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Publications

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DISPLAYING 6051 - 6100 OF 16662 RESULTS

Peripheral blood gene expression predicts clinical benefit from anti–IL-13 in asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
David F. Choy; Guiquan Jia; Abbas Alexander; Katrina B. Morshead; Nicholas Lewin-Koh; Rajiv Dua; Pauline Rivera; Priscilla Moonsamy; Marcel Fontecha; Aarthi Balasubramanyam; Chris Santini; Ekaterina Bassett; Jill M. Ray; Christopher R. Cabanski; Mary S. Bradley; Romeo MacIuca; Mosesova; Heleen Scheerens; Joseph R. Arron
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Corticosteroid-related adverse events in patients with giant cell arteritis: A claims-based analysis
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Michael S. Broder; Khaled Sarsour; Eunice Chang; Neil Collinson; Katie Tuckwell; Pavel Napalkov; Micki Klearman
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Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites in Drug Development: How Can Physiologically Based Pharmacokinetic Modeling Help?
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Ian E. Templeton; Yuan Chen; Jialin Mao; Jian Lin; Hongbin Yu; Peters; Shebley; Varma
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Randomized phase 3 study in low-grade lymphoma comparing maintenance anti-CD20 antibody with observation after induction therapy: A trial of the ECOG-ACRIN cancer research group (E1496)
Cancer, ISSN: 10970142 0008543X
Stefan K. Barta; Hailun Li; Hochster; Fangxin Hong; Edie Weller; Randy D. Gascoyne; Thomas M. Habermann; Leo I. Gordon; Natalia Colocci; Elizabeth M. Bengtson; Sandra J. Horning; Brad Kahl
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Using the HistoPress embedding tool to process murine colon samples for histopathology
Journal of Histotechnology, ISSN: 20460236 01478885
Susan Haller; Victor Nunez; Charles Havnar; Noa Safra; Oded Foreman
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Ritonavir-boosted danoprevir plus peginterferon alfa-2a and ribavirin in Asian chronic hepatitis C patients with or without cirrhosis
Journal of Gastroenterology and Hepatology (Australia), ISSN: 14401746 08159319
Jia-Horng Kao; Shui-Yi Tung; Younjae Lee; Satawat Thongsawat; Tanwandee; I.-Shyan Sheen; Jinzi J. Wu; Hui Li; Barbara J. Brennan; Julian Zhou; Sophie Le Pogam; Nájera; James A. Thommes; George Hill
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Considerations on Endpoint Selection, Weighting Determination, and Uncertainty Evaluation in the Benefit-Risk Assessment of Medical Product
Statistics in Biopharmaceutical Research, ISSN: 19466315
Haijun Ma; Qi Jiang; Christy Chuang-Stein; Scott R. Evans; Weili He; George Quartey; John Scott; Shihua Wen; Ramin Arani
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Selecting and Integrating Data Sources in Benefit–Risk Assessment: Considerations and Future Directions
Statistics in Biopharmaceutical Research, ISSN: 19466315
Rachael L. DiSantostefano; Jesse A. Berlin; Christy Chuang-Stein; George Quartey; Gary Eichenbaum; Bennett Levitan
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Practical Analysis and Visualization Tools for Benefit-Risk Assessment in Drug Development: A Review of Recent FDA Advisory Committee Meeting Packages
Statistics in Biopharmaceutical Research, ISSN: 19466315
Shihua Wen; Weili He; Scott R. Evans; George Quartey; Jonathan D. Norton; Christy Chuang-Stein; Qi Jiang; Haijun Ma; Mondira Bhattacharya
