Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5251 - 5300 OF 15390 RESULTS

January 1, 2016

The INNs and outs of antibody nonproprietary names

mAbs, ISSN: 19420870 19420862

Tim D. Jones; Paul J. Carter; Pluckthun; Max Vásquez; Robert G. E. Holgate; Isidro Hötzel; Andrew G. Popplewell; Paul W. H. I. Parren; Markus Enzelberger; Hendrik J. Rademaker; Michael R. Clark; David C. Lowe; Bassil I. Dahiyat; Victoria Smith; John M. Lambert; Herren Wu; Mary Reilly; John S. Haurum; Stefan Dübel; James S. Huston; Thomas Schirrmann; Richard A. J. Janssen; Martin Steegmaier; Jane A. Gross; Andrew Bradbury; Dennis R. Burton; Dimiter S. Dimitrov; Kerry A. Chester; Martin J. Glennie; Julian Davies; Adam Walker; Steve Martin; John McCafferty; Matthew P. Baker

January 1, 2016

Estimating the population benefits and costs of Rituximab therapy in the United States from 1998 to 2013 using real-world data

Medical Care, ISSN: 15371948 00257079

Mark Danese; Carolina Reyes; Michelle Gleeson; Marc Halperin; Sandra Skettino; Joseph Mikhael

January 1, 2016

Application of a plug-and-play immunogenicity assay in cynomolgus monkey serum for ADCs at early stages of drug development

Journal of Immunology Research, ISSN: 23147156 23148861

Montserrat Carrasco-Triguero; Helen Davis; Yuda Zhu; Daniel A. Coleman; Denise Nazzal; Paul Vu; Surinder Kaur

January 1, 2016

Detecting Data Quality Issues in Clinical Trials: Current Practices and Recommendations

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

David Knepper; Christian Fenske; Patrick Nadolny; Alun Bedding; Elena Gribkova; John Polzer; Jennifer Neumann; Brett Wilson; Joanne Benedict; Andy Lawton

January 1, 2016

VH-VL orientation prediction for antibody humanization candidate selection: A case study

mAbs, ISSN: 19420870 19420862

Alexander Bujotzek; Florian Lipsmeier; Seth F. Harris; Jörg Benz; Andreas Kuglstatter; Guy J. Georges

January 1, 2016

Quantitative evaluation of first, second, and third generation hairpin systems reveals the limit of mammalian vector-based RNAi

RNA Biology, ISSN: 15558584 15476286

Colin K. Watanabe; Trinna L. Cuellar; Benjamin Haley

January 1, 2016

Short-Term Efficacy Reliably Predicts Long-Term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-Based Meta-Analysis

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Yehong Wang; Rui Zhu; Jim J. Xiao; John C. Davis; Jaap W. Mandema; Jin Y. Jin; Meina Tao Tang

January 1, 2016

Preexisting antibodies to an F(ab′)2 Antibody therapeutic and novel method for immunogenicity assessment

Journal of Immunology Research, ISSN: 23147156 23148861

Jane Ruppel; Ann Brady; Rebecca Elliott; Cecilia Leddy; Marco Palencia; Daniel A. Coleman; Jessica A. Couch; Eric Wakshull

January 1, 2016

De novo guanine biosynthesis but not the riboswitch-regulated purine salvage pathway is required for Staphylococcus aureus infection in vivo

Journal of Bacteriology, ISSN: 10985530 00219193

Eric M. Kofoed; Donghong Yan; Anand K. Katakam; Mike Reichelt; Baiwei Lin; Janice Kim; Summer Park; Shailesh V. Date; Ian R. Monk; Min Xu; Cary D. Austin; Till Maurer; Man-Wah Tan

January 1, 2016

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Wendy Lee; James J. Crawford; Ignacio Aliagas; Lesley J. Murray; Suzanne Tay; Weiru Wang; Christopher E. Heise; Klaus P. Hoeflich; Hank La; Simon Mathieu; Robert Mintzer; Sreemathy Ramaswamy; Lionel Rouge; Joachim Rudolph

January 1, 2016

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Jun Liang; Birong Zhang; Sharada Labadie; Daniel F. Ortwine; Maia Vinogradova; James R. Kiefer; Victor S Gehling; Jean-Christophe Harmange; Richard T Cummings; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Yichin Liu; Amy Gustafson; Erica Vanderporten; Weifeng Mao; Bianca M. Liederer; Gauri Deshmukh; Marie Classon; Patrick Trojer; Peter Dragovich; Lesley J. Murray

January 1, 2016

Identification of potent, selective KDM5 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Victor S Gehling; Steve Bellon; Jean-Christophe Harmange; Yves Leblanc; Florence Poy; Shobu Odate; Shane Buker; Fei Lan; Shilpi Arora; Kaylyn E Williamson; Peter Sandy; Richard T Cummings; Christopher Bailey; Louise Bergeron; Weifeng Mao; Amy Gustafson; Yichin Liu; Erica Vanderporten; James E. Audia; Patrick Trojer; Brian K Albrecht

January 1, 2016

Assessment of placental transfer and the effect on embryo-fetal development of a humanized monoclonal antibody targeting lymphotoxin-alpha in non-human primates

