Genentech: Publications

January 1, 2015

MEK inhibitors beyond monotherapy: Current and future development

Current Opinion in Pharmacology, ISSN: 14714973 14714892

Ian E. Templeton; Luna Musib

January 1, 2015

Dual B cell immunotherapy is superior to individual Anti-CD20 depletion or baff blockade in murine models of spontaneous or accelerated lupus

Arthritis and Rheumatology, ISSN: 23265205 23265191

Wei Yu Lin; Dhaya Seshasayee; Wyne P. Lee; Patrick Caplazi; Sami McVay; Eric Suto; Allen Nguyen; Zhonghua Lin; Yonglian Sun; Laura DeForge; Mercedesz Balazs; Flavius Martin; Ali A. Zarrin

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January 1, 2015

Antibody isotype switching in vertebrates

Results and Problems in Cell Differentiation, ISSN: 18610412 00801844

Kate Senger; Jason A. Hackney; Jian Payandeh; Ali A. Zarrin

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January 1, 2015

Mericitabine and ritonavir-boosted danoprevir with or without ribavirin in treatment-naive HCV genotype 1 patients: INFORM-SVR study

Liver International, ISSN: 14783231 14783223

Edward J. Gane; Pockros; Stefan Zeuzem; Marcellin; Anna Shikhman; Coen A. Bernaards; Julian Zhou; Ellen S. Yetzer; Rosa Ballester; Cindy Dwyer; Xiao Tong; Nájera; Anne Bertasso; Janet Hammond; Amy Kindrick; Peter N. Morcos; Patrick F. Smith; Saray Stancic; Nancy Shulman

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January 1, 2015

Reply

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Aidan Long; Kenneth J. Rothman; Hubert Chen; Gillis Carrigan; Stanley J. Szefler

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January 1, 2015

Functional and structural abnormalities in deferoxamine retinopathy: A review of the literature

BioMed Research International, ISSN: 23146141 23146133

Maura Di Nicola; Giulio Barteselli; Laura Dell'Arti; Roberto Ratiglia; Francesco Viola

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January 1, 2015

CMC considerations when a drug development project is assigned breakthrough therapy status

Pharmaceutical Engineering, ISSN: 02738139

Earl S. Dye; John Groskoph; Kelley; George Millili; Moheb Nasr; Christopher J. Potter; Eric Thostesen; Hans Vermeersch

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January 1, 2015

Imaging the distribution of an antibody-drug conjugate constituent targeting mesothelin with 89Zr and IRDye 800CW in mice bearing human pancreatic tumor xenografts

Oncotarget, ISSN: 19492553

Eva J. ter Weele; Anton G.T. Terwisscha van Scheltinga; Jos G.W. Kosterink; Linda Pot; Silke R. Vedelaar; Laetitia E. Lamberts; Simon P. Williams; Marjolijn N. Lub-de Hooge; Elisabeth G. E. De Vries

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January 1, 2015

Antibody engineering & therapeutics 2015: The antibody society’s annual meeting december 7–10, 2015, San Diego, CA

mAbs, ISSN: 19420870 19420862

Paul W. H. I. Parren; Dennis R. Burton; Andrew Bradbury; James S. Huston; Paul J. Carter; Trudi Veldman; Kerry A. Chester; James W. Larrick; Mark R. Alfenito; Jamie K. Scott; Louis M. Weiner; Gregory P. Adams; Janice M. Reichert

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January 1, 2015

Ocular angiogenesis: Vascular endothelial growth factor and other factors

Developments in Ophthalmology, ISSN: 16622790 02503751

Roman G. Rubio; Anthony P. Adamis

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January 1, 2015

100% Container closure integrity testing of lyophilized drug products by the oxygen head space analysis methodology

Pharmazeutische Industrie, ISSN: 0031711X

Tobias Posset; Misael Schleger; Fred Lim; Mumenthaler; Sebastian Schneider; Thomas Kaiser

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January 1, 2015

Prediction of Drug Distribution in Subcutaneous Xenografts of Human Tumor Cell Lines and Healthy Tissues in Mouse: Application of the Tissue Composition-Based Model to Antineoplastic Drugs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Yunghsiang Chen; Xiao Ding; Stephen Gould; Cornelis E. Hop; Kirsten Messick; Jason Oeh; Bianca M. Liederer

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January 1, 2015

Derivation of phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 2: Exposure-response analyses for efficacy and safety variables

