Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 15101 - 15150 OF 15583 RESULTS

January 1, 1987

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

EMBO Journal, ISSN: 02614189

Ernest G. Peralta; Avi Ashkenazi; Winslow; Smith; Ramachandran; Capon

January 1, 1987

Effect of phorbol esters on down-regulation and redistribution of cell surface receptors for tumor necrosis factor-alpha.

Journal of Biological Chemistry, ISSN: 00219258

Aggarwal; Eessalu

January 1, 1987

α2-antiplasmin enschede: Alanine insertion and abolition of plasmin inhibitory activity

Science, ISSN: 00368075

William E. Holmes; Lijnen; Nelles; Kluft; Nieuwenhuis; Rijken; Desire Collen

January 1, 1987

Corticotropin Receptors

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Ramachandran; TSUBOKAWA; GOHIL

January 1, 1987

Characterization of Recombinant Human a2-Antiplasmin and of Mutants Obtained by Site-Directed Mutagenesis of the Reactive Site

Biochemistry, ISSN: 15204995 00062960

William E. Holmes; Lijnen; Desire Collen

January 1, 1987

Possible relationships between in vivo antitumour activity and toxicity of tumour necrosis factor-alpha.

CIBA Foundation Symposia, ISSN: 03005208

Michael A. Palladino; John R. Patton; Figari; Shalaby

January 1, 1987

Monoclonal antibodies to human tumor necrosis factors alpha and beta: application for affinity purification, immunoassays, and as structural probes

Hybridoma, ISSN: 0272457X

Timothy S. Bringman; Aggarwal

January 1, 1987

Growth hormone receptor and serum binding protein: Purification, cloning and expression

Nature, ISSN: 00280836

Leung; Steven A. Spencer; Cachianes; R. Glenn Hammonds; Collins; William J. Henzel; Ross Barnard; Michael J. Waters; William I. Wood

January 1, 1987

Primary structure and mRNA localization of protein F1, a growth-related protein kinase C substrate associated with synaptic plasticity.

EMBO Journal, ISSN: 02614189

Rosenthal; Chan; William J. Henzel; Haskell; Wun-Jing Kuang; Ellson Y. Chen; Josiah N. Wilcox; Axel Ullrich; David V. Goeddel; Routtenberg

January 1, 1987

Structural basis of muscarinic acetylcholine receptor subtype diversity

Trends in Pharmacological Sciences, ISSN: 0165604X

Ernest G. Peralta; Winslow; Avi Ashkenazi; Smith; Ramachandran; Capon

January 1, 1987

A repetitive sequence element 3′ of the human c‐Ha‐ras1 gene has enhancer activity

Journal of Cellular Physiology, ISSN: 10974652 00219541

Justus B. Cohen; Walter; Levinson

January 1, 1987

A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression

Science, ISSN: 00368075

Suva; Genine Winslow; Wettenhall; R. Glenn Hammonds; Moseley; Diefenbach-Jagger; Rodda; Kemp; Rodriguez; Ellson Y. Chen; Hudson; Martin; William I. Wood

January 1, 1987

Production of Recombinant Coagulation Proteins

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Gordon A. Vehar

January 1, 1987

Interaction of One-Chain and Two-Chain Tissue Plasminogen Activator with Intact and Plasmin-Degraded Fibrin

Biochemistry, ISSN: 15204995 00062960

Deborah L. Higgins; Gordon A. Vehar

January 1, 1987

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

Nature, ISSN: 00280836

S. Joseph Leibovich; Peter J. Polverini; Shepard; David M. Wiseman; Vera Shively; Nureddin Nuseir

January 1, 1987

Directing Ribosomes to a Single mRNA Species: A Method to Study Ribosomal Rna Mutations and Their Effects on Translation of a Single Messenger in Escherichia coli

Methods in Enzymology, ISSN: 15577988 00766879

Hui; Jhurani; Herman A. de Boer

January 1, 1987

Identification of human uromodulin as the tamm-horsfall urinary glycoprotein

Science, ISSN: 00368075

Diane Pennica; William J. Kohr; Wun-Jing Kuang; Debbie Glaister; Aggarwal; Ellson Y. Chen; David V. Goeddel