Reproductive Toxicology, ISSN: 18731708 08906238

Hong Wang; Chris Schuetz; Akihiro Arima; Yutaka Chihaya; Gerhard F. Weinbauer; Gunnar Habermann; Jim J. Xiao; Cynthia Woods; Jane L. Grogan; Thomas R. Gelzleichter; Cain

January 1, 2016

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

Oncotarget, ISSN: 19492553

Sonja C. Lueck; Annika C. Russ; Ursula Botzenhardt; Richard F. Schlenk; Zobel; Deshayes; Domagoj Vucic; Hartmut Doḧner; Konstanze Döhner; Fulda; Lars Bullinger

January 1, 2016

In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats

Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782

Karen E. Parrish; Jialin Mao; Jacob Z. Chen; Allan Jaochico; Justin Ly; Quynh Ho; Sophie Mukadam; Matthew Wright

January 1, 2016

Evaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) based macrocyclic chelator for 89Zr4+ and its use for immunoPET imaging of HER2 positive model of ovarian carcinoma in mice

Theranostics, ISSN: 18387640

Jeff N. Tinianow; Darpan N. Pandya; Sylvie L. Pailloux; Annie Ogasawara; Alexander N. Vanderbilt; Herman S. Gill; Simon P. Williams; Thaddeus J. Wadas; Darren Magda; Jan Marik

January 1, 2016

HER2-targeted polyinosine/polycytosine therapy inhibits tumor growth and modulates the tumor immune microenvironment

Cancer immunology research, ISSN: 23266074 23266066

Maya Zigler; Alexei Shir; Salim Joubran; Anna Sagalov; Shoshana Klein; Nufar Edinger; Jeffrey Lau; Shang-Fan Yu; Gabriel Mizraji; Anat Globerson Levin; Mark X. Sliwkowski; Alexander Levitzki

January 1, 2016

Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development

Journal of Immunology Research, ISSN: 23147156 23148861

Yanmei Lu; Leslie A. Khawli; Shobha Purushothama; Frank-Peter Theil; Michael A. Partridge

January 1, 2016

Knockout and humanised animal models to study membrane transporters in drug development

RSC Drug Discovery Series, ISSN: 20413211 20413203

Nico Scheer; Xiaoyan Chu; Laurent Salphati; Zamek-Gliszczynski

January 1, 2016

Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies

Journal of Immunology Research, ISSN: 23147156 23148861

Michael A. Partridge; Shobha Purushothama; Chinnasamy Elango; Yanmei Lu

January 1, 2016

Malignancy rates in patients with rheumatoid arthritis treated with tocilizumab

RMD Open, ISSN: 20565933

Rubbert-Roth; Anthony Sebba; Laura Brockwell; Ariella Kelman; Benjamin Porter-Brown; Jennifer Pulley; Pavel Napalkov; Ronald Van Vollenhoven

January 1, 2016

Application of LCMS in small-molecule drug development

European Pharmaceutical Review, ISSN: 13608606

Chunang Gu; David J. Russell; Peter M. Yehl

January 1, 2016

Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody–drug conjugates

Bioorganic and Medicinal Chemistry, ISSN: 14643391 09680896

Anna C. Giddens; Ho H. Lee; Guo-Liang Lu; Christian K. Miller; Jun Guo; Gail L. Phillips; Thomas H. Pillow; Moana Tercel

January 1, 2016

Single-step synthesis of 3-hydroxycarbazoles by annulation of electron-rich anilines and quinones

Tetrahedron Letters, ISSN: 18733581 00404039

Eugenia Pushkarskaya; Brian Wong; Chong Han; Simona S. Capomolla; Christine Gu; Brian M. Stoltz; Haiming Zhang

January 1, 2016

Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma

Oncotarget, ISSN: 19492553

Anne Lynn S. Chang; Karl Lewis; Sarah T. Arron; Michael R. Migden; James A. Solomon; Simon Yoo; Bann-Mo Day; Edward McKenna; Aleksandar Sekulic

January 1, 2016

Human monoclonal antibody 81.39a effectively neutralizes emerging influenza A viruses of group 1 and 2 hemagglutinins

Journal of Virology, ISSN: 10985514 0022538X

Henju Marjuki; Vasiliy P. Mishin; Ning Chai; Man-Wah Tan; Elizabeth Newton; John Tegeris; Karl Erlandson; Melissa Willis; Joyce Jones; Todd Davis; James Stevens; Larisa V. Gubareva

January 1, 2016

The Medicinal Chemistry and Commercial Manufacturing behind the Discovery and Development of the Hedgehog Inhibitor Vismodegib

ACS Symposium Series, ISSN: 19475918 00976156

Remy Angelaud; Daniel P. Sutherlin; Mark E. Reynolds; Scott Savage; Andreas Stumpf

January 1, 2016

The Discovery and Process Chemistry Development of GDC-0084, a Brain Penetrating Inhibitor of PI3K and mTOR

ACS Symposium Series, ISSN: 19475918 00976156

Timothy P. Heffron; Andrew McClory; Andreas Stumpf

January 1, 2016

Discovery and Process Development of Class i PI3K and Class i PI3K/mTOR Inhibitors GDC-0941 and GDC-0980

ACS Symposium Series, ISSN: 19475918 00976156

Srinivasan Babu; Francis Gosselin; Theresa Humphries; Alan G. Olivero; Daniel P. Sutherlin; Qingping Tian

