Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5001 - 5050 OF 15390 RESULTS

Does caspase-12 suppress inflammasome activation?
Nature, ISSN: 14764687 00280836
Vande Walle; Daniel Jiménez Fernández; Dieter Demon; Naomi Van Laethem; Filip Van Hauwermeiren; Hanne Van Gorp; Nina Van Opdenbosch; Nobuhiko Kayagaki; Lamkanfi
View on Scopus
Necroptosis and Inflammation
Annual Review of Biochemistry, ISSN: 15454509 00664154
Kim Newton; Gerard Manning
View on Scopus
Serum periostin is associated with type 2 immunity in severe asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Mats W. Johansson; Michael D. Evans; Gina M. Crisafi; Cécile T.J. Holweg; Matthews; Jarjour
View on Scopus
Molecular simulations of micellar aggregation of polysorbate 20 ester fractions and their interaction with N-phenyl-1-naphthylamine dye
Biophysical Chemistry, ISSN: 18734200 03014622
Mauro Lapelosa; Thomas W. Patapoff; Isidro E. Zarraga
View on Scopus
Prediction of drug-drug interactions arising from CYP3A induction using a physiologically based dynamic models
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Lisa M. Almond; Sophie Mukadam; Iain Gardner; Krystle Okialda; Susan C. Wong; Oliver Hatley; Suzanne Tay; Karen Rowland-Yeo; Masoud Jamei; Amin Rostami-Hodjegan; Jane R. Kenny
View on Scopus
Investigation of Dose-Dependent Factors Limiting Oral Bioavailability: Case Study with the PI3K-δ Inhibitor
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Daniel P. Sutherlin; Jodie Pang; Laurent Salphati
View on Scopus
Examining Manufacturing Readiness for Breakthrough Drug Development
AAPS PharmSciTech, ISSN: 15309932
Earl S. Dye; Annie Sturgess; Gargi Maheshwari; Kimberly May; Colleen Ruegger; Usha Ramesh; Heow Tan; Keith Cockerill; John Groskoph; Emanuela Lacana; Sau L. Lee; Sarah Pope Miksinski
View on Scopus
Relationship between Baseline and Early Changes in C-Reactive Protein and Interleukin-6 Levels and Clinical Response to Tocilizumab in Rheumatoid Arthritis
Arthritis Care and Research, ISSN: 21514658 2151464X
Jianmei Wang; Jenny Devenport; Jason M. Low; Dale Yu; Hitraya
View on Scopus
Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice
Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X
Dong U. Lee; Paula Katavolos; Gopinath S. Palanisamy; Arna Katewa; Charly Sioson; Janice Corpuz; Jodie Pang; Kevin Dement; Edna F. Choo; Nico Ghilardi; Dolores Diaz; Dimitry Danilenko
View on Scopus
Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug–Drug Interaction Prediction
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Yuan Chen; Fang Ma; Tong Lu; Nageshwar Budha; Jin Y. Jin; Jane R. Kenny; Harvey Wong; Cornelis E. Hop; Jialin Mao
View on Scopus
An Overview of the Pathogenesis of Immune-mediated Skin Injury
Toxicologic Pathology, ISSN: 15331601 01926233
Dimitry Danilenko
View on Scopus
Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial
The Lancet Oncology, ISSN: 14745488 14702045
Ian E. Krop; Ingrid A. Mayer; Vinod Ganju; Maura N. Dickler; Stephen Johnston; Serafin Morales; Denise A. Yardley; Melichar; Andres Forero; Soo Chin Lee; Richard de Boer; Katarina Petrakova; Susanne Vallentin; Edith A. Perez; Martine Piccart; Matthew Ellis; Eric P. Winer; Steven Gendreau; Mika K. Derynck; Lackner; Gallia Levy; Jiaheng Qiu; Jing He; Schmid
View on Scopus
Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: A randomised, double-blind, placebo-controlled, phase 2 trial
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Jürgen Behr; Elisabeth Bendstrup; Bruno Crestani; Andreas Günther; Horst Olschewski; C Magnus Sköld; Athol Wells; Wim Wuyts; Dirk Koschel; Michael Kreuter; Benoît Wallaert; Chin-Yu Lin; Jürgen Beck; Carlo Albera
