Genentech: Publications

January 1, 2015

Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on h 1 antihistamines: A randomized, placebo-controlled study

Journal of Investigative Dermatology, ISSN: 15231747 0022202X

Sarbjit S. Saini; Carsten Bindslev-Jensen; Marcus Maurer; Jean-Jacques Grob; Emel Bülbül Baskan; Mary S. Bradley; Janice Canvin; Abdelkader Rahmaoui; Panayiotis Georgiou; Oral Alpan; Sheldon Spector; Karin Rosén

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January 1, 2015

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

Cell Death and Disease, ISSN: 20414889

Joel D. Leverson; Haichao Zhang; Jun Chen; Stephen K. Tahir; Darren C. Phillips; John Xue; Paul M. Nimmer; Sha Jin; Morey L. Smith; Yu Xiao; Peter J. Kovar; Tanaka; Bruncko; Sheppard; Le Wang; Sarah Gierke; Kategaya; Daniel J Anderson; Wong; Jeffrey Eastham-Anderson; Ludlam; Deepak Sampath; Wayne J. Fairbrother; Ingrid E. Wertz; Saul H. Rosenberg; Chris Tse; Steven W. Elmore; Andrew J. Souers

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January 1, 2015

Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Melissa Junttila; Vidusha Devasthali; Jason H. Cheng; Joseph Castillo; Ciara Metcalfe; Anne C. Clermont; Doug Den Otter; Emily Chan; Hani Bou-Reslan; Tim C. Cao; William F. Forrest; Michelle Nannini; French; Richard A. D. Carano; Mark Merchant; Klaus P. Hoeflich; Mallika Singh

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January 1, 2015

Clinical outcomes and medication adherence in acute coronary syndrome patients with and without type 2 diabetes mellitus: A longitudinal analysis 2006-2011

Journal of Managed Care Pharmacy, ISSN: 10834087

Mark J. Cziraky; Vanessa S. Reddy; Rakesh Luthra; Yaping Xu; Kenneth Wilhelm; Thomas P. Power; Maxine D. Fisher

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January 1, 2015

HSP105 recruits protein phosphatase 2A To dephosphorylate ß-catenin

Molecular and Cellular Biology, ISSN: 10985549 02707306

Nancy Yu; Michael Kakunda; Victoria Pham; Jennie R. Lill; Pan Du; Matthew Wongchenko; Yibing Yan; Ron Firestein; Xiaodong Huang

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January 1, 2015

Retinal ganglion cells thinning in eyes with nonproliferative idiopathic macular telangiectasia type 2A

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Abhilash Goud; Ganesh Babu Jonnadulla

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January 1, 2015

Neurodegeneration in type 2 diabetes: Evidence from spectral-domain optical coherence tomography

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Apoorva Sharma; Abhilash Goud; Hari Kumar Peguda; Harsha L. Rao; Viquar Unnisa Begum; Giulio Barteselli

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January 1, 2015

Strain engineering to prevent norleucine incorporation during recombinant protein production in Escherichia coli

Biotechnology Progress, ISSN: 15206033 87567938

Karthik Veeravalli; Mike Laird; Mark Fedesco; Yu Zhang; X. Christopher Yu

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January 1, 2015

IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Deepti R. Nagarkar; Vladimir Ramirez-Carrozzi; David F. Choy; Kevin Lee; Robert Soriano; Guiquan Jia; Abbas Alexander; Zora Modrusan; Rajita Pappu; Joseph R. Arron

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January 1, 2015

Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Clinical Pharmacokinetics, ISSN: 11791926 03125963

Yuan Chen; Divya Samineni; Sophie Mukadam; Harvey Wong; Shen; Dan Lu; Sandhya Girish; Cornelis E. Hop; Jin Y. Jin; Chunze Li

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January 1, 2015

Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer

European Journal of Cancer, ISSN: 18790852 09598049

Gilles Vassal; Raphaël F. Rousseau; Patricia Blanc; Lucas Moreno; Gerlind Bode; Stefan Schwoch; Martin Schrappe; Jeffrey Skolnik; Bergmann; Mary Brigid Bradley-Garelik; Vaskar Saha; Andy Pearson; Heinz Zwierzina

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January 1, 2015

Clinical and economic burden of commercially insured patients with acromegaly in the United States: A retrospective analysis

Journal of Managed Care Pharmacy, ISSN: 10834087

Hilary Placzek; Yaping Xu; Yunming Mu; Susan M. Begelman; Maxine D. Fisher

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January 1, 2015

Excess of heme induces tissue factor-dependent activation of coagulation in mice

Haematologica, ISSN: 15928721 03906078

Erica Sparkenbaugh; Pichika Chantrathammachart; Shaobin Wang; Will Jonas; Daniel Kirchhofer; David Gailani; Andras Gruber; Raj Kasthuri; Nigel S. Key; Nigel Mackman; Rafal Pawlinski

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January 1, 2015

Performance bounds for particle filters using the optimal proposal

Monthly Weather Review, ISSN: 15200493 00270644

Chris Snyder; Thomas Bengtsson; Mathias Morzfeld

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January 1, 2015

Using lysine-reactive fluorescent dye for surface characterization of a mAb

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Ming Lei; Kao; Christian Schöneich

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January 1, 2015

Onartuzumab with or without bevacizumab in combination with weekly paclitaxel does not prolong QTc or adversely affect other ECG parameters in patients with locally recurrent or metastatic triple-negative breast cancer