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Matthew Hruska; Xiaodong Wang; Phyllis Chan; Alaa Ahmad; Jeremy Freeman; Maria Arantxa Horga; Jan Hillson; Vikram Kansra; Juan-Carlos Lopez-Talavera

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January 1, 2015

Dusp5 negatively regulates IL-33-mediated eosinophil survival and function

EMBO Journal, ISSN: 14602075 02614189

Derek A. Holmes; Jung-Hua Yeh; Donghong Yan; Min Xu; Andrew A. Chan

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January 1, 2015

Randomized study of danoprevir/ritonavir-based therapy for HCV genotype 1 patients with prior partial or null responses to peginterferon/ribavirin

Journal of Hepatology, ISSN: 16000641 01688278

Jordan J. Feld; Ira M. Jacobson; Donald Jensen; Graham R. Foster; Stanislas Pol; Edward Tam; Maciej Jablkowski; Hanna Berak; John M. Vierling; Eric Yoshida; Héctor R. Perez-Gomez; Astrid Scalori; Gregory J. Hooper; Jorge A. Tavel; Mercidita T. Navarro; Saba Shahdad; Rohit Kulkarni; Sophie Le Pogam; Nájera; Simon Eng; Chin Yin Lim; Nancy Shulman; Ellen S. Yetzer

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January 1, 2015

Tocilizumab in rheumatoid arthritis: A case study of safety evaluations of a large postmarketing data set from multiple data sources

Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172

Jeffrey R. Curtis; Susana Perez-Gutthann; Samy Suissa; Pavel Napalkov; Natasha Singh; Liz Thompson; Benjamin Porter-Brown

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January 1, 2015

Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma

Genes and Cancer, ISSN: 19476027 19476019

Chen; James Lee; Noelyn Kljavin; Benjamin Haley; Anneleen Daemen; Leisa Johnson; Yuxin Liang

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January 1, 2015

The VEGF receptor family

Receptor Tyrosine Kinases: Family and Subfamilies,

Guanglei Zhuang; Napoleone Ferrara

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January 1, 2015

Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control

Journal of Neuroscience, ISSN: 15292401 02706474

Shih-Ching Lo; Yuanyuan Wang; Martin Weber; Jessica L. Larson; Kimberly Scearce-Levie; Morgan Sheng

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January 1, 2015

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis

Thorax, ISSN: 14683296 00406376

Daryle J. DePianto; Sanjay Chandriani; Abbas Alexander; Guiquan Jia; Elsa N. N'Diaye; Patrick Caplazi; Steven E. Kauder; Sabyasachi Biswas; Satyajit K. Karnik; Connie Ha; Zora Modrusan; Michael A. Matthay; Kukreja; Harold R. Collard; Jackson G. Egen; Paul J. Wolters; Joseph R. Arron

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January 1, 2015

Neoadjuvant breast cancer treatment as a sensitive setting for trastuzumab biosimilar development and extrapolation

Future Oncology, ISSN: 17448301 14796694

Christian Jackisch; Frank A. Scappaticci; Dominik Heinzmann; Fabio Bisordi; Thomas Schreitmüller; Gunter Von Minckwitz; Javier Cortés

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January 1, 2015

Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?

Scientific World Journal, ISSN: 1537744X 23566140

Savita V. Dandapani; Ying Zhang; Richard Jennelle; Yvonne G. Lin

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January 1, 2015

Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked toll-like receptor 8

Frontiers in Immunology, ISSN: 16643224

Gabrielle McDonald; Nicholas Cabal; Augustin Vannier; Benjamin Umiker; Raymund H. Yin; Arturo V. Orjalo; Hans E. Johansson; Jin-Hwan Han; Thereza Imanishi-Kari

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January 1, 2015

Toward an era of utilizing methionine overproducing hosts for recombinant protein production in Escherichia coli

Bioengineered, ISSN: 21655987 21655979

Karthik Veeravalli; Mike Laird

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January 1, 2015

Separation science in drug development, part 1: High-throughput purification

LC-GC Europe, ISSN: 14716577

Mengling Wong; Brent Murphy; Joseph H. Pease; Michael W. Dong

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January 1, 2015

Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma

Oncotarget, ISSN: 19492553

Lindi Chen; Raphaël F. Rousseau; Steven A. Middleton; Gwen L. Nichols; David R. Newell; John Lunec; Deborah A. Tweddle

