Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 14801 - 14850 OF 15578 RESULTS

January 1, 1989

Human transforming growth factor-β3: Recombinant expression, purification, and biological activities in comparison with transforming growth factors-β1 and -β2

Molecular Endocrinology, ISSN: 19449917 08888809

Graycar; Duncan A. Miller; Arrick; Lyons; Moses; Rik Derynck

January 1, 1989

Protein Engineering of Disulfide Bonds in Subtilisin BPN'

Biochemistry, ISSN: 15204995 00062960

Colin Mitchinson; James A. Wells

January 1, 1989

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

Science, ISSN: 00368075

Dennis J. Slamon; William Godolphin; Lovell A. Jones; John A. Holt; Steven Wong; Duane E. Keith; Wendy J. Levin; Susan G. Stuart; Judy Udove; Axel Ullrich; Michael F. Press

January 1, 1989

Designing CD4 immunoadhesins for AIDS therapy

Nature, ISSN: 00280836

Capon; Steven M. Chamow; Joyce Mordenti; Scot A. Marsters; Timothy Gregory; Hiroaki Mitsuya; Randal A. Byrn; Catherine Lucas; Florian M. Wurm; Jerome E. Groopman; Samuel Broder; Smith

January 1, 1989

Fibroblasts transformed with v-src show enhanced formation of an inositol tetrakisphosphate

Science, ISSN: 00368075

Johnson; Wasilenko; Matringly; Weber; Garrison

January 1, 1989

Peptide-based radioimmunoassay for insulin receptor. Detection of insulin-stimulated downregulation in IM-9 lymphocytes

Diabetes, ISSN: 00121797

McFarland; Ramachandran; Grunfeld

January 1, 1989

Pharmacologic basis for the safety assessment of recombinant human proteins

Journal of the American College of Toxicology, ISSN: 07300913

Cossum

January 1, 1989

Monoclonal Antibodies: Production, Purification, and Technology

Advances in Clinical Chemistry, ISSN: 00652423

David Vetterlein

January 1, 1989

Synthesis of novel polycyclic nucleoside analogues incorporation into oligodeoxynucleotides, and interaction with complementary sequences

Journal of the American Chemical Society, ISSN: 15205126 00027863

Norbert Bischofberger; Matteucci

January 1, 1989

Cloning and expression of the cDNA for the murine interferon γ receptor

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Patrick W. Gray; Leong; Fennie; Farrar; Pingel; Fernandez-Luna; Schreiber

January 1, 1989

A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast

Nature, ISSN: 00280836

Duncan W. Wilson; Celeste A. Wilcox; Gregory C. Flynn; Ellson Y. Chen; Wun-Jing Kuang; William J. Henzel; Marc R. Block; Axel Ullrich; James E. Rothman

January 1, 1989

A common language for physical mapping of the human genome

Science, ISSN: 00368075

Maynard Olson; Leroy Hood; Charles Cantor; David Botstein

January 1, 1989

Engineering subtilisin BPN′ for site‐specific proteolysis

Proteins: Structure, Function and Bioinformatics, ISSN: 10970134 08873585

Paul J. Carter; Björn Nilsson; Burnier; Burdick; James A. Wells

January 1, 1989

Endothelial interleukin-8: A novel inhibitor of leukocyte-endothelial interactions

Science, ISSN: 00368075

Gimbrone Jr.; Obin; Brock; Luis; Hass; Hébert; Yip; Leung; Lowe; William J. Kohr; Darbonne; Bechtol; Baker

January 1, 1989

1H NMR Structural Characterization of a Recombinant Kringle 2 Domain from Human Tissue-Type Plasminogen Activator

Biochemistry, ISSN: 15204995 00062960

In-Ja L. Byeon; Robert F. Kelley; Miguel Llinás

January 1, 1989

Inflammatory destruction of pancreatic β cells in γ-interferon transgenic mice

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Sarvetnick; Shizuru; Liggitt; Stewart

January 1, 1989

Effect of residue 65 substitutions on thermal stability of tissue plasminogen activator kringle-2 domain

Biochemistry, ISSN: 15204995 00062960

Robert F. Kelley; Scott Cleary

January 1, 1989

Amino acid sequence of rubber elongation factor protein associated with rubber particles in Hevea latex.

