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Publications

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DISPLAYING 5701 - 5750 OF 15390 RESULTS

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits
PLoS ONE, ISSN: 19326203
Dorothée Diogo; Lisa Bastarache; Katherine P. Liao; Robert R. Graham; Robert S. Fulton; Greenberg; Steve Eyre; John Bowes; Jing Cui; Annette T. Lee; Dimitrios A. Pappas; Joel M. Kremer; Anne Barton; Marieke J.H. Coenen; Barbara Franke; Lambertus A. Kiemeney; Xavier Mariette; Corrine Richard-Miceli; Helena Canhão; João E. Fonseca; Niek De Vries; Paul P. Tak; J. Bart A. Crusius; Michael T. Nurmohamed; Fina Kurreeman; Ted R. Mikuls; Yukinori Okada; Eli A. Stahl; David E. Larson; Tracie L. Deluca; Michelle O'Laughlin; Catrina C. Fronick; Lucinda L. Fulton; Kosoy; Michael Ransom; Tushar Bhangale; Ward Ortmann; Andrew Cagan; Vivian Gainer; Elizabeth W. Karlson; Isaac Kohane; Shawn N. Murphy; Javier Martin; Alexandra Zhernakova; Lars Klareskog; Leonid Padyukov; Jane Worthington; Elaine R. Mardis; Michael F. Seldin; Peter K. Gregersen; Timothy W. Behrens; Soumya Raychaudhuri; Joshua C. Denny; Robert M. Plenge
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Structural analysis of bacterial ABC transporter inhibition by an antibody fragment
Structure, ISSN: 18784186 09692126
Shivani Ahuja; Lionel Rouge; Danielle L. Swem; Jawahar Sudhamsu; Ping Wu; Russell; Mary Kate Alexander; Christine Tam; Mireille Nishiyama; Melissa A. Starovasnik; Christopher M. Koth
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Opposing activities of notch and wnt signaling regulate intestinal stem cells and gut homeostasis
Cell Reports, ISSN: 22111247
Hua Tian; Brian Biehs; Cecilia Chiu; Christian W. Siebel; Yan Wu; Michael Costa; Frederic J. De Sauvage; Ophir D. Klein
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MET gene copy number alterations and expression of MET and hepatocyte growth factor are potential biomarkers in angiosarcomas and undifferentiated pleomorphic sarcomas
PLoS ONE, ISSN: 19326203
Katja Schmitz; Koeppen; Elke Binot; Jana Fassunke; Helen Künstlinger; Michaela A. Ihle; Carina Heydt; Eva Wardelmann; Reinhard Büttner; Sabine Merkelbach-Bruse; Josef Rüschoff; Hans-Ulrich Schildhaus
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Development of orthogonally protected hypusine for solid-phase peptide synthesis
Journal of Organic Chemistry, ISSN: 15206904 00223263
Aimin Song; Jeffrey Tom; Zhiyong Yu; Victoria Pham; Dajin Tan; Dengxiong Zhang; Guoyong Fang; Tao Yu; Deshayes
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Using oxidation-reduction chemistry in sample preparation for sub-PPM quantitation by LC/MS
Journal of Liquid Chromatography and Related Technologies, ISSN: 1520572X 10826076
Mohammad Al-Sayah; Yong Liu; Roy Helmy; Peter M. Yehl
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Statistical methods for estimating the minimum thickness along a pipeline
Technometrics, ISSN: 15372723 00401706
Shiyao Liu; William Q. Meeker
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Contribution of metabolites to P450 inhibition-Based Drug-Drug interactions: Scholarship from the drug metabolism leadership group of the innovation and quality consortium metabolite group
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Hongbin Yu; Suresh K. Balani; Weichao Chen; Donghui Cui; Ling He; W. Griffith Humphreys; Jialin Mao; W. George Lai; Anthony J. Lee; Heng-Keang Lim; Christopher MacLauchlin; Chandra Prakash; Sekhar Surapaneni; Susanna Tse; Alana Upthagrove; Robert L. Walsky; Bo Wen; Zhaopie Zeng
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Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: The OLIVIA multinational randomised phase II trial
Annals of Oncology, ISSN: 15698041 09237534
Thomas Gruenberger; Bridgewater; Chau; Garcia Alfonso; Rivoire; Mudan; Susan F. Lasserre; Frank Hermann; Waterkamp; Adam
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The quintessence of immunogenicity reporting for biotherapeutics
Nature Biotechnology, ISSN: 15461696 10870156
Gopi Shankar; Arkin; Viswanath Devanarayan; Kromminga; Quarmby; Richards; Subramanyam; Steven J. Swanson
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Immunohistochemical Detection of FLAG-Tagged Endogenous Proteins in Knock-In Mice
Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554
Ron Ferrando; Kim Newton; Felix Chu; Webster; French