View on Scopus
Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: Prospective placebo-controlled clinical studies
EMBO Molecular Medicine, ISSN: 17574684 17574676
Jérémie Decalf; Kristin V. Tarbell; Armanda Casrouge; Jeffrey D. Price; Grace Linder; Estelle Mottez; Philippe Sultanik; Vincent Mallet; Stanislas Pol; Darragh Duffy; Matthew L. Albert
View on Scopus
In Vitro Skin Models and Their PredictabilProliferative Lesions in Thyroid Follicular Cells of Dwarfs Derived from Wistar Hannover GALAS Rats Lesions in Thyroid Follicular Cells of Dwarfs Derived from Wistar Hannover GALAS Ratsng Normal and Disease Biology, Pharmacology, and Toxicity
Toxicologic Pathology, ISSN: 15331601 01926233
Dimitry Danilenko; Gail L. Phillips; Dolores Diaz
View on Scopus
A new triglycyl peptide linker for antibody-drug conjugates (ADCs) with improved targeted killing of cancer cells
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Rajeeva Singh; Yulius Y. Setiady; Jose Ponte; Yelena Kovtun; Katharine C. Lai; E. Erica Hong; Nathan Fishkin; Ling Dong; Gregory Jones; Jennifer A. Coccia; Leanne Lanieri; Karen Veale; Juliet A. Costoplus; Anna Skaletskaya; Rabih Gabriel; Paulin Salomon; Rui Wu; Qifeng Qiu; Hans Erickson; John M. Lambert; Ravi Chari; Wayne C. Widdison
View on Scopus
Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras
Leukemia, ISSN: 14765551 08876924
Jon Akutagawa; Huang; Epstein; Tiffany Chang; Quirindongo-Crespo; Cottonham; Monique Dail; Slusher; Lori S. Friedman; Deepak Sampath; Benjamin S. Braun
View on Scopus
Rituximab extended schedule or retreatment trial for low tumour burden non-follicular indolent B-cell non-Hodgkin lymphomas: Eastern Cooperative Oncology Group Protocol E4402
British Journal of Haematology, ISSN: 13652141 00071048
Marna Williams; Fangxin Hong; Randy D. Gascoyne; Lynne I. Wagner; John C. Krauss; Thomas M. Habermann; Lode J. Swinnen; Stephen J. Schuster; Christopher G. Peterson; Mark D. Sborov; S. Eric Martin; Matthias Weiss; W. Christopher Ehmann; Sandra J. Horning; Brad Kahl
View on Scopus
Plasma metabolomic changes following PI3K inhibition as pharmacodynamic biomarkers: Preclinical discovery to phase I trial evaluation
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Joo Ern Ang; Rupinder Pandher; Joo Chew Ang; Yasmin J. Asad; Alan T. Henley; Melanie Valenti; Gary Box; Alexis Haven De Brandon; Richard Baird; Lori S. Friedman; Mika K. Derynck; Bart Vanhaesebroeck; Suzanne A. Eccles; Stanley B. Kaye; Paul Workman; De Bono; Florence I. Raynaud
View on Scopus
Ten years of anti-vascular endothelial growth factor therapy
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Napoleone Ferrara; Anthony P. Adamis
View on Scopus
Rate-Determining and rate-limiting steps in the clearance and excretion of a potent and selective p21-activated kinase inhibitor: A case study of rapid hepatic uptake and slow elimination in rat
Drug Metabolism Letters, ISSN: 18723128
Peter W. Fan; Jacob Z. Chen; Allan Jaochico; Hank La; Ning Liu; Teresa Mulder; Robert T. Cass; Matthew Durk; Kirsten Messick; Nicole R. Valle; Shannon Liu; Wendy Lee; James J. Crawford; Joachim Rudolph; Lesley J. Murray; S. Cyrus Khojasteh; Matthew Wright
View on Scopus
Elucidating the mechanism of tofacitinib oxidative decyanation
Drug Metabolism Letters, ISSN: 18723128
Hoa Le; Peter W. Fan; Susan C. Wong; Shuguang Ma; James Driscoll; Cornelis E. Hop; S. Cyrus Khojasteh
View on Scopus
Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody
