Genentech: Publications

January 1, 2019

From Discovery to Market Readiness: The Research and Development of the β-Sparing Phosphatidylinositol 3-Kinase Inhibitor Taselisib

ACS Symposium Series, ISSN: 19475918 00976156

Remy Angelaud; Steven T. Staben; Timothy P. Heffron; Andreas M. Schuster; Frederic St-Jean

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January 1, 2019

Discovery and Development of the First Antibody-Antibiotic Conjugate Linker-Drug

ACS Symposium Series, ISSN: 19475918 00976156

Stefan G. Koenig; Thomas H. Pillow

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January 1, 2019

The Discovery of the Nav1.7 Inhibitor GDC-0276 and Development of an Efficient Large-Scale Synthesis

ACS Symposium Series, ISSN: 19475918 00976156

Andreas Stumpf; Daniel P. Sutherlin; Christoph Dehnhardt; Remy Angelaud

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January 1, 2019

Discovery and Development of Non-Covalent, Reversible Bruton's Tyrosine Kinase Inhibitor Fenebrutinib (GDC-0853)

ACS Symposium Series, ISSN: 19475918 00976156

James J. Crawford; Haiming Zhang

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January 1, 2019

Discovery of two highly divergent negative-sense RNA viruses associated with the parasitic nematode, Capillaria hepatica, in wild Mus musculus from New York City

Journal of General Virology, ISSN: 14652099 00221317

Simon H. Williams; Xiaoyu Che; Alexandra Oleynik; Joel A. Garcia; Dorothy Muller; Tanja S. Zabka; Cadhla Firth; Robert M. Corrigan; Thomas Briese; Komal Jain; W. Ian Lipkin

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January 1, 2019

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

Journal of Experimental Medicine, ISSN: 15409538 00221007

Quang T. Le; Jonathan J. Lyons; Andrea N. Naranjo; Ana Olivera; Lazarus; Dean D. Metcalfe; Joshua D. Milner; Lawrence B. Schwartz

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January 1, 2019

Investigating the impact of albumin on the liver uptake of pitavastatin and warfarin in nagase analbuminemic rats

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Jae H. Chang; Yi-Chen Chen; Jonathan Cheong; Robert S. Jones; Jodie Pang

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January 1, 2019

Physician characteristics associated with treatment initiation patterns in idiopathic pulmonary fibrosis

Chronic Respiratory Disease, ISSN: 14799731 14799723

Peter P. LaCamera; Susan L. Limb; Tmirah Haselkorn; Elizabeth A. Morgenthien; John L. Stauffer; Mark L. Wencel

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January 1, 2019

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

PLoS Biology, ISSN: 15457885 15449173

Vande Walle; Irma B. Stowe; Pavel Šácha; Bettina L. Lee; Dieter Demon; Amelie Fossoul; Filip Van Hauwermeiren; Pedro H.V. Saavedra; Petr Šimon; Vladimír Šubrt; Libor Kostka; Craig E. Stivala; Victoria Pham; Steven T. Staben; Sayumi Yamazoe; Jan Konvalinka; Nobuhiko Kayagaki; Lamkanfi

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January 1, 2019

Perspectives from the innovation and quality consortium induction working group on factors impacting clinical drug-drug interactions resulting from induction: Focus on cytochrome 3a substrates

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Diane Ramsden; Conrad Fung; Niresh Hariparsad; Jane R. Kenny; Michael A. Mohutsky; Neil Parrott; Sarah M. Robertson; Donald J. Tweedie

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January 1, 2019

Drug concentration asymmetry in tissues and plasma for small molecule-related therapeutic modalities

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Donglu Zhang; Cornelis E. Hop; Gabriela Patilea-Vrana; Gautham Gampa; Herana Kamal Seneviratne; Jashvant D. Unadkat; Jane R. Kenny; Karthik Nagapudi; Li Di; Lian Zhou; Mark Zak; Matthew Wright; Namandjé N. Bumpus; Richard Zang; Xingrong Liu; Yurong Lai; Cyrus Khojasteh