January 1, 2016

Periostin levels and eosinophilic inflammation in poorly-controlled asthma

BMC Pulmonary Medicine, ISSN: 14712466

Jodie L. Simpson; Ian A. Yang; John W. Upham; Paul N. Reynolds; Sandra Hodge; Alan L. James; Christine Jenkins; Matthew J. Peters; Guiquan Jia; Cécile T.J. Holweg; Peter G. Gibson

January 1, 2016

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Chemical Science, ISSN: 20416539 20416520

Thomas H. Pillow; Jack D. Sadowsky; Donglu Zhang; Shang-Fan Yu; Geoffrey Del Rosario; Keyang Xu; Jintang He; Sunil Bhakta; Rachana Ohri; Katherine R. Kozak; Edward Ha; Jagath R. Junutula; Flygare

January 1, 2016

Bitpacking techniques for indexing genomes: II. Enhanced suffix arrays

Algorithms for Molecular Biology, ISSN: 17487188

Thomas D Wu

January 1, 2016

Bitpacking techniques for indexing genomes: I. Hash tables

Algorithms for Molecular Biology, ISSN: 17487188

Thomas D Wu

January 1, 2016

Natural killer cell granules converge to avoid collateral damage

Journal of Cell Biology, ISSN: 15408140 00219525

Alex T. Ritter; Ira Mellman

January 1, 2016

Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-An Industry Perspective

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Tonika Bohnert; Aarti H. Patel; Ian E. Templeton; Yuan Chen; Chuang Lu; George Lai; Louis Leung; Susanna Tse; Heidi J. Einolf; Ying-Hong Wang; Michael Sinz; Ralph Stearns; Robert L. Walsky; Wanping Geng; Sirimas Sudsakorn; David J. Moore; Ling He; Jan Wahlstrom; Jim Keirns; Rangaraj Narayanan; Dieter Lang; Xiaoqing Yang

January 1, 2016

Impact of vial capping on residual seal force and container closure integrity

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Roman Mathaes; Hanns-Christian Mahler; Yves Roggo; Robert Ovadia; Philippe Lam; Oliver B. Stauch; Martin Vogt; Holger Roehl; Joerg Huwyler; Silke Mohl; Alexander Streubel

January 1, 2016

De-risking immunotherapy: Report of a consensus workshop of the cancer immunotherapy consortium of the cancer research institute

Cancer immunology research, ISSN: 23266074 23266066

Ira Mellman; Vanessa M. Hubbard-Lucey; Matthew J. Tontonoz; Michael D. Kalos; Daniel S. Chen; James P. Allison; Charles G. Drake; Hy Levitsky; Nils Lonberg; Sjoerd H. van der Burg; Douglas T. Fearon; E. John Wherry; Israel Lowy; Robert Hvonderheide; Patrick Hwu

January 1, 2016

Interfacial properties of POPC/GDO liquid crystalline nanoparticles deposited on anionic and cationic silica surfaces

Physical Chemistry Chemical Physics, ISSN: 14639076

Debby P. Chang; Aleksandra P. Dabkowska; Richard A. Campbell; Maria Wadsäter; Justas Barauskas; Fredrik Tiberg; Tommy Nylander

January 1, 2016

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Autophagy, ISSN: 15548635 15548627

