Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5151 - 5200 OF 15390 RESULTS

Enhancement of microbiota in healthy macaques results in beneficial modulation of mucosal and systemic immune function
Journal of Immunology, ISSN: 15506606 00221767
Jennifer A. Manuzak; Tiffany Hensley-McBain; Alexander S. Zevin; Charlene Miller; Rafael Cubas; Brian Agricola; Jill Gile; Laura Richert-Spuhler; Gabriela Patilea; Jacob D. Estes; Stanley Langevin; R. Keith Reeves; Elias K. Haddad; Nichole R. Klatt
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Physiologically based pharmacokinetic models of small molecules and therapeutic antibodies: A mini-review on fundamental concepts and applications
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Gregory Z. Ferl; Frank-Peter Theil; Harvey Wong
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Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: Comparative evaluation of prediction approaches in early drug development
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Jing Wang; Suhasini Iyer; Fielder; John Davis; Rong Deng
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Phase I study of DMOT4039A, an antibody-drug conjugate targeting mesothelin, in patients with unresectable pancreatic or platinum-resistant ovarian cancer
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Colin D. Weekes; Laetitia E. Lamberts; Mitesh J. Borad; Johannes Voortman; Robert R. McWilliams; Jennifer R. Diamond; Elisabeth G. E. De Vries; Henk M. W. Verheul; Christopher H. Lieu; George P. Kim; Wang; Suzie J. Scales; Divya Samineni; Flavia Brunstein; Younjeong Choi; Daniel Maslyar; Gerardo Colon-Otero
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Filling of high-concentration monoclonal antibody formulations: Investigating underlying mechanisms that affect precision of low-volume Fill by peristaltic pump
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Wendy Shieu; Dax Lamar; Oliver B. Stauch; Maa
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Voices of biotech
Nature Biotechnology, ISSN: 15461696
Ido Amit; David Baker; Roger Barker; Bonnie Berger; Carolyn Bertozzi; Sangeeta Bhatia; Alessandra Biffi; Francesca Demichelis; Jennifer A. Doudna; Steven F. Dowdy; Drew Endy; Moritz Helmstaedter; Howard Junca; Carl June; Sasha Kamb; Anastasia Khvorova; Dae-Hyeong Kim; Jin-Soo Kim; Yamuna Krishnan; Melike Lakadamyali; Tuuli Lappalainen; Sharon Lewin; James Liao; Nick Loman; Emma Lundberg; Lee Lynd; Cathie Martin; Ira Mellman; Atsushi Miyawaki; Christine Mummery; Karen Nelson; Jeanne Paz; Pamela Peralta-Yahya; Paola Picotti; Kornelia Polyak; Kristala Prather; Jun Qin; Stephen Quake; Aviv Regev; John A. Rogers; Reshma Shetty; Morten Sommer; Molly Stevens; Gustavo Stolovitzky; Masayo Takahashi; Fuchou Tang; Sarah Teichmann; Maria-Elena Torres-Padilla; Leena Tripathi; Praveen Vemula; Greg Verdine; Frank Vollmer; Jun Wang; Jackie Y. Ying; Feng Zhang; Tian Zhang
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Early panretinal abnormalities on fundus autofluorescence and spectral domain optical coherence tomography after intravitreal ocriplasmin
Acta Ophthalmologica, ISSN: 17553768 1755375X
Giulio Barteselli; Elisa Carini; Alessandro Invernizzi; Roberto Ratiglia; Francesco Viola
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Comparison of antidepressant classes and the risk and time course of suicide attempts in adults: Propensity matched, retrospective cohort study
British Journal of Psychiatry, ISSN: 14721465 00071250
Robert J. Valuck; Anne M. Libby; Heather D. Anderson; Richard R. Allen; Indiana Strombom; Lauren B. Marangell; David Perahia
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Conduct, Oversight, and Ethical Considerations of Clinical Trials in Companion Animals with Cancer: Report of a Workshop on Best Practice Recommendations
