Scientists / Publications

Publications

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DISPLAYING 5051 - 5100 OF 15477 RESULTS

Mechanism-Based Competitive Binding Model to Investigate the Effect of Neonatal Fc Receptor Binding Affinity on the Pharmacokinetic of Humanized Anti-VEGF Monoclonal IgG1 Antibody in Cynomolgus Monkey
AAPS Journal, ISSN: 15507416
Chee Ng; Fielder; Jin Y. Jin; Rong Deng
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A role for FOXO1 in BCR-ABL1-independent tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Leukemia, ISSN: 14765551 08876924
Marie-Claire Wagle; Eiring; Matthew Wongchenko; Shan Lu; Yinghui Guan; Wang; Lackner; Lukas Amler; Garret M. Hampton; Deininger; O'Hare; Yibing Yan
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Implementation of mechanism of action biology-driven early drug development for children with cancer
European Journal of Cancer, ISSN: 18790852 09598049
Andy Pearson; Ralf Herold; Raphaël F. Rousseau; Chris Copland; Brigid Bradley-Garelik; Debbie Binner; Renaud Capdeville; Hubert Caron; Jacqueline Carleer; Louis Chesler; Birgit Geoerger; Pamela Kearns; Lynley V. Marshall; Stefan M. Pfister; Gudrun Schleiermacher; Jeffrey Skolnik; Cesare Spadoni; Jaroslav Sterba; Hendrick Van Den Berg; Martina Uttenreuther-Fischer; Olaf Witt; Koen Norga; Gilles Vassal; Georger; Iannone; Jakacki; Russo
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The Impact of Systemic Factors on Clinical Response to Ranibizumab for Diabetic Macular Edema Presented in part at: 38th Macula Society Annual Meeting, February 2015, Scottsdale, Arizona.
Ophthalmology, ISSN: 15494713 01616420
Rishi Singh; Karishma Habbu; Justis P. Ehlers; M. Cecilia Lansang; Lauren Hill; Ivaylo Stoilov
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Native MS and ECD Characterization of a Fab–Antigen Complex May Facilitate Crystallization for X-ray Diffraction
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Ying Zhang; Weidong Cui; Aaron T. Wecksler; Hao Zhang; Patricia Molina; Galahad Deperalta; Michael L. Gross
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Evaluation of Heavy-Chain C-Terminal Deletion on Product Quality and Pharmacokinetics of Monoclonal Antibodies
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Guoying Jiang; X. Christopher Yu; Daniela Bumbaca; Zhilan Hu; Annamarie Amurao; Duenas; Marc Wong; Iverson; Kai Zheng; Lam; Jia Chen; Roxanne Vega; Sheila Ulufatu; Cecilia Leddy; Helen Davis; Amy Shen; Wong; Reed J. Harris; Y. John Wang; Dongwei Li
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Engineering highly potent and selective microproteins against Nav1.7 sodium channel for treatment of pain
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Anatoly Shcherbatko; Andrea Rossi; Davide Foletti; Guoyun Zhu; Oren Bogin; Meritxell Galindo Casas; Mathias Rickert; Adela Hasa-Moreno; Victor Bartsevich; Andreas Crameri; Alexander R. Steiner; Robert A. Henningsen; Avinash Gill; Jaume Pons; David L. Shelton; Arvind Rajpal; Pavel Strop
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Uncovering a dual regulatory role for caspases during endoplasmic reticulum stress-induced cell death
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Veronica G. Anania; Kebing Yu; Florian Gnad; Rebecca R. Pferdehirt; Han Li; Taylur P. Ma; Diana Jeon; Nikolaus Fortelny; William F. Forrest; Avi Ashkenazi; Christopher Overall; Jennie R. Lill
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Quantitative comparison of DNA methylation assays for biomarker development and clinical applications
Nature Biotechnology, ISSN: 15461696 10870156