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January 1, 2015

Derivation of phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 1: Modeling optimal treatment duration and sustained virologic response rates

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Xiaodong Wang; Matthew Hruska; Phyllis Chan; Alaa Ahmad; Jeremy Freeman; Maria Arantxa Horga; Jan Hillson; Vikram Kansra; Juan-Carlos Lopez-Talavera

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January 1, 2015

Erlotinib therapy after initial platinum doublet therapy in patients with EGFR wild type non-small cell lung cancer: Results of a combined patient-level analysis of the NCIC CTG BR.21 and SATURN trials

Translational Lung Cancer Research, ISSN: 22264477 22186751

Raymond U. Osarogiagbon; Federico Cappuzzo; Tudor Ciuleanu; Larry Leon; Barbara Klughammer

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January 1, 2015

89Zr-Bevacizumab PET visualizes heterogeneous tracer accumulation in tumor lesions of renal cell carcinoma patients and differential effects of antiangiogenic treatment

Journal of Nuclear Medicine, ISSN: 01615505

Sjoukje F. Oosting; Adrienne H. Brouwers; Suzanne C. Van Es; Wouter B. Nagengast; Thijs H. Oude Munnink; Marjolijn N. Lub-de Hooge; Harry Hollema; Johan R. De Jong; Igle J. De Jong; Sanne De Haas; Stefan J. Scherer; Wim J. Sluiter; Rudi A. Dierckx; Alfons H.H. Bongaerts; Jourik A. Gietema; Elisabeth G. E. De Vries

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January 1, 2015

Nanomedicine based on nucleic acids: Pharmacokinetic and pharmacodynamic perspectives

Current Pharmaceutical Biotechnology, ISSN: 18734316 13892010

Chenguang Zhou; Zhaogang Yang; Lesheng Teng

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January 1, 2015

Biophysical techniques for characterizing the higher order structure and interactions of monoclonal antibodies

ACS Symposium Series, ISSN: 19475918 00976156

Yatin Gokarn; Sanjeev Agarwal; Kelly Arthur; Alexander Bepperling; Eric S. Day; Dana I. Filoti; Daniel G. Greene; David Hayes; Rachel Kroe-Barrett; Thomas M. Laue; Jasper C. Lin; Brian McGarry; Vladimir Razinkov; Sanjaya Singh; Rosalynn Taing; Sathyadevi Venkataramani; William Weiss; Danlin Yang; Isidro E. Zarraga

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January 1, 2015

Design and pharmacokinetic characterization of novel antibody formats for ocular therapeutics

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Kapil Gadkar; Cinthia V Pastuskovas; Jennifer Le Couter; J. Michael Elliott; Jianhuan Zhang; Chingwei V. Lee; Sarah Sanowar; Fuh; Hok Seon Kim; T. Noelle Lombana; Christoph Spiess; Makia Nakamura; Hass; Whitney Shatz; Meng; Justin M. Scheer

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January 1, 2015

Adventitious Agent Testing of Biologicals: Changing to a New Frontier of Technology, Cell-Based to Nucleic Acid-Based Detection

ACS Symposium Series, ISSN: 19475918 00976156

Ivar Kljavin; Kevin McCarthy; Dieter Schmalzing

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January 1, 2015

Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: A retrospective, exploratory analysis in EMILIA

Annals of Oncology, ISSN: 15698041 09237534

Ian E. Krop; Lin; Kimberly Blackwell; Ellie Guardino; Huober; Michael W. Lu; David W. Miles; Meghna Samant; Manfred Welslau; Diéras

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January 1, 2015

Sorbitol crystallization-induced aggregation in frozen mAb formulations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Deirdre Murphy Piedmonte; Alison Hair; Priti Baker; Lejla Brych; Karthik Nagapudi; Hong Lin; Wenjin Cao; Susan Hershenson; Gayathri Ratnaswamy

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January 1, 2015

Gas-wall partitioning of oxygenated organic compounds: Measurements, structure-activity relationships, and correlation with gas chromatographic retention factor

Aerosol Science and Technology, ISSN: 15217388 02786826

Geoffrey K. Yeh; Paul J. Ziemann

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January 1, 2015

Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on h 1 antihistamines: A randomized, placebo-controlled study

