Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5101 - 5150 OF 15477 RESULTS

In Vitro Skin Models and Their PredictabilProliferative Lesions in Thyroid Follicular Cells of Dwarfs Derived from Wistar Hannover GALAS Rats Lesions in Thyroid Follicular Cells of Dwarfs Derived from Wistar Hannover GALAS Ratsng Normal and Disease Biology, Pharmacology, and Toxicity
Toxicologic Pathology, ISSN: 15331601 01926233
Dimitry Danilenko; Gail L. Phillips; Dolores Diaz
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A new triglycyl peptide linker for antibody-drug conjugates (ADCs) with improved targeted killing of cancer cells
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Rajeeva Singh; Yulius Y. Setiady; Jose Ponte; Yelena Kovtun; Katharine C. Lai; E. Erica Hong; Nathan Fishkin; Ling Dong; Gregory Jones; Jennifer A. Coccia; Leanne Lanieri; Karen Veale; Juliet A. Costoplus; Anna Skaletskaya; Rabih Gabriel; Paulin Salomon; Rui Wu; Qifeng Qiu; Hans Erickson; John M. Lambert; Ravi Chari; Wayne C. Widdison
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Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras
Leukemia, ISSN: 14765551 08876924
Jon Akutagawa; Huang; Epstein; Tiffany Chang; Quirindongo-Crespo; Cottonham; Monique Dail; Slusher; Lori S. Friedman; Deepak Sampath; Benjamin S. Braun
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Rituximab extended schedule or retreatment trial for low tumour burden non-follicular indolent B-cell non-Hodgkin lymphomas: Eastern Cooperative Oncology Group Protocol E4402
British Journal of Haematology, ISSN: 13652141 00071048
Marna Williams; Fangxin Hong; Randy D. Gascoyne; Lynne I. Wagner; John C. Krauss; Thomas M. Habermann; Lode J. Swinnen; Stephen J. Schuster; Christopher G. Peterson; Mark D. Sborov; S. Eric Martin; Matthias Weiss; W. Christopher Ehmann; Sandra J. Horning; Brad Kahl
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Plasma metabolomic changes following PI3K inhibition as pharmacodynamic biomarkers: Preclinical discovery to phase I trial evaluation
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Joo Ern Ang; Rupinder Pandher; Joo Chew Ang; Yasmin J. Asad; Alan T. Henley; Melanie Valenti; Gary Box; Alexis Haven De Brandon; Richard Baird; Lori S. Friedman; Mika K. Derynck; Bart Vanhaesebroeck; Suzanne A. Eccles; Stanley B. Kaye; Paul Workman; De Bono; Florence I. Raynaud
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Ten years of anti-vascular endothelial growth factor therapy
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Napoleone Ferrara; Anthony P. Adamis
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Rate-Determining and rate-limiting steps in the clearance and excretion of a potent and selective p21-activated kinase inhibitor: A case study of rapid hepatic uptake and slow elimination in rat
Drug Metabolism Letters, ISSN: 18723128
Peter W. Fan; Jacob Z. Chen; Allan Jaochico; Hank La; Ning Liu; Teresa Mulder; Robert T. Cass; Matthew Durk; Kirsten Messick; Nicole R. Valle; Shannon Liu; Wendy Lee; James J. Crawford; Joachim Rudolph; Lesley J. Murray; S. Cyrus Khojasteh; Matthew Wright
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Elucidating the mechanism of tofacitinib oxidative decyanation
Drug Metabolism Letters, ISSN: 18723128
Hoa Le; Peter W. Fan; Susan C. Wong; Shuguang Ma; James Driscoll; Cornelis E. Hop; S. Cyrus Khojasteh
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Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody
PLoS Pathogens, ISSN: 15537374 15537366
Ning Chai; Lee R. Swem; Mike Reichelt; Haiyin Chen-Harris; Luis; Summer Park; Ashley Fouts; Patrick J. Lupardus; Thomas D Wu; Olga Li; Jacqueline McBride; Michael Lawrence; Min Xu; Man-Wah Tan
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Therapeutic antibody-induced vascular toxicity due to off-target activation of nitric oxide in cynomolgus monkeys
Toxicological Sciences, ISSN: 10960929 10966080
Rama Pai; Ning Ma; Anu V. Connor; Dimitry Danilenko; Jacqueline M. Tarrant; Dany Salvail; Lisa Wong; Dylan P. Hartley; Misner; Stefanich; Yan Wu; Yongmei Chen; Hong Wang; Donna M. Dambach
