Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 14651 - 14700 OF 15578 RESULTS

January 1, 1990

Purification and characterization of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Tetsuya Gatanaga; Chenduen Hwang; William J. Kohr; Fabio Cappuccini; Joseph A. Lucci III; Edward W. B. Jeffes; Rigdon Lentz; John Tomich; Robert S. Yamamoto; Gale A. Granger

January 1, 1990

Transforming growth factor‐α

Molecular Reproduction and Development, ISSN: 10982795 1040452X

Rik Derynck

January 1, 1990

Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2

Science, ISSN: 00368075

Ruth Lupu; Ramon Colomer; Gerhard Zugmaier; Jay Sarup; Michael H. Shepard; Dennis J. Slamon; Marc E. Lippman

January 1, 1990

Transforming Growth Factor‐β Effect on Soft Tissue Repair

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Arthur J. Ammann; L. Steven Beck; Leo Deguzman; Sue E. Hirabayashi; Wyne P. Lee; Lorrie L. Mcfatridge; Tue H. Nguyen; Yvette Xu; THOMAS A. MUSTOE

January 1, 1990

Structure and function of lipopolysaccharide binding protein

Science, ISSN: 00368075

Ralf R. Schumann; Leong; Gail W. Flaggs; Patrick W. Gray; Samuel D. Wright; John C. Mathison; Peter S. Tobias; Richard J. Ulevitch

January 1, 1990

The autocrine production of transforming growth factor-β1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA

Journal of Immunology, ISSN: 00221767

Catherine Lucas; Bald; Brian M. Fendly; Mora-Worms; Figari; Patzer; Michael A. Palladino

January 1, 1990

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

Nature, ISSN: 00280836

Sarvetnick; Shizuru; Liggitt; Martin; Burly Mclntyre; Anita Gregory; Tristram Parslow; Stewart

January 1, 1990

Induced expression using yeast copper metallothionein promoter

Methods in Enzymology, ISSN: 15577988 00766879

Etcheverry

January 1, 1990

Inducible expression of regulatory genes in Bacillus subtilis

Methods in Enzymology, ISSN: 15577988 00766879

Henner

January 1, 1990

Systems for heterologous gene expression

Methods in Enzymology, ISSN: 15577988 00766879

David V. Goeddel

January 1, 1990

Use of heterologous and homologous signal sequences for secretion of heterologous proteins from yeast

Methods in Enzymology, ISSN: 15577988 00766879

Ronald A. Hitzeman; Christina Y. Chen; Dowbenko; Renz; Liu; Roger Pai; Simpson; William J. Kohr; Arjun Singh; Chisholm; Robert W. Hamilton; Chung N. Chang

January 1, 1990

Expression of heterologous genes in mammalian cells

Methods in Enzymology, ISSN: 00766879

Levison

January 1, 1990

Use of Escherichia coli trp promoter for direct expression of proteins

Methods in Enzymology, ISSN: 15577988 00766879

Yansura; Henner

January 1, 1990

Expression as trpE fusion

Methods in Enzymology, ISSN: 15577988 00766879

Yansura

January 1, 1990

Optimizing cell and culture environment for production of recombinant proteins

Methods in Enzymology, ISSN: 15577988 00766879

Mather

January 1, 1990

Expression of heterologous genes in Bacillus subtilis

Methods in Enzymology, ISSN: 15577988 00766879

Henner

January 1, 1990

Gene expression technology: Preface

Methods in Enzymology, ISSN: 00766879

David V. Goeddel

January 1, 1990

Molecular and Genetic Approach to Enhancing Protein Secretion

Methods in Enzymology, ISSN: 15577988 00766879

Chisholm; Christina Y. Chen; Simpson; Ronald A. Hitzeman

January 1, 1990

Macrophage deactivating factor and transforming growth factors-β1, -β2, and -β3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ

Journal of Immunology, ISSN: 00221767

Aihao Ding; Carl Nathan; Graycar; Rik Derynck; Dennis J. Stuehr; Srimal

January 1, 1990

Functional interaction among catalytic residues in subtilisin BPN′

Proteins: Structure, Function and Bioinformatics, ISSN: 10970134 08873585

Paul J. Carter; James A. Wells

January 1, 1990

Crystal structure of subtilisin BPN′ variants containing disulfide bonds and cavities: Concerted structural rearrangements induced by mutagenesis