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Comparison of lipid and lipid-associated cardiovascular risk marker changes after treatment with tocilizumab or adalimumab in patients with rheumatoid arthritis
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Cem Gabay; McInnes; Arthur Kavanaugh; Katie Tuckwell; Micki Klearman; Jennifer Pulley; Naveed Sattar
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Somatic mutation, copy number and transcriptomic profiles of primary and matched metastatic estrogen receptor-positive breast cancers
Annals of Oncology, ISSN: 15698041 09237534
Fumagalli; Wilson; Roberto Salgado; Xuyang Lu; Yu; Carol O'Brien; Kimberly Walter; Huw; Carmen Criscitiello; Laios; Jose; Brown; Rothé; Maetens; Zardavas; Peter Savas; Denis Larsimont; Martine Piccart; Stefan Michiels; Lackner; Christos Sotiriou; Sherene Loi
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Specialist-led diabetes registries and prevalence of poor glycemic control in type 2 diabetes: The Diabetes Registry Outcomes Project for A1C reduction (DROP A1C)
Diabetes Care, ISSN: 19355548 01495992
Ronnie Aronson; Naomi Orzech; Chenglin Ye; Ruth E. Brown; Ronald M. Goldenberg; Vivien Brown
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Randomized phase 3 study in low-grade lymphoma comparing maintenance anti-CD20 antibody with observation after induction therapy: A trial of the ECOG-ACRIN cancer research group (E1496)
Cancer, ISSN: 10970142 0008543X
Stefan K. Barta; Hailun Li; Hochster; Fangxin Hong; Edie Weller; Randy D. Gascoyne; Thomas M. Habermann; Leo I. Gordon; Natalia Colocci; Elizabeth M. Bengtson; Sandra J. Horning; Wojciech Jurczak
View on Scopus
Atezolizumab (atezo) in platinum (plat)-treated locally advanced/metastatic urothelial carcinoma (mUC): Updated OS, safety and biomarkers from the Ph II IMvigor210 study
Annals of Oncology, ISSN: 15698041 09237534
Yohann Loriot; Jonathan E. Rosenberg; Thomas Powles; Andrea Necchi; Syed Hussain; Morales; Margitta M. Retz; Günter Niegisch; Ignacio Durán; Christine Théodore; Jose Luis Perez-Gracia; Grande Pulido; AnnChristine Thåström; Bradford Danner; Sanjeev Mariathasan; Oyewale Abidoye; Michiel S Van Der Heijden
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Second-line metastatic urothelial carcinoma treatment and survival in real-world patients in the US
Annals of Oncology, ISSN: 15698041 09237534
Sumanta Kumar Pal; Matthew D. Galsky; Shih Wen Lin; Sarika Ogale; Marko Zivkovic; Simpson; Christina L. Derleth; Guru Sonpavde
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PTEN loss as a predictive biomarker for the Akt inhibitor ipatasertib combined with abiraterone acetate in patients with metastatic castration-resistant prostate cancer (mCRPC)
Annals of Oncology, ISSN: 15698041 09237534
De Bono; De Giorgi; Christophe Massard; Sergio Bracarda; Nava Rodrigues; Ivo Kocak; Albert Font; J. Arranz Arija; Shih; George Daniel Radavoi; Yu; Wai Y. Chan; Steven Gendreau; Zhang; Ruth Riisnaes; Matthew Wongchenko; Daniel Maslyar; Viorel Jinga
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A real-world study of patterns of Bacillus Calmette-Guerin (BCG) use and associated adverse events (AEs) in non-muscle invasive bladder cancer (NMIBC) patients in the United States
Annals of Oncology, ISSN: 15698041 09237534
Kathleen Wilson; Elisabetta Malangone-Monaco; Sacha Satram-Hoang; Diakun; Lin; Darren Tayama; Sarika Ogale