Journal of Veterinary Internal Medicine, ISSN: 19391676 08916640
Page; Baneux; Vail; Duda; Olson; Anestidou; Noel Dybdal; Golab; Shelton; Salgaller; Hardy
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Meta-analysis of published efficacy and safety data for docetaxel in second-line treatment of patients with advanced non-small-cell lung cancer
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Mark Stroh; Michelle Green; Edward Cha; Nancy Zhang; Russell D. Wada; Jin Y. Jin
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Aberrant association of misfolded SOD1 with Na+/K+ATPase-α3 impairs its activity and contributes to motor neuron vulnerability in ALS
Acta Neuropathologica, ISSN: 14320533 00016322
Céline Ruegsegger; Niran Maharjan; Anand Goswami; Audrey Filézac de L’Etang; Joachim Weis; Dirk Troost; Manfred Heller; Heinz Gut; Smita Saxena
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Effect of ambient light on IgG1 monoclonal antibodies during drug product processing and development
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Alavattam Sreedhara; Jian Yin; Michael Joyce; Kimberly Lau; Aaron T. Wecksler; Galahad Deperalta; Li Yi; Y. John Wang; Bruce Kabakoff; Ravuri S.K. Kishore
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Evaluation of predictive tools for cell culture clarification performance
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Anna Senczuk; Krista Petty; Anne Thomas; McNerney; John Moscariello; Yinges Yigzaw
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A survey of new oncology drug approvals in the USA from 2010 to 2015: A focus on optimal dose and related postmarketing activities
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Dan Lu; Tong Lu; Mark Stroh; Richard A. Graham; Priya Agarwal; Luna Musib; Chi-Chung Li; Bert L. Lum; Amita Joshi
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Bruton tyrosine kinase–Dependent immune cell cross-talk drives pancreas cancer
Cancer Discovery, ISSN: 21598290 21598274
Andrew J. Gunderson; Megan M. Kaneda; Takahiro Tsujikawa; Abraham V. Nguyen; Nesrine I. Affara; Brian Ruffell; Sara Gorjestani; Shannon M. Liudahl; Morgan Truit; Peter Olson; Grace Kim; Douglas Hanahan; Margaret A. Tempero; Brett Sheppard; Bryan Irving; Betty Chang; Judith A. Varner; Lisa Coussens
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Industry view on the relative importance of "clonality" of biopharmaceutical-producing cell lines
Biologicals, ISSN: 10958320 10451056
Christopher Frye; Rohini Deshpande; Scott Estes; Kathleen Francissen; John C. Joly; Lubiniecki; Trent Munro; Reb Russell; Tongtong Wang; Karin Anderson
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Pre-existing Antibody: Biotherapeutic Modality-Based Review
AAPS Journal, ISSN: 15507416
Boris Gorovits; Adrienne Clements-Egan; Mary Birchler; Meina Liang; Heather Myler; Kun Peng; Shobha Purushothama; Manoj Rajadhyaksha; Laura Salazar-Fontana; Crystal Sung; Li Xue
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Comparison of different clinical development plans for confirmatory subpopulation selection
Contemporary Clinical Trials, ISSN: 15592030 15517144
Kaspar Rufibach; Meng Chen; Hoa P. Nguyen
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Advancing Product Quality: a Summary of the Second FDA/PQRI Conference
AAPS Journal, ISSN: 15507416
Lawrence X. Yu; Ilgaz Akseli; Barbara Allen; Gregory Amidon; Tara Gooen Bizjak; Ashley Boam; Margaret Caulk; David Doleski; Joseph Famulare; Adam C. Fisher; Scott Furness; Brian Hasselbalch; Henry Havel; Stephen W. Hoag; Robert Iser; Bruce D. Johnson; Robert Ju; Paula Katz; Emanuela Lacana; Sau L. Lee; Richard Lostritto; Grace McNally; Mehul Mehta; Ganapathy Mohan; Moheb Nasr; Roger Nosal; Mary Oates; Thomas O’Connor; Jim Polli; Raju; Mahesh Ramanadham; Giuseppe Randazzo; Susan Rosencrance; Anna Schwendeman; Arzu Selen; Paul Seo; Vinod Shah; Ramesh Sood; Michael P. Thien; Tony Tong; Bernhardt L. Trout; Katherine Tyner; Siva Vaithiyalingam; Martin VanTrieste; Fionnuala Walsh; Russell Wesdyk; Janet Woodcock; Geoffrey Wu; Larisa Wu; Louis Yu; Diane Zezza