Daniel J. Klionsky; Kotb Abdelmohsen; Akihisa Abe; Md Joynal Abedin; Hagai Abeliovich; Abraham Acevedo-Arozena; Hiroaki Adachi; Christopher M. Adams; Peter D. Adams; Khosrow Adeli; Peter J. Adhihetty; Sharon G. Adler; Galila Agam; Rajesh Agarwal; Manish K. Aghi; Maria Agnello; Patrizia Agostinis; Patricia V. Aguilar; Julio Aguirre-Ghiso; Edoardo M. Airoldi; Slimane Ait-Si-Ali; Takahiko Akematsu; Emmanuel T. Akporiaye; Mohamed Al-Rubeai; Guillermo M. Albaiceta; Chris Albanese; Diego Albani; Matthew L. Albert; Jesus Aldudo; Hana Algül; Mehrdad Alirezaei; Iraide Alloza; Alexandru Almasan; Maylin Almonte-Beceril; Alnemri; Covadonga Alonso; Nihal Altan-Bonnet; Dario C. Altieri; Silvia Alvarez; Lydia Alvarez-Erviti; Sandro Alves; Giuseppina Amadoro; Atsuo Amano; Consuelo Amantini; Santiago Ambrosio; Ivano Amelio; Amal O. Amer; Mohamed Amessou; Angelika Amon; Zhenyi An; Frank A. Anania; Stig U. Andersen; Usha P. Andley; Catherine K. Andreadi; Nathalie Andrieu-Abadie; Alberto Anel; David K. Ann; Shailendra Anoopkumar-Dukie; Manuela Antonioli; Hiroshi Aoki; Nadezda Apostolova; Saveria Aquila; Katia Aquilano; Koichi Araki; Eli Arama; Agustin Aranda; Jun Araya; Alexandre Arcaro; Spencer B. Gibson; Hirokazu Arimoto; Aileen R. Ariosa; Jane L. Armstrong; Thierry Arnould; Ivica Arsov; Katsuhiko Asanuma; Valerie Askanas; Eric Asselin; Ryuichiro Atarashi; Sally S. Atherton; Julie D. Atkin; Laura D. Attardi; Patrick Auberger; Georg Auburger; Laure Aurelian; Riccardo Autelli; Laura Avagliano; Maria Laura Avantaggiati; Limor Avrahami; Neelam Azad; Suresh Awale; Tiziana Bachetti; Jonathan M. Backer; Dong-Hun Bae; Jae-Sung Bae; Ok-Nam Bae; Soo Han Bae; Eric H. Baehrecke; Seung-Hoon Baek; Stephen Baghdiguian; Agnieszka Bagniewska-Zadworna; Hua Bai; Jie Bai; Xue-Yuan Bai; Yannick Bailly; Kithiganahalli Narayanaswamy Balaji; Walter Balduini; Andrea Ballabio; Rena Balzan; Rajkumar Banerjee; Gábor Bánhegyi; Haijun Bao; Benoit Barbeau; Maria D. Barrachina; Esther Barreiro; Bonnie Bartel; Alberto Bartolomé; Diane C. Bassham; Maria Teresa Bassi; Robert C. Bast Jr.; Alakananda Basu; Maria Teresa Batista; Henri Batoko; Maurizio Battino; Kyle Bauckman; Bradley L. Baumgarner; K. Ulrich Bayer; Rupert Beale; Jean-François Beaulieu; George R. Beck; Christoph Becker; J. David Beckham; Pierre-André Bédard; Patrick J. Bednarski; Thomas J. Begley; Christian Behl; Christian Behrends; Georg M. N. Behrens; Kevin E. Behrns; Eloy Bejarano; Amine Belaid; Francesca Belleudi; Giovanni Bénard; Guy Berchem; Daniele Bergamaschi; Matteo Bergami; Ben Berkhout; Laura Berliocchi; Amélie Bernard; Monique Bernard; Francesca Bernassola; Anne Bertolotti; Amanda S. Bess; Sébastien Besteiro; Saverio Bettuzzi; Savita Bhalla; Shalmoli Bhattacharyya; Sujit K. Bhutia; Caroline Biagosch; Michele Wolfe Bianchi; Martine Biard-Piechaczyk; Viktor Billes; Claudia Bincoletto; Baris Bingol; Sara W. Bird; Marc Bitoun; Ivana Bjedov; Craig Blackstone; Lionel Blanc; Guillermo A. Blanco; Heidi Kiil Blomhoff; Emilio Boada-Romero; Stefan Böckler; Marianne Boes; Kathleen Boesze-Battaglia; Lawrence H. Boise; Alessandra Bolino; Andrea Boman; Paolo Bonaldo; Matteo Bordi; Jürgen Bosch; Luis M. Botana; Joelle Botti; German Bou; Marina Bouché; Marion Bouchecareilh; Marie-Josée Boucher; Michael E. Boulton; Sebastien G. Bouret; Patricia Boya; Michaël Boyer-Guittaut; Peter V. Bozhkov; Nathan R. Brady; Vania M.M. Braga; Claudio Brancolini; Gerhard H. Braus; Bravo-San Pedro; Lisa A. Brennan; Emery H. Bresnick; Patrick Brest; Dave Bridges; Marie-Agnès Bringer; Marisa Brini; Glauber C. Brito; Bertha Brodin; Paul S. Brookes; Eric J. Brown; Brown; Hal E. Broxmeyer; Alain Bruhat; Patricia Chakur Brum; John H. Brumell; Nicola Brunetti-Pierri; Robert J. Bryson-Richardson; Shilpa Buch; Alastair M. Buchan; Hikmet Budak; Dmitry V. Bulavin; Scott J. Bultman; Geert Bultynck; Vladimir Bumbasirevic; Yan Burelle; Robert E. Burke; Margit Burmeister; Peter Bütikofer; Laura Caberlotto; Ken Cadwell; Monika Cahová; Dongsheng Cai; Jingjing Cai; Qian