View on Scopus
Safety, clinical activity and biomarkers of atezolizumab (atezo) in advanced ovarian cancer (OC)
Annals of Oncology, ISSN: 15698041 09237534
Jeffery R. Infante; Fadi S. Braiteh; Leisha A. Emens; Ani Balmanoukian; Ana Oaknin; Yan Wang; Liu; Luciana L. Molinero; Marcella Fassò; Carol E. O'Hear; Michael S. Gordon
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A retrospective, real-world study of treatment patterns and outcomes among metastatic urothelial cancer (mUC) patients in the United States
Annals of Oncology, ISSN: 15698041 09237534
Elisabetta Malangone-Monaco; Sacha Satram-Hoang; Kathleen Wilson; Helen Varker; Lin; Darren Tayama; Sarika Ogale
View on Scopus
Primary analysis from OAK, a randomized phase III study comparing atezolizumab with docetaxel in 2L/3L NSCLC
Annals of Oncology, ISSN: 15698041 09237534
Fabrice Barlesi; Park; Fortunato Ciardiello; Joachim Von Pawel; Shirish M. Gadgeel; Toyoaki Hida; Dariusz M Kowalski; Manuel Cobo Dols; Diego L Cortinovis; Joseph W. Leach; Jonathan Polikoff; David R. Gandara; Carlos H. Barrios; Daniel S. Chen; Pei He; Marcin Kowanetz; Ballinger; Waterkamp; Alan Sandler; Achim Rittmeyer
View on Scopus
A phase I study evaluating DLYE5953A, an antibody-drug conjugate targeting the tumor-associated antigen lymphocyte antigen 6 complex locus E (Ly6E), in patients (Pts) with solid tumors
Annals of Oncology, ISSN: 15698041 09237534
Shanu Modi; Joseph Paul Eder; Patricia M. LoRusso; Colin D. Weekes; Sarat Chandarlapaty; Tolaney; McLaughlin; D. Ross Camidge; Chang; Denise Nazzal; Chen; Schuth; Flavia Brunstein; Darbonne; W. Michael Flanagan; Alexander Ungewickell; Geoffrey I. Shapiro
View on Scopus
First-line cobimetinib (C) + paclitaxel (P) in patients (pts) with advanced triple-negative breast cancer (TNBC): Updated results and tumoral immune cell infiltration data from the phase 2 COLET study
Annals of Oncology, ISSN: 15698041 09237534
David W. Miles; Kim; Velu; Garcia-Saenz; Elizabeth Tan-Chiu; Sohn; Luc Dirix; Vanˇásek; Borms; J. Ilgado De Mingorance; Liu; Moezi; Kozloff; Joseph Sparano; Xu; Yan; Matthew Wongchenko; Brian Simmons; Virginia McNally; Adam Brufsky
View on Scopus
The SP142 PD-L1 IHC assay for atezolizumab (atezo) reflects pre-existing immune status in NSCLC and correlates with PD-L1 mRNA
Annals of Oncology, ISSN: 15698041 09237534
Williams; Marcin Kowanetz; Koeppen; Zachary Boyd; Edward E. Kadel III; Dustin Smith; Mark L. McCleland; Wei Zou; Priti Hegde
View on Scopus
SANDPIPER: Phase III study of the PI3-kinase (PI3K) inhibitor taselisib (GDC-0032) plus fulvestrant in patients (pts) with oestrogen receptor (ER)-positive, HER2-negative locally advanced or metastatic breast cancer (BC) enriched for pts with PIK3CA-mutant tumours
Annals of Oncology, ISSN: 15698041 09237534
Baselga; Cortes Castan; De Laurentiis; Diéras; Nadia Harbeck; Hsu; Huan Jin; Frauke Schimmoller; Wilson; Im; William Jacot; Ian E. Krop; Sunil Verma
View on Scopus
Analytic validation of a clinical circulating tumor DNA assay for patients with solid tumors
Annals of Oncology, ISSN: 15698041 09237534
Phillip J. Stephens; Travis A. Clark; Mark Kennedy; He; Young; Mandy Zhao; Michael Coyne; Virginia Breese; Young; Shan Zhong; Mark Bailey; Bernard Fendler; Vincent A. Miller; Erica Schleifman; Peters; Geoff A. Otto; Doron Lipson; Jeffrey S. Ross
View on Scopus
Genomic features of complete responders (CR) versus fast progressors (PD) in patients with BRAFV600-mutated metastatic melanoma treated with cobimetinib + vemurafenib or vemurafenib alone