PLoS Pathogens, ISSN: 15537374 15537366
Ning Chai; Lee R. Swem; Mike Reichelt; Haiyin Chen-Harris; Luis; Summer Park; Ashley Fouts; Patrick J. Lupardus; Thomas D Wu; Olga Li; Jacqueline McBride; Michael Lawrence; Min Xu; Man-Wah Tan
View on Scopus
Therapeutic antibody-induced vascular toxicity due to off-target activation of nitric oxide in cynomolgus monkeys
Toxicological Sciences, ISSN: 10960929 10966080
Rama Pai; Ning Ma; Anu V. Connor; Dimitry Danilenko; Jacqueline M. Tarrant; Dany Salvail; Lisa Wong; Dylan P. Hartley; Misner; Stefanich; Yan Wu; Yongmei Chen; Hong Wang; Donna M. Dambach
View on Scopus
Bridging polymer science and biotechnology applications with single-use technologies
BioProcess International, ISSN: 15426319
Ekta Mahajan; Gary Lye
View on Scopus
Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Alexander Amberg; Lisa Beilke; Joel P. Bercu; Dave Bower; Alessandro Brigo; Kevin P. Cross; Laura Custer; Krista Dobo; Eric Dowdy; Kevin A. Ford; Susanne Glowienke; Jacky Van Gompel; James Harvey; Catrin Hasselgren; Masamitsu Honma; Robert A. Jolly; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Penny Leavitt; Scott Miller; Wolfgang Muster; John Nicolette; Andreja Plaper; Mark Powley; Donald P. Quigley; M. Vijayaraj Reddy; Hans-Peter Spirkl; Lidiya Stavitskaya; Andrew Teasdale; Sandy Weiner; Dennie S. Welch; Angela White; Joerg Wichard; Glenn J. Myatt
View on Scopus
Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Ernst Ahlberg; Alexander Amberg; Lisa Beilke; Dave Bower; Kevin P. Cross; Laura Custer; Kevin A. Ford; Jacky Van Gompel; James Harvey; Masamitsu Honma; Robert A. Jolly; Elisabeth Joossens; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Lara Kuhnke; Penny Leavitt; Russell Naven; Claire Neilan; Donald P. Quigley; Dana Shuey; Hans-Peter Spirkl; Lidiya Stavitskaya; Andrew Teasdale; Angela White; Joerg Wichard; Craig Zwickl; Glenn J. Myatt
View on Scopus
Cycling in the nucleus: Regulation of RNA 3' processing and nuclear organization of replication-dependent histone genes
Current Opinion in Cell Biology, ISSN: 18790410 09550674
Valentina Romeo; Daniel Schümperli
View on Scopus
Cost-Effectiveness Model for Chemoimmunotherapy Options in Patients with Previously Untreated Chronic Lymphocytic Leukemia Unsuitable for Full-Dose Fludarabine-Based Therapy
Value in Health, ISSN: 15244733 10983015
Ursula Becker; Andrew Briggs; Santiago G. Moreno; Joshua A. Ray; Phuong Ngo; Kunal Samanta
View on Scopus
Assessment of disease-related therapeutic protein drug-drug interaction for etrolizumab in patients with moderately to severely active ulcerative colitis
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Xiaohui Wei; Jane R. Kenny; Leslie Dickmann; Romeo MacIuca; Looney; Meina Tao Tang
View on Scopus
Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Sebastian Unizony; Villarreal; Miloslavsky; Na Lu; Merkel; Spiera; Seo; Langford; Hoffman; Kallenberg; E. William St. Clair; Iklé; Tchao; Linna Ding; Paul Brunetta; Hyon Choi; Paul A. Monach; Fervenza; John H. Stone; Specks
View on Scopus
Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Gerd R. Burmester; William F. Rigby; Ronald Van Vollenhoven; Jonathan Kay; Rubbert-Roth; Ariella Kelman; Sophie Dimonaco; Nina Mitchell
View on Scopus
Visual and Anatomic Outcomes in Patients with Diabetic Macular Edema with Limited Initial Anatomic Response to Ranibizumab in RIDE and RISE Presented in part at: American Academy of Ophthalmology Annual Meeting, October 2014, Chicago, Illinois; And 38th Macula Society Annual Meeting, February 2015, Scottsdale, Arizona.