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Marie T. Borin; Meng Chen; Mocci; Igor Rubets; Jason Chittenden; Wassim Aldairy; Mark Stroh

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January 1, 2015

Semiconductor-based sequencing of formalin-fixed, paraffin-embedded colorectal cancer samples

Oncologist, ISSN: 1549490X 10837159

Shidong Jia; Liangxuan Zhang; Gary J. Latham

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January 1, 2015

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Sharada Labadie; Peter Dragovich; Jinhua Chen; Benjamin P. Fauber; Jason Boggs; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Qunh Ho; Kwong Wah Lai; Shuguang Ma; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Laurent Salphati; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou

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January 1, 2015

Cell-specific aptamer characterization

Aptamers Selected by Cell-SELEX for Theranostics,

Tao Chen; Cuichen Wu; Weihong Tan

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January 1, 2015

Clinical impact of chemotherapy-related adverse events in patients with metastatic breast cancer in an integrated health care system

Journal of Managed Care Pharmacy, ISSN: 10834087

Nazia Rashid; Han A. Koh; Hilda C. Baca; Zhaoliang Li; Susan Malecha; Oyewale Abidoye; Anthony Masaquel

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January 1, 2015

New HPLC systems and products introduced at Pittcon 2015: A brief review

LC-GC Europe, ISSN: 14716577

Michael W. Dong

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January 1, 2015

miRNAs in Transitions: EMT, MET, and EndoMT

MicroRNA in Regenerative Medicine,

Sato; David S. Shames; Yoshinori Hasegawa

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January 1, 2015

Analytical technologies for genotoxic impurities in pharmaceutical compounds

LCGC North America, ISSN: 15275949

Archana Kumar; Kelly Zhang; Larry Wigman

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January 1, 2015

Separation science in drug development, part I: High-throughput purification

LCGC North America, ISSN: 15275949

Joseph H. Pease; Brent Murphy; Mengling Wong; Michael W. Dong

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January 1, 2015

Separation science in drug development, part II: High-throughput characterization

LCGC North America, ISSN: 15275949

Baiwei Lin; Joseph H. Pease; Michael W. Dong

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January 1, 2015

Iridium(III)-catalyzed benzylic amine directed C-H sulfonamidation of arenes with sulfonyl azides

ChemCatChem, ISSN: 18673899 18673880

Heng Chen; Malcolm P. Huestis

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January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun J. Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J. Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N. Kinch; Nick V Grishin; Matthias Peter; Bernard Chow; Julian S. Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

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January 1, 2015

Manufacturing of High-Concentration Monoclonal Antibody Formulations via Spray Drying-the Road to Manufacturing Scale

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Benson Gikanga; Robert Turok; Ada Hui; Mayumi Bowen; Oliver B. Stauch; Maa

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January 1, 2015

Cognitive deficits, changes in synaptic function, and brain pathology in a mouse model of normal aging

eNeuro, ISSN: 23732822

Martin Weber; Tiffany Wu; Jesse E. Hanson; Nazia M. Alam; Hilda Solanoy; Hai Ngu; Benjamin E. Lauffer; Han H. Lin; Sara L. Dominguez; Jens Reeder; Jennifer A. Tom; Pascal Steiner; Oded Foreman; Glen T. Prusky; Kimberly Scearce-Levie

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January 1, 2015

Comparison of Healthcare Costs Between Rheumatoid Arthritis Patients Treated with Infused Biologics After Switching from Another Biologic

Drugs - Real World Outcomes, ISSN: 21989788 21991154

Stephen S. Johnston; Donna McMorrow; Amanda M. Farr; Paul Juneau; Sarika Ogale

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January 1, 2015

Exploring protein-protein interactions using peptide libraries displayed on phage

Phage Display in Biotechnology and Drug Discovery, Second Edition,

Deshayes; Jacob E. Corn

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January 1, 2015

Antibody humanization and affinity maturation using phage display

Phage Display in Biotechnology and Drug Discovery, Second Edition,

Jonathan S. Marvin; Henry B. Lowman

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January 1, 2015

Viral clearance of traditional unit operations: virus-retentive filtration

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Qi Chen; Dayue Chen

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January 1, 2015

Challenges and considerations for development of therapeutic proteins in pediatric patients

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Yi Zhang; Xiaohui Wei; Gaurav Bajaj; Jeffrey S. Barrett; Bernd Meibohm; Amita Joshi; Manish Gupta

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January 1, 2015

Oxidative degradation of polysorbate surfactants studied by liquid chromatography-mass spectrometry

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Oleg V. Borisov; Junyan A. Ji; Y. John Wang

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January 1, 2015

Sensitive and direct determination of lithium by mixed-mode chromatography and charged aerosol detection

Journal of Chromatography A, ISSN: 18733778 00219673

Lulu Dai; Larry Wigman; Kelly Zhang

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January 1, 2015

Effect of individual fc methionine oxidation on FcRn binding: Met252 oxidation impairs fcrn binding more profoundly than Met428 oxidation

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Xuan Gao; Junyan A. Ji; Karthik Veeravalli; Y. John Wang; Taylor Zhang; William Mcgreevy; Kai Zheng; Robert F. Kelley; Mike Laird; Jun Liu; Cromwell

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January 1, 2015

Solid state considerations for early development

American Pharmaceutical Review, ISSN: 10998012

Jeffrey Stults

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January 1, 2015

Molecular assessment of monoclonal antibody-based therapeutics enabling lead selection for clinical development