Annals of Oncology, ISSN: 15698041 09237534
Yan; Caroline Robert; James Larkin; Paolo A. Ascierto; Brigitte Dréno; Michele Maio; Claus Garbe; Paul B. Chapman; Jeffrey A. Sosman; Matthew Wongchenko; Jessie Hsu; Ilsung Chang; Ivor Caro; Isabelle Rooney; McArthur; Antoni Ribas
View on Scopus
Clinical activity, safety and predictive biomarkers results from a phase Ia atezolizumab (atezo) trial in extensive-stage small cell lung cancer (ES-SCLC)
Annals of Oncology, ISSN: 15698041 09237534
Lecia V. Sequist; Chiang; Gilbert; Michael S. Gordon; Paul Conkling; Thompson; Marcoux; Scott J. Antonia; Liu; David S. Shames; Ariel Lopez-Chavez; Carol E. O'Hear; Marcella Fassò; Scott Gettinger
View on Scopus
Prognostic subgroups and impact of treatment for post-progression overall survival (ppOS) in patients (pts) with BRAFV600-mutated metastatic melanoma treated with dacarbazine (DTIC) or vemurafenib (VEM) ± cobimetinib (COBI): A pooled analysis
Annals of Oncology, ISSN: 15698041 09237534
Paolo A. Ascierto; Antoni Ribas; James Larkin; McArthur; Karl Lewis; Axel Hauschild; Keith Flaherty; Edward McKenna; Qian Zhu; Yong Mun; Brigitte Dréno
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Efficacy and safety of cobimetinib (cobi) and atezolizumab (atezo) in an expanded phase 1b study of microsatellite-stable (MSS) metastatic colorectal cancer (mCRC)
Annals of Oncology, ISSN: 15698041 09237534
Jayesh Desai; Hong; Kim; Kim; Han; Bang; Chee; Heong; McRee; Laura Q.M. Chow; Eunice Kwak; Jeffery R. Infante; Jeffery J. Wallin; M. Das Thakur; Mwawasi; Paul Foster; Edward Cha; Bendell
View on Scopus
Preliminary safety and clinical activity of atezolizumab combined with cobimetinib and vemurafenib in BRAF V600-mutant metastatic melanoma
Annals of Oncology, ISSN: 15698041 09237534
Patrick Hwu; Omid Hamid; Rene Gonzalez; Jeffery R. Infante; Manish R. Patel; F. Stephen Hodi; Karl Lewis; Jeffery J. Wallin; Mwawasi; Edward Cha; Nicole A. Richie; Ballinger; Richard Sullivan
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Tumor mutation load assessed by FoundationOne (FM1) is associated with improved efficacy of atezolizumab (atezo) in patients with advanced NSCLC
Annals of Oncology, ISSN: 15698041 09237534
Marcin Kowanetz; Wei Zou; David S. Shames; Cummings; Naiyer A. Rizvi; Alexander Spira; Garrett M Frampton; Vincent Leveque; Susan Flynn; Mocci; Geetha Shankar; Roel Funke; Ballinger; Waterkamp; Alan Sandler; Garret M. Hampton; Lukas Amler; Priti Hegde; Matthew D. Hellmann
View on Scopus
A real-world study of patterns of Bacillus Calmette-Guerin (BCG) use and associated adverse events (AEs) in non-muscle invasive bladder cancer (NMIBC) patients in the United States
Annals of Oncology, ISSN: 15698041 09237534
Kathleen Wilson; Elisabetta Malangone-Monaco; Sacha Satram-Hoang; Diakun; Shih-Wen Lin; Darren Tayama; Sarika Ogale
View on Scopus
Tumor mutation load assessed by FoundationOne (FM1) is associated with improved efficacy of atezolizumab (atezo) in patients with advanced NSCLC
Annals of Oncology, ISSN: 15698041 09237534
Marcin Kowanetz; Wei Zou; David S. Shames; Cummings; Naiyer A. Rizvi; Alexander Spira; Garrett M Frampton; Vincent Leveque; Susan Flynn; Mocci; Geetha Shankar; Roel Funke; Ballinger; Waterkamp; Alan Sandler; Garret M. Hampton; Lukas Amler; Priti Hegde; Matthew D. Hellmann
View on Scopus
A retrospective, real-world study of treatment patterns and outcomes among metastatic urothelial cancer (mUC) patients in the United States
