Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5751 - 5800 OF 15390 RESULTS

Gaps and Future Challenges
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,
Joerg Bluemel; Sven Korte; Emanuel Schenck; Gerhard F. Weinbauer
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Opportunities for Implementing the 3 Rs in Drug Development and Safety Assessment Studies Using Nonhuman Primates
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,
Kathryn Chapman; Kathryn Bayne; Jessica A. Couch; Thierry Decelle; John Finch; Lolke de Haan; Tina Koban; Lars Fris Mikkelsen; Wolfgang Müller; Helen Palmer; Mark Prescott
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Developmental and Reproductive Toxicity Testing
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,
Gerhard F. Weinbauer; Christopher J. Bowman; Wendy Halpern; Gary Chellman
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Rapid antidepressants stimulate the decoupling of GABA B receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η
Molecular Psychiatry, ISSN: 14765578 13594184
Workman; Patrick C. G. Haddick; Bush; Dilly; Niere; Zemelman; Raab-Graham
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IgE/FcεRI-mediated antigen cross-presentation by dendritic cells enhances anti-tumor immune responses
Cell Reports, ISSN: 22111247
Barbara Platzer; KutluG. Elpek; Viviana Cremasco; Kristi Baker; MadeleineM. Stout; Cornelia Schultz; Eleonora Dehlink; Kai-TingC. Shade; RobertM. Anthony; Blumberg; Shannon J. Turley; Edda Fiebiger
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Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma
Cancer Cell, ISSN: 18783686 15356108
Hayley J. Sharpe; Gregoire Pau; Gerrit J. P. Dijkgraaf; Nicole Basset-Seguin; Zora Modrusan; Thomas Januario; Vickie Tsui; Alison B. Durham; Andrzej A. Dlugosz; Matthias Peter; Richard Bourgon; Jean Y. Tang; Kavita Y. Sarin; Luc Dirix; David C. Fisher; Charles M. Rudin; Howard Sofen; Michael R. Migden; Robert Yauch; Frederic J. De Sauvage
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β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Chunmei Fu; Xinjun Liang; Weiguo Cui; Julia L. Ober-Blöbaum; Joseph Vazzana; Protul A. Shrikant; Kelvin P. Lee; Björn E. Clausen; Ira Mellman; Aimin Jiang
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Investigation of Drug-Excipient Interactions in Lapatinib Amorphous Solid Dispersions Using Solid-State NMR Spectroscopy
Molecular Pharmaceutics, ISSN: 15438392 15438384
Yang Song; Xinghao Yang; Xin Chen; Haichen Nie; Stephen Byrn; Joseph W. Lubach
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Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T
Current Biology, ISSN: 18790445 09609822
Florencia Rago; Karen Gascoigne; Iain M. Cheeseman
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Anxiety and health-related quality of life among patients with low-tumor burden non-Hodgkin lymphoma randomly assigned to two different rituximab dosing regimens: Results from ECOG Trial E4402 (RESORT)
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Lynne I. Wagner; Fengmin Zhao; Fangxin Hong; Marna Williams; Randy D. Gascoyne; John C. Krauss; Ranjana H. Advani; Ronald S. Go; Thomas M. Habermann; Joseph W. Leach; Brian O'Connor; Stephen J. Schuster; Cella; Sandra J. Horning; Wojciech Jurczak
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A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Xuejun Fan; Randall J. Brezski; Hui Deng; Pooja M. Dhupkar; Yun Shi; Anneliese Gonzalez; Songlin Zhang; Michael Rycyzyn; William R. Strohl; Robert E. Jordan; Ningyan Zhang; Zhiqiang An
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Comparison of statistical and operational properties of subject randomization procedures for large multicenter clinical trial treating medical emergencies
Contemporary Clinical Trials, ISSN: 15592030 15517144
Wenle Zhao; Yunming Mu; Darren Tayama; Sharon D. Yeatts
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A prospective observational study of oseltamivir safety and tolerability in infants and young children ≤24 months
Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569
Barbara A. Rath; William A. Blumentals; Mary K. Miller; Kathryn Starzyk; Boguslaw Tetiurka; Martina Wollenhaupt