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January 1, 2019

Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody-drug conjugates

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Donglu Zhang; Aimee Fourie-O'Donohue; Peter Dragovich; Thomas H. Pillow; Jack D. Sadowsky; Katherine R. Kozak; Robert T. Cass; Liling Liu; Yuzhong Deng; Yichin Liu; Cornelis E. Hop; Cyrus Khojasteh

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January 1, 2019

Exposure-efficacy analysis of antibody-drug conjugates delivering an excessive level of payload to tissues

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Donglu Zhang; Peter Dragovich; Shang-Fan Yu; Yong Ma; Thomas H. Pillow; Jack D. Sadowsky; Dian Su; Wei Wang; Andrew G. Polson; Cyrus Khojasteh; Cornelis E. Hop

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January 1, 2019

Absence of pharmacokinetic interactions between the Bruton’s tyrosine kinase inhibitor fenebrutinib and methotrexate

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Nicholas Steven Jones; Helen Winter; Tamiko R. Katsumoto; Marilyn Florero; Elaine R. Murray; Helen Walker; Nand Singh; Leslie Chinn

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January 1, 2019

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

eLife, ISSN: 2050084X

Anna Shemorry; Jonathan M. Harnoss; Ofer Guttman; Scot A. Marsters; László Kömüves; David Lawrence; Avi Ashkenazi

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January 1, 2019

Pharmacokinetics of pertuzumab administered concurrently with trastuzumab in Chinese patients with HER2-positive early breast cancer

Anti-Cancer Drugs, ISSN: 14735741 09594973

Yang Luo; Wei Li; Zefei Jiang; Qingyuan Zhang; Liwei Wang; Yixiang Mao; Vivianne C G Tjan-Heijnen; Seock-Ah Im; Robin McConnell; Sara Bejarano; Fumagalli; José Bines; Wang; Amit Garg; Whitney P. Kirschbrown; Binghe Xu

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January 1, 2019

GDC-0810 pharmacokinetics and transporter-mediated drug interaction evaluation with an endogenous biomarker in the first-in-human, dose escalation study

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Kit Wun Kathy Cheung; Yoshida; Sravanthi Cheeti; Buyun Chen; Roland Morley; Iris Chan; Srikumar Sahasranaman; Lichuan Liu

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January 1, 2019

The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs

Life Science Alliance, ISSN: 25751077

Mattias Rydenfelt; Matthew Wongchenko; Bertram Klinger; Yibing Yan; Nils Blüthgen

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January 1, 2019

Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging

JCI insight, ISSN: 23793708

Denise P. Muñoz; Steven M. Yannone; Anneleen Daemen; Yu Sun; Funda Vakar-Lopez; Misako Kawahara; Adam M. Freund; Francis Rodier; Jennifer D. Wu; Pierre-Yves Desprez; David H. Raulet; Peter S. Nelson; Laura J. van't Veer; Judith Campisi; Jean-Philippe Coppé

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January 1, 2019

Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Advances in Therapy, ISSN: 18658652 0741238X

Marilyn K Glassberg; Steven D Nathan; Chin-Yu Lin; Elizabeth A. Morgenthien; John L. Stauffer; Willis Chou; Paul W. Noble

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January 1, 2019

A potent and effective suicidal listeria vaccine platform

Infection and Immunity, ISSN: 10985522 00199567

William G. Hanson; Erin L. Benanti; Edward E. Lemmens; Weiqun Liu; Justin Skoble; Meredith L. Leong; Chris S. Rae; Marcella Fassò; Dirk Brockstedt; Chen Chen; Daniel A. Portnoy; Thomas W. Dubensky; Peter Lauer