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Outcomes following watchful waiting for stage II-IV follicular lymphoma patients in the modern era
British Journal of Haematology, ISSN: 13652141 00071048
Loretta J. Nastoupil; Sinha; Michelle Byrtek; Ryan Ziemiecki; Zhou; Taylor; Jonathan W. Friedberg; Brian K. Link; James R. Cerhan; Keith Dawson; Christopher R. Flowers
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Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Christina S. Yee; Michel J. Massaad; Wayne Bainter; Toshiro K. Ohsumi; Niko Föger; Andrew A. Chan; Nurten A. Akarsu; Caner Aytekin; Deniz Çagdas Ayvaz; Ilhan Tezcan; Özden Sanal; Raif S. Geha; Janet Chou
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Challenges and advances in the assessment of the disposition of antibody-drug conjugates
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Amrita Kamath; Suhasini Iyer
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Quality-adjusted life years for the retina specialist: Understanding qalys can help ophthalmologists see the bigger picture of treatment impact on patients’ health-related quality of life
Retina Today, ISSN: 18250572
Nancy M. Holekamp; Steven B. Duff; Yamina Rajput
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Activating mutations in PIK3CB confer resistance to PI3K inhibition and define a novel oncogenic role for p110β
Cancer Research, ISSN: 15387445 00085472
Yoshito Nakanishi; Kimberly Walter; Jill M. Spoerke; Carol O'Brien; Huw; Garret M. Hampton; Lackner
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Comparison of different clinical development plans for confirmatory subpopulation selection
Contemporary Clinical Trials, ISSN: 15592030 15517144
Kaspar Rufibach; Meng Chen; Hoa Nguyen
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Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses
Scientific Reports, ISSN: 20452322
Yanchuan Li; Hui Wang; Xiaofei Zhou; Xiaoping Xie; Xiang Chen; Zuliang Jie; Qiang Zou; Hongbo Hu; Lele Zhu; Xuhong Cheng; Hans D. Brightbill; Lawren C. Wu; Linfang Wang; Shao-Cong Sun
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The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Kevin W. Kuntz; John E. Campbell; Heike Keilhack; Roy M. Pollock; Sarah K. Knutson; Margaret Porter Scott; Victoria M. Richon; Chris J. Sneeringer; Tim J. Wigle; Christina J. Allain; Christina R. Majer; Mikel P. Moyer; Robert A. Copeland; Richard Chesworth
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Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
F. Anthony Romero; Alexander M. Taylor; Terry Crawford; Vickie Tsui; Alexandre Côté; Steven Magnuson
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Polyclonal antibody production for membrane proteins via genetic immunization
Scientific Reports, ISSN: 20452322
Debra T. Hansen; Mark D. Robida; Felicia M. Craciunescu; Andrey V. Loskutov; Katerina Dörner; John-Charles Rodenberry; Xiao Wang; Tien L. Olson; Hetal Patel; Petra Fromme; Kathryn F. Sykes
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Process Development of the Synthesis and Purification of a Reactive Immuno-PET Conjugate Intermediate
Organic Process Research and Development, ISSN: 1520586X 10836160
Diane Carrera; Tina Nguyen; Colin D. Medley; Yi Li; Remy Angelaud; Francis Gosselin
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Process Development of the Synthesis and Purification of a Reactive Immuno-PET Conjugate Intermediate