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Bridging polymer science and biotechnology applications with single-use technologies
BioProcess International, ISSN: 15426319
Ekta Mahajan; Gary Lye
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Rituximab extended schedule or retreatment trial for low tumour burden non-follicular indolent B-cell non-Hodgkin lymphomas: Eastern Cooperative Oncology Group Protocol E4402
British Journal of Haematology, ISSN: 13652141 00071048
Marna Williams; Fangxin Hong; Randy D. Gascoyne; Lynne I. Wagner; John C. Krauss; Thomas M. Habermann; Lode J. Swinnen; Stephen J. Schuster; Christopher G. Peterson; Mark D. Sborov; S. Eric Martin; Matthias Weiss; W. Christopher Ehmann; Sandra J. Horning; Wojciech Jurczak
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Dosing of Intravenous Tocilizumab in a Real-World Setting of Rheumatoid Arthritis: Analyses from the Corrona Registry
Rheumatology and Therapy, ISSN: 21986584 21986576
Dimitrios A. Pappas; Ani John; Jeffrey R. Curtis; Reed; Chitra Karki; Robert Magner; Joel M. Kremer; Ashwini Shewade; Jeffrey D. Greenberg
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Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Alexander Amberg; Lisa Beilke; Joel P. Bercu; Dave Bower; Alessandro Brigo; Kevin P. Cross; Laura Custer; Krista Dobo; Eric Dowdy; Kevin A. Ford; Susanne Glowienke; Jacky Van Gompel; James Harvey; Catrin Hasselgren; Masamitsu Honma; Robert A. Jolly; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Penny Leavitt; Scott Miller; Wolfgang Muster; John Nicolette; Andreja Plaper; Mark Powley; Donald P. Quigley; M. Vijayaraj Reddy; Hans-Peter Spirkl; Lidiya Stavitskaya; Andrew Teasdale; Sandy Weiner; Dennie S. Welch; Angela White; Joerg Wichard; Glenn J. Myatt
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Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Ernst Ahlberg; Alexander Amberg; Lisa Beilke; Dave Bower; Kevin P. Cross; Laura Custer; Kevin A. Ford; Jacky Van Gompel; James Harvey; Masamitsu Honma; Robert A. Jolly; Elisabeth Joossens; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Lara Kuhnke; Penny Leavitt; Russell Naven; Claire Neilan; Donald P. Quigley; Dana Shuey; Hans-Peter Spirkl; Lidiya Stavitskaya; Andrew Teasdale; Angela White; Joerg Wichard; Craig Zwickl; Glenn J. Myatt
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Cycling in the nucleus: Regulation of RNA 3' processing and nuclear organization of replication-dependent histone genes
Current Opinion in Cell Biology, ISSN: 18790410 09550674
Valentina Romeo; Daniel Schümperli
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Cost-Effectiveness Model for Chemoimmunotherapy Options in Patients with Previously Untreated Chronic Lymphocytic Leukemia Unsuitable for Full-Dose Fludarabine-Based Therapy
Value in Health, ISSN: 15244733 10983015
Ursula Becker; Andrew Briggs; Santiago G. Moreno; Joshua A. Ray; Phuong Ngo; Kunal Samanta
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Assessment of disease-related therapeutic protein drug-drug interaction for etrolizumab in patients with moderately to severely active ulcerative colitis
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Xiaohui Wei; Jane R. Kenny; Leslie Dickmann; Romeo MacIuca; Looney; Meina Tao Tang
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Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Sebastian Unizony; Villarreal; Miloslavsky; Na Lu; Merkel; Spiera; Seo; Langford; Hoffman; Kallenberg; E. William St. Clair; Iklé; Tchao; Linna Ding; Paul Brunetta; Hyon Choi; Paul A. Monach; Fervenza; John H. Stone; Specks
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Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Gerd R. Burmester; William F. Rigby; Ronald Van Vollenhoven; Jonathan Kay; Rubbert-Roth; Ariella Kelman; Sophie Dimonaco; Nina Mitchell
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Visual and Anatomic Outcomes in Patients with Diabetic Macular Edema with Limited Initial Anatomic Response to Ranibizumab in RIDE and RISE Presented in part at: American Academy of Ophthalmology Annual Meeting, October 2014, Chicago, Illinois; And 38th Macula Society Annual Meeting, February 2015, Scottsdale, Arizona.
