Genentech: Publications

July 18, 2015

Big data analysis of treatment patterns and outcomes among elderly acute myeloid leukemia patients in the United States

Annals of Hematology, ISSN: 14320584 09395555

Bruno C. Medeiros; Sacha Satram-Hoang; Deborah Hurst; Khang Q. Hoang; Faiyaz Momin; Carolina Reyes

July 17, 2015

Single-Step Synthesis of 5,6,7,8-Tetrahydroindolizines via Annulation of 2-Formylpiperidine and 1,3-Dicarbonyl Compounds

Organic Letters, ISSN: 15237052 15237060

Simona S. Capomolla; Ngiap-Kie Lim; Haiming Zhang

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July 15, 2015

Detection and dynamic changes of EGFR mutations from circulating tumor DNA as a predictor of survival outcomes in NSCLC Patients treated with first-line intercalated erlotinib and chemotherapy

Clinical Cancer Research, ISSN: 15573265 10780432

Tony Mok; Yi-Long Wu; Jin Soo Lee; Chong-Jen Yu; Virote Sriuranpong; Jennifer Sandoval-Tan; Guia Ladrera; Sumitra Thongprasert; Vichien Srimuninnimit; Meilin Liao; Yunzhong Zhu; Caicun Zhou; Fatima Fuerte; Benjamin Margono; Wei Wen; Julie Tsai; Matt Truman; Barbara Klughammer; David S. Shames; Lin Wu

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July 15, 2015

A novel anti-CD22 anthracycline-based antibody-drug conjugate (ADC) that overcomes resistance to auristatin-based ADCs

Clinical Cancer Research, ISSN: 15573265 10780432

Shang-Fan Yu; Bing Zheng; MaryAnn Go; Jeffrey Lau; Spencer; Helga Raab; Robert Soriano; Suchit Jhunjhunwala; Robert Cohen; Michele Caruso; Paul G. Polakis; Flygare; Andrew G. Polson

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July 15, 2015

An antibody-drug conjugate directed against lymphocyte antigen 6 complex, locus E (LY6E) provides robust tumor killing in a wide range of solid tumor malignancies

Clinical Cancer Research, ISSN: 15573265 10780432

Jyoti Asundi; Lisa Crocker; Jarrod Tremayne; Peter Chang; Sakanaka; Josh Tanguay; Spencer; Sreedevi Chalasani; Luis; Karen Gascoigne; Rupal Desai; Rajiv Raja; Brad A. Friedman; Matthias Peter; Paul G. Polakis; Ron Firestein

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July 14, 2015

Design of a selective substrate and activity based probe for human neutrophil serine protease 4

PLoS ONE, ISSN: 19326203

Paulina Kasperkiewicz; Marcin Poreba; Scott J. Snipas; S. Jack Lin; Daniel Kirchhofer; Guy S. Salvesen; Marcin Drag

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July 13, 2015

Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes

Leukemia, ISSN: 14765551 08876924

Pfeifer; Bing Zheng; Erdmann; Koeppen; Mccord; Grau; Staiger; Akiko Chai; Thomas Sandmann; Madle; Dörken; Yu-Waye Chu; Chen; Lebovic; Gilles Salles; Myron S. Czuczman; Palanca-Wessels; Oliver W. Press; Ranjana H. Advani; Morschhauser; Bruce D. Cheson; Lenz; Ott; Andrew G. Polson; Kirsten E. Mundt; Lenz

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July 11, 2015

Comparative healthcare costs in patients with metastatic melanoma in the USA

Melanoma Research, ISSN: 14735636 09608931

Chun-Lan Chang; Vernon F. Schabert; Julie Munakata; Prina Donga; Sarang Abhyankar; Carolina Reyes; Yeun Mi Yim

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July 10, 2015

Using whole genome analysis to examine recombination across diverse sequence types of Staphylococcus aureus

PLoS ONE, ISSN: 19326203

Elizabeth M. Driebe; Jason W. Sahl; Chandler Roe; Jolene R. Bowers; James M. Schupp; John D. Gillece; Erin Kelley; Lance B. Price; Talima R. Pearson; Crystal M. Hepp; Pius M. Brzoska; Craig A. Cummings; Manohar Furtado; Paal S. Andersen; Marc Stegger; David M. Engelthaler; Paul S. Keim

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July 9, 2015

Discovery of 1-{4-[3-Fluoro-4-((3 S,6 R)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Benjamin P. Fauber; Olivier René; Yuzhong Deng; Jason Devoss; Celine Eidenschenk; Christine Everett; Arunima Ganguli; Alberto Gobbi; Julie Hawkins; Adam R. Johnson; Hank La; Justin Lesch; Peter Lockey; Maxine Norman; Wenjun Ouyang; Susan Summerhill; Harvey Wong