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Clinical outcomes in elderly patients with advanced non-small cell lung cancer: Results from ARIES, a bevacizumab observational cohortstudy
Clinical Oncology, ISSN: 14332981 09366555
Antoinette J. Wozniak; Michael Kosty; Mohammad Jahanzeb; Julie Brahmer; David Spigel; Larry Leon; Susan Fish; E. Dawn Flick; Sebastien J. Hazard; Thomas J. Lynch
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Feasibility and cardiac safety of trastuzumab emtansine after anthracycline-based chemotherapy as (neo)adjuvant therapy for human epidermal growth factor receptor 2-positive early-stage breast cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Ian E. Krop; Suter; Chau T. Dang; Luc Dirix; Romieu; Claudio Zamagni; Marc L. Citron; Mario Campone; Xu; Melanie Smitt; Luca Gianni
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Basal cells contribute to innate immunity of the airway epithelium through production of the antimicrobial protein RNase 7
Journal of Immunology, ISSN: 15506606 00221767
Gimano D. Amatngalim; Yolanda Van Wijck; Yvonne De Mooij-Eijk; Renate M. Verhoosel; Jürgen Harder; Annemarie N. Lekkerkerker; Richard A. J. Janssen; Pieter S. Hiemstra
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Incidence of liver injury among cancer patients receiving chemotherapy in an integrated health system
Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569
Marianne Ulcickas Yood; Michele Bortolini; Deborah Casso; Jean G. Beck; Susan A. Oliveria; Karen E. Wells; Kimberley J. Woodcroft; Lisa I. Wang
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Effects of intravitreal ranibizumab on retinal hard exudate in diabetic macular edema: Findings from the RIDE and RISE phase III clinical trials
Ophthalmology, ISSN: 15494713 01616420
Amitha Domalpally; Michael S. Ip; Jason S. Ehrlich
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Reported consent processes and demographics: A substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial
HIV Medicine, ISSN: 14681293 14642662
Denning; Sharma; Smolskis; Touloumi; Walker; Babiker; Clewett; Ezekiel Emanuel; Florence; Papadopoulos; Sánchez; Jorge A. Tavel; Christine Grady
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Rituximab versus cyclophosphamide for ANCA-associated vasculitis with renal involvement
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Duvuru Geetha; Specks; John H. Stone; Merkel; Seo; Spiera; Langford; Hoffman; Cees Kallenberg; St.clair; Barri J. Fessler; Linna Ding; Tchao; Iklé; Brett Jepson; Paul Brunetta; Fervenza
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Risk factors for hemorrhagic cystitis in pediatric allogeneic hematopoietic stem cell transplant recipients
Transplant Infectious Disease, ISSN: 13993062 13982273
Hayden; Gu; Liu; Lovins; Kasow; Woodard; Srivastava; Leung
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Differential effects of tyrosine kinase inhibitors on normal and oncogenic EGFR signaling and downstream effectors
Molecular Cancer Research, ISSN: 15573125 15417786
Youngjoo Kim; Mihaela Apetri; Beibei Luo; Jeffrey Settleman; Karen S. Anderson
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Mass spectrometric quantification of histone post-translational modifications by a hybrid chemical labeling method
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Tobias Maile; Anita Izrael-Tomasevic; Tommy K. Cheung; Gulfem D. Guler; Charles Tindell; Alexandre Masselot; Jun Liang; Feng Zhao; Patrick Trojer; Marie Classon; David Arnott
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Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Melissa Mun; Stefanie Khoo; Aline Do Minh; James Dvornicky; Melody Trexler-Schmidt; Kao; Mike Laird
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Impact of age and medical comorbidity on adjuvant treatment outcomes for stage III colon cancer: A pooled analysis of individual patient data from four randomized, controlled trials
Annals of Oncology, ISSN: 15698041 09237534
Daniel Haller; Michael J O'Connell; Cartwright; Chris Twelves; Edward McKenna; Sun; Muhammad Saif; Lee; Greg Yothers; Hans-Joachim Schmoll
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cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection
Journal of Immunology, ISSN: 15506606 00221767
Kelly M. Storek; Nina A. Gertsvolf; Maikke B. Ohlson; Denise M. Monack
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Characteristics and temporal trends in patient registries: Focus on the life sciences industry, 1981-2012
Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569
Karin Travers; Rachel H. Sallum; Meghan D. Burns; Charles E. Barr; Beattie; Chris L. Pashos; Bryan R. Luce
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Does patient rurality predict quality colon cancer care?: A population-based study
Diseases of the Colon and Rectum, ISSN: 15300358 00123706
Christopher J. Chow; Waddah B. Al-Refaie; Anasooya Abraham; Abraham Markin; Wei Zhong; David A. Rothenberger; Mary R. Kwaan; Elizabeth B. Habermann
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Breast Cancer Resistance Protein (ABCG2) in Clinical Pharmacokinetics and Drug Interactions: Practical Recommendations for Clinical Victim and Perpetrator Drug-Drug Interaction Study Design
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Caroline A. Lee; Meeghan A. O'connor; Tasha K. Ritchie; Aleksandra Galetin; Cook; Isabelle Ragueneau-Majlessi; Harma Ellens; Bo Feng; Mitchell E. Taub; Mary F. Paine; Polli; Joseph A. Ware; Zamek-Gliszczynski
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Functional analysis of protective IL1RL1 variants associated with asthma risk: To the editor
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Vladimir Ramirez-Carrozzi; Amy Dressen; Patrick J. Lupardus; Brian L. Yaspan; Rajita Pappu
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Dulanermin with rituximab in patients with relapsed indolent B-cell lymphoma: an open-label phase 1b/2 randomised study
The Lancet Haematology, ISSN: 23523026
Chan Yoon Cheah; David Belada; Michelle A. Fanale; Andrea Janikova; Myron S. Czucman; Ian Flinn; Amy V. Kapp; Avi Ashkenazi; Kelley; Gordon L. Bray; Scott N. Holden; John F. Seymour
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Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse
Molecular Biology of the Cell, ISSN: 19394586 10591524
Anne Reversat; Maria-Isabel Yuseff; Danielle Lankar; Odile Malbec; Dorian Obino; Mathieu Maurin; Naga Venkata Gayathri Penmatcha; Alejandro Amoroso; Lucie Sengmanivong; Gregg G. Gundersen; Ira Mellman; François Darchen; Claire Desnos; Paolo Pierobon; Ana-Maria Lennon-Duménil
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Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing
Journal of Molecular Biology, ISSN: 10898638 00222836
Thomas Van Blarcom; Andrea Rossi; Davide Foletti; Purnima Sundar; Steven Pitts; Christine Bee; Jody Melton Witt; Zea Melton; Adela Hasa-Moreno; Lee Shaughnessy; Dilduz Telman; Lora Zhao; Wai Ling Cheung; Jan Berka; Wenwu Zhai; Pavel Strop; Javier Chaparro-Riggers; David L. Shelton; Jaume Pons; Arvind Rajpal
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MAP4K4 regulates integrin-FERM binding to control endothelial cell motility
Nature, ISSN: 14764687 00280836
Philip Vitorino; Stacey Yeung; Ailey Crow; Jesse Bakke; Tanya Smyczek; Kristina West; Erin McNamara; Jeffrey Eastham-Anderson; Stephen Gould; Seth F. Harris; Chudi O. Ndubaku; Weilan Ye
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Atom-Atom-Path similarity and Sphere Exclusion clustering: Tools for prioritizing fragment hits
Journal of Cheminformatics, ISSN: 17582946
Alberto Gobbi; Anthony M. Giannetti; Huifen Chen; Man-Ling Lee
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Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues
PLoS ONE, ISSN: 19326203
Scott D. Patterson; John M. Rossi; Katherine L. Paweletz; Dan Fitzpatrick; C. Glenn Begley; Leigh Busse; Steve Elliott; Ian McCaffery
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A novel Respiratory Syncytial Virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models
PLoS ONE, ISSN: 19326203
Stacie L. Lambert; Shahin Aslam; Elizabeth Stillman; Mia MacPhail; Christine Nelson; Bodrey Ro; Rosemary Sweetwood; Yuk Man Lei; Jennifer C. Woo; Roderick S. Tang
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An industry statistician's perspective on personalized health care drug development
Design and Analysis of Clinical Trials for Predictive Medicine,
Jane Fridlyand; Ru-Fang Yeh; Howard M. Mackey; Thomas Bengtsson; Paul Delmar; Spaniolo; Lieberman
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Regulation of the oncoprotein Smoothened by small molecules
Nature Chemical Biology, ISSN: 15524469 15524450
Hayley J. Sharpe; Weiru Wang; Rami N. Hannoush; Frederic J. De Sauvage