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January 1, 2019

CHAPTER 11: Duocarmycin-PBD Dimers as Antibody-Drug Conjugate (ADC) Payloads

RSC Drug Discovery Series, ISSN: 20413211 20413203

Thomas H. Pillow; Moana Tercel

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January 1, 2019

Carfilzomib is not an appropriate payload of antibody-drug conjugates due to rapid inactivation by lysosomal enzymes

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Yong Ma; Josefa Dela Cruz-Chuh; S. Cyrus Khojasteh; Peter Dragovich; Thomas H. Pillow; Donglu Zhang

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January 1, 2019

Early notch signals induce a pathogenic molecular signature during priming of alloantigen-specific conventional CD4+ T cells in graft-versus-host disease

Journal of Immunology, ISSN: 15506606 00221767

Jooho Chung; Vedran Radojcic; Eric Perkey; Timothy J. Parnell; Yashar Niknafs; Xi Jin; Ann Friedman; Nathalie Labrecque; Bruce R. Blazar; Todd V. Brennan; Christian W. Siebel; Ivan Maillard

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January 1, 2019

A clinically applicable gene-expression classifier reveals intrinsic and extrinsic contributions to consensus molecular subtypes in primary and metastatic colon cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Robert Piskol; Huw; Ismail Sergin; Christiaan Kljin; Zora Modrusan; Doris Kim; Noelyn Kljavin; Rachel Tam; Rajesh Patel; Jeremy B. Burton; Elicia M. Penuel; Xueping Qu; Koeppen; Teiko Sumiyoshi; Frederic J. De Sauvage; Lackner; Felipe de Sousa e Melo; Omar Kabbarah

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January 1, 2019

Semiautomated small-scale purification method for high-throughput expression analysis of recombinant proteins

Methods in Molecular Biology, ISSN: 19406029 10643745

Edward Kraft; Yvonne Franke; Katharine Heeringa; Stephanie K. Shriver; Inna Zilberleyb; Christine Kugel; Trisha Dela Vega; Athena W. Wong; Bobby Brillantes; Claudio Ciferri; George Dutina; Grace Lee; Isabelle Lehoux; Zhong Rong Li; Lee Lior-Hoffmann; Jiyoung Hwang; Chris Lonergan; Lynn Martin; Kyle Mortara; Lananh Nguyen; Jian Payandeh; Andrew Perez; Jun Sampang; Lovejit Singh; Kurt A. Schroeder; Christine Tam; Shu Ti; Ye Naing Win; Krista K. Bowman

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January 1, 2019

A flexible and scalable high-throughput platform for recombinant membrane protein production

Methods in Molecular Biology, ISSN: 19406029 10643745

Hui Xu; Thomas Clairfeuille; Christine C. Jao; Hoangdung Ho; Zachary K. Sweeney; Jian Payandeh; Christopher M. Koth

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January 1, 2019

High-throughput protein analysis using negative stain electron microscopy and 2D classification

Methods in Molecular Biology, ISSN: 19406029 10643745

Christopher P. Arthur; Claudio Ciferri

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January 1, 2019

Time-to-Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine-Citrulline-Monomethylauristatin E Antibody–Drug Conjugates

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Kagedal; Divya Samineni; Gillespie; Dan Lu; Bernard M. Fine; Sandhya Girish; Chunze Li; Jin Y. Jin

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January 1, 2019

Quantitative Comparison of Conventional and t-SNE-guided Gating Analyses

Frontiers in Immunology, ISSN: 16643224

Shadi Toghi Eshghi; Amelia Au-Yeung; Chikara Takahashi; Christopher R. Bolen; Maclean N. Nyachienga; Sean P. Lear; Cherie Green; William Mathews; William E. O'Gorman

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January 1, 2019

Effects of PI3K inhibition on afucosylated antibody-driven FcgRIIIa events and phospho-S6 activity in NK cells

Journal of Immunology, ISSN: 15506606 00221767

Valentina Romeo; Sarah Gierke; Kyle A. Edgar; Scot D. Liu

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January 1, 2019

Bioanalytical challenges in development of ultrasensitive Home Brew assays: A case study using IL-13