Christoph Bock; Florian Halbritter; Francisco J. Carmona; Sascha Tierling; Paul Datlinger; Yassen Assenov; María Berdasco; Anke K. Bergmann; Keith Booher; Florence Busato; Mihaela Campan; Christina Dahl; Christina M. Dahmcke; Dinh Diep; Agustín F. Fernández; Clarissa Gerhauser; Andrea Haake; Katharina Heilmann; Thomas Holcomb; Dianna Hussmann; Mitsuteru Ito; Ruth Kläver; Martin Kreutz; Marta Kulis; Virginia Lopez; Shalima S. Nair; Dirk S. Paul; Nongluk Plongthongkum; Wenjia Qu; Ana C. Queirós; Frank Reinicke; Guido Sauter; Thorsten Schlomm; Aaron Statham; Clare Stirzaker; Ruslan Strogantsev; Rocío G. Urdinguio; Kimberly Walter; Dieter Weichenhan; Daniel J. Weisenberger; Beck; Susan J. Clark; Manel Esteller; Anne C. Ferguson-Smith; Mario F. Fraga; Per Guldberg; Lise Lotte Hansen; Peter W. Laird; José I. Martín-Subero; Anders O. H. Nygren; Ralf Peist; Christoph Plass; David S. Shames; Reiner Siebert; Xueguang Sun; Jörg Tost; Jörn Walter; Kun Zhang
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Simulations to Predict Clinical Trial Outcome of Bevacizumab Plus Chemotherapy vs. Chemotherapy Alone in Patients With First-Line Gastric Cancer and Elevated Plasma VEGF-A
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Kelong Han; Laurent Claret; Piao; Priti Hegde; Amita Joshi; Powell; Jin Y. Jin; Rene Bruno
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Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network
Proteomics, ISSN: 16159861 16159853
Florian Gnad; Jeffery J. Wallin; Kyle A. Edgar; Sophia Doll; David Arnott; Liliane Robillard; Donald S. Kirkpatrick; Matthew P. Stokes; Ulka Vijapurkar; Georgia Hatzivassiliou; Lori S. Friedman; Marcia Belvin
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Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms
Proteomics, ISSN: 16159861 16159853
Florian Gnad; Sophia Doll; Kyung Song; Matthew P. Stokes; John Moffat; Bonnie Liu; David Arnott; Jeffery J. Wallin; Lori S. Friedman; Georgia Hatzivassiliou; Marcia Belvin
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Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling
PLoS Computational Biology, ISSN: 15537358 1553734X
Javier Estrada; Natalie Andrew; Daniel Gibson; Frederick Chang; Florian Gnad; Jeremy Gunawardena
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Reply
Gastroenterology, ISSN: 15280012 00165085
Mary E. Keir; Tew; Jason A. Hackney
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Preclinical safety profile of a depleting antibody against CRTh2 for asthma: Well tolerated despite unexpected CRTh2 expression on vascular pericytes in the central nervous system and gastric mucosa
Toxicological Sciences, ISSN: 10960929 10966080
Kathila S. Rajapaksa; Tao Huang; Neeraj Sharma; Shannon Liu; Margaret Solon; Arthur Reyes; Sarah Paul; Angie Yee; Janet Tao; Sreedevi Chalasani; Nga Bien-Ly; Kai H. Barck; Richard A. D. Carano; Jianyong Wang; Linda Rangell; Meire C. Bremer; Dimitry Danilenko; Paula Katavolos; Isidro Hötzel; Karin Reif; Cary D. Austin
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A spectral method for color quantitation of a protein drug solution
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Trevor E. Swartz; Jian Yin; Thomas W. Patapoff; Travis A. Horst; Susan M. Skieresz; Gordon Leggett; Charles Morgan; Kimia Rahimi; Joseph C. Marhoul; Bruce Kabakoff
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Hydrolysis of polysorbate 20 and 80 by a range of carboxylester hydrolases
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Andrew C. McShan; Pervina Kei; Junyan A. Ji; Daniel C. Kim; Y. John Wang
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Validation of a spectral method for quantitative measurement of color in protein drug solutions
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Jian Yin; Trevor E. Swartz; Jian Zhang; Thomas W. Patapoff; Bartolo Chen; Joseph C. Marhoul; Norman Shih; Bruce Kabakoff; Kimia Rahimi
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Protective and detrimental effects of neuroectodermal cell–derived tissue factor in mouse models of stroke
JCI insight, ISSN: 23793708
Shaobin Wang; Brandi Reeves; Erica Sparkenbaugh; Janice Russell; Zbigniew Soltys; Hua Zhang; James E. Faber; Nigel S. Key; Daniel Kirchhofer; D. Neil Granger; Nigel Mackman; Rafal Pawlinski
