Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5251 - 5300 OF 15477 RESULTS

March 1, 2016

Bruton tyrosine kinase–Dependent immune cell cross-talk drives pancreas cancer

Cancer Discovery, ISSN: 21598290 21598274

Andrew J. Gunderson; Megan M. Kaneda; Takahiro Tsujikawa; Abraham V. Nguyen; Nesrine I. Affara; Brian Ruffell; Sara Gorjestani; Shannon M. Liudahl; Morgan Truit; Peter Olson; Grace Kim; Douglas Hanahan; Margaret A. Tempero; Brett Sheppard; Bryan Irving; Betty Chang; Judith A. Varner; Lisa Coussens

March 1, 2016

Industry view on the relative importance of "clonality" of biopharmaceutical-producing cell lines

Biologicals, ISSN: 10958320 10451056

Christopher Frye; Rohini Deshpande; Scott Estes; Kathleen Francissen; John C. Joly; Lubiniecki; Trent Munro; Reb Russell; Tongtong Wang; Karin Anderson

March 1, 2016

Pre-existing Antibody: Biotherapeutic Modality-Based Review

AAPS Journal, ISSN: 15507416

Boris Gorovits; Adrienne Clements-Egan; Mary Birchler; Meina Liang; Heather Myler; Kun Peng; Shobha Purushothama; Manoj Rajadhyaksha; Laura Salazar-Fontana; Crystal Sung; Li Xue

March 1, 2016

Comparison of different clinical development plans for confirmatory subpopulation selection

Contemporary Clinical Trials, ISSN: 15592030 15517144

Kaspar Rufibach; Meng Chen; Hoa P. Nguyen

March 1, 2016

Advancing Product Quality: a Summary of the Second FDA/PQRI Conference

AAPS Journal, ISSN: 15507416

Lawrence X. Yu; Ilgaz Akseli; Barbara Allen; Gregory Amidon; Tara Gooen Bizjak; Ashley Boam; Margaret Caulk; David Doleski; Joseph Famulare; Adam C. Fisher; Scott Furness; Brian Hasselbalch; Henry Havel; Stephen W. Hoag; Robert Iser; Bruce D. Johnson; Robert Ju; Paula Katz; Emanuela Lacana; Sau L. Lee; Richard Lostritto; Grace McNally; Mehul Mehta; Ganapathy Mohan; Moheb Nasr; Roger Nosal; Mary Oates; Thomas O’Connor; Jim Polli; Raju; Mahesh Ramanadham; Giuseppe Randazzo; Susan Rosencrance; Anna Schwendeman; Arzu Selen; Paul Seo; Vinod Shah; Ramesh Sood; Michael P. Thien; Tony Tong; Bernhardt L. Trout; Katherine Tyner; Siva Vaithiyalingam; Martin VanTrieste; Fionnuala Walsh; Russell Wesdyk; Janet Woodcock; Geoffrey Wu; Larisa Wu; Louis Yu; Diane Zezza

March 1, 2016

Outcomes following watchful waiting for stage II-IV follicular lymphoma patients in the modern era

British Journal of Haematology, ISSN: 13652141 00071048

Loretta J. Nastoupil; Sinha; Michelle Byrtek; Ryan Ziemiecki; Zhou; Taylor; Jonathan W. Friedberg; Brian K. Link; James R. Cerhan; Keith Dawson; Christopher R. Flowers

March 1, 2016

Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Christina S. Yee; Michel J. Massaad; Wayne Bainter; Toshiro K. Ohsumi; Niko Föger; Andrew A. Chan; Nurten A. Akarsu; Caner Aytekin; Deniz Çagdas Ayvaz; Ilhan Tezcan; Özden Sanal; Raif S. Geha; Janet Chou

March 1, 2016

Challenges and advances in the assessment of the disposition of antibody-drug conjugates

Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782

Amrita Kamath; Suhasini Iyer

March 1, 2016

Comparison of different clinical development plans for confirmatory subpopulation selection

Contemporary Clinical Trials, ISSN: 15592030 15517144

Kaspar Rufibach; Meng Chen; Hoa Nguyen

March 1, 2016

Quality-adjusted life years for the retina specialist: Understanding qalys can help ophthalmologists see the bigger picture of treatment impact on patients’ health-related quality of life