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July 9, 2015

Key challenges in the treatment of rare pediatric skeletal genetic disorders: from bench to bedside

Drug Discovery Today, ISSN: 18785832 13596446

Florence Lorget; Laurence Legeai-Mallet

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July 7, 2015

BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase

Nature Communications, ISSN: 20411723

Asad M. Taherbhoy; Oscar W Huang; Andrea G Cochran

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July 6, 2015

Solid-State Characterization of Novel Propylene Glycol Ester Solvates Isolated from Lipid Formulations

Molecular Pharmaceutics, ISSN: 15438392 15438384

Paroma Chakravarty; Sanjeev Kothari; Alan Deese; Joseph W. Lubach

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July 6, 2015

Oral immunotherapy and anti-IgE antibody treatment for food allergy

World Allergy Organization Journal, ISSN: 19394551

Dale T. Umetsu; Rima Rachid; Lynda C. Schneider

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July 3, 2015

Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: Comparative analysis, molecular docking, bioactivation and toxicological implications

Drug Metabolism Reviews, ISSN: 10979883 03602532

Kevin A. Ford; Gregory Ryslik; Jasleen K. Sodhi; Jason S Halladay; Dolores Diaz; Donna M. Dambach; Melisa Masuda

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July 3, 2015

Understanding and Addressing the Unbounded “Likelihood” Problem

American Statistician, ISSN: 15372731 00031305

Shiyao Liu; Huaiqing Wu; William Q. Meeker

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July 2, 2015

Direct and indirect targeting of MYC to treat acute myeloid leukemia

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Sam Brondfield; Sushma Umesh; Alexandra Corella; Johannes Zuber; Amy R. Rappaport; Coline Gaillard; Scott W. Lowe; Andrei Goga; Scott Kogan

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July 2, 2015

Direct and indirect targeting of MYC to treat acute myeloid leukemia

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Sam Brondfield; Sushma Umesh; Alexandra Corella; Johannes Zuber; Amy R. Rappaport; Coline Gaillard; Scott W. Lowe; Andrei Goga; Scott C. Kogan

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July 1, 2015

Vented Spikes Improve Delivery from Intravenous Bags with No Air Headspace

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

William J. Galush; Travis A. Horst

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July 1, 2015

Predictors of Functional and Anatomic Outcomes in Patients with Diabetic Macular Edema Treated with Ranibizumab

Ophthalmology, ISSN: 15494713 01616420

Raafay Sophie; Na Lu; Peter A. Campochiaro

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July 1, 2015

Health-related quality of life in a randomized phase III study of bevacizumab, temozolomide, and radiotherapy in newly diagnosed glioblastoma

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Martin J. B. Taphoorn; Roger Henriksson; Andrew Bottomley; Timothy Cloughesy; Wick; Warren Mason; Frank Saran; Ryo Nishikawa; Magalie Hilton; Christina Theodore-Oklota; Arliene Ravelo; Olivier L. Chinot

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July 1, 2015

Comparative Study of Analytical Techniques for Determining Protein Charge

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Dana I. Filoti; Steven J. Shire; Sandeep Yadav; Thomas M. Laue

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July 1, 2015

Use of cassette dosing to enhance the throughput of rat brain microdialysis studies

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Gauri Deshmukh; Kefeng Sun; Bianca M. Liederer; Xiao Ding; Xingrong Liu

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July 1, 2015

Conformational Isomerism in Solid State of AMG 853 - Structure Studies Using Solid-State Nuclear Magnetic Resonance and X-ray Diffraction

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Kiang; Karthik Nagapudi; Tian Wu; Matthew L. Peterson; Janan Jona; Richard J. Staples; Peter W. Stephens

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July 1, 2015

Intratumoral heterogeneity: From diversity comes resistance

Clinical Cancer Research, ISSN: 15573265 10780432

Ariel Pribluda; Cecile C. de la Cruz; Erica L. Jackson

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July 1, 2015

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

EBioMedicine, ISSN: 23523964

Ganesh Kolumam; Mark Chen; Raymond K. Tong; Jose Zavala-Solorio; Lance Kates; Nicholas Van Bruggen; Ross; Shelby K. Wyatt; Vineela D. Gandham; Richard A. D. Carano; Diana Ronai Dunshee; Ai-Luen Wu; Benjamin Haley; Keith R. Anderson; Søren Warming; Xin Y. Rairdan; Nicholas Lewin-Koh; Yingnan Zhang; Johnny Gutierrez; Amos Baruch; Thomas R. Gelzleichter; Dale Stevens; Sharmila Rajan; Travis W. Bainbridge; Jean-Michel Vernes; Meng; James Ziai; Robert Soriano; Matthew J. Brauer; Yongmei Chen; Scott Stawicki; Hok Seon Kim; Laetitia Comps-Agrar; Luis; Christoph Spiess; Yan Wu; James A. Ernst; Owen P. McGuinness; Andrew S. Peterson; Junichiro Sonoda