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Protective and detrimental effects of neuroectodermal cell–derived tissue factor in mouse models of stroke
JCI insight,
Shaobin Wang; Brandi Reeves; Erica Sparkenbaugh; Janice Russell; Zbigniew Soltys; Hua Zhang; James E. Faber; Nigel S. Key; Daniel Kirchhofer; D. Neil Granger; Nigel Mackman; Rafal Pawlinski
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Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial
The Lancet, ISSN: 1474547X 01406736
Dinesh Khanna; Christopher P. Denton; Angelika Jahreis; Jacob M. Van Laar; Tracy M. Frech; Marina E. Anderson; Murray Baron; Lorinda Chung; Gerhard Fierlbeck; Santhanam Lakshminarayanan; Yannick Allanore; Janet E. Pope; Gabriela Riemekasten; Virginia D. Steen; Ulf Müller-Ladner; Robert Lafyatis; Giuseppina Stifano; Helen Spotswood; Haiyin Chen-Harris; Sebastian Dziadek; Alyssa M. Morimoto; Thierry Sornasse; Jeffrey N. Siegel; Daniel E. Furst
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Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
James F. Blake; Michael Burkard; Jocelyn Chan; Huifen Chen; Kang-Jye Chou; Dolores Diaz; Danette Dudley; John J. Gaudino; Stephen Gould; Jonas Grina; Thomas Hunsaker; Lichuan Liu; Matthew Martinson; David Moreno; Lars Mueller; Christine Orr; Patricia Pacheco; Ann R. Qin; Kevin Rasor; Li Ren; Kirk D. Robarge; Sheerin Shahidi-Latham; Jeffrey Stults; Francis Sullivan; Weiru Wang; Jianping Yin; Aihe Zhou; Marcia Belvin; Mark Merchant; John Moffat; Jacob B. Schwarz
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Using Mass Spectrometry to Quantify Rituximab and Perform Individualized Immunoglobulin Phenotyping in ANCA-Associated Vasculitis
Analytical Chemistry, ISSN: 15206882 00032700
John R. Mills; Divi Cornec; Surendra Dasari; Paula M. Ladwig; Amber M. Hummel; Melissa Cheu; David L. Murray; Maria A. Willrich; Melissa R. Snyder; Hoffman; Cees Kallenberg; Langford; Peter A. Merkel; Paul A. Monach; Seo; Spiera; E. William St. Clair; John H. Stone; Specks; David R. Barnidge
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Expression profiling of constitutive mast cells reveals a unique identity within the immune system
Nature Immunology, ISSN: 15292916 15292908
Daniel F. Dwyer; Nora A. Barrett; K Frank Austen; Edy Y. Kim; Michael B. Brenner; Laura Shaw; Bingfei Yu; Ananda Goldrath; Sara Mostafavi; Aviv Regev; Andrew Rhoades; Devapregasan Moodley; Hideyuki Yoshida; Mathis; Christophe Benoist; Tsukasa Nabekura; Viola Lam; Lewis L. Lanier; Brian Brown; Miriam Merad; Viviana Cremasco; Shannon J. Turley; Monach; Michael L. Dustin; Yuesheng Li; Susan A. Shinton; Richard R. Hardy; Tal Shay; Yilin Qi; Katelyn Sylvia; Joonsoo Kang; Keke Fairfax; Gwendalyn J. Randolph; Michelle L. Robinette; Anja Fuchs; Marco Colonna
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Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Howard L. Kaufman; Lisa H. Butterfield; Pierre G. Coulie; Sandra Demaria; Robert L. Ferris; Jérôme Galon; Samir N. Khleif; Ira Mellman; Pamela S. Ohashi; Willem W. Overwijk; Suzanne L. Topalian; Francesco M. Marincola
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Regulatory T cell modulation by CBP/EP300 bromodomain inhibition
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Srimoyee Ghosh; Alexander M. Taylor; Melissa Chin; Hon-Ren Huang; Andrew R. Conery; Jennifer A. Mertz; Andres Salmeron; Pranal J. Dakle; Deanna Mele; Alexandre Côté; Hariharan Jayaram; Jeremy Setser; Florence Poy; Georgia Hatzivassiliou; Denise DeAlmeida-Nagata; Peter Sandy; Charlie Hatton; F. Anthony Romero; Eugene Y. Chiang; Thornik Reimer; Terry Crawford; Eneida Pardo; Venita G. Watson; Vickie Tsui; Andrea G Cochran; Laura E. Zawadzke; Jean-Christophe Harmange; James E. Audia; Barbara M. Bryant; Richard T Cummings; Steven Magnuson; Jane L. Grogan; Steve Bellon; Brian K Albrecht; Robert J. Sims; Jose M. Lora
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Phase I study of apitolisib (GDC-0980), dual phosphatidylinositol-3-kinase and mammalian target of rapamycin kinase inhibitor, in patients with advanced solid tumors