Retina Today, ISSN: 18250572

Nancy M. Holekamp; Steven B. Duff; Yamina Rajput

March 1, 2016

Activating mutations in PIK3CB confer resistance to PI3K inhibition and define a novel oncogenic role for p110β

Cancer Research, ISSN: 15387445 00085472

Yoshito Nakanishi; Kimberly Walter; Jill M. Spoerke; Carol O'Brien; Huw; Garret M. Hampton; Lackner

February 25, 2016

Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses

Scientific Reports, ISSN: 20452322

Yanchuan Li; Hui Wang; Xiaofei Zhou; Xiaoping Xie; Xiang Chen; Zuliang Jie; Qiang Zou; Hongbo Hu; Lele Zhu; Xuhong Cheng; Hans D. Brightbill; Lawren C. Wu; Linfang Wang; Shao-Cong Sun

February 25, 2016

The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Kevin W. Kuntz; John E. Campbell; Heike Keilhack; Roy M. Pollock; Sarah K. Knutson; Margaret Porter Scott; Victoria M. Richon; Chris J. Sneeringer; Tim J. Wigle; Christina J. Allain; Christina R. Majer; Mikel P. Moyer; Robert A. Copeland; Richard Chesworth

February 25, 2016

Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

F. Anthony Romero; Alexander M. Taylor; Terry Crawford; Vickie Tsui; Alexandre Côté; Steven Magnuson

February 24, 2016

Polyclonal antibody production for membrane proteins via genetic immunization

Scientific Reports, ISSN: 20452322

Debra T. Hansen; Mark D. Robida; Felicia M. Craciunescu; Andrey V. Loskutov; Katerina Dörner; John-Charles Rodenberry; Xiao Wang; Tien L. Olson; Hetal Patel; Petra Fromme; Kathryn F. Sykes

February 19, 2016

Process Development of the Synthesis and Purification of a Reactive Immuno-PET Conjugate Intermediate

Organic Process Research and Development, ISSN: 1520586X 10836160

Diane Carrera; Tina Nguyen; Colin D. Medley; Yi Li; Remy Angelaud; Francis Gosselin

February 19, 2016

Process Development of the Synthesis and Purification of a Reactive Immuno-PET Conjugate Intermediate

Organic Process Research and Development, ISSN: 1520586X 10836160

Diane Carrera; Nguyen; Colin D. Medley; Yi Li; Remy Angelaud; Francis Gosselin

February 15, 2016

Fc gamma receptor 3A and 2A polymorphisms do not predict response to rituximab in follicular lymphoma

Clinical Cancer Research, ISSN: 15573265 10780432

Vaishalee P. Kenkre; Fangxin Hong; James R. Cerhan; Marcia Lewis; Leslie Sullivan; Marna Williams; Randy D. Gascoyne; Sandra J. Horning; Brad Kahl

February 15, 2016

Fc gamma receptor 3A and 2A polymorphisms do not predict response to rituximab in follicular lymphoma

Clinical Cancer Research, ISSN: 15573265 10780432

Vaishalee P. Kenkre; Fangxin Hong; James R. Cerhan; Marcia Lewis; Leslie Sullivan; Marna Williams; Randy D. Gascoyne; Sandra J. Horning; Wojciech Jurczak

February 13, 2016

Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies

Journal of Molecular Biology, ISSN: 10898638 00222836

Qianting Zhai; Meng He; Aimin Song; Deshayes; Vishva M. Dixit; Paul J. Carter

February 12, 2016

The rapid identification of elution conditions for therapeutic antibodies from cation-exchange chromatography resins using high-throughput screening

Journal of Chromatography A, ISSN: 18733778 00219673

Paul McDonald; Benjamin Tran; Christopher R. Williams; Marc Wong; Ti Zhao; Kelley; Philip M. Lester

February 11, 2016

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Timothy P. Heffron; Robert Heald; Chudi O. Ndubaku; Binqing Wei; Martin Augistin; Steven Do; Kyle A. Edgar; Eigenbrot; Lori S. Friedman; Emanuela Gancia; Philip Jackson; Graham Jones; Aleksandr Kolesnikov; Leslie Lee; John Lesnick; Lewis; Neville J. McLean; Mario Mörtl; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Steven T. Staben; Stefan Steinbacher; Vickie Tsui; Jeffery J. Wallin; Deepak Sampath; Alan G. Olivero