Bioanalysis, ISSN: 17576199 17576180

Gizette Sperinde; Martha Hokom; Kun Peng; Saloumeh Kadkhodayan Fischer

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January 1, 2019

Structural and Functional Variation in Outer Membrane Polysaccharide Export (OPX) Proteins from the Two Major Capsule Assembly Pathways Present in Escherichia coli

Journal of Bacteriology, ISSN: 10985530 00219193

Caitlin Sande; Catrien Bouwman; Elisabeth Kell; Nicholas N. Nickerson; Sharookh B. Kapadia; Chris Whitfield

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January 1, 2019

Palladium-catalyzed enantioselective decarboxylative allylic alkylation of fully substituted: N -acyl indole-derived enol carbonates

Chemical Science, ISSN: 20416539 20416520

Eric J. Alexy; Tyler J. Fulton; Haiming Zhang; Brian M. Stoltz

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January 1, 2019

Durable remissions with obinutuzumab-based chemoimmunotherapy: Long-term follow-up of the phase 1b GALTON trial in CLL

Blood, ISSN: 15280020 00064971

Jennifer R. Brown; Susan O'Brien; C. Daniel Kingsley; Herbert Eradat; John M. Pagel; Jamie Hirata; Tammy McIver; Rodica Morariu-Zamfir; Thomas J. Kipps

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January 1, 2019

Correction: First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL (Oncotarget(2018) 9 (13023 -13035) DOI: 10.18632/oncotarget.24310)

Oncotarget, ISSN: 19492553

John C. Byrd; Stephen Smith; Nina D. Wagner-Johnston; Jeff P. Sharman; Chen; Ranjana H. Advani; Bradley Augustson; Paula Marlton; Renee Commerford; Kwame Okrah; Lichuan Liu; Elaine R. Murray; Elicia M. Penuel; Ashley F. Ward; Ian W. Flinn

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January 1, 2019

Unequal absorption of radiolabeled and nonradiolabeled drug from the oral dose leads to incorrect estimates of drug absorption and circulating metabolites in a mass balance study

Drug Metabolism Letters, ISSN: 18723128

Ryan Takahashi; Jae H. Chang; Jodie Pang; Xiaorong Liang; Shuguang Ma

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January 1, 2019

Probing interaction of lipid-modified wnt protein and its receptors by ELISA

Methods in Molecular Biology, ISSN: 19406029 10643745

Aaron H Nile; Rami N. Hannoush

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January 1, 2019

Cellular mechanisms of etrolizumab treatment in inflammatory bowel disease

Frontiers in Pharmacology, ISSN: 16639812

Charlotte Lichnog; Sha Klabunde; Emily Becker; Franklin Fuh; Philipp Tripal; Raja Atreya; Entcho Klenske; Erickson; Chiu; Chae Reed; Shan Chung; Clemens Neufert; Imke Atreya; Jacqueline McBride; Markus F. Neurath; Sebastian Zundler

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January 1, 2019

Visualization of mass cytometry signal background to enable optimal core panel customization and signal threshold gating

Methods in Molecular Biology, ISSN: 10643745

Amelia Au-Yeung; Chikara Takahashi; W Rodney Mathews; William E. O'Gorman

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January 1, 2019

Mutational analysis of patients with colorectal cancer in CALGB/SWOG 80405 identifies new roles of microsatellite instability and tumor mutational burden for patient outcome

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Federico Innocenti; Fang-Shu Ou; Xueping Qu; Tyler J. Zemla; Donna Niedzwiecki; Rachel Tam; Shilpi Mahajan; Richard M. Goldberg; Monica M. Bertagnolli; Charles D. Blanke; Hanna Sanoff; James Atkins; Blase Polite; Alan P. Venook; Heinz-Josef Lenz; Omar Kabbarah

