elevation MI in the National Registry of Myocardial Infarction 3

JAMA - Journal of the American Medical Association, ISSN: 00987484

David A. Morrow; Elliott M. Antman; Lori Parsons; James A. De Lemos; Christopher P. Cannon; Robert P. Giugliano; Carolyn H. McCabe; Hal V. Barron; Eugene Braunwald

September 18, 2001

Crystal structure of human insulin-like growth factor-1: Detergent binding inhibits binding protein interactions

Biochemistry, ISSN: 00062960

Vajdos; Ultsch; Schaffer; Deshayes; Jinfeng Liu; Nicholas J. Skelton; De Vos

September 15, 2001

Phage display: Increasing the rewards from genomic information

Drug Discovery Today, ISSN: 13596446

Sachdev S. Sidhu

September 12, 2001

Mutant β-spectrin 4 causes auditory and motor neuropathies in quivering mice

Nature Genetics, ISSN: 10614036

Nicholas J. Parkinson; Christine Olsson; Janice L. Hallows; Jennifer Mckee-Johnson; Bart P. Keogh; Konrad Noben-Trauth; Sharon G. Kujawa; Bruce L Tempel

September 12, 2001

Manipulation of ligand binding affinity by exploitation of conformational coupling

Nature Structural Biology, ISSN: 10728368

Jonathan S. Marvin; Homme W. Hellinga

September 7, 2001

Characterization and humanization of a monoclonal antibody that neutralizes human leukocyte interferon: A candidate therapeutic for IDDM and SLE

Cytokine, ISSN: 10434666

Anan Chuntharapai; Lai; Huang; Gibbs; K.Jin Kim; Presta; Stewart

September 1, 2001

Training future chemical biologists

Chemical Innovation, ISSN: 15274799

Gregory A. Weiss

September 1, 2001

Similarity of the Escherichia coli proteome upon completion of different biopharmaceutical fermentation processes.

Proteomics, ISSN: 16159853

Kathleen M. Champion; Julie C. Nishihara; John C. Joly; David Arnott

September 1, 2001

Capillary Electrophoresis as a routine analytical tool in pharmaceutical analysis

LCGC North America, ISSN: 15275949

Kevin D. Altria; Chen; Lilian Clohs

August 31, 2001

Dissociation of Heparan Sulfate and Receptor Binding Domains of Hepatocyte Growth Factor Reveals that Heparan Sulfate-c-Met Interaction Facilitates Signaling

Journal of Biological Chemistry, ISSN: 00219258

Jeffrey S. Rubin; Regina M. Day; Diane Breckenridge; Nese Atabey; William G. Taylor; Stephen J. Stahl; Paul T. Wingfield; Joshua D. Kaufman; Ralph H. Schwall; Donald P. Bottaro

August 30, 2001

Identification of an angiogenic mitogen selective for endocrine gland endothelium

Nature, ISSN: 00280836

Jennifer Lecouter; Joe Kowalski; Foster; Hass; Zemin Zhang; Lisa Dillard-Telm; Gretchen D. Frantz; Linda Rangell; Leo Deguzman; Gilbert-Andre Keller; Franklin V. Peale Jr.; Austin L. Gurney; Kenneth J. Hillan; Napoleone Ferrara

August 24, 2001

Affinity-reversed-phase liquid chromatography assay to quantitate recombinant antibodies and antibody fragments in fermentation broth

Journal of Chromatography A, ISSN: 00219673

John E. Battersby; Snedecor; Christina Y. Chen; Kathleen M. Champion; Riddle; Vanderlaan

August 21, 2001

A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor

Biochemistry, ISSN: 00062960

Nakamura; Melissa A. Starovasnik; Mark E. Reynolds; Henry B. Lowman

August 21, 2001

Use of pilot plant facilities to aid validation programs

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440

O'Leary; Etcheverry; Bezy; Vincent R. Anicetti; Burton

August 16, 2001

Sorbitol dehydrogenase inhibitors (SDIs): A new potent, enantiomeric SDI, 4-[2-1R-hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic acid dimethylamide