February 11, 2016

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

ACS Medicinal Chemistry Letters, ISSN: 19485875

Kenneth W. Duncan; Nathalie Rioux; P Ann Boriack-Sjodin; Michael J. Munchhof; Lawrence A. Reiter; Christina R. Majer; Lei Jin; L Danielle Johnston; Elayne Chan-Penebre; Kristy G. Kuplast; Margaret Porter Scott; Roy M. Pollock; Nigel J. Waters; Jesse J. Smith; Mikel P. Moyer; Robert A. Copeland; Richard Chesworth

February 11, 2016

Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor

ACS Medicinal Chemistry Letters, ISSN: 19485875

Lorna H. Mitchell; P Ann Boriack-Sjodin; Sherri Smith; Michael Thomenius; Nathalie Rioux; Michael J. Munchhof; James E. Mills; Christine R. Klaus; Jennifer Totman; Thomas V. Riera; Alejandra Raimondi; Suzanne L. Jacques; Kip A. West; Megan Foley; Nigel J. Waters; Kevin W. Kuntz; Tim J. Wigle; Margaret Porter Scott; Robert A. Copeland; Jesse J. Smith; Richard Chesworth

February 8, 2016

IL-33 amplifies an innate immune response in the degenerating retina

Journal of Experimental Medicine, ISSN: 15409538 00221007

Hongkang Xi; Kenneth J. Katschke Jr.; Yun Li; Tom Truong; Wyne P. Lee; Laurie Diehl; Linda Rangell; Jianhua Tao; Rommel Arceo; Jeffrey Eastham-Anderson; Jason A. Hackney; Antonio Iglesias; Javier Cote-Sierra; Justin Elstrott; Robby M. Weimer; Menno Van Lookeren Campagne

February 4, 2016

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

Cell Stem Cell, ISSN: 18759777 19345909

Paul W. Tetteh; Onur Basak; Henner F. Farin; Kay Wiebrands; Kai Kretzschmar; Harry Begthel; Maaike Van Den Born; Jeroen Korving; Frederic J. De Sauvage; Johan H. Van Es; Alexander Van Oudenaarden; Hans Clevers

February 2, 2016

Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions

Nature Communications, ISSN: 20411723

Lovorka Stojic; Malwina Niemczyk; Arturo V. Orjalo; Yoko Ito; Anna Elisabeth Maria Ruijter; Santiago Uribe-Lewis; Nimesh Joseph; Stephen Weston; Suraj Menon; Duncan T. Odom; John Rinn; Fanni Gergely; Adele Murrell

February 1, 2016

Using local multiplicity to improve effect estimation from a hypothesis-generating pharmacogenetics study

Pharmacogenomics Journal, ISSN: 14731150 1470269X

Zou; Ouyang

February 1, 2016

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

Thorax, ISSN: 14683296 00406376

Liam G. Heaney; Ratko Djukanovic; Ashley Woodcock; Samantha Walker; Matthews; Ian D. Pavord; Peter Bradding; Robert Niven; Chris E. Brightling; Rekha Chaudhuri; Joseph R. Arron; David F. Choy; Douglas Cowan; Adel Mansur; Andrew Menzies-Gow; Ian Adcock; Kian Fan Chung; Chris Corrigan; Peter Coyle; Timothy Harrison; Sebastian Johnston; Peter Howarth; James Lordan; Ian Sabroe; Jeannette Bigler; Dirk Smith; Matthew Catley; Richard May; Lisa Pierre; Chris Stevenson; Glenn Crater; Frank Keane; Richard W. Costello; Val Hudson; David Supple; Tim Hardman

February 1, 2016

Timing and duration of omalizumab response in patients with chronic idiopathic/spontaneous urticaria

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Allen P. Kaplan; Marta Ferrer; Jonathan A. Bernstein; Evgeniya Antonova; Benjamin L. Trzaskoma; Karina Raimundo; Karin Rosén; Theodore A. Omachi; Sam Khalil; James L. Zazzali

February 1, 2016

Surrogate analyte approach for quantitation of endogenous NAD+ in human acidified blood samples using liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232

Liling Liu; Zhiyi Cui; Yuzhong Deng; Brian J. Dean; Cornelis E. Hop; Xiaorong Liang

February 1, 2016

Reply

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Yvonne J. Huang; Joseph R. Arron; Homer Boushey

February 1, 2016

Compound Transfer by Acoustic Droplet Ejection Promotes Quality and Efficiency in Ultra-High-Throughput Screening Campaigns