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Preclinical Pharmacokinetic/Pharmacodynamic Modeling and Simulation in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape
AAPS Journal, ISSN: 15507416
Edgar Schuck; Tonika Bohnert; Arijit Chakravarty; Valeriu Damian-Iordache; Christopher Gibson; Cheng-Pang Hsu; Tycho Heimbach; Anu Shilpa Krishnatry; Bianca M. Liederer; Jing Lin; Tristan Maurer; Jerome T Mettetal; Daniel R Mudra; Marjoleen JMA Nijsen; Joseph Raybon; Patricia Schroeder; Virna Schuck; Satyendra Suryawanshi; Yaming Su; Patrick Trapa; Alice Tsai; Majid Vakilynejad; Shining Wang; Harvey Wong
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Anxiety and health-related quality of life among patients with low-tumor burden non-Hodgkin lymphoma randomly assigned to two different rituximab dosing regimens: Results from ECOG Trial E4402 (RESORT)
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Lynne I. Wagner; Fengmin Zhao; Fangxin Hong; Marna Williams; Randy D. Gascoyne; John C. Krauss; Ranjana H. Advani; Ronald S. Go; Thomas M. Habermann; Joseph W. Leach; Brian O'Connor; Stephen J. Schuster; Cella; Sandra J. Horning; Brad Kahl
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Efficacy of Hedgehog pathway inhibitors in basal cell carcinoma
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Nicole Basset-Seguin; Hayley J. Sharpe; Frederic J. De Sauvage
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Symptom burden and quality of life among women with HER2+ metastatic breast cancer
Breast Journal, ISSN: 15244741 1075122X
Musa Mayer; Kathleen Lang; Sara A. Hurvitz; Deepa Lalla; Victoria Federico; Melissa Brammer; Joseph Menzin; Debasish Tripathy
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Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayerss
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565
Tianxiang Han; William R. Proctor; Chester L. Costales; Hao Cai; Ruth S. Everett; Dhiren R. Thakker
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Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid
Toxicology Mechanisms and Methods, ISSN: 15376524 15376516
Jacqueline M. Tarrant; Preeti Dhawan; Jatinder Singh; Tanja S. Zabka; Emer Clarke; Garry Dossantos; Peter Dragovich; Deepak Sampath; Tori Lin; Bobbi McCray; Nghi La; Trung Nguyen; Ariel Kauss; Donna M. Dambach; Misner; Dolores Diaz; Hirdesh Uppal
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Catch-up growth during tocilizumab therapy for systemic juvenile idiopathic arthritis: Results from a phase iii trial
Arthritis and Rheumatology, ISSN: 23265205 23265191
Fabrizio De Benedetti; Hermine Brunner; Nicolino Ruperto; Rayfel Schneider; Ricardo Xavier; Roger Allen; Diane E. Brown; Jeffrey Chaitow; Manuela Pardeo; Graciela Espada; Valeria Gerloni; Barry L. Myones; James W. Frane; Jianmei Wang; Terri H. Lipman; Kamal N. Bharucha; Alberto Martini; Daniel Lovell
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Primary tumor location as a prognostic factor in metastatic colorectal cancer
Journal of the National Cancer Institute, ISSN: 14602105 00278874
Fotios Loupakis; Dongyun Yang; Linda Yau; Shibao Feng; Chiara Cremolini; Wu Zhang; Martin K. H. Maus; Carlotta Antoniotti; Christiane Langer; Stefan J. Scherer; Thomas Müller; Herbert Hurwitz; Leonard Saltz; Alfredo Falcone; Heinz-Josef Lenz
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In response to L.N. Newcomer et al
Journal of Oncology Practice, ISSN: 1935469X 15547477
Art Small; Melissa Brammer
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Bioprocessing roundtable
American Pharmaceutical Review, ISSN: 10998012
Todd Kapp; Nick Hutchinson; Melvin G. Whitehead; Michael Hodgkinson; Jerry Martin
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Author reply
Ophthalmology, ISSN: 15494713 01616420
Sophie J. Bakri; Darius M. Moshfeghi; Steve Francom; Amy Chen Rundle; Daniel S. Reshef; Paul P. Lee; Carol Schaeffer; Roman G. Rubio; Phillip Lai
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Incidence of giant cell arteritis and characteristics of patients: Data-driven analysis of comorbidities
Arthritis Care and Research, ISSN: 21514658 2151464X