January 1, 1987

Gonadal Development and Gametogenesis in the Hypogonadal Mouse Are Restored by Gene Transfer

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Anthony J. Mason; Pitts; Nikolics; Szonyi; Josiah N. Wilcox; Peter H. Seeburg; Stewart

January 1, 1987

Ovomucoid Third Domains from 100 Avian Species: Isolation, Sequences, and Hypervariability of Enzyme-Inhibitor Contact Residues

Biochemistry, ISSN: 15204995 00062960

Michael Laskowski Jr.; Ikunoshin Kato; Wojciech Ardelt; James Cook; Andrew Denton; Mark W. Emnie; William J. Kohr; Soon Jae Park; Kevin Parks; Barbara L. Schatzley; Oeyvind L. Schoenberger; Misao Tashiro; Gisela Vichot; Harry E. Whatley; Anna Wieczorek; Maciej Wieczorek

January 1, 1987

On the evolution of specificity and catalysis in subtilisin

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

James A. Wells; Cunningham; Graycar; David A. Estell; Paul J. Carter

January 1, 1987

Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene

Science, ISSN: 00368075

Dennis J. Slamon; Gary M. Clark; Steven Wong; Wendy J. Levin; Axel Ullrich; William L. McGuire

January 1, 1987

Regulation of neutrophil migration and superoxide production by recombinant tumor necrosis factors-α and -β: Comparison to recombinant interferon-γ and interleukin-1α

Blood, ISSN: 00064971

Figari; Mori; Michael A. Palladino

January 1, 1987

Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen

Science, ISSN: 00368075

Smith; Randal A. Byrn; Scot A. Marsters; Timothy Gregory; Jerome E. Groopman; Capon

January 1, 1987

A national cooperative growth study on protropin

Acta Paediatrica Scandinavica, ISSN: 0001656X

Barry M. Sherman

January 1, 1987

Chicken Ovomucoid: Determination of Its Amino Acid Sequence, Determination of the Trypsin Reactive Site, and Preparation of All Three of Its Domains

Biochemistry, ISSN: 15204995 00062960

Ikunoshin Kato; James Schrode; William J. Kohr; Michael Laskowski Jr.

January 1, 1987

Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-α in rodents

Journal of Clinical Investigation, ISSN: 00219738

John R. Patton; Peters; McCabe; Crase; Hansen; Chen; Liggitt

January 1, 1987

Equilibrium and Kinetic Measurements of the Conformational Transition of Reduced Thioredoxin

Biochemistry, ISSN: 15204995 00062960

Robert F. Kelley; William Shalongc; Jagannadham; Earle Stellwagen

January 1, 1987

Alternative Splicing Increases the Diversity of the Human Protein Kinase C Family

DNA, ISSN: 15577430 01980238

Lisa Coussens; Lucy M. Rhee; Parker; Axel Ullrich

January 1, 1987

Industrial Scale Protein Purification: A Perspective

Bio/Technology, ISSN: 15206033 87567938

Nikos K. Harakas; Stuart E. Builder

January 1, 1987

Functional Role of Proteolytic Cleavage at Arginine-275 of Human Tissue Plasminogen Activator As Assessed by Site-Directed Mutagenesis

Biochemistry, ISSN: 15204995 00062960

Gordon A. Vehar; Keri M. Tate; Deborah L. Higgins; William E. Holmes; Winkler; Herbert Heyneker

January 1, 1987

Human tumour necrosis factors: structure and receptor interactions.