Ophthalmology, ISSN: 15494713 01616420
Dante Joseph Pieramici; Pin-Wen Wang; Beiying Ding; Shamika Gune
View on Scopus
Visual phenomena perceived during pars plana vitrectomy under peribulbar block and monitored anaesthesia care
British Journal of Ophthalmology, ISSN: 14682079 00071161
Hema L. Ramkumar; Azadeh Khatibi; William R. Freeman; Giulio Barteselli; Isaac C. Ezon; Payam Amini; Lucie Sharpsten; Cheryl A. Arcinue; Joseph T. Nezgoda; Henry A. Ferreyra; Michael H. Goldbaum
View on Scopus
Age-related macular degeneration: Complement in action
Immunobiology, ISSN: 18783279 01712985
Menno Van Lookeren Campagne; Erich C. Strauss; Brian L. Yaspan
View on Scopus
Dosing of Intravenous Tocilizumab in a Real-World Setting of Rheumatoid Arthritis: Analyses from the Corrona Registry
Rheumatology and Therapy, ISSN: 21986584 21986576
Dimitrios A. Pappas; Ani John; Jeffrey R. Curtis; Reed; Chitra Karki; Robert Magner; Joel M. Kremer; Ashwini Shewade; Jeffrey D. Greenberg
View on Scopus
Rituximab extended schedule or retreatment trial for low tumour burden non-follicular indolent B-cell non-Hodgkin lymphomas: Eastern Cooperative Oncology Group Protocol E4402
British Journal of Haematology, ISSN: 13652141 00071048
Marna Williams; Fangxin Hong; Randy D. Gascoyne; Lynne I. Wagner; John C. Krauss; Thomas M. Habermann; Lode J. Swinnen; Stephen J. Schuster; Christopher G. Peterson; Mark D. Sborov; S. Eric Martin; Matthias Weiss; W. Christopher Ehmann; Sandra J. Horning; Wojciech Jurczak
View on Scopus
NLRP3 recruitment by NLRC4 during Salmonella infection
Journal of Experimental Medicine, ISSN: 15409538 00221007
Yan Qu; Shahram Misaghi; Kim Newton; Maltzman; Anita Izrael-Tomasevic; David Arnott; Vishva M. Dixit
View on Scopus
Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight, ISSN: 23793708
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
View on Scopus
Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight, ISSN: 23793708
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
View on Scopus
Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight,
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
View on Scopus
Reproducible pharmacogenomic profiling of cancer cell line panels
Nature, ISSN: 14764687 00280836
Matthias Peter; Eva Lin; Jenille Tan; Yihong Yu; Billy Lam; Steve Lianoglou; Richard M. Neve; Scott E. Martin; Jeffrey Settleman; Robert Yauch; Richard Bourgon
View on Scopus
An enzymatic deconjugation method for the analysis of small molecule active drugs on antibody-drug conjugates
mAbs, ISSN: 19420870 19420862
Yi Li; Christine Gu; Jason Gruenhagen; Peter M. Yehl; Nik P. Chetwyn; Colin D. Medley
View on Scopus
Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Alexander Heifetz; Giancarlo Trani; Matteo Aldeghi; Colin H. Mackinnon; Paul A. McEwan; Frederick A. Brookfield; Ewa I. Chudyk; Mike Bodkin; Zhonghua Pei; Jason D. Burch; Daniel F. Ortwine