Proteins: Structure, Function and Bioinformatics, ISSN: 10970134 08873585

Katz; Anthony A. Kossiakoff

January 1, 1990

From virus to vaccine: Recombinant mammalian cell lines as substrates for the production of herpes simplex virus vaccines

Journal of Medical Virology, ISSN: 10969071 01466615

Lasky

January 1, 1990

Synergistic induction of polypeptides by tumor necrosis factor and interferon‐gamma in cells sensitive or resistant to tumor necrosis factor: Assessment by computer based analysis of two‐dimensional gels using the PDQUEST system

Electrophoresis, ISSN: 15222683 01730835

Beresini; Sugarman; Shepard; Lois B. Epstein

January 1, 1990

Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160

Nature, ISSN: 00280836

Berman; Timothy Gregory; Riddle; Nakamura; Mark Champe; James P. Porter; Florian M. Wurm; Robert D. Hershberg; E. Kathy Cobb; Eichberg

January 1, 1990

Expression of recombinant proteins in Escherichia coli using an oxygen-responsive promoter

Nature Biotechnology, ISSN: 0733222X

Chaitan Khosla; Joseph E. Curtis; Pat Bydalek; James R. Swartz; James E. Baileya

January 1, 1990

Epidermal Growth Factor Receptor Cytoplasmic Domain Mutations Trigger Ligand-Independent Transformation

Molecular and Cellular Biology, ISSN: 02707306

Sharon Massoglia; Gray; Dull; Munemitsu; Hsing-Jien Kung; Schlessinger; Axel Ullrich

January 1, 1990

Recombinant murine interferon‐γ inhibits the fusion of mouse alveolar macrophages in vitro but stimulates the formation of osteoclastlike cells on implanted syngeneic bone particles in mice in vivo

Journal of Bone and Mineral Research, ISSN: 15234681 08840431

Agnès Vignery; Tracy Niven-Fairchild; Michael H. Shepard

January 1, 1990

Relaxin in the peri-implantation period

Journal of Clinical Endocrinology and Metabolism, ISSN: 19457197 0021972X

Dennis R. Stewart; Abbie Celniker; Clinton A. Taylor Jr.; Jeffrey R. Cragun; James W. Overstreet

January 1, 1990

Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor

Journal of Immunology, ISSN: 00221767

Virginia C. Broudy; Kaushansky; Sara G. Shoemaker; Aggarwal; John W. Adamson

January 1, 1990

Tissue plasminogen activator: The biochemistry and pharmacology of variants produced by mutagenesis

Annual Review of Pharmacology and Toxicology, ISSN: 00664251

Deborah L. Higgins; William F. Bennett

January 1, 1990

Engineering human prolactin to bind to the human growth hormone receptor

Science, ISSN: 00368075

Cunningham; Henner; James A. Wells

January 1, 1990

Biological properties of a CD4 immunoadhesin

Nature, ISSN: 00280836

Randal A. Byrn; Joyce Mordenti; Catherine Lucas; Smith; Scot A. Marsters; Jennifer S. Johnson; Cossum; Steven M. Chamow; Florian M. Wurm; Timothy Gregory; Jerome E. Groopman; Capon

January 1, 1990

Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C

EMBO Journal, ISSN: 02614189

Jakobovits; Rosenthal; Capon

January 1, 1990

Characterization of a soluble form of human CD4: Peptide analyses confirm the expected amino acid sequence, identify glycosylation sites and demonstrate the presence of three disulfide bonds

European Journal of Biochemistry, ISSN: 14321033 00142956

Reed J. Harris; Steven M. Chamow; Timothy Gregory; Spellman

January 1, 1990

The simian virus 40 small-t intron, present in many common expression vectors, leads to aberrant splicing

Molecular and Cellular Biology, ISSN: 02707306

Huang; Cornelia M. Gorman

January 1, 1990

The testicular receptor for follicle stimulating hormone: Structure and functional expression of cloned cDNA