Journal of Medicinal Chemistry, ISSN: 00222623

Mylari; Oates; Beebe; Brackett; Coutcher; Dina; Zembrowski

August 14, 2001

The Sec6/8 complex in mammalian cells: Characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Hugo T. Matern; Charles Yeaman; W. James Nelson; Richard H. Scheller

August 14, 2001

Selection and characterization of a new class of peptide exosite inhibitors of coagulation factor VIIa

Biochemistry, ISSN: 00062960

Dennis; Roberge; Quan; Lazarus

August 11, 2001

The factor VII zymogen structure reveals reregistration of β strands during activation

Structure, ISSN: 09692126

Eigenbrot; Daniel Kirchhofer; Dennis; Santell; Lazarus; Jennifer Stamos; Ultsch

August 11, 2001

Cardiotrophin-1 can protect cardiac myocytes from injury when added both prior to simulated ischaemia and at reoxygenation

Cardiovascular Research, ISSN: 00086363

Bhawanjit K. Brar; Anastatis Stephanou; Zhihong Liao; O'Leary; Diane Pennica; Derek M Yellon; David S. Latchman

August 6, 2001

TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice

Nature Immunology, ISSN: 15292908

Hua Wang; Scot A. Marsters; Thad Baker; Betty Chan; Wyne P. Lee; Ling Fu; Daniel B. Tumas; Minhong Yan; Vishva M. Dixit; Avi Ashkenazi; Iqbal S. Grewal

August 6, 2001

Activation and accumulation of B cells in TACI-deficient mice

Nature Immunology, ISSN: 15292908

Minhong Yan; Hua Wang; Betty Chan; Merone Roose-Girma; Sharon Erickson; Thad Baker; Daniel B. Tumas; Iqbal S. Grewal; Vishva M. Dixit

August 6, 2001

αvβ3 antagonists based on a central thiophene scaffold

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Peyman; Karl-Heinz Scheunemann; Will; Knolle; Volkmar Wehner; Breipohl; Stilz; Denis Carniato; Ruxer; Gourvest; Auberval; Doucet; Roland Baron; Gaillard; Thomas Gadek; Bodary

August 1, 2001

Mapping protein-protein interactions with combinatorial biology methods

Current Opinion in Biotechnology, ISSN: 09581669

Joelle Pelletier; Sachdev S. Sidhu

August 1, 2001

Physiological modulation of rabphilin phosphorylation

Journal of Neuroscience, ISSN: 02706474

Davide Foletti; Jeremy T. Blitzer; Richard H. Scheller

August 1, 2001

Developmental regulation and specific brain distribution of phosphorabphilin

Journal of Neuroscience, ISSN: 02706474

Davide Foletti; Richard H. Scheller

July 31, 2001

A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Hiromi Yamashita; Makoto Takenoshita; Masaharu Sakurai; Richard K. Bruick; William J. Henzel; Wendy Shillinglaw; David Arnot; Kosaku Uyeda

July 31, 2001

Dose schedule of recombinant murine thrombopoietin prior to myelosuppressive and myeloablative therapy in mice

Cancer Chemotherapy and Pharmacology, ISSN: 03445704

Stefanich; Carlson-Zermeno; McEvoy; Mike Reich; Fielder

July 31, 2001

Glycoengineering of therapeutic glycoproteins: In vitro galactosylation and sialylation of glycoproteins with terminal N-acetylglucosamine and galactose residues

Biochemistry, ISSN: 00062960

T. Shantha Raju; Briggs; Steven M. Chamow; Winkler; Andrew J.S. Jones

July 27, 2001

A Discontinuous SNAP-25 C-terminal Coil Supports Exocytosis

Journal of Biological Chemistry, ISSN: 00219258

Yu A. Chen; Suzie J. Scales; Jagath R. Junutula; Richard H. Scheller

July 24, 2001

Three SNARE complexes cooperate to mediate membrane fusion

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Yuanyuan Hua; Richard H. Scheller

July 24, 2001

Structure - Function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1

Biochemistry, ISSN: 00062960

Nicholas J. Skelton; Chen; Dubree; Quan; Jackson; Andrea G Cochran; Zobel; Deshayes; Baca; Pisabarro; Henry B. Lowman

July 20, 2001

The general concepts of an equivalence trial, applied to ASSENT-2, a large-scale mortality study comparing two fibrinolytic agents in acute myocardial infarction