Cai; Sara Calatayud; Nadine Camougrand; Michelangelo Campanella; Grant R. Campbell; Matthew Campbell; Silvia Campello; Robin Candau; Isabella Caniggia; Lavinia Cantoni; Lizhi Cao; Allan B. Caplan; Michele Caraglia; Claudio Cardinali; Sandra M. Cardoso; Jennifer S. Carew; Laura A. Carleton; Cathleen R. Carlin; Silvia Carloni; Sven R. Carlsson; Didac Carmona-Gutierrez; Leticia A. M. Carneiro; Oliana Carnevali; Serena Carra; Alice Carrier; Bernadette Carroll; Caty Casas; Josefina Casas; Giuliana Cassinelli; Perrine Castets; Susana Castro-Obregon; Gabriella Cavallini; Isabella Ceccherini; Francesco Cecconi; Arthur I. Cederbaum; Valentín Ceña; Simone Cenci; Claudia Cerella; Davide Cervia; Silvia Cetrullo; Hassan Chaachouay; Han-Jung Chae; Andrei S. Chagin; Chee-Yin Chai; Gopal Chakrabarti; Georgios Chamilos; Edmond Y. Chan; Matthew T.V. Chan; Dhyan Chandra; Pallavi Chandra; Chih-Peng Chang; Raymond Chuen-Chung Chang; Ta Yuan Chang; John C. Chatham; Saurabh Chatterjee; Santosh Chauhan; Yongsheng Che; Michael E. Cheetham; Rajkumar Cheluvappa; Chun-Jung Chen; Gang Chen; Guang-Chao Chen; Guoqiang Chen; Hongzhuan Chen; Jeff W. Chen; Jian-Kang Chen; Min Chen; Mingzhou Chen; Peiwen Chen; Qi Chen; Quan Chen; Shang-Der Chen; Si Chen; Steve S.-L. Chen; Wei Chen; Wei-Jung Chen; Wen Qiang Chen; WenLi Chen; Xiangmei Chen; Yau-Hung Chen; Ye-Guang Chen; Yin Chen; Yingyu Chen; Yongshun Chen; Yu-Jen Chen; Yue-Qin Chen; Yujie Chen; Zhen Chen; Zhong Chen; Alan Cheng; Christopher H. K. Cheng; Hua Cheng; Heesun Cheong; Sara Cherry; Jason Chesney; Chun Hei Antonio Cheung; Eric Chevet; Hsiang Cheng Chi; Sung-Gil Chi; Fulvio Chiacchiera; Hui-Ling Chiang; Roberto Chiarelli; Mario Chiariello; Marcello Chieppa; Lih-Shen Chin; Mario Chiong; Gigi N.C. Chiu; Dong-Hyung Cho; Ssang-Goo Cho; William C. Cho; Yong-Yeon Cho; Young-Seok Cho; Augustine M. K. Choi; Eui-Ju Choi; Eun-Kyoung Choi; Jayoung Choi; Mary E. Choi; Seung-Il Choi; Tsui-Fen Chou; Salem Chouaib; Divaker Choubey; Vinay Choubey; Kuan-Chih Chow; Kamal Chowdhury; Charleen T. Chu; Tsung-Hsien Chuang; Taehoon Chun; Hyewon Chung; Taijoon Chung; Yuen-Li Chung; Yong-Joon Chwae; Valentina Cianfanelli; Roberto Ciarcia; Iwona A. Ciechomska; Maria R. Ciriolo; Mara Cirone; Sofie Claerhout; Michael J. Clague; Joan Cl� ria; Peter G. H. Clarke; Robert Clarke; Emilio Clementi; Cédric Cleyrat; Miriam Cnop; Eliana M. Coccia; Tiziana Cocco; Patrice Codogno; Jörn Coers; Ezra E W Cohen; David Colecchia; Luisa Coletto; Núria S. Coll; Emma Colucci-Guyon; Sergio Comincini; Maria Condello; Katherine L. Cook; Graham H. Coombs; Cynthia D. Cooper; J. Mark Cooper; Isabelle Coppens; Maria Tiziana Corasaniti; Marco Corazzari; Ramon Corbalan; Elisabeth Corcelle-Termeau; Mario D. Cordero; Cristina Corral-Ramos; Olga Corti; Andrea Cossarizza; Paola Costelli; Safia Costes; Susan L. Cotman; Ana Coto-Montes; Sandra Cottet; Eduardo Couve; Lori R. Covey; L. Ashley Cowart; Jeffery S. Cox; Fraser P. Coxon; Carolyn B. Coyne; Mark S. Cragg; Rolf J. Craven; Tiziana Crepaldi; José L. Crespo; Alfredo Criollo; Valeria Crippa; Maria Teresa Cruz; Ana Maria Cuervo; Jose M. Cuezva; Taixing Cui; Pedro R. Cutillas; Mark J. Czaja; Maria F. Czyzyk-Krzeska; Ruben K. Dagda; Uta Dahmen; Chunsun Dai; Wenjie Dai; Yun Dai; Kevin N. Dalby; Luisa Dalla Valle; Guillaume Dalmasso; Marcello D'Amelio; Markus Damme; Arlette Darfeuille-Michaud; Catherine Dargemont; Victor M. Darley-Usmar; Srinivasan Dasarathy; Biplab Dasgupta; Srikanta Dash; Crispin R. Dass; Hazel Marie Davey; Lester M. Davids; David Dávila; Roger J. Davis; Dawson; Dawson; Paula Daza; Jackie de Belleroche; Paul de Figueiredo; Regina Celia Bressan Queiroz de Figueiredo; José de la Fuente; Luisa De Martino; Antonella De Matteis; Guido R.Y. De Meyer; Angelo De Milito; Mauro De Santi; Wanderley de Souza; Vincenzo De Tata; Daniela De Zio; Jayanta Debnath; Reinhard Dechant; Jean-Paul Decuypere; Shane Deegan; Benjamin Dehay; Barbara Del Bello; Dominic P. Del Re; Régis Delage-Mourroux; Lea M. D. Delbridge; Louise