Ophthalmology, ISSN: 15494713 01616420
Dante Joseph Pieramici; Pin-Wen Wang; Beiying Ding; Shamika Gune
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Visual phenomena perceived during pars plana vitrectomy under peribulbar block and monitored anaesthesia care
British Journal of Ophthalmology, ISSN: 14682079 00071161
Hema L. Ramkumar; Azadeh Khatibi; William R. Freeman; Giulio Barteselli; Isaac C. Ezon; Payam Amini; Lucie Sharpsten; Cheryl A. Arcinue; Joseph T. Nezgoda; Henry A. Ferreyra; Michael H. Goldbaum
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Age-related macular degeneration: Complement in action
Immunobiology, ISSN: 18783279 01712985
Menno Van Lookeren Campagne; Erich C. Strauss; Brian L. Yaspan
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NLRP3 recruitment by NLRC4 during Salmonella infection
Journal of Experimental Medicine, ISSN: 15409538 00221007
Yan Qu; Shahram Misaghi; Kim Newton; Maltzman; Anita Izrael-Tomasevic; David Arnott; Vishva M. Dixit
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Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight,
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
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Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight, ISSN: 23793708
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
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Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight, ISSN: 23793708
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
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Reproducible pharmacogenomic profiling of cancer cell line panels
Nature, ISSN: 14764687 00280836
Matthias Peter; Eva Lin; Jenille Tan; Yihong Yu; Billy Lam; Steve Lianoglou; Richard M. Neve; Scott E. Martin; Jeffrey Settleman; Robert Yauch; Richard Bourgon
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An enzymatic deconjugation method for the analysis of small molecule active drugs on antibody-drug conjugates
mAbs, ISSN: 19420870 19420862
Yi Li; Christine Gu; Jason Gruenhagen; Peter M. Yehl; Nik P. Chetwyn; Colin D. Medley
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Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Alexander Heifetz; Giancarlo Trani; Matteo Aldeghi; Colin H. Mackinnon; Paul A. McEwan; Frederick A. Brookfield; Ewa I. Chudyk; Mike Bodkin; Zhonghua Pei; Jason D. Burch; Daniel F. Ortwine
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Mechanistic Insights into Radical-Mediated Oxidation of Tryptophan from ab Initio Quantum Chemistry Calculations and QM/MM Molecular Dynamics Simulations
Journal of Physical Chemistry A, ISSN: 15205215 10895639
Geoffrey P. F. Wood; Alavattam Sreedhara; Jamie M. R. Moore; John Wang; Bernhardt L. Trout
