Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6151 - 6200 OF 15477 RESULTS

November 1, 2014

Rituximab for the treatment of relapses in antineutrophil cytoplasmic antibody-associated vasculitis

Arthritis and Rheumatology, ISSN: 23265205 23265191

Miloslavsky; Specks; Merkel; Seo; Spiera; Langford; Hoffman; Cees Kallenberg; St.clair; Tchao; Viviano; Linna Ding; Iklé; Villarreal; Brett Jepson; Paul Brunetta; Allen; Fervenza; Duvuru Geetha; Keogh; Kissin; Monach; Peikert; Stegeman; Steven R. Ytterberg; John H. Stone

November 1, 2014

VEGF modulates synaptic activity in the developing spinal cord

Developmental Neurobiology, ISSN: 1932846X 19328451

Sylvaine Guérit; Anne-Emilie Allain; Céline Léon; William Cazenave; Napoleone Ferrara; Pascal Branchereau; Andréas Bikfalvi

November 1, 2014

Standardized extractables testing protocol for single-use systems in biomanufacturing

Pharmaceutical Engineering, ISSN: 02738139

Weibing Ding; Gary Madsen; Ekta Mahajan; Seamus O'Connor; Ken Wong

November 1, 2014

It's time to regulate: Coping with product-induced nongenetic clonal instability in CHO cell lines via regulated protein expression

Biotechnology Progress, ISSN: 15206033 87567938

Shahram Misaghi; Chang; Snedecor

November 1, 2014

A generic UHPLC-UV-MS method for cleaning verification of highly potent drugs

American Pharmaceutical Review, ISSN: 10998012

Syed Salman Lateef; Vinayak Ak; Michael W. Dong; Christine Gu

November 1, 2014

An antimesothelin-monomethyl auristatin E conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Suzie J. Scales; Nidhi Gupta; Glenn Pacheco; Ron Firestein; French; Koeppen; Linda Rangell; Vivian Barry-Hamilton; Luis; Josefa Chuh; Yin Zhang; Gladys S. Ingle; Aimee Fourie-O'Donohue; Katherine R. Kozak; Ross; Dennis; Spencer

October 30, 2014

Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: A head-to-head phase 2 randomized controlled study (The ALTARA Study)

Arthritis Research and Therapy, ISSN: 14786362 14786354

William P. Kennedy; J. Abraham Simon; Carolyn Offutt; Priscilla Horn; Ann E. Herman; Michael J. Townsend; Meina Tao Tang; Jane L. Grogan; Frank Hsieh; John C. Davis

October 29, 2014

Assessment of HER 2 testing patterns, HER 2+ disease, and the utilization of HER 2-directed therapy in early breast cancer

Breast Cancer: Targets and Therapy, ISSN: 11791314

David D. Stenehjem; Minkyoung Yoo; Sudhir K. Unni; Mukul Singhal; Hillevi Bauer; Kim Saverno; Quah; Anthony Masaquel; Diana I. Brixner

October 23, 2014

Rational use of plasma protein and tissue binding data in drug design

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Xingrong Liu; Matthew Wright; Cornelis E. Hop

October 23, 2014

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

Nature, ISSN: 14764687 00280836

Sophie E. Acton; Aaron J. Farrugia; Jillian L. Astarita; Diego Mourão-Sá; Robert P. Jenkins; Emma Nye; Steven Hooper; Janneke Van Blijswijk; Neil C. Rogers; Kathryn J. Snelgrove; Ian Rosewell; Luis F. Moita; Gordon Stamp; Shannon J. Turley; Erik Sahai; Caetano Reise Sousa

October 23, 2014

A structural portrait of the PDZ domain family

Journal of Molecular Biology, ISSN: 10898638 00222836

Andreas Ernst; Brent A. Appleton; Ylva Ivarsson; Yingnan Zhang; David Gfeller; Wiesmann; Sachdev S. Sidhu

October 19, 2014

Composite end points to assess delay of disability progression by MS treatments

Multiple Sclerosis Journal, ISSN: 14770970 13524585

Jiameng Zhang; Waubant; Cutter; Wolinsky; Leppert

October 17, 2014

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

Science, ISSN: 10959203 00368075

Nathan A. Baird; Peter M. Douglas; Milos S. Simic; Ana P. C. Rodrigues; James J. Moresco; Suzanne C. Wolff; John R. Yates; Gerard Manning; Andrew Dillin