Journal of Investigative Dermatology, ISSN: 15231747 0022202X

Sarbjit S. Saini; Carsten Bindslev-Jensen; Marcus Maurer; Jean-Jacques Grob; Emel Bülbül Baskan; Mary S. Bradley; Janice Canvin; Abdelkader Rahmaoui; Panayiotis Georgiou; Oral Alpan; Sheldon Spector; Karin Rosén

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January 1, 2015

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

Cell Death and Disease, ISSN: 20414889

Joel D. Leverson; Haichao Zhang; Jun Chen; Stephen K. Tahir; Darren C. Phillips; John Xue; Paul M. Nimmer; Sha Jin; Morey L. Smith; Yu Xiao; Peter J. Kovar; Tanaka; Bruncko; Sheppard; Le Wang; Sarah Gierke; Kategaya; Daniel J Anderson; Wong; Jeffrey Eastham-Anderson; Ludlam; Deepak Sampath; Wayne J. Fairbrother; Ingrid E. Wertz; Saul H. Rosenberg; Chris Tse; Steven W. Elmore; Andrew J. Souers

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January 1, 2015

Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Melissa Junttila; Vidusha Devasthali; Jason H. Cheng; Joseph Castillo; Ciara Metcalfe; Anne C. Clermont; Doug Den Otter; Emily Chan; Hani Bou-Reslan; Tim C. Cao; William F. Forrest; Michelle Nannini; French; Richard A. D. Carano; Mark Merchant; Klaus P. Hoeflich; Mallika Singh

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January 1, 2015

Clinical outcomes and medication adherence in acute coronary syndrome patients with and without type 2 diabetes mellitus: A longitudinal analysis 2006-2011

Journal of Managed Care Pharmacy, ISSN: 10834087

Mark J. Cziraky; Vanessa S. Reddy; Rakesh Luthra; Yaping Xu; Kenneth Wilhelm; Thomas P. Power; Maxine D. Fisher

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January 1, 2015

HSP105 recruits protein phosphatase 2A To dephosphorylate ß-catenin

Molecular and Cellular Biology, ISSN: 10985549 02707306

Nancy Yu; Michael Kakunda; Victoria Pham; Jennie R. Lill; Pan Du; Matthew Wongchenko; Yibing Yan; Ron Firestein; Xiaodong Huang

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January 1, 2015

Retinal ganglion cells thinning in eyes with nonproliferative idiopathic macular telangiectasia type 2A

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Abhilash Goud; Ganesh Babu Jonnadulla

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January 1, 2015

Neurodegeneration in type 2 diabetes: Evidence from spectral-domain optical coherence tomography

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Apoorva Sharma; Abhilash Goud; Hari Kumar Peguda; Harsha L. Rao; Viquar Unnisa Begum; Giulio Barteselli

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January 1, 2015

Analytical technologies for genotoxic impurities in pharmaceutical compounds

LCGC North America, ISSN: 15275949

Archana Kumar; Kelly Zhang; Larry Wigman

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January 1, 2015

Separation science in drug development, part I: High-throughput purification

LCGC North America, ISSN: 15275949

Joseph H. Pease; Brent Murphy; Mengling Wong; Michael W. Dong

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January 1, 2015

Separation science in drug development, part II: High-throughput characterization

LCGC North America, ISSN: 15275949

Baiwei Lin; Joseph H. Pease; Michael W. Dong

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January 1, 2015

Iridium(III)-catalyzed benzylic amine directed C-H sulfonamidation of arenes with sulfonyl azides

ChemCatChem, ISSN: 18673899 18673880

Heng Chen; Malcolm P. Huestis

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January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun J. Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J. Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N. Kinch; Nick V Grishin; Matthias Peter; Bernard Chow; Julian S. Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

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January 1, 2015

Manufacturing of High-Concentration Monoclonal Antibody Formulations via Spray Drying-the Road to Manufacturing Scale

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Benson Gikanga; Robert Turok; Ada Hui; Mayumi Bowen; Oliver B. Stauch; Maa

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January 1, 2015

Cognitive deficits, changes in synaptic function, and brain pathology in a mouse model of normal aging

eNeuro, ISSN: 23732822

Martin Weber; Tiffany Wu; Jesse E. Hanson; Nazia M. Alam; Hilda Solanoy; Hai Ngu; Benjamin E. Lauffer; Han H. Lin; Sara L. Dominguez; Jens Reeder; Jennifer A. Tom; Pascal Steiner; Oded Foreman; Glen T. Prusky; Kimberly Scearce-Levie

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