Journal of Laboratory Automation, ISSN: 22110690 22110682

Timothy D. Dawes; Rebecca Turincio; Steven W Jones; Richard A. Rodriguez; Dhireshan Gadiagellan; Peter Thana; Clark; Amy Gustafson; Linda O. Elliott; Marya Liimatta; Daniel P. Gross; Till Maurer; Beresini

February 1, 2016

Agreement between Rectosigmoidoscopy and Colonoscopy Analyses of Disease Activity and Healing in Patients with Ulcerative Colitis

Gastroenterology, ISSN: 15280012 00165085

Jean-Frédéric Colombel; Ingrid Ordás; Thomas Ullman; Paul J. Rutgeerts; Akiko Chai; Sharon O'Byrne; Timothy T. Lu; Julián Panés

February 1, 2016

Simultaneous achiral-chiral analysis of pharmaceutical compounds using two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography

Talanta, ISSN: 00399140

Venkatramani; Mohammad Al-Sayah; Guannan Li; Meenakshi Goel; James Girotti; Lisa Zang; Larry Wigman; Peter M. Yehl; Nik P. Chetwyn

February 1, 2016

The pharmaceutical vial capping process: Container closure systems, capping equipment, regulatory framework, and seal quality tests

European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411

Roman Mathaes; Hanns-Christian Mahler; Jean-Pierre Buettiker; Holger Roehl; Philippe Lam; Helen Brown; Joerg Luemkemann; Michael Adler; Joerg Huwyler; Alexander Streubel; Silke Mohl

February 1, 2016

Association between Response to Etrolizumab and Expression of Integrin αe and Granzyme A in Colon Biopsies of Patients with Ulcerative Colitis

Gastroenterology, ISSN: 15280012 00165085

Tew; Jason A. Hackney; Don L. Gibbons; Christopher A. Lamb; Diana Luca; Jackson G. Egen; Laurie Diehl; Jeffrey Eastham-Anderson; Severine Vermeire; John C Mansfield; Brian G. Feagan; Julián Panés; Daniel C. Baumgart; Stefan Schreiber; Iris Dotan; William J. Sandborn; John A. Kirby; Peter M. Irving; Gert De Hertogh; Gert Van Assche; Paul J. Rutgeerts; Sharon O'Byrne; Adrian C. Hayday; Mary E. Keir

February 1, 2016

Interpreting the multi-biomarker disease activity score in the context of tocilizumab treatment for patients with rheumatoid arthritis

Rheumatology International, ISSN: 1437160X 01728172

William Reiss; Jenny Devenport; Jason M. Low; George Wu; Eric H. Sasso

February 1, 2016

Societal costs associated with neovascular age-related macular degeneration in the United States

Retina, ISSN: 15392864 0275004X

Melissa M. Brown; Gary C. Brown; Heidi B. Lieske; Irwin Tran; Adam Turpcu; Shoshana Colman

February 1, 2016

Developments in the Implementation of Acoustic Droplet Ejection for Protein Crystallography

Journal of Laboratory Automation, ISSN: 22110690 22110682

Ping Wu; Cameron Noland; Ultsch; Bonnie Edwards; David Harris; Robert Mayer; Seth F. Harris

February 1, 2016

Training the next generation of biomedical investigators in glycosciences

Journal of Clinical Investigation, ISSN: 15588238 00219738

Peter Agre; Carolyn Bertozzi; Mina J. Bissell; Kevin P. Campbell; Richard D. Cummings; Umesh R. Desai; Mary K. Estes; Terence Flotte; Guy Fogleman; Fred Gage; David Ginsburg; Jeffrey I. Gordon; Gerald Hart; Vincent Hascall; Laura Kiessling; Stuart Kornfeld; John Lowe; John Magnani; Lara K. Mahal; Ruslan Medzhitov; Richard J. Roberts; Robert Sackstein; Rita Sarkar; Ronald Schnaar; Nancy Schwartz; Ajit Varki; David R Walt; Irving L. Weissman

February 1, 2016

Immune Checkpoint inhibitors: An introduction to the next-generation cancer immunotherapy

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Lucy Lee; Manish Gupta; Srikumar Sahasranaman

February 1, 2016

Effect of ranibizumab on the decision to drive and vision function relevant to driving in patients with diabetic macular edema: Report from RESTORE, RIDE, and RISE trials