Hans Petri; Alan Nevitt; Khaled Sarsour; Pavel Napalkov; Neil Collinson
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Economic evaluation of tocilizumab monotherapy compared to adalimumab monotherapy in the treatment of severe active rheumatoid arthritis
Value in Health, ISSN: 15244733 10983015
Josh J. Carlson; Sarika Ogale; Fred Dejonckheere; Sean D. Sullivan
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The Consequences of Diminishing Industry Support on the Independent Education Landscape: An Evidence-Based Analysis of the Perceived and Realistic Impact on Professional Development and Patient Care Among Oncologists
Journal of Cancer Education, ISSN: 15430154 08858195
Caroline Robinson; John Ruggiero; Mazi Abdolrasulnia; B. Stephen Burton
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Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X
Laura M. Paulin; Gregory B. Diette; Paul D. Blanc; Nirupama Putcha; Mark D. Eisner; Richard E. Kanner; Andrew J. Belli; Stephanie Christenson; Donald P. Tashkin; MeiLan Han; Graham Barr; Nadia N. Hansel
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Differential effects of targeting Notch receptors in a mouse model of liver cancer
Hepatology, ISSN: 15273350 02709139
Erik G. Huntzicker; Kathy Hötzel; Lisa Choy; Li Che; Ross; Gregoire Pau; Neeraj Sharma; Christian W. Siebel; Xin Chen; French
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Necroptosis: Pathway diversity and characteristics
Seminars in Cell and Developmental Biology, ISSN: 10963634 10849521
Maria Cristina De Almagro; Domagoj Vucic
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Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase
Toxicological Sciences, ISSN: 10960929 10966080
Tanja S. Zabka; Jatinder Singh; Preeti Dhawan; Bianca M. Liederer; Jason Oeh; Ariel Kauss; Yang Xiao; Mark Zak; Tori Lin; Bobbi McCray; Nghi La; Trung Nguyen; Joseph Beyer; Cindy A. Farman; Hirdesh Uppal; Peter Dragovich; Thomas O'Brien; Deepak Sampath; Misner
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Relationship between serum low-density lipoprotein cholesterol and in-hospital mortality following acute myocardial infarction (the lipid paradox)
American Journal of Cardiology, ISSN: 18791913 00029149
Vanessa S. Reddy; Quang T. Bui; Joan R. Jacobs; Susan M. Begelman; Dave P. Miller; William J. French
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Metrics that give voice to quality
Pharmaceutical Engineering, ISSN: 02738139
Joseph Famulare
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What patients need
American Pharmaceutical Review, ISSN: 10998012
Larry Wigman
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In-use physicochemical and microbiological stability of biological parenteral products
American Journal of Health-System Pharmacy, ISSN: 15352900 10792082
Margaret Ricci; Michelle Frazier; Jamie M. R. Moore; Cromwell; William J. Galush; Ankit Patel; Michael Adler; Ulrike Altenburger; Ulla Grauschopf; Pierre Goldbach; Jonas L. Fast; Irene Krämer; Hanns-Christian Mahler
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Mixing monoclonal antibody formulations using bottom-mounted mixers: impact of mechanism and design on drug product quality
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124
Benson Gikanga; Yufei Chen; Oliver B. Stauch; Maa
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Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Li Ren; Jonas Grina; David Moreno; James F. Blake; John J. Gaudino; Rustam Garrey; Andrew T. Metcalf; Michael Burkard; Matthew Martinson; Kevin Rasor; Huifen Chen; Brian J. Dean; Stephen Gould; Patricia Pacheco; Sheerin Shahidi-Latham; Jianping Yin; Kristina West; Weiru Wang; John Moffat; Jacob B. Schwarz
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Inhibiting the deubiquitinating enzymes (DUBs)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Chudi O. Ndubaku; Vickie Tsui
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Human biosample authentication using the high-throughput, cost-effective SNPtraceTM system
PLoS ONE, ISSN: 19326203
May M. Y. Liang-Chu; Mamie Yu; Matthias Peter; Julie Koeman; Janet Ziegle; Marie Lee; Richard Bourgon; Richard M. Neve