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July 1, 2015

Upregulation of periostin and reactive stroma is associated with primary chemoresistance and predicts clinical outcomes in epithelial ovarian cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Lisa Ryner; Yinghui Guan; Ron Firestein; Yuanyuan Xiao; Younjeong Choi; Christina Rabe; Shan Lu; Eloisa Fuentes; Huw; Lackner; Ling Fu; Lukas Amler; Carlos Bais; Wang

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July 1, 2015

Sulfonic Acid Salts of Donepezil and Stabilization of Amorphous Donepezil via Formation of Amorphous Salts

Crystal Growth and Design, ISSN: 15287505 15287483

Sun Hye Lee; Jae Ho Bae; Yeojin Park; Bishal Raj Adhikari; Chen Mao; Daeyoung Kim; Kyung Im Kim; Sung Kwon Kang; Eun Hee Lee

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July 1, 2015

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer

Pharmacology and Therapeutics, ISSN: 1879016X 01637258

Deepak Sampath; Tanja S. Zabka; Misner; Thomas O'Brien; Peter Dragovich

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July 1, 2015

Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice

Diabetologia, ISSN: 14320428 0012186X

Samantha L. Hocking; Rebecca L. Stewart; Amanda E. Brandon; Eurwin Suryana; Ella Stuart; Emily M. Baldwin; Ganesh Kolumam; Zora Modrusan; Jagath R. Junutula; Jenny E. Gunton; Michael Medynskyj; Sinead P. Blaber; Elisabeth Karsten; Benjamin R. Herbert; David E. James; Gregory J. Cooney; Michael M. Swarbrick

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July 1, 2015

The Cost-Effectiveness of Ranibizumab for the Treatment of Diabetic Macular Edema

Ophthalmology, ISSN: 15494713 01616420

Gary C. Brown; Melissa M. Brown; Adam Turpcu; Yamina Rajput

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July 1, 2015

Risk of corticosteroid-related adverse events in asthma patients with high oral corticosteroid use

Allergy and Asthma Proceedings, ISSN: 15396304 10885412

James L. Zazzali; Michael S. Broder; Theodore A. Omachi; Eunice Chang; Gordon H. Sun; Karina Raimundo

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July 1, 2015

Response-adapted therapy for aggressive non-Hodgkin's lymphomas based on early [18F] FDG-PET scanning: ECOG-ACRIN Cancer Research Group study (E3404)

British Journal of Haematology, ISSN: 13652141 00071048

Lode J. Swinnen; Hailun Li; Andrew Quon; Randy D. Gascoyne; Fangxin Hong; Erik A. Ranheim; Thomas M. Habermann; Brad Kahl; Sandra J. Horning; Ranjana H. Advani

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July 1, 2015

A phase II, multicenter, open-label, 3-cohort trial evaluating the efficacy and safety of vismodegib in operable basal cell carcinoma

Journal of the American Academy of Dermatology, ISSN: 10976787 01909622

Howard Sofen; Kenneth G. Gross; Leonard Goldberg; Harry Sharata; Tiffani K. Hamilton; Barbara Egbert; Benjamin Lyons; Jeannie Hou; Ivor Caro

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July 1, 2015

Changes in asthma control, work productivity, and impairment with omalizumab: 5-year EXCELS study results

Allergy and Asthma Proceedings, ISSN: 15396304 10885412

James L. Zazzali; Karina Raimundo; Benjamin L. Trzaskoma; Karin Rosén; Michael Schatz

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July 1, 2015

Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma-related mortality in elderly follicular lymphoma in the United States

British Journal of Haematology, ISSN: 13652141 00071048

Chadi Nabhan; Michelle Byrtek; Ashish Rai; Keith Dawson; Zhou; Brian K. Link; Jonathan W. Friedberg; Zelenetz; Matthew J. Maurer; James R. Cerhan; Christopher R. Flowers

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July 1, 2015

Hydrophobic interaction chromatography for antibody drug conjugate drug distribution analysis

American Pharmaceutical Review, ISSN: 10998012

Tao Chen; Kelly Zhang; Jason Gruenhagen; Colin D. Medley

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July 1, 2015

Effectiveness of rituximab for the treatment of rheumatoid arthritis in patients with prior exposure to anti-TNF: Results from the CORRONA registry

Journal of Rheumatology, ISSN: 14992752 0315162X

Leslie R. Harrold; Reed; Ashwini Shewade; Robert Magner; Katherine C. Saunders; Ani John; Joel M. Kremer; Jeffrey D. Greenberg