JAMA Ophthalmology, ISSN: 21686165

Neil M. Bressler; Rohit Varma; Paul Mitchell; Ivan J. Suñer; Chantal M. Dolan; James Ward; Alberto Ferreira; Jason S. Ehrlich; Adam Turpcu

February 1, 2016

Unlocking the Potential of High-Throughput Drug Combination Assays Using Acoustic Dispensing

Journal of Laboratory Automation, ISSN: 22110690 22110682

Grace Chan; Stacy Wilson; Stephen Schmidt; John Moffat

February 1, 2016

Quality adjusted life year gains associated with administration of recombinant tissue-type plasminogen activator for treatment of acute ischemic stroke: 1998-2011

International Journal of Stroke, ISSN: 17474949 17474930

Deborah Lubeck; Mark Danese; Jennifer Duryea; Marc Halperin; Darren Tayama; Elaine B. Yu; Deepa Lalla; James C. Grotta

February 1, 2016

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Nature Genetics, ISSN: 15461718 10614036

Jessica Cooke Bailey; Stephanie J. Loomis; Jae H. Kang; R. Rand Allingham; Puya Gharahkhani; Chiea Chuen Khor; Kathryn P. Burdon; Hugues Aschard; Daniel I. Chasman; Robert P. Igo; Pirro G. Hysi; Craig A. Glastonbury; Allison Ashley-Koch; Murray Brilliant; Andrew A. Brown; Donald L. Budenz; Alfonso Buil; Ching-Yu Cheng; Hyon Choi; Christen; Gary Curhan; Immaculata De Vivo; John Fingert; Paul J. Foster; Charles Fuchs; Douglas Gaasterland; Terry Gaasterland; Alex W. Hewitt; Frank Hu; David J. Hunter; Anthony P. Khawaja; Richard K. Lee; Zheng Li; Paul R. Lichter; David A. Mackey; Peter McGuffin; Paul Mitchell; Sayoko E. Moroi; Shamira A. Perera; Keating W. Pepper; Qibin Qi; Tony Realini; Julia E. Richards; Paul M. Ridker; Eric Rimm; Robert Ritch; Marylyn Ritchie; Schuman; William K. Scott; Kuldev Singh; Arthur J. Sit; Yeunjoo E. Song; Rulla M. Tamimi; Fotis Topouzis; Ananth C. Viswanathan; Shefali Setia Verma; Douglas Vollrath; Jie Jin Wang; Nicole Weisschuh; Bernd Wissinger; Gadi Wollstein; Andrew K. Wong; Brian L. Yaspan; Donald J. Zack; Kang Zhang; Robert N. Weinreb; Brian W. Kunkle; Kerrin Small; Christopher J. Hammond; Tin Aung; Yutao Liu; Eranga N. Vithana; David A. Mackey; Jamie E. Craig; Peter Kraft; Gareth Howell; Michael A. Hauser; Louis R. Pasquale; Jonathan L. Haines; Janey L. Wiggs

February 1, 2016

Best practices for the use of itraconazole as a replacement for ketoconazole in drug-drug interaction studies

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Lichuan Liu; Akintunde Bello; Mark J. Dresser; Donald Heald; Steven Ferenc Komjathy; Edward O'Mara; Mark Rogge; S. Aubrey Stoch; Sarah M. Robertson

February 1, 2016

Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1

Toxicologic Pathology, ISSN: 15331601 01926233

Yu Zhong; Paula Katavolos; Trung Nguyen; Ted Lau; Jason Boggs; Amy Sambrone; David Kan; Mark Merchant; Eric Harstad; Dolores Diaz; Michael Costa; Melissa Schutten

February 1, 2016

Mammalian Genotyping Using Acoustic Droplet Ejection for Enhanced Data Reproducibility, Superior Throughput, and Minimized Cross-Contamination

Journal of Laboratory Automation, ISSN: 22110690 22110682

Carol Cain-Hom; Ryan Pabalate; Anna Pham; Hetal Patel; Rhonda Wiler; J. Colin Cox

February 1, 2016

CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer

Journal of Clinical Investigation, ISSN: 15588238 00219738

Mark L. McCleland; Kathryn Mesh; Edward Lorenzana; Vivek S. Chopra; Ehud Segal; Colin K. Watanabe; Benjamin Haley; Oleg Mayba; Murat Yaylaoglu; Florian Gnad; Ron Firestein

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