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Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)
ACS Medicinal Chemistry Letters, ISSN: 19485875
Alexander M. Taylor; Alexandre Côté; Michael C. Hewitt; Richard Pastor; Yves Leblanc; Christopher G. Nasveschuk; F. Anthony Romero; Terry Crawford; Nico Cantone; Hariharan Jayaram; Jeremy Setser; Jeremy Murray; Beresini; Gladys De Leon Boenig; Zhongguo Chen; Andrew R. Conery; Richard T Cummings; Leslie A. Dakin; E. Megan Flynn; Oscar W Huang; Susan Kaufman; Patricia J. Keller; James R. Kiefer; Tommy Lai; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Henry Lu; Eneida Pardo; Vickie Tsui; Jian Wang; Yongyun Wang; Zhaowu Xu; Fen Yan; Dong Yu; Laura E. Zawadzke; Xiaoqin Zhu; Xiaoyu Zhu; Robert J. Sims; Andrea G Cochran; Steve Bellon; James E. Audia; Steven Magnuson; Brian K Albrecht
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Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms
Cell Reports, ISSN: 22111247
Karen Yap; Yixin Xiao; Brad A. Friedman; H. Shawn Je; Eugene V. Makeyev
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Randomized open-label phase II trial of apitolisib (GDC-0980), a novel inhibitor of the PI3K/mammalian target of rapamycin pathway, versus everolimus in patients with metastatic renal cell carcinoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Thomas Powles; Lackner; Stephane Oudard; Bernard Escudier; Christy Ralph; Janet E. Brown; Robert E. Hawkins; Daniel Castellano; Brian I. Rini; Michael D. Staehler; Alain Ravaud; Wei Lin; Bridget O'Keeffe; Wang; Shan Lu; Jill M. Spoerke; Huw; Michelle Byrtek; Rui Zhu; Joseph A. Ware; Robert J. Motzer
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Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
The Lancet, ISSN: 1474547X 01406736
Jonathan E. Rosenberg; Jean Hoffman-Censits; Thomas Powles; Michiel S Van Der Heijden; Arjun V. Balar; Andrea Necchi; Nancy Dawson; Peter H O'Donnell; Ani Balmanoukian; Yohann Loriot; Sandy Srinivas; Margitta M. Retz; Petros Grivas; Richard W. Joseph; Matthew D. Galsky; Mark T. Fleming; Petrylak; Jose Luis Perez-Gracia; Howard A. Burris; Daniel Castellano; Christina Canil; Joaquim Bellmunt; Dean Bajorin; Dorothee Nickles; Richard Bourgon; Garrett M Frampton; Na Cui; Sanjeev Mariathasan; Oyewale Abidoye; Gregg D. Fine; Robert Dreicer
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The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation
Nature Communications, ISSN: 20411723
Nadia Martinez-Martin; Sree R. Ramani; Jason A. Hackney; Irene Tom; Bernd Wranik; Michelle Chan; Johnny Wu; Maciej Paluch; Kentaro Takeda; Hass; Hilary F. Clark; Lino C. Gonzalez Jr.