View on Scopus
Mechanistic Insights into Radical-Mediated Oxidation of Tryptophan from ab Initio Quantum Chemistry Calculations and QM/MM Molecular Dynamics Simulations
Journal of Physical Chemistry A, ISSN: 15205215 10895639
Geoffrey P. F. Wood; Alavattam Sreedhara; Jamie M. R. Moore; John Wang; Bernhardt L. Trout
View on Scopus
Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)
ACS Medicinal Chemistry Letters, ISSN: 19485875
Alexander M. Taylor; Alexandre Côté; Michael C. Hewitt; Richard Pastor; Yves Leblanc; Christopher G. Nasveschuk; F. Anthony Romero; Terry Crawford; Nico Cantone; Hariharan Jayaram; Jeremy Setser; Jeremy Murray; Beresini; Gladys De Leon Boenig; Zhongguo Chen; Andrew R. Conery; Richard T Cummings; Leslie A. Dakin; E. Megan Flynn; Oscar W Huang; Susan Kaufman; Patricia J. Keller; James R. Kiefer; Tommy Lai; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Henry Lu; Eneida Pardo; Vickie Tsui; Jian Wang; Yongyun Wang; Zhaowu Xu; Fen Yan; Dong Yu; Laura E. Zawadzke; Xiaoqin Zhu; Xiaoyu Zhu; Robert J. Sims; Andrea G Cochran; Steve Bellon; James E. Audia; Steven Magnuson; Brian K Albrecht
View on Scopus
Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms
Cell Reports, ISSN: 22111247
Karen Yap; Yixin Xiao; Brad A. Friedman; H. Shawn Je; Eugene V. Makeyev
View on Scopus
Randomized open-label phase II trial of apitolisib (GDC-0980), a novel inhibitor of the PI3K/mammalian target of rapamycin pathway, versus everolimus in patients with metastatic renal cell carcinoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Thomas Powles; Lackner; Stephane Oudard; Bernard Escudier; Christy Ralph; Janet E. Brown; Robert E. Hawkins; Daniel Castellano; Brian I. Rini; Michael D. Staehler; Alain Ravaud; Wei Lin; Bridget O'Keeffe; Wang; Shan Lu; Jill M. Spoerke; Huw; Michelle Byrtek; Rui Zhu; Joseph A. Ware; Robert J. Motzer
View on Scopus
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
The Lancet, ISSN: 1474547X 01406736
Jonathan E. Rosenberg; Jean Hoffman-Censits; Thomas Powles; Michiel S Van Der Heijden; Arjun V. Balar; Andrea Necchi; Nancy Dawson; Peter H O'Donnell; Ani Balmanoukian; Yohann Loriot; Sandy Srinivas; Margitta M. Retz; Petros Grivas; Richard W. Joseph; Matthew D. Galsky; Mark T. Fleming; Petrylak; Jose Luis Perez-Gracia; Howard A. Burris; Daniel Castellano; Christina Canil; Joaquim Bellmunt; Dean Bajorin; Dorothee Nickles; Richard Bourgon; Garrett M Frampton; Na Cui; Sanjeev Mariathasan; Oyewale Abidoye; Gregg D. Fine; Robert Dreicer
View on Scopus
The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation
Nature Communications, ISSN: 20411723
Nadia Martinez-Martin; Sree R. Ramani; Jason A. Hackney; Irene Tom; Bernd Wranik; Michelle Chan; Johnny Wu; Maciej Paluch; Kentaro Takeda; Hass; Hilary F. Clark; Lino C. Gonzalez Jr.
View on Scopus
© 2024 Genentech, Inc. All rights reserved. This site is intended for US residents only.