Annals of Oncology, ISSN: 15698041 09237534
Elisabetta Malangone-Monaco; Sacha Satram-Hoang; Kathleen Wilson; Helen Varker; Shih-Wen Lin; Darren Tayama; Sarika Ogale
View on Scopus
Safety, clinical activity and biomarkers of atezolizumab (atezo) in advanced ovarian cancer (OC)
Annals of Oncology, ISSN: 15698041 09237534
Jeffery R. Infante; Fadi S. Braiteh; Leisha A. Emens; Ani Balmanoukian; Ana Oaknin; Yan Wang; Bo Liu; Luciana L. Molinero; Marcella Fassò; Carol E. O'Hear; Michael S. Gordon
View on Scopus
Analytic validation of a clinical circulating tumor DNA assay for patients with solid tumors
Annals of Oncology, ISSN: 15698041 09237534
Phillip J. Stephens; Travis A. Clark; Mark Kennedy; He; Young; Mandy Zhao; Michael Coyne; Virginia Breese; Young; Shan Zhong; Mark Bailey; Bernard Fendler; Vincent A. Miller; Erica Schleifman; Peters; Geoff A. Otto; Doron Lipson; Jeffrey S. Ross
View on Scopus
A phase I study evaluating DLYE5953A, an antibody-drug conjugate targeting the tumor-associated antigen lymphocyte antigen 6 complex locus E (Ly6E), in patients (Pts) with solid tumors
Annals of Oncology, ISSN: 15698041 09237534
Modi; Joseph Paul Eder; Patricia M. LoRusso; Colin D. Weekes; Sarat Chandarlapaty; Tolaney; McLaughlin; D. Ross Camidge; Chang; Denise Nazzal; Chen; Schuth; Flavia Brunstein; Darbonne; W. Michael Flanagan; Alexander Ungewickell; Geoffrey I. Shapiro
View on Scopus
PTEN loss as a predictive biomarker for the Akt inhibitor ipatasertib combined with abiraterone acetate in patients with metastatic castration-resistant prostate cancer (mCRPC)
Annals of Oncology, ISSN: 15698041 09237534
De Bono; Ugo De Giorgi; Christophe Massard; Sergio Bracarda; Nava Rodrigues; Ivo Kocak; Albert Font; Jose Angel Arranz Arija; Shih; George Daniel Radavoi; Wei Yu; Wai Y. Chan; Steven Gendreau; Liangxuan Zhang; Ruth Riisnaes; Matthew Wongchenko; Daniel Maslyar; Viorel Jinga
View on Scopus
Primary analysis from OAK, a randomized phase III study comparing atezolizumab with docetaxel in 2L/3L NSCLC
Annals of Oncology, ISSN: 15698041 09237534
Fabrice Barlesi; Park; Fortunato Ciardiello; Joachim Von Pawel; Shirish M. Gadgeel; Hida; Dariusz M Kowalski; Manuel Cobo Dols; Diego L Cortinovis; Joseph W. Leach; Jonathan Polikoff; David R. Gandara; Carlos H. Barrios; Chen; Pei He; Marcin Kowanetz; Ballinger; Waterkamp; Alan Sandler; Achim Rittmeyer
View on Scopus
First-line cobimetinib (C) + paclitaxel (P) in patients (pts) with advanced triple-negative breast cancer (TNBC): Updated results and tumoral immune cell infiltration data from the phase 2 COLET study
Annals of Oncology, ISSN: 15698041 09237534
David W. Miles; Sung-Bae Kim; Velu; Garcia-Saenz; Elizabeth Tan-Chiu; Sohn; Luc Dirix; Vanˇásek; Borms; J. Ilgado De Mingorance; Liu; Moezi; Kozloff; Joseph Sparano; Xu; Yibing Yan; Matthew Wongchenko; Brian Simmons; Virginia McNally; Adam Brufsky
View on Scopus
Atezolizumab (atezo) in platinum (plat)-treated locally advanced/metastatic urothelial carcinoma (mUC): Updated OS, safety and biomarkers from the Ph II IMvigor210 study
Annals of Oncology, ISSN: 15698041 09237534
Yohann Loriot; Jonathan E. Rosenberg; Thomas Powles; Andrea Necchi; Syed Hussain; Morales; Margitta M. Retz; Günter Niegisch; Ignacio Durán; Christine Théodore; Jose Luis Perez-Gracia; Grande Pulido; AnnChristine Thåström; Bradford Danner; Sanjeev Mariathasan; Oyewale Abidoye; Michiel S Van Der Heijden
View on Scopus