Organic Process Research and Development, ISSN: 1520586X 10836160
Diane Carrera; Nguyen; Colin D. Medley; Yi Li; Remy Angelaud; Francis Gosselin
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Fc gamma receptor 3A and 2A polymorphisms do not predict response to rituximab in follicular lymphoma
Clinical Cancer Research, ISSN: 15573265 10780432
Vaishalee P. Kenkre; Fangxin Hong; James R. Cerhan; Marcia Lewis; Leslie Sullivan; Marna Williams; Randy D. Gascoyne; Sandra J. Horning; Brad Kahl
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Fc gamma receptor 3A and 2A polymorphisms do not predict response to rituximab in follicular lymphoma
Clinical Cancer Research, ISSN: 15573265 10780432
Vaishalee P. Kenkre; Fangxin Hong; James R. Cerhan; Marcia Lewis; Leslie Sullivan; Marna Williams; Randy D. Gascoyne; Sandra J. Horning; Wojciech Jurczak
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Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies
Journal of Molecular Biology, ISSN: 10898638 00222836
Qianting Zhai; Meng He; Aimin Song; Deshayes; Vishva M. Dixit; Paul J. Carter
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The rapid identification of elution conditions for therapeutic antibodies from cation-exchange chromatography resins using high-throughput screening
Journal of Chromatography A, ISSN: 18733778 00219673
Paul McDonald; Benjamin Tran; Christopher R. Williams; Marc Wong; Ti Zhao; Kelley; Philip M. Lester
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The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Timothy P. Heffron; Robert Heald; Chudi O. Ndubaku; Binqing Wei; Martin Augistin; Steven Do; Kyle A. Edgar; Eigenbrot; Lori S. Friedman; Emanuela Gancia; Philip Jackson; Graham Jones; Aleksandr Kolesnikov; Leslie Lee; John Lesnick; Lewis; Neville J. McLean; Mario Mörtl; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Steven T. Staben; Stefan Steinbacher; Vickie Tsui; Jeffery J. Wallin; Deepak Sampath; Alan G. Olivero
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Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666
ACS Medicinal Chemistry Letters, ISSN: 19485875
Kenneth W. Duncan; Nathalie Rioux; P Ann Boriack-Sjodin; Michael J. Munchhof; Lawrence A. Reiter; Christina R. Majer; Lei Jin; L Danielle Johnston; Elayne Chan-Penebre; Kristy G. Kuplast; Margaret Porter Scott; Roy M. Pollock; Nigel J. Waters; Jesse J. Smith; Mikel P. Moyer; Robert A. Copeland; Richard Chesworth
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Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor
ACS Medicinal Chemistry Letters, ISSN: 19485875
Lorna H. Mitchell; P Ann Boriack-Sjodin; Sherri Smith; Michael Thomenius; Nathalie Rioux; Michael J. Munchhof; James E. Mills; Christine R. Klaus; Jennifer Totman; Thomas V. Riera; Alejandra Raimondi; Suzanne L. Jacques; Kip A. West; Megan Foley; Nigel J. Waters; Kevin W. Kuntz; Tim J. Wigle; Margaret Porter Scott; Robert A. Copeland; Jesse J. Smith; Richard Chesworth
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IL-33 amplifies an innate immune response in the degenerating retina
Journal of Experimental Medicine, ISSN: 15409538 00221007
Hongkang Xi; Kenneth J. Katschke Jr.; Yun Li; Tom Truong; Wyne P. Lee; Laurie Diehl; Linda Rangell; Jianhua Tao; Rommel Arceo; Jeffrey Eastham-Anderson; Jason A. Hackney; Antonio Iglesias; Javier Cote-Sierra; Justin Elstrott; Robby M. Weimer; Menno Van Lookeren Campagne
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Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
Cell Stem Cell, ISSN: 18759777 19345909
Paul W. Tetteh; Onur Basak; Henner F. Farin; Kay Wiebrands; Kai Kretzschmar; Harry Begthel; Maaike Van Den Born; Jeroen Korving; Frederic J. De Sauvage; Johan H. Van Es; Alexander Van Oudenaarden; Hans Clevers