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January 1, 2019

Exposure-effect relationships in established rat adjuvant-induced and collagen-induced arthritis: A translational pharmacokinetic-pharmacodynamic analysis

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Harvey Wong; Lichuan Liu; Wenjun Ouyang; Yuzhong Deng; Matthew Wright; Cornelis E. Hop

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January 1, 2019

MAVERICC, a randomized, biomarker-stratified, phase II study of mFOLFOX6-Bevacizumab versus FOLFIRI-bevacizumab as first-line chemotherapy in metastatic colorectal cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Aparna R. Parikh; Fa-Chyi Lee; Linda Yau; Han Koh; James Knost; Edith Mitchell; Ivan Bosanac; Nicholas Choong; Frank A. Scappaticci; Christoph Mancao; Heinz-Josef Lenz

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January 1, 2019

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1

Science, ISSN: 10959203 00368075

Meng He; Mira S. Chaurushiya; Webster; Sarah K. Kummerfeld; Rohit Reja; Subhra Chaudhuri; Ying-Jiun Chen; Zora Modrusan; Benjamin Haley; Dugger; Jeffrey Eastham-Anderson; Shari Lau; Anwesha Dey; Roger Caothien; Merone Roose-Girma; Kim Newton; Vishva M. Dixit

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January 1, 2019

Rheumatoid arthritis-interstitial lung disease in the United States: Prevalence, incidence, and healthcare costs and mortality

Journal of Rheumatology, ISSN: 14992752 0315162X

Karina Raimundo; Joshua J. Solomon; Amy L. Olson; Amanda M. Kong; Ashley L. Cole; Aryeh Fischer; Jeffrey J. Swigris

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January 1, 2019

Making the move towards modernized greener separations: Introduction of the analytical method greenness score (AMGS) calculator

Green Chemistry, ISSN: 14639270 14639262

Michael B. Hicks; William P. Farrell; Christine Aurigemma; Laurent Lehmann; Lauren Weisel; Kelly Nadeau; Heewon Lee; Carol Moraff; Mengling Wong; Yun Huang; Paul Ferguson

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January 1, 2019

Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to induce type 2 inflammation from human lymphocytes

Journal of Immunology, ISSN: 15506606 00221767

Vladimir Ramirez-Carrozzi; Naruhisa Ota; Arivazhagan Sambandam; Kit Wong; Jason A. Hackney; Nadia Martinez-Martin; Wenjun Ouyang; Rajita Pappu

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January 1, 2019

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Xiaojing Wang; Wesley P. Blackaby; Vivienne Allen; Grace Chan; Jae H. Chang; Po-Chang Chiang; Coura Diène; Jason H. Drummond; Steven Do; Eric Fan; Eric Harstad; Alastair J. Hodges; Huiyong Hu; Wei Jia; William Kofie; Aleksandr Kolesnikov; Joseph P. Lyssikatos; Justin Ly; Mizio Matteucci; John Moffat; Veerendra Munugalavadla; Jeremy Murray; David Nash; Cameron Noland; Geoffrey Del Rosario; Leanne Ross; Craig Rouse; Andrew Sharpe; Dionysos S. Slaga; Minghua Sun; Vickie Tsui; Heidi J. A. Wallweber; Shang-Fan Yu; Allen Ebens

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January 1, 2019

Current trends in biotherapeutic higher order structure characterization by irreversible covalent footprinting mass spectrometry

Protein and Peptide Letters, ISSN: 18755305 09298665

Natalie K. Garcia; Galahad Deperalta; Aaron T. Wecksler

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January 1, 2019

Timely, consistent, transparent assessment of market access evidence: Implementing tools based on the HTA Core Model® in a pharmaceutical company

International Journal of Technology Assessment in Health Care, ISSN: 14716348 02664623

Pierre Ducournau; Cornelia Irl; Iain Tatt; Mary McCarvil; Marlene Gyldmark

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