Deldicque; Elizabeth Delorme-Axford; Yizhen Deng; Jörn Dengjel; Melanie Denizot; Paul Dent; Channing J. Der; Vojo Deretic; Benoît Derrien; Eric Deutsch; Timothy P. Devarenne; Rodney J. Devenish; Sabrina Di Bartolomeo; Di Daniele; Fabio Di Domenico; Alessia Di Nardo; Simone Di Paola; Antonio Di Pietro; Livia Di Renzo; Aaron Di Antonio; Guillermo Díaz-Araya; Inés Díaz-Laviada; Maria T. Diaz-Meco; Javier Diaz-Nido; Chad A. Dickey; Robert C. Dickson; Marc Diederich; Paul Digard; Ivan Dikic; Savithrama P. Dinesh-Kumar; Chan Ding; Wen-Xing Ding; Zufeng Ding; Luciana Dini; Jörg H.W. Distler; Abhinav Diwan; Mojgan Djavaheri-Mergny; Kostyantyn Dmytruk; Renwick C.J. Dobson; Volker Doetsch; Karol Dokladny; Svetlana Dokudovskaya; Massimo Donadelli; X. Charlie Dong; Louise Deldicque; Zheng Dong; Terrence M. Donohue; Terrence M. Donohue-Jr; Kelly S. Doran; Gabriella D'orazi; Gerald W. Dorn II; Victor Dosenko; Sami Dridi; Liat Drucker; Jie Du; Li-Lin Du; Lihuan Du; André du Toit; Priyamvada Dua; Lei Duan; Pu Duann; Vikash Kumar Dubey; Michael R. Duchen; Michel A. Duchosal; Helene Duez; Isabelle Dugail; Verónica I. Dumit; Mara C. Duncan; Elaine A. Dunlop; William A. Dunn; Nicolas Dupont; Luc Dupuis; Raúl V. Durán; Thomas M. Durcan; Stéphane Duvezin-Caubet; Umamaheswar Duvvuri; Vinay Eapen; Darius Ebrahimi-Fakhari; Arnaud Echard; Leopold Eckhart; Charles L. Edelstein; Aimee L. Edinger; Ludwig Eichinger; Tobias Eisenberg; Avital Eisenberg-Lerner; N. Tony Eissa; Wafik S. El-Deiry; Victoria El-Khoury; Zvulun Elazar; Hagit Eldar-Finkelman; Chris J.H. Elliott; Enzo Emanuele; Urban Emmenegger; Nikolai Engedal; Anna-Mart Engelbrecht; Simone Engelender; Jorrit M. Enserink; Ralf Erdmann; Jekaterina Erenpreisa; Rajaraman Eri; Jason L. Eriksen; Andreja Erman; Ricardo Escalante; Eeva-Liisa Eskelinen; Lucile Espert; Lorena Esteban-Martínez; Thomas J. Evans; Mario Fabri; Gemma Fabrias; Cinzia Fabrizi; Antonio Facchiano; Nils J. Færgeman; Alberto Faggioni; Fairlie; Chunhai Fan; Daping Fan; Jie Fan; Shengyun Fang; Manolis Fanto; Alessandro Fanzani; Thomas Farkas; Mathias Faure; Francois B. Favier; Howard Fearnhead; Massimo Federici; Erkang Fei; Tania C. Felizardo; Hua Feng; Yibin Feng; Yuchen Feng; Thomas A. Ferguson; Álvaro F. Fernández; Maite G. Fernandez-Barrena; Jose C. Fernandez-Checa; Arsenio Fernández-López; Martin E. Fernandez-Zapico; Olivier Feron; Elisabetta Ferraro; Carmen Veríssima Ferreira-Halder; László Fésüs; Ralph Feuer; Fabienne C. Fiesel; Eduardo C. Filippi-Chiela; Giuseppe Filomeni; Gian Maria Fimia; John Fingert; Steven Finkbeiner; Toren Finkel; Filomena Fiorito; Paul B. Fisher; Marc Flajolet; Flavio Flamigni; Oliver Florey; Salvatore Florio; R. Andres Floto; Marco Folini; Carlo Follo; Edward A. Fon; Francesco Fornai; Franco Fortunato; Alessandro Fraldi; Chunhai Fan; Arnaud Francois; Aurélie François; Lisa B. Frankel; Iain D.C. Fraser; Norbert Frey; Damien G. Freyssenet; Christian Frezza; Scott L. Friedman; Daniel E. Frigo; Dongxu Fu; José M. Fuentes; Juan Fueyo; Yoshio Fujitani; Yuuki Fujiwara; Mikihiro Fujiya; Mitsunori Fukuda; Fulda; Carmela Fusco; Bozena Gabryel; Matthias Gaestel; Philippe Gailly; Malgorzata Gajewska; Sehamuddin Galadari; Gad Galili; Inmaculada Galindo; Maria F. Galindo; Giovanna Galliciotti; Galluzzi; Luca Galluzzi; Vincent Galy; Noor Gammoh; Sam Gandy; Anand K. Ganesan; Swamynathan Ganesan; Ian G. 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Tooze; Ivan Topisirovic; Maria Lyngaas Torgersen; Liliana Torosantucci; Alicia Torriglia; Maria Rosaria Torrisi; Cathy Tournier; Roberto Towns; Vladimir Trajkovic; Leonardo H. Travassos; Gemma Triola; Durga Nand Tripathi; Daniela Trisciuoglio; Rodrigo Troncoso; Ioannis P. Trougakos; Anita C. Truttmann; Kuen-Jer Tsai; Mario P. Tschan; Yi-Hsin Tseng; Takayuki Tsukuba; Allan Tsung; Andrey S. Tsvetkov; Shuiping Tu; Hsing-Yu Tuan; Marco Tucci; David A. Tumbarello; Boris Turk; Vito Turk; Robin F.B. Turner; Anders A. Tveita; Suresh C. Tyagi; Makoto Ubukata; Yasuo Uchiyama; Andrej