Journal of Biological Chemistry, ISSN: 00219258

Dennis; William J. Henzel; Bell; William J. Kohr; Light

January 1, 1989

Purification of a prenyltransferase that elongates cis-polyisoprene rubber from the latex of Hevea brasiliensis.

Journal of Biological Chemistry, ISSN: 00219258

Light; Dennis

January 1, 1989

Rubber elongation factor from Hevea brasiliensis. Identification, characterization, and role in rubber biosynthesis.

Journal of Biological Chemistry, ISSN: 00219258

Dennis; Light

January 1, 1989

Rubber elongation by farnesyl pyrophosphate synthases involves a novel switch in enzyme stereospecificity.

Journal of Biological Chemistry, ISSN: 00219258

Light; Lazarus; Dennis

January 1, 1989

Purity analysis of protein pharmaceuticals produced by recombinant DNA technology

Trends in Biotechnology, ISSN: 01677799

Vincent R. Anicetti; Keytand; William S. Hancock

January 1, 1989

Production of human immune interferon by recombinant mammalian cells cultivated on microcarriers

Biotechnology and Bioengineering, ISSN: 10970290 00063592

Smiley; Hu; Daniel I. C. Wang

January 1, 1989

Prevention of the graft-versus-host reaction in newborn mice by antibodies to tumor necrosis factor-alpha

Transplantation, ISSN: 00411337

Shalaby; Brian M. Fendly; Kathleen C. Sheehan; Schreiber; Arthur J. Ammann

January 1, 1989

Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium

Journal of Biological Chemistry, ISSN: 00219258

Axel Perianin; Snydeman

January 1, 1989

Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases

Nature, ISSN: 00280836

Chang; David G Lowe; Lewis; Renate Hellmiss; Ellson Y. Chen; David V. Goeddel

January 1, 1989

An enzyme-linked immunosorbent assay to study human relaxin in human pregnancy and in pregnant rhesus monkeys

Journal of Endocrinology, ISSN: 00220795

Catherine Lucas; Bald; Martin; Robert B. Jaffe; Drolet; Mora-Worms; Bennett; Chen; Paul D. Johnston

January 1, 1989

Intravenous recombinant tumor necrosis factor in the treatment of aids-related kaposi’s sarcoma

Journal of Acquired Immune Deficiency Syndromes, ISSN: 10779450 15254135

David Aboulafia; Steven A. Miles; Samuel Saks; Ronald T. Mitsuyasu

January 1, 1989

Characterization of a human homologue of the murine peripheral lymph node homing receptor

Journal of Cell Biology, ISSN: 00219525

Bowen; Nguyen; Lasky

January 1, 1989

Recombinant TGF-β1 is synthesized as a two-component latent complex that shares some structural features with the native platelet latent TGF-β1 complex

Growth Factors, ISSN: 08977194

Lalage M. Wakefield; Diane M. Smith; Susan D. Broz; Mark L. Jackson; Levinson; Michael B. Sporn

January 1, 1989

The human cytomegalovirus major immediate early promoter can be trans-activated by adenovirus early proteins

Virology, ISSN: 10960341 00426822

Cornelia M. Gorman; Gies; Glynis McCray; Huang

January 1, 1989

Expression and secretion of gro/MGSA by stimulated human endothelial cells

EMBO Journal, ISSN: 02614189

Duanzhi Wen; Rowland; Rik Derynck

January 1, 1989

Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor β gene superfamily

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Karen M. Lyons; Graycar; Angela Lee; Hashmi; Patricia B. Lindquist; Ellson Y. Chen; Brigid L.M. Hogan; Rik Derynck

January 1, 1989

Characterization and affinity cross-linking of receptors for human recombinant lymphotoxin (tumor necrosis factor-β) on a human histiocytic lymphoma cell line, U-937