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July 1, 2015

Notch receptor-ligand engagement maintains hematopoietic stem cell quiescence and niche retention

Stem Cells, ISSN: 15494918 10665099

Weihuan Wang; Shuiliang Yu; Grant Zimmerman; Yiwei Wang; Jay Myers; Vionnie W. C. Yu; Dan Huang; Xiaoran Huang; Jeongsup Shim; Yuanshuai Huang; William Xin; Peter Qiao; Minhong Yan; Wei Xin; David T. Scadden; Pamela Stanley; John Lowe; Alex Y. Huang; Christian W. Siebel; Lan Zhou

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July 1, 2015

Projected clinical, resource use, and fiscal impacts of implementing low-dose computed tomography lung cancer screening in Medicare

Journal of Oncology Practice, ISSN: 1935469X 15547477

Joshua A. Roth; Sean D. Sullivan; Bernardo H. L. Goulart; Arliene Ravelo; Joanna C. Sanderson; Scott D. Ramsey

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July 1, 2015

Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Ada Hui; Lam; Christopher Kuehl; Ulla Grauschopf; Y. John Wang

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July 1, 2015

Response-adapted therapy for aggressive non-Hodgkin's lymphomas based on early [18F] FDG-PET scanning: ECOG-ACRIN Cancer Research Group study (E3404)

British Journal of Haematology, ISSN: 13652141 00071048

Lode J. Swinnen; Hailun Li; Andrew Quon; Randy D. Gascoyne; Fangxin Hong; Erik A. Ranheim; Thomas M. Habermann; Wojciech Jurczak; Sandra J. Horning; Ranjana H. Advani

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June 30, 2015

The evolutionary divergence of TRPA1 channel: heat-sensitive, cold-sensitive and temperature-insensitive

Temperature, ISSN: 23328959 23328940

Jun Chen

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June 30, 2015

Responses to discussants of 'Joint modeling of survival and longitudinal non-survival data: Current methods and issues. report of the DIA Bayesian joint modeling working group'

Statistics in Medicine, ISSN: 10970258 02776715

A. Lawrence Gould; Mark Ernest Boye; Michael J. Crowther; Joseph G. Ibrahim; George Quartey; Sandrine Micallef; Frederic Y. Bois

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June 30, 2015

Joint modeling of survival and longitudinal non-survival data: Current methods and issues. Report of the DIA Bayesian joint modeling working group

Statistics in Medicine, ISSN: 10970258 02776715

A. Lawrence Gould; Mark Ernest Boye; Michael J. Crowther; Joseph G. Ibrahim; George Quartey; Sandrine Micallef; Frederic Y. Bois

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June 29, 2015

Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

Journal of Experimental Medicine, ISSN: 15409538 00221007

Derek A. Holmes; Eric Suto; Wyne P. Lee; Qinglin Ou; Qian Gong; Hamish R.C. Smith; Patrick Caplazi; Andrew A. Chan

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June 26, 2015

Final report on exposure during pregnancy from a pregnancy registry for quadrivalent human papillomavirus vaccine

Vaccine, ISSN: 18732518 0264410X

Mary Ann Goss; Fabio Lievano; Karyn M. Buchanan; Margaret M. Seminack; Michael L. Cunningham; Adrian Dana

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June 26, 2015

The role of FcεRI expressed in dendritic cells and monocytes

Cellular and Molecular Life Sciences, ISSN: 14209071 1420682X

Jeoung-Sook Shin; Alexandra M. Greer

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June 25, 2015

Structure-Guided Design of Group i Selective p21-Activated Kinase Inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

James J. Crawford; Wendy Lee; Ignacio Aliagas; Simon Mathieu; Klaus P. Hoeflich; Wei Zhou; Weiru Wang; Lionel Rouge; Lesley J. Murray; Hank La; Ning Liu; Peter W. Fan; Jonathan Cheong; Christopher E. Heise; Sreemathy Ramaswamy; Robert Mintzer; Yanzhou Liu; Qi Chao; Joachim Rudolph

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June 25, 2015

Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Lewis Gazzard; Karen Williams; Huifen Chen; Lorraine Axford; Elizabeth M. Blackwood; Brenda Burton; Kerry Chapman; Peter H. Crackett; Joy Drobnick; Charles Ellwood; Jennifer A. Epler; Michael Flagella; Emanuela Gancia; Matthew Gill; Simon Goodacre; Jason S Halladay; Joanne F. M. Hewitt; Hazel Hunt; Samuel Kintz; Joseph P. Lyssikatos; Calum Macleod; Sarah Major; Guillaume Médard; Raman Narukulla; Judi Ramiscal; Stephen Schmidt; Eileen Seward; Wiesmann; Ping Wu; Sharon Fong Yee; Ivana Yen; Shiva Malek

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