Udelnow; Takashi Ueno; Midori Umekawa; Rika Umemiya-Shirafuji; Benjamin R. Underwood; Christian Ungermann; Rodrigo P. Ureshino; Ryo Ushioda; Vladimir N. Uversky; Néstor L. Uzcátegui; Thomas Vaccari; Maria I. Vaccaro; Libuše Váchová; Helin Vakifahmetoglu-Norberg; Rut Valdor; Enza Maria Valente; Francois Vallette; Angela M. Valverde; Greet Van Den Berghe; Ludo Van Den Bosch; Gijs R. Van Den Brink; F. Gisou Van Der Goot; Ida J. Van Der Klei; Luc J.W. van der Laan; Wouter G. Van Doorn; Marjolein Van Egmond; Kenneth L. van Golen; Luc Van Kaer; Menno van Lookeren Campagne; Vandenabeele; Wim P. Vandenberghe; Ilse Vanhorebeek; Isabel Varela-Nieto; M. Helena Vasconcelos; Radovan Vasko; Demetrios G. Vavvas; Ignacio Vega-Naredo; Guillermo Velasco; Athanassios D. Velentzas; Panagiotis D. Velentzas; Tibor Vellai; Edo Vellenga; Mikkel Holm Vendelbo; Kartik Venkatachalam; Natascia Ventura; Salvador Ventura; Patrícia S.T. Veras; Mireille Verdier; Beata G. Vertessy; Andrea Viale; Michel Vidal; Helena L.A. Vieira; Richard D. Vierstra; Nadarajah Vigneswaran; Neeraj Vij; Miquel Vila; Margarita Villar; Victor H. Villar; Joan Villarroya; Cécile Vindis; Giampietro Viola; Maria Teresa Viscomi; Giovanni Vitale; Dan T. Vogl; Olga V. Voitsekhovskaja; Clarissa Von Haefen; Karin von Schwarzenberg; Daniel E. Voth; Valérie Vouret-Craviari; Kristina Vuori; Jatin M. Vyas; Christian Waeber; Cheryl L. Walker; Mark J. Walker; Jochen Walter; Lei Wan; Xiangbo Wan; Bo Wang; Caihong Wang; Chao-Yung Wang; Chengshu Wang; Chenran Wang; Chuangui Wang; Dong Wang; Fen Wang; Fuxin Wang; Guanghui Wang; Hai-Jie Wang; Haichao Wang; Hong-Gang Wang; Hongmin Wang; Horng-Dar Wang; Jing Wang; Junjun Wang; Mei Wang; Mei-Qing Wang; Pei-Yu Wang; Peng Wang; Richard C. Wang; Shuo Wang; Ting-Fang Wang; Xian Wang; Xiao-Jia Wang; Xiao-Wei Wang; Xin Wang; Xuejun Wang; Yan Wang; Yanming Wang; Ying Wang; Ying-Jan Wang; Yipeng Wang; Yu Wang; Yu Tian Wang; Yuqing Wang; Zhinong Wang; Pablo Wappner; Carl Ward; Diane M. Ward; Gary Warnes; Hirotaka Watada; Yoshihisa Watanabe; Kei Watase; Timothy E. Weaver; Colin D. Weekes; Jiwu Wei; Thomas Weide; Conrad C. Weihl; Günther Weindl; Simone Nardin Weis; Long-Ping Wen; Xin Wen; Yunfei Wen; Benedikt Westermann; Cornelia M. Weyand; Anthony R. White; White; J. Lindsay Whitton; Alexander J. Whitworth; Joëlle Wiels; Franziska Wild; Manon E. Wildenberg; Tom Wileman; Deepti Srinivas Wilkinson; Simon Wilkinson; Dieter Willbold; Chris Williams; Katherine Williams; Peter R. Williamson; Konstanze F. Winklhofer; Steven S. Witkin; Stephanie E. Wohlgemuth; Thomas Wollert; Ernst J. Wolvetang; Esther Wong; G. William Wong; Richard W. Wong; Vincent Kam Wai Wong; Elizabeth A. Woodcock; Karen L. Wright; Chunlai Wu; Defeng Wu; Gen Sheng Wu; Jian Wu; Junfang Wu; Mian Wu; Min Wu; Shengzhou Wu; William K. K. Wu; Yaohua Wu; Zhenlong Wu; Cristina P.R. Xavier; Ramnik J. 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Young; Huixin Yu; Jane J. Yu; Jin-Tai Yu; Jun Yu; Li Yu; W. Haung Yu; Xiao-Fang Yu; Zhengping Yu; Yuan; Zhi-Min Yuan; Beatrice Y.J.T. Yue; Jianbo Yue; Zhenyu Yue; David N. Zacks; Eldad Zacksenhaus; Nadia Zaffaroni; Tania Zaglia; Zahra Zakeri; Vincent Zecchini; Jinsheng Zeng; Min Zeng; Qi Zeng; Antonis S. Zervos; Donna D. Zhang; Fan Zhang; Guo Zhang; Guo-Chang Zhang; Hao Zhang; Hong Zhang; Hongbing Zhang; Jian Zhang; Jiangwei Zhang; Jianhua Zhang; Jing-Pu Zhang; Li Zhang; Lin Zhang; Long Zhang; Ming-Yong Zhang; Xiangnan Zhang; Xu Dong Zhang; Yan Zhang; Yang Zhang; Yanjin Zhang; Yingmei Zhang; Yunjiao Zhang; Mei Zhao; Wei-Li Zhao; Xiaonan Zhao; Yan G. Zhao; Ying Zhao; Yongchao Zhao; Yu-Xia Zhao; Zhendong Zhao; Zhizhuang J. Zhao; Dexian Zheng; Xi-Long Zheng; Xiaoxiang Zheng; Boris Zhivotovsky; Qing Zhong; Guang-Zhou Zhou; Guofei Zhou; Huiping Zhou; Shu-Feng Zhou; Xu-Jie Zhou; Hongxin Zhu; Hua Zhu; Wei-Guo Zhu; Wenhua Zhu; Xiao-Feng Zhu; Yuhua Zhu; Shi-Mei Zhuang; Xiaohong Zhuang; Elio Ziparo; Christos E. Zois; Teresa Zoladek; Wei-Xing Zong; Antonio Zorzano; Susu M. Zughaier