CIBA Foundation Symposia, ISSN: 03005208

Aggarwal; Aiyer; Diane Pennica; Patrick W. Gray; David V. Goeddel

January 1, 1987

Replacement of Proline-76 with Alanine Eliminates the Slowest Kinetic Phase in Thioredoxin Folding

Biochemistry, ISSN: 15204995 00062960

Robert F. Kelley; Frederic M. Richards

January 1, 1987

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

EMBO Journal, ISSN: 02614189

Yarden; Wun-Jing Kuang; Yang-Feng; Lisa Coussens; Munemitsu; Dull; Ellson Y. Chen; Schlessinger; Uta Francke; Axel Ullrich

January 1, 1987

Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

DNA, ISSN: 15577430 01980238

Gray; Tam; Dull; Hayflick; Pintar; Cavenee; Koufos; Axel Ullrich

January 1, 1987

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Hudziak; Schlessinger; Axel Ullrich

January 1, 1987

Cloning and sequencing of human cholesteryl ester transfer protein cDNA

Nature, ISSN: 00280836

Drayna; Jarnagin; McLean; William J. Henzel; William J. Kohr; Fielding; Lawn

January 1, 1987

Assignment of the human gene for cholesteryl ester transfer protein to chromosome 16q12-16q21

Genomics, ISSN: 10898646 08887543

Aldons J. Lusis; Susan Zollman; Robert S. Sparkes; Ivana Klisak; Mohandas; Drayna; Lawn

January 1, 1987

Codon replacement in the PGK1 gene of Saccharomyces cerevisiae: experimental approach to study the role of biased codon usage in gene expression.

Molecular and Cellular Biology, ISSN: 02707306

Hoekema; Kastelein; Vasser; Herman A. de Boer

January 1, 1987

Heterologous expression and characterization of the human R-ras gene product.

Molecular and Cellular Biology, ISSN: 02707306

David G Lowe; David V. Goeddel

January 1, 1987

Primary structure and biochemical properties of an M2 muscarinic receptor

Science, ISSN: 00368075

Ernest G. Peralta; Winslow; Gary L. Peterson; Smith; Avi Ashkenazi; Ramachandran; Michael I. Schimerlik; Capon

January 1, 1987

Engineering enzyme specificity by "substrate-assisted catalysis"

Science, ISSN: 00368075

Paul J. Carter; James A. Wells

January 1, 1987

Receptor binding and activation of polymorphonuclear neutrophils by tumor necrosis factor-alpha

Journal of Leukocyte Biology, ISSN: 07415400

Shalaby; Michael A. Palladino; Sue E. Hirabayashi; Eessalu; Gail D. Lewis; Shepard; Aggarwal

January 1, 1987

Cloning of decay-Accelerating factor suggests novel use of splicing to generate two proteins

Nature, ISSN: 00280836

Caras; Davitz; Lucy M. Rhee; Weddell; Martin Jr.; Nussenzweig

January 1, 1987

Human lipoprotein lipase complementary DNA sequence

Science, ISSN: 00368075

Karen L. Wion; Kirchgessner; Aldons J. Lusis; Schotz; Lawn

January 1, 1987

Mutants of bovine pancreatic trypsin inhibitor lacking cysteines 14 and 38 can fold properly

Science, ISSN: 00368075

Cara Berman Marks; Hossein Naderi; Kosen; Kuntz; Anderson

January 1, 1987

Effects of growth factors on the antiproliferative activity of tumor necrosis factors

Cancer Research, ISSN: 15387445 00085472

Sugarman; Gail D. Lewis

January 1, 1987

Human purine nucleoside phosphorylase and adenosine deaminase: Gene transfer into cultured cells and murine hematopoietic stem cells by using recombinant amphotropic retroviruses

Molecular and Cellular Biology, ISSN: 02707306

R.Scott McIvor; Johnson; Miller; Pitts; Steven R. Williams; Valerio; Martin Jr.; Verma

January 1, 1987

Harnessing disulfide bonds using protein engineering

Trends in Biochemical Sciences, ISSN: 09680004

Wetzel

January 1, 1987

GnRH-prohormone-containing neurons in the primate brain: Immunostaining for the GnRH-Associated peptide

Peptides, ISSN: 01969781

Tianbao Song; Nikolics; Peter H. Seeburg; Paul C. Goldsmith

January 1, 1987

Construction and properties of an intracellular serine protease mutant of Bacillus subtilis

Journal of Bacteriology, ISSN: 00219193

Louise Band; Henner; Ruppen

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