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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Science Translational Medicine, ISSN: 19466242 19466234
Joel D. Leverson; Darren C. Phillips; Michael J. Mitten; Erwin R. Boghaert; Dolores Diaz; Stephen K. Tahir; Lisa D. Belmont; Paul M. Nimmer; Yu Xiao; Xiaoju Max Ma; Kym N Lowes; Peter J. Kovar; Jun Chen; Sha Jin; Morey L. Smith; John Xue; Haichao Zhang; Anatol Oleksijew; Terrance J. Magoc; Kedar S. Vaidya; Daniel H. Albert; Jacqueline M. Tarrant; Nghi La; Le Wang; Zhi-Fu Tao; Michael D. Wendt; Deepak Sampath; Saul H. Rosenberg; Chris Tse; David C.S. Huang; Wayne J. Fairbrother; Steven W. Elmore; Andrew J. Souers
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GPU-accelerated compartmental modeling analysis of DCE-MRI data from glioblastoma patients treated with bevacizumab
PLoS ONE, ISSN: 19326203
Yu-Han H. Hsu; Ziyin Huang; Gregory Z. Ferl; Chee Ng
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TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation
Journal of Immunology, ISSN: 15506606 00221767
Jarod A. Zepp; Ling Wu; Wen Qian; Wenjun Ouyang; Mark Aronica; Serpil Erzurum; Xiaoxia Li
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A probabilistic method to report predictions from a human liver microsomes stability QSAR model: A practical tool for drug discovery
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Ignacio Aliagas; Alberto Gobbi; Timothy P. Heffron; Man-Ling Lee; Daniel F. Ortwine; Mark Zak; S. Cyrus Khojasteh
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Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Wendy B. Young; Jim Barbosa; Peter Blomgren; Meire C. Bremer; James J. Crawford; Donna M. Dambach; Steven L. Gallion; Sarah G. Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Daniel F. Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; C. Gregory Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie
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Transient blockade of delta-like notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation
Journal of Immunology, ISSN: 15506606 00221767
Sherri Wood; Jiane Feng; Jooho Chung; Vedran Radojcic; Ashley R. Sandy-Sloat; Ann Friedman; Amy Shelton; Minhong Yan; Christian W. Siebel; D. Keith Bishop; Ivan Maillard
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Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis
Mucosal Immunology, ISSN: 19353456 19330219
Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Jiabing Ding; Ho; Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl
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Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis
Mucosal Immunology, ISSN: 19353456 19330219
Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Jiabing Ding; Ho; Scot D. Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl
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Effect of a Modified Saquinavir/Ritonavir Dosing Regimen with Lower Dose Lead-In Phase on QTc Interval, Pharmacokinetics, Antiviral Activity and Safety in Treatment-Naïve HIV-1-Infected Patients
Drugs in R and D, ISSN: 11796901 11745886
Marta Boffito; Akil Jackson; Anton Pozniak; Mylene Giraudon; Rohit Kulkarni; Maria Connie Abelardo; Indravadan H. Patel; Peter N. Morcos
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Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis
Mucosal Immunology, ISSN: 19353456 19330219
Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Ding; Ho; Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl
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Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Jacomijn P. Dijksterhuis; Bolormaa Baljinnyam; Karen Stanger; Hakki O. Sercan; Yun Ji; Osler Andres; Jeffrey S. Rubin; Rami N. Hannoush; Gunnar Schulte
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Considerations on Immunogenicity
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,
Thomas R. Gelzleichter; Eric Wakshull
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Minor structural change to tertiary sulfonamide RORC ligands led to opposite mechanisms of action
ACS Medicinal Chemistry Letters, ISSN: 19485875
Olivier René; Benjamin P. Fauber; Gladys De Leon Boenig; Brenda Burton; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Sarah G. Hymowitz; Adam R. Johnson; James R. Kiefer; Marya Liimatta; Peter Lockey; Maxine Norman; Wenjun Ouyang; Heidi J. A. Wallweber; Harvey Wong
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