January 1, 2016

Disposition and metabolism of [14C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects

Xenobiotica, ISSN: 13665928 00498254

Jimmy Flarakos; Yancy Du; Timothy Bedman; Qusai Al-Share; Pierre Jordaan; Priya Chandra; Diego Albrecht; Lai Wang; Helen Gu; Heidi J. Einolf; Su-Er Huskey; James B. Mangold

January 1, 2016

Absorption, metabolism, excretion, and the contribution of intestinal metabolism to the oral disposition of [14C]cobimetinib, a MEK inhibitor, in humans

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Ryan Takahashi; Edna F. Choo; Shuguang Ma; Susan C. Wong; Jason S Halladay; Yuzhong Deng; Isabelle Rooney; Mary Gates; Cornelis E. Hop; S. Cyrus Khojasteh; Mark J. Dresser; Luna Musib

January 1, 2016

Inhibition of Notch Signaling during Mouse Incisor Renewal Leads to Enamel Defects

Journal of Bone and Mineral Research, ISSN: 15234681 08840431

Andrew H. Jheon; Michaela Prochazkova; Bo Meng; Timothy Wen; Young-Jun Lim; Adrien Naveau; Ruben Espinoza; Timothy C. Cox; Eli D. Sone; Bernhard Ganss; Christian W. Siebel; Ophir D. Klein

January 1, 2016

Population pharmacokinetic and exposure-response analysis for trastuzumab administered using a subcutaneous "manual syringe" injection or intravenously in women with HER2-positive early breast cancer

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Angelica Quartino; Carina Hillenbach; Jing Li; Hanbin Li; Russell D. Wada; Jennifer Visich; Chunze Li; Dominik Heinzmann; Jin Y. Jin; Bert L. Lum

January 1, 2016

Population Pharmacokinetic Model of Cabozantinib in Patients with Medullary Thyroid Carcinoma and Its Application to an Exposure-Response Analysis

Clinical Pharmacokinetics, ISSN: 11791926 03125963

Dale Miles; Nelson L'ntshotsholé Jumbe; Steven Lacy; Linh Nguyen

January 1, 2016

Effects of enzastaurin and its metabolites on the QT interval in cancer patients

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Pamela A. Welch; Wee Teck Ng; Christelle L. Darstein; Luna Musib; Thierry Lesimple

January 1, 2016

Developing antagonists for the Met-HGF/SF protein-protein interaction using a fragment-based approach

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Anja Winter; Anna G. Sigurdardottir; Danielle DiCara; Giovanni Valenti; Tom L. Blundell; Ermanno Gherardi

January 1, 2016

Development of a patient-reported outcome instrument to assess complex activities of daily living and interpersonal functioning in persons with mild cognitive impairment: The qualitative research phase

Alzheimer's and Dementia, ISSN: 15525279 15525260

Mark Forrest Gordon; William R. Lenderking; Amy Duhig; Julie Chandler; J. Jason Lundy; David S. Miller; Elisabeth Piault-Louis; Rachelle S. Doody; Douglas Galasko; Serge Gauthier; Lori Frank

January 1, 2016

Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach

Journal of Lipid Research, ISSN: 15397262 00222275

Kapil Gadkar; James Lu; Srikumar Sahasranaman; John Davis; Norman A. Mazer; Ramanujan

January 1, 2016

Efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA)

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Gerd R. Burmester; Rubbert-Roth; Alain Cantagrel; Stephen Hall; Piotr Leszczynski; Daniel Feldman; Madura J. Rangaraj; Georgia Roane; Charles Ludivico; Bao; Lucy Rowell; Claire Davies; Eduardo F. Mysler

January 1, 2016

Recommendations for Use and Fit-for-Purpose Validation of Biomarker Multiplex Ligand Binding Assays in Drug Development

AAPS Journal, ISSN: 15507416

Darshana Jani; John Allinson; Flora Berisha; Kyra J. Cowan; Viswanath Devanarayan; Carol Gleason; Andreas Jeromin; Steve Keller; Masood U. Khan; Bill Nowatzke; Paul Rhyne; Laurie Stephen

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