Molecular Endocrinology, ISSN: 19449917 08888809

Rolf Sprengel; Thomas Braun; Nikolics; Deborah L. Segaloff; Peter H. Seeburg

January 1, 1990

Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: Evidence for a family of platelet-aggregation inhibitors

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Dennis; William J. Henzel; Pitti; Michael T. Lipari; Napier; Theresa A. Deisher; Bunting; Lazarus

January 1, 1990

A monoclonal-antibody-based enzyme-linked immunosorbent assay of lipoprotein(a)

Clinical Chemistry, ISSN: 00099147

Wai Lee T. Wong; Dan L. Eaton; Berloui; Brian M. Fendly; Hass

January 1, 1990

Gilvocarcin Photobiology.1 Isolation and Characterization of the DNA Photoadduct

Journal of the American Chemical Society, ISSN: 15205126 00027863

Lawrence R. McGee; Renuka Misra1

January 1, 1990

The extracellular domain of HER2/neu is a potential immunogen for active specific immunotherapy of breast cancer

Journal of Biological Response Modifiers, ISSN: 07326580

Brian M. Fendly; Claire Kotts; David Vetterlein; Gail D. Lewis; Marcy Winget; Monique E. Carver; Susan R. Watson; Jay Sarup; Samuel Saks; Axel Ullrich; Michael H. Shepard

January 1, 1990

Selection for transformation and met protooncogene amplification in NIH 3T3 fibroblasts using tumor necrosis factor alpha.

Cell Growth and Differentiation, ISSN: 10449523

Hudziak; Gail D. Lewis; William E. Holmes; Axel Ullrich; Shepard

January 1, 1990

Phase II study of recombinant human interferon gamma for treatment of cutaneous T-cell lymphoma

Journal of the National Cancer Institute, ISSN: 00278874

Edward H. Kaplan; Steven T. Rosen; David B. Norris; Henry H. Roenigk Jr.; Samuel Saks; Paul A. Bunn Jr.

January 1, 1990

Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I

Nature, ISSN: 00280836

Drubin; Jon Mulholland; Zhimin Zhu; David Botstein

January 1, 1990

Improved infarct-related arterial patency after high dose, weight-adjusted, rapid infusion of tissue-type plasminogen activator in myocardial infarction: Results of a multicenter randomized trial of two dosage regimens

Journal of the American College of Cardiology, ISSN: 07351097

Richard W. Smalling; Richard Schumacher; Douglas Morris; Karen Harder; Francisco Fuentes; Russell P. Valentine; Louis L. Battey Jr.; Michael Merhige; Douglas E. Pitts; Henry A. Lieberman; Akira Nishikawa; Ajit Adyanthaya; Allan Hopkins; Grossbard

January 1, 1990

Characterization of chemically synthesized human relaxin by high-performance liquid chromatography

Journal of Chromatography A, ISSN: 00219673

Eleanor Canova-Davis; Ida P. Baldonado; Glen Teshima

January 1, 1990

Maitotoxin increases free calcium and inositol phosphates in rat anterior pituitary cells

Pharmacological Research, ISSN: 10961186 10436618

Sortino; Yasumoto; Cronin

January 1, 1990

Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3

Growth Factors, ISSN: 08977194

Peter D. Brownh; Lalage M. Wakefiel; Levinson; Michael B. Sporn

January 1, 1990

A transcribed gene in an intron of the human factor VIII gene

Genomics, ISSN: 10898646 08887543

Barbara Levinson; Susan Kenwrick; Delia Lakich; Glenn Hammonds Jr.; Jane Gitschier

January 1, 1990

Primary structure and biological activity of a novel human neurotrophic factor

Neuron, ISSN: 08966273

Rosenthal; David V. Goeddel; Tue H. Nguyen; Lewis; Shih; Laramee; Nikolics; Winslow

January 1, 1990

Conditioned medium from mouse sarcoma 180 cells contains vascular endothelial growth factor

Growth Factors, ISSN: 08977194

Rosalind A. Rosenthal; Joseph F. Megyesi; William J. Henzel; Napoleone Ferrara; Judah Folkman

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