Clinical Cancer Research, ISSN: 15573265 10780432
Saoirse O. Dolly; Andrew Wagner; Bendell; Hedy L. Kindler; Lee M. Krug; Tanguy Y. Seiwert; Marjorie G. Zauderer; Martijn P. Lolkema; Doris Apt; Ru-Fang Yeh; Jill Fredrickson; Jill M. Spoerke; Koeppen; Joseph A. Ware; Jennifer O. Lauchle; Howard A. Burris; De Bono
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Outsourcing the immune response to cancer
Science, ISSN: 10959203 00368075
Mahesh Yadav; Lélia Delamarre
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Phase II randomized preoperative window-of-opportunity study of the PI3K inhibitor pictilisib plus anastrozole compared with anastrozole alone in patients with estrogen receptor-positive breast cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Schmid; Sarah Pinder; Duncan Wheatley; Jane Macaskill; Charles Zammit; Jennifer Hu; Robert Price; Nigel Bundred; Sirwan Hadad; Alice Shia; Shah-Jalal Sarker; Louise Lim; Patrycja Gazinska; Natalie Woodman; Darren Korbie; Matt Trau; Paul Mainwaring; Steven Gendreau; Lackner; Mika K. Derynck; Wilson; Hannah Butler; Gemma Earl; Parker; Arnie Purushotham; Alastair Thompson
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Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8
ACS Medicinal Chemistry Letters, ISSN: 19485875
Philippe Bergeron; Michael F. T. Koehler; Elizabeth M. Blackwood; Krista K. Bowman; Clark; Ron Firestein; James R. Kiefer; Klaus Maskos; Mark L. McCleland; Linda O. Elliott; Sreemathy Ramaswamy; Laurent Salphati; Stephen Schmidt; Elisabeth V. Schneider; Jiansheng Wu; Beresini
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Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Terry Crawford; Vickie Tsui; E. Megan Flynn; Shumei Wang; Alexander M. Taylor; Alexandre Côté; James E. Audia; Beresini; Burdick; Richard T Cummings; Leslie A. Dakin; Martin Duplessis; Andrew C. Good; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; James R. Kiefer; Ying Jiang; Jeremy Murray; Christopher G. Nasveschuk; Eneida Pardo; Florence Poy; F. Anthony Romero; Yong Tang; Jian Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoyu Zhu; Brian K Albrecht; Steven Magnuson; Steve Bellon; Andrea G Cochran
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Chemically Diverse Group i p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Joachim Rudolph; Lesley J. Murray; Chudi O. Ndubaku; Thomas O'Brien; Elizabeth M. Blackwood; Weiru Wang; Ignacio Aliagas; Lewis Gazzard; James J. Crawford; Joy Drobnick; Wendy Lee; Xianrui Zhao; Klaus P. Hoeflich; David A. Favor; Ping Dong; Haiming Zhang; Christopher E. Heise; Angela Oh; Christy C. Ong; Hank La; Paroma Chakravarty; Connie Chan; Diana Jakubiak; Jennifer A. Epler; Sreemathy Ramaswamy; Roxanne Vega; Cain; Dolores Diaz; Yu Zhong
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The Structural Basis for Class II Cytokine Receptor Recognition by JAK1
Structure, ISSN: 18784186 09692126
Ryan Ferrao; Heidi J. A. Wallweber; Hoangdung Ho; Christine Tam; Yvonne Franke; John Quinn; Patrick J. Lupardus
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Isolation and Characterization of Monoclonal Antibody Charge Variants by Free Flow Isoelectric Focusing
Analytical Chemistry, ISSN: 15206882 00032700
Brian Hosken; Charlene Li; Berny Mullappally; Carl Co; Boyan Zhang
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Post-use assay of vaginal rings (VRs) as a potential measure of clinical trial adherence
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Patrick Spence; Annalene Nel; Neliëtte van Niekerk; Tiffany Derrick; Susan Wilder; Bríd Devlin
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On the accuracy of calculation of the mean residence time of drug in the body and its volumes of distribution based on the assumption of central elimination
Xenobiotica, ISSN: 13665928 00498254
Leonid M. Berezhkovskiy
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Does caspase-12 suppress inflammasome activation?