Genomic features of complete responders (CR) versus fast progressors (PD) in patients with BRAFV600-mutated metastatic melanoma treated with cobimetinib + vemurafenib or vemurafenib alone
Annals of Oncology, ISSN: 15698041 09237534
Yibing Yan; Caroline Robert; James Larkin; Paolo A. Ascierto; Brigitte Dréno; Michele Maio; Claus Garbe; Paul B. Chapman; Jeffrey A. Sosman; Matthew Wongchenko; Hsu; Chang; Ivor Caro; Isabelle Rooney; McArthur; Antoni Ribas
View on Scopus
SANDPIPER: Phase III study of the PI3-kinase (PI3K) inhibitor taselisib (GDC-0032) plus fulvestrant in patients (pts) with oestrogen receptor (ER)-positive, HER2-negative locally advanced or metastatic breast cancer (BC) enriched for pts with PIK3CA-mutant tumours
Annals of Oncology, ISSN: 15698041 09237534
Baselga; Cortes Castan; De Laurentiis; Diéras; Nadia Harbeck; Jerry Y. Hsu; Jin; Frauke Schimmoller; Wilson; Im; William Jacot; Ian E. Krop; Sunil Verma
View on Scopus
Clinical activity, safety and predictive biomarkers results from a phase Ia atezolizumab (atezo) trial in extensive-stage small cell lung cancer (ES-SCLC)
Annals of Oncology, ISSN: 15698041 09237534
Lecia V. Sequist; Chiang; Gilbert; Michael S. Gordon; Paul Conkling; Thompson; Marcoux; Scott J. Antonia; Bo Liu; David S. Shames; Ariel Lopez-Chavez; Carol E. O'Hear; Marcella Fassò; Scott Gettinger
View on Scopus
The SP142 PD-L1 IHC assay for atezolizumab (atezo) reflects pre-existing immune status in NSCLC and correlates with PD-L1 mRNA
Annals of Oncology, ISSN: 15698041 09237534
Williams; Marcin Kowanetz; Koeppen; Zachary Boyd; Edward E. Kadel III; Dustin Smith; Mark L. McCleland; Wei Zou; Priti Hegde
View on Scopus
Preliminary safety and clinical activity of atezolizumab combined with cobimetinib and vemurafenib in BRAF V600-mutant metastatic melanoma
Annals of Oncology, ISSN: 15698041 09237534
Patrick Hwu; Omid Hamid; Rene Gonzalez; Jeffery R. Infante; Manish R. Patel; F. Stephen Hodi; Karl Lewis; Jeffery J. Wallin; Mwawasi; Edward Cha; Nicole A. Richie; Ballinger; Ryan J. Sullivan
View on Scopus
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Mark Zak; Po-Wai Yuen; Xiongcai Liu; Snahel Patel; Deepak Sampath; Jason Oeh; Bianca M. Liederer; Weiru Wang; Thomas O'Brien; Yang Xiao; Nicholas J. Skelton; Rongbao Hua; Jasleen K. Sodhi; Yunli Wang; Lei Zhang; Guiling Zhao; Xiaozhang Zheng; Yen-Ching Ho; Kenneth W. Bair; Peter Dragovich
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Developing HSCs become Notch independent by the end of maturation in the AGM region
Blood, ISSN: 15280020 00064971
Céline Souilhol; Javier G. Lendinez; Stanislav Rybtsov; Fiona Murphy; Heather Wilson; David Hills; Antoniana Batsivari; Anahí Binagui-Casas; Alison C. McGarvey; H. Robson MacDonald; Kageyama; Christian W. Siebel; Suling Zhao; Alexander Medvinsky
View on Scopus
Structural Characterization of Cross-Linked Species in Trastuzumab Emtansine (Kadcyla)
Bioconjugate Chemistry, ISSN: 15204812 10431802
Yan Chen; Michael Kim; Laura Zheng; Galahad Deperalta; Fred Jacobson
View on Scopus
Interfering with the chronic immune response rescues chronic degeneration after traumatic brain injury
Journal of Neuroscience, ISSN: 15292401 02706474
Ali Ertürk; Susanne Mentz; Erik E. Stout; Maj Hedehus; Sara L. Dominguez; Lisa Neumaier; Franziska Krammer; Gemma Llovera; Karpagam Srinivasan; David V. Hansen; Arthur Liesz; Kimberly Scearce-Levie; Morgan Sheng
View on Scopus
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