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Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells
Nature, ISSN: 14764687 00280836
Sascha Rutz; Nobuhiko Kayagaki; Qui Phung; Celine Eidenschenk; Rajkumar Noubade; Xiaoting Wang; Justin Lesch; Rongze Lu; Kim Newton; Oscar W Huang; Andrea G Cochran; Vasser; Benjamin P. Fauber; Jason Devoss; Webster; Laurie Diehl; Zora Modrusan; Donald S. Kirkpatrick; Jennie R. Lill; Wenjun Ouyang; Vishva M. Dixit
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Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening
Journal of Neuroscience, ISSN: 15292401 02706474
York Rudhard; Arundhati Sengupta Ghosh; Beatrix Lippert; Alexander Böcker; Mehdi Pedaran; Joachim Krämer; Hai Ngu; Oded Foreman; Yichin Liu; Joe Lewcock
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Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection
Immunity, ISSN: 10974180 10747613
Melba Muñoz; Celine Eidenschenk; Naruhisa Ota; Kit Wong; Uwe Lohmann; Anja A. Kühl; Xiaoting Wang; Paolo Manzanillo; Yun Li; Sascha Rutz; Yan Zheng; Laurie Diehl; Nobuhiko Kayagaki; Menno Van Lookeren Campagne; Oliver Liesenfeld; Markus Heimesaat; Wenjun Ouyang
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USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
Nature Cell Biology, ISSN: 14764679 14657392
Christian N. Cunningham; Joshua M. Baughman; Lilian Phu; Joy S. Tea; Christine Yu; Mary Coons; Donald S. Kirkpatrick; Baris Bingol; Jacob E. Corn
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Ubiquitination profiling identifies sensitivity factors for iap antagonist treatment
Biochemical Journal, ISSN: 14708728 02646021
Eugene Varfolomeev; Anita Izrael-Tomasevic; Kebing Yu; Daisy J. Bustos; Tatiana Goncharov; Lisa D. Belmont; Alexandre Masselot; Corey Bakalarski; Donald S. Kirkpatrick; Domagoj Vucic
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Vascular patterning regulates interdigital cell death by a ros-mediated mechanism
Development (Cambridge), ISSN: 14779129 09501991
Idit Eshkar-Oren; Sharon Krief; Napoleone Ferrara; Alison M. Elliott; Elazar Zelzer
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Fibroblastic reticular cells: Organization and regulation of the T lymphocyte life cycle
Journal of Immunology, ISSN: 15506606 00221767
Flavian D. Brown; Shannon J. Turley
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The cryptophycins as potent payloads for antibody drug conjugates
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Vishal A. Verma; Thomas H. Pillow; Laura DePalatis; Guangmin Li; Gail L. Phillips; Andrew G. Polson; Helga Raab; Spencer; Bing Zheng
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A practical, protecting-group-free synthesis of a PI3K/mTOR inhibitor
Organic Process Research and Development, ISSN: 1520586X 10836160
Qingping Tian; Ursula Hoffmann; Theresa Humphries; Zhigang Cheng; Pirmin Hidber; Herbert M. Yajima; Maud Guillemot-Plass; Jane Li; Ulrike Bromberger; Srinivasan Babu; David Askin; Francis Gosselin
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Structural and biochemical studies of HCMV gH/gL/gO and pentamer reveal mutually exclusive cell entry complexes
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Claudio Ciferri; Sumana Chandramouli; Danilo Donnarumma; Pavel A. Nikitin; Michael A. Cianfrocco; Rachel Gerrein; Adam L. Feire; Susan W. Barnett; Anders E. Lilja; Rino Rappuoli; Nathalie Norais; Ethan C. Settembre; Andrea Carfi
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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
Science Translational Medicine, ISSN: 19466242 19466234
Reina N. Fuji; Michael Flagella; Miriam Baca; Marco A. S Baptista; Jens Brodbeck; Bryan K. Chan; Brian K. Fiske; Lee Honigberg; Adrian M. Jubb; Paula Katavolos; Donna W. Lee; Sock-Cheng Lewin-Koh; Tori Lin; Xingrong Liu; Shannon Liu; Joseph P. Lyssikatos; Jennifer O'Mahony; Mike Reichelt; Merone Roose-Girma; Zejuan Sheng; Todd Sherer; Ashley Smith; Margaret Solon; Zachary K. Sweeney; Jacqueline M. Tarrant; Alison Urkowitz; Søren Warming; Murat Yaylaoglu; Shuo Zhang; Haitao Zhu; Anthony A. Estrada; Ryan J. Watts
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