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EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells
Nature, ISSN: 14764687 00280836
Jianhua Li; Erick Lu; Tangsheng Yi; Jason G. Cyster
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Mismatch repair deficiency testing in clinical practice
Expert Review of Molecular Diagnostics, ISSN: 17448352 14737159
Natalia Buza; James Ziai; Pei Hui
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The impact of persistence with therapy on inpatient admissions and emergency room visits in the US among patients with multiple sclerosis
Journal of Medical Economics, ISSN: 1941837X 13696998
Nina Parikh Thomas; Suellen Curkendall; Amanda M. Farr; Elaine B. Yu; Hurley
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NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
Journal of Clinical Investigation, ISSN: 15588238 00219738
Marianne R. Spalinger; Stephanie Kasper; Claudia Gottier; Silvia Lang; Kirstin Atrott; Stephan R. Vavricka; Sylvie Scharl; Petrus M. Gutte; Markus G. Grütter; Hans-Dietmar Beer; Emmanuel Contassot; Andrew A. Chan; Xuezhi Dai; David J. Rawlings; Florian Mair; Burkhard Becher; Werner Falk; Fried; Gerhard Rogler; Michael Scharl
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Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Xiaorong Liang; Michael Van Parys; Xiao Ding; Ning Zeng; Luke Bi; Drew Dorshort; McKnight; Dennis Milanowski; Jialin Mao; Yuan Chen; Joseph A. Ware; Brian J. Dean; Cornelis E. Hop; Yuzhong Deng
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Fc-galactosylation modulates antibody-dependent cellular cytotoxicity of therapeutic antibodies
Molecular Immunology, ISSN: 18729142 01615890
Marco Thomann; Katharina Reckermann; Dietmar Reusch; Jessica Prasser; Max L. Tejada
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Current approaches for absorption, distribution, metabolism, and excretion characterization of antibody-drug conjugates: An industry white paper
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Eugenia Kraynov; Amrita Kamath; Markus Walles; Edit Tarcsa; Antoine Deslandes; Ramaswamy A. Iyer; Amita Datta-Mannan; Priya Sriraman; Michaela Bairlein; Johnny J. Yang; Matthew Barfield; Guangqing Xiao; Escandon; Weirong Wang; Dan A. Rock; Nagendra V. Chemuturi; David J. Moore
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A biologist's field guide to multiplexed quantitative proteomics
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Corey Bakalarski; Donald S. Kirkpatrick
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ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1
Oncotarget, ISSN: 19492553
Simon P. Williams; Annie Ogasawara; Jeff N. Tinianow; Judith E. Flores; David Kan; Jeffrey Lau; MaryAnn Go; Alexander N. Vanderbilt; Herman S. Gill; Li Miao; Joshua Goldsmith; Bonnee Rubinfeld; Mao; Ron Firestein; Shang-Fan Yu; Jan Marik; Anton G.T. Terwisscha van Scheltinga
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Generation and characterization of a Breast cancer resistance protein humanized mouse model s
Molecular Pharmacology, ISSN: 15210111 0026895X
Shannon Dallas; Laurent Salphati; David Gomez-Zepeda; Thomas Wanek; Liangfu Chen; Xiaoyan Chu; Jeevan Kunta; Mario Mezler; Marie-Claude Menet; Stephanie Chasseigneaux; Xavier Declèves; Oliver Langer; Esaie Pierre; Karen Diloreto; Carolin Hoft; Loic Laplanche; Jodie Pang; Tony Pereira; Clara Andonian; Damir Simic; Anja Rode; Jocelyn Yabut; Xiaolin Zhang; Nico Scheer
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A six-stage workflow for robust application of systems pharmacology
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Kapil Gadkar; Kirouac; Donald E. Mager; Van Der Graaf; Ramanujan
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Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice
Bioanalysis, ISSN: 17576199 17576180
Yanmei Lu; Kwame Hoyte; William H. Montgomery; Wilman Luk; Dongping He; William J. Meilandt; Y. Joy Yu Zuchero; Jasvinder K. Atwal; Kimberly Scearce-Levie; Ryan J. Watts; Laura DeForge
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Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha-Positive, PIK3CA-Mutant Breast Cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Wei Yang; Sarah R. Hosford; Lloye M. Dillon; Kevin Shee; Stephanie C. Liu; Jennifer R. Bean; Laurent Salphati; Jodie Pang; Xiaolin Zhang; Michelle Nannini; Eugene Demidenko; Darcy Bates; Lionel D. Lewis; Jonathan D. Marotti; Alan R. Eastman; Todd W. Miller
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Serum periostin in obstructive airways Disease
European Respiratory Journal, ISSN: 13993003 09031936
James Fingleton; Irene Braithwaite; Justin Travers; Darren Bowles; Rianne Strik; Rob Siebers; Cécile T.J. Holweg; Matthews; Mark Weatherall; Beasley
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