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Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
Nature Communications, ISSN: 20411723
Lovorka Stojic; Malwina Niemczyk; Arturo V. Orjalo; Yoko Ito; Anna Elisabeth Maria Ruijter; Santiago Uribe-Lewis; Nimesh Joseph; Stephen Weston; Suraj Menon; Duncan T. Odom; John Rinn; Fanni Gergely; Adele Murrell
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Using local multiplicity to improve effect estimation from a hypothesis-generating pharmacogenetics study
Pharmacogenomics Journal, ISSN: 14731150 1470269X
Zou; Ouyang
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Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
Thorax, ISSN: 14683296 00406376
Liam G. Heaney; Ratko Djukanovic; Ashley Woodcock; Samantha Walker; Matthews; Ian D. Pavord; Peter Bradding; Robert Niven; Chris E. Brightling; Rekha Chaudhuri; Joseph R. Arron; David F. Choy; Douglas Cowan; Adel Mansur; Andrew Menzies-Gow; Ian Adcock; Kian Fan Chung; Chris Corrigan; Peter Coyle; Timothy Harrison; Sebastian Johnston; Peter Howarth; James Lordan; Ian Sabroe; Jeannette Bigler; Dirk Smith; Matthew Catley; Richard May; Lisa Pierre; Chris Stevenson; Glenn Crater; Frank Keane; Richard W. Costello; Val Hudson; David Supple; Tim Hardman
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Timing and duration of omalizumab response in patients with chronic idiopathic/spontaneous urticaria
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Allen P. Kaplan; Marta Ferrer; Jonathan A. Bernstein; Evgeniya Antonova; Benjamin L. Trzaskoma; Karina Raimundo; Karin Rosén; Theodore A. Omachi; Sam Khalil; James L. Zazzali
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Surrogate analyte approach for quantitation of endogenous NAD+ in human acidified blood samples using liquid chromatography coupled with electrospray ionization tandem mass spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Liling Liu; Zhiyi Cui; Yuzhong Deng; Brian J. Dean; Cornelis E. Hop; Xiaorong Liang
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Reply
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Yvonne J. Huang; Joseph R. Arron; Homer Boushey
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Compound Transfer by Acoustic Droplet Ejection Promotes Quality and Efficiency in Ultra-High-Throughput Screening Campaigns
Journal of Laboratory Automation, ISSN: 22110690 22110682
Timothy D. Dawes; Rebecca Turincio; Steven W Jones; Richard A. Rodriguez; Dhireshan Gadiagellan; Peter Thana; Clark; Amy Gustafson; Linda O. Elliott; Marya Liimatta; Daniel P. Gross; Till Maurer; Beresini
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Agreement between Rectosigmoidoscopy and Colonoscopy Analyses of Disease Activity and Healing in Patients with Ulcerative Colitis
Gastroenterology, ISSN: 15280012 00165085
Jean-Frédéric Colombel; Ingrid Ordás; Thomas Ullman; Paul J. Rutgeerts; Akiko Chai; Sharon O'Byrne; Timothy T. Lu; Julián Panés
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Simultaneous achiral-chiral analysis of pharmaceutical compounds using two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography
Talanta, ISSN: 00399140
Venkatramani; Mohammad Al-Sayah; Guannan Li; Meenakshi Goel; James Girotti; Lisa Zang; Larry Wigman; Peter M. Yehl; Nik P. Chetwyn
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The pharmaceutical vial capping process: Container closure systems, capping equipment, regulatory framework, and seal quality tests
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Roman Mathaes; Hanns-Christian Mahler; Jean-Pierre Buettiker; Holger Roehl; Philippe Lam; Helen Brown; Joerg Luemkemann; Michael Adler; Joerg Huwyler; Alexander Streubel; Silke Mohl
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