European Heart Journal, ISSN: 0195668X

Emmanuel Lesaffre; Bluhmki; Wang-Clow; Berioli; Danays; Fox; Frans Van De Werf

July 17, 2001

Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Baohe Shen; Liu; Edward Y. Skolnik; James L. Manley

July 15, 2001

Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

Genes and Development, ISSN: 08909369

Weikang Tao; Diane Pennica; Lifeng Xu; Robert F. Kalejta; Arnold J. Levine

July 13, 2001

Calcium Regulation of Exocytosis in PC12 Cells

Journal of Biological Chemistry, ISSN: 00219258

Yu A. Chen; Suzie J. Scales; Vikas Duvvuri; Mala Murthy; Sejal M. Patel; Howard Schulman; Richard H. Scheller

July 13, 2001

Signaling Pathways Leading to Transcription and Translation Cooperatively Regulate the Transient Increase in Expression of c-Fos Protein

Journal of Biological Chemistry, ISSN: 00219258

Kenji Takeuchi; Sayumi Shibamoto; Kentaro Nagamine; Ichiro Shigemori; Satoshi Omura; Naomi Kitamura; Fumiaki Ito

July 10, 2001

Mass spectrometry innovations in drug discovery and development

Pharmaceutical Research, ISSN: 07248741

Damon I. Papac; Shahrokh

July 10, 2001

Surface properties, fibrinogen adsorption, and cellular interactions of a novel phosphorylcholine-containing self-assembled monolayer on gold

Langmuir, ISSN: 07437463

Vassiliki A. Tegoulia; Weisun Rao; Anand T. Kalambur; John F. Rabolt; Stuart L. Cooper

July 1, 2001

Solvent migration in a paraffin deposit

Fuel, ISSN: 00162361

Cordoba; Schall

July 1, 2001

Application of a heat transfer method to determine wax deposition in a hydrocarbon binary mixture

Fuel, ISSN: 00162361

Cordoba; Schall

June 26, 2001

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

Nature Genetics, ISSN: 10614036

Kui Lin; Honor Hsin; Natasha Libina; Cynthia Kenyon

June 19, 2001

Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: High-pressure and cosolute studies on recombinant human IFN-γ

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Jonathan N. Webb; Serena D. Webb; Cleland; John F. Carpenter; Theodore W. Randolph

June 19, 2001

Recognition of 16S rRNA by ribosomal protein S4 from Bacillus stearothermophilus

Biochemistry, ISSN: 00062960

Gerstner; Pak; Draper

June 15, 2001

PTEN 2, a Golgi-associated Testis-specific Homologue of the PTEN Tumor Suppressor Lipid Phosphatase

Journal of Biological Chemistry, ISSN: 00219258

Yan Wu; Dowbenko; Pisabarro; Lisa Dillard-Telm; Koeppen; Lasky

June 6, 2001

Effects of cardiotrophin-1 (CT-1) in a mouse motor neuron disease

Muscle and Nerve, ISSN: 0148639X

Hiroshi Mitsumoto; Bogdan Klinkosz; Erik P. Pioro; Kazufumi Tsuzaka; Takeo Ishiyama; O'Leary; Diane Pennica

June 5, 2001

Early initiation of growth hormone treatment allows age-appropriate estrogen use in Turner's syndrome

Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X

Edward O. Reiter; Sandra L. Blethen; Joyce Baptista; Lisa Price

June 1, 2001

More than one way to skin a catenin

Cell, ISSN: 00928674

Paul G. Polakis

June 1, 2001

A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4

Cancer Research, ISSN: 00085472

Hakjoo Lee; Robert W. Akita; Mark X. Sliwkowski; Nita J. Maihle

May 29, 2001

Stimulus properties of 7-OH-DPAT versus auto- and postsynaptic receptor-specific doses of quinpirole

Pharmacology Biochemistry and Behavior, ISSN: 00913057

Christina L. Zuch; Deborah A. Cory-Slechta

May 17, 2001

A persistent carbenium ion on the methanol-to-olefin catalyst HSAPO-34: Acetone shows the way

Journal of Physical Chemistry B, ISSN: 10895647

Weiguo Song; John B. Nicholas; James F. Haw

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