Nature, ISSN: 14764687 00280836
Vande Walle; Daniel Jiménez Fernández; Dieter Demon; Naomi Van Laethem; Filip Van Hauwermeiren; Hanne Van Gorp; Nina Van Opdenbosch; Nobuhiko Kayagaki; Lamkanfi
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Necroptosis and Inflammation
Annual Review of Biochemistry, ISSN: 15454509 00664154
Kim Newton; Gerard Manning
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Serum periostin is associated with type 2 immunity in severe asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Mats W. Johansson; Michael D. Evans; Gina M. Crisafi; Cécile T.J. Holweg; Matthews; Jarjour
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Molecular simulations of micellar aggregation of polysorbate 20 ester fractions and their interaction with N-phenyl-1-naphthylamine dye
Biophysical Chemistry, ISSN: 18734200 03014622
Mauro Lapelosa; Thomas W. Patapoff; Isidro E. Zarraga
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Prediction of drug-drug interactions arising from CYP3A induction using a physiologically based dynamic models
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Lisa M. Almond; Sophie Mukadam; Iain Gardner; Krystle Okialda; Susan C. Wong; Oliver Hatley; Suzanne Tay; Karen Rowland-Yeo; Masoud Jamei; Amin Rostami-Hodjegan; Jane R. Kenny
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Investigation of Dose-Dependent Factors Limiting Oral Bioavailability: Case Study with the PI3K-δ Inhibitor
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Daniel P. Sutherlin; Jodie Pang; Laurent Salphati
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Examining Manufacturing Readiness for Breakthrough Drug Development
AAPS PharmSciTech, ISSN: 15309932
Earl S. Dye; Annie Sturgess; Gargi Maheshwari; Kimberly May; Colleen Ruegger; Usha Ramesh; Heow Tan; Keith Cockerill; John Groskoph; Emanuela Lacana; Sau L. Lee; Sarah Pope Miksinski
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Relationship between Baseline and Early Changes in C-Reactive Protein and Interleukin-6 Levels and Clinical Response to Tocilizumab in Rheumatoid Arthritis
Arthritis Care and Research, ISSN: 21514658 2151464X
Jianmei Wang; Jenny Devenport; Jason M. Low; Dale Yu; Hitraya
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Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice
Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X
Dong U. Lee; Paula Katavolos; Gopinath S. Palanisamy; Arna Katewa; Charly Sioson; Janice Corpuz; Jodie Pang; Kevin Dement; Edna F. Choo; Nico Ghilardi; Dolores Diaz; Dimitry Danilenko
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Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug–Drug Interaction Prediction
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Yuan Chen; Fang Ma; Tong Lu; Nageshwar Budha; Jin Y. Jin; Jane R. Kenny; Harvey Wong; Cornelis E. Hop; Jialin Mao
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An Overview of the Pathogenesis of Immune-mediated Skin Injury
Toxicologic Pathology, ISSN: 15331601 01926233
Dimitry Danilenko
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Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial
The Lancet Oncology, ISSN: 14745488 14702045
Ian E. Krop; Ingrid A. Mayer; Vinod Ganju; Maura N. Dickler; Stephen Johnston; Serafin Morales; Denise A. Yardley; Melichar; Andres Forero; Soo Chin Lee; Richard de Boer; Katarina Petrakova; Susanne Vallentin; Edith A. Perez; Martine Piccart; Matthew Ellis; Eric P. Winer; Steven Gendreau; Mika K. Derynck; Lackner; Gallia Levy; Jiaheng Qiu; Jing He; Schmid
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Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: A randomised, double-blind, placebo-controlled, phase 2 trial
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Jürgen Behr; Elisabeth Bendstrup; Bruno Crestani; Andreas Günther; Horst Olschewski; C Magnus Sköld; Athol Wells; Wim Wuyts; Dirk Koschel; Michael Kreuter; Benoît Wallaert; Chin-Yu Lin; Jürgen Beck; Carlo Albera
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Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: Prospective placebo-controlled clinical studies
EMBO Molecular Medicine, ISSN: 17574684 17574676
Jérémie Decalf; Kristin V. Tarbell; Armanda Casrouge; Jeffrey D. Price; Grace Linder; Estelle Mottez; Philippe Sultanik; Vincent Mallet; Stanislas Pol; Darragh Duffy; Matthew L. Albert
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