Journal of Biological Chemistry, ISSN: 00219258

Stauber; Aggarwal

January 1, 1989

Intralesional recombinant tumor necrosis factor-a for AIDS-associated kaposis sarcoma: A randomized, double-blind trial

Journal of Acquired Immune Deficiency Syndromes, ISSN: 10779450 15254135

Kahn; Lawrence D. Kaplan; Paul Volberding; John L. Ziegler; Suzanne Crowe; Samuel Saks; Donald Abrams

January 1, 1989

Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction

EMBO Journal, ISSN: 02614189

David G Lowe; Chang; Renate Hellmiss; Ellson Y. Chen; Singh; Garbers; David V. Goeddel

January 1, 1989

Multiple actions of recombinant activin-a in vivo

Endocrinology, ISSN: 19457170 00137227

Ralph H. Schwall; Charles H. Schmelzer; Matsuyama; Anthony J. Mason

January 1, 1989

The gene encoding GnRH and its associated peptide GAP: Some insights into hypogonadism

Journal of Steroid Biochemistry, ISSN: 00224731

Peter H. Seeburg; Anthony J. Mason; Young III; Stewart; Nikolics

January 1, 1989

Localization of enkephalinase mRNA in rat brain by in situ hybridization: Comparison with immunohistochemical localization of the protein

Neuropeptides, ISSN: 01434179

Josiah N. Wilcox; Pollard; Moreau; Jean-Charles Schwartz; Bernard Malfroy

January 1, 1989

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

Molecular and Cellular Biology, ISSN: 02707306

Himmler; Drechsel; Kirschner; Martin Jr.

January 1, 1989

Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Godowski; Leung; Meacham; Galgani; Renate Hellmiss; Keret; Rotwein; Parks; Laron; William I. Wood

January 1, 1989

Expression of human plasminogen cDNA in a baculovirus vector-infected insect cell system

Archives of Biochemistry and Biophysics, ISSN: 10960384 00039861

Joann Whitefleet-Smith; Elliot Rosen; James McLinden; Victoria A. Ploplis; Malcolm J. Fraser; James E. Tomlinson; McLean; Francis J. Castellino

January 1, 1989

Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations

Journal of Biological Chemistry, ISSN: 00219258

Patrick W. Gray; Gail W. Flaggs; Leong; Gumina; Weiss; Ooi; Elsbach

January 1, 1989

Tumor necrosis factor-α inhibits growth hormone secretion from cultured anterior pituitary cells

Endocrinology, ISSN: 19457170 00137227

Walton; Cronin

January 1, 1989

Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets

Journal of Biological Chemistry, ISSN: 00219258

Paul G. Polakis; Weber; Nevins; Didsbury; Tony Evans; Ralph Snyderman

January 1, 1989

Characterization of human growth hormone by capillary electrophoresis

Journal of Chromatography A, ISSN: 00219673

John Frenz; Shiaw-Lin Wu; William S. Hancock

January 1, 1989

Interferon-gamma in a family with X-linked lymphoproliferative syndrome with acute Epstein-Barr virus infection

Journal of Clinical Immunology, ISSN: 02719142 15732592

Motohiko Okano; Geoffrey M. Thiele; Roger H. Kobayashi; Jack R. Davis; Mark S. Synovec; Helen L. Grierson; Howard S. Jaffe; David T. Purtilo

January 1, 1989

Inhibition of tumor cell growth by interferon-γ is mediated by two distinct mechanisms dependent upon oxygen tension: Induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide

Journal of Clinical Investigation, ISSN: 00219738

Aune; Pogue

January 1, 1989

Interleukin 2 responsive lymphocytes in patients with adenosine deaminase deficiency

Clinical Immunology and Immunopathology, ISSN: 00901229

Morton J Cowan; Wayne Smith; Arthur J. Ammann

January 1, 1989

Current status of recombinant cytokines as clinical therapeutics

Drugs of Today, ISSN: 00257656

Howard S. Jaffe; Stephen A. Sherwin

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