October 15, 2014

Synthesis of (+)-crocacin D and simplified bioactive analogues

Bioorganic and Medicinal Chemistry, ISSN: 14643391

Adele E. Pasqua; Frank D. Ferrari; James J. Crawford; William G. Whittingham; Rodolfo Marquez

October 15, 2014

AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs

Cancer Research, ISSN: 15387445 00085472

Catherine Wilson; Ye; Thinh Q. Pham; Eva Lin; Sara M. Chan; Eric Cheng; Richard M. Neve; Lisa D. Belmont; Koeppen; Robert Yauch; Avi Ashkenazi; Jeffrey Settleman

October 15, 2014

Real-time immuno-polymerase chain reaction in a 384-well format: Detection of vascular endothelial growth factor and epidermal growth factor-like domain 7

Analytical Biochemistry, ISSN: 10960309 00032697

Jianhuan Zhang; Jean-Michel Vernes; Jennifer Ni; Nelson; Anne Wong; Steven T. Chen; Aarati Asundi; Richard L. Vandlen; Meng

October 14, 2014

Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Aisa Sakaguchi; Peter Sarkies; Matt Simon; Anna-Lisa Doebley; Leonard D. Goldstein; Ashley Hedges; Kohta Ikegami; Stacy M. Alvares; Liwei Yang; Jeannine R. LaRocque; Julie Hall; Eric A. Miska; Shawn Ahmed; Gary Ruvkun

October 14, 2014

A comprehensive collection of systems biology data characterizing the host response to viral infection

Scientific Data, ISSN: 20524463

Brian D. Aevermann; Brett E. Pickett; Sanjeev Kumar; Edward B. Klem; Sudhakar Agnihothram; Peter S. Askovich; Armand Bankhead; Meagen Bolles; Victoria Carter; Jean Chang; Therese Clauss; Pradyot Dash; Alan H. Diercks; Amie J. Eisfeld; Amy Ellis; Shufang Fan; Martin T. Ferris; Lisa E. Gralinski; Richard R. Green; Marina A. Gritsenko; Masato Hatta; Robert A. Heegel; Jon M. Jacobs; Sophia Jeng; Laurence Josset; Shari M. Kaiser; Sara Kelly; G. Lynn Law; Chengjun Li; Jiangning Li; Casey Long; Maria L. Luna; Melissa Matzke; Jason McDermott; Vineet Menachery; Thomas O. Metz; Hugh Mitchell; Matthew E. Monroe; Garnet Navarro; Gabriele Neumann; Rebecca L. Podyminogin; Samuel O. Purvine; Carrie M. Rosenberger; Catherine J. Sanders; Athena A. Schepmoes; Anil K. Shukla; Amy Sims; Pavel Sova; Vincent C. Tam; Nicolas Tchitchek; Paul G. Thomas; Susan C. Tilton; Allison Totura; Jing Wang; Bobbie-Jo Webb-Robertson; Ji Wen; Jeffrey M. Weiss; Feng Yang; Boyd Yount; Qibin Zhang; Shannon McWeeney; Richard D. Smith; Katrina M. Waters; Yoshihiro Kawaoka; Ralph Baric; Alan Aderem; Michael G. Katze; Richard H. Scheuermann

October 12, 2014

Cost-effectiveness of recombinant tissue-type plasminogen activator within 3 hours of acute ischemic stroke: Current evidence

Stroke, ISSN: 15244628 00392499

Denise M. Boudreau; Gregory F. Guzauskas; Er Chen; Deepa Lalla; Darren Tayama; Susan C. Fagan; David L. Veenstra

October 12, 2014

The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes

Respiratory Research, ISSN: 1465993X 14659921

Brendan J. Carolan; Grant Hughes; Jarrett D. Morrow; Craig P. Hersh; Wanda K. O'Neal; Stephen I. Rennard; Sreekumar G. Pillai; Paula Belloni; Debra A. Cockayne; Alejandro P. Comellas; MeiLan Han; Rachel L. Zemans; Katerina Kechris; Russell P. Bowler

October 9, 2014

Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Thomas H. Pillow; Janet Y. Tien; Kathryn Parsons; Sunil Bhakta; Hao Li; Leanna Staben; Guangmin Li; Josefa Chuh; Aimee Fourie-O'Donohue; Martine Darwish; Victor Yip; Luna Liu; Douglas Leipold; Dian Su; Elmer Wu; Spencer; Shen; Keyang Xu; Katherine R. Kozak; Helga Raab; Richard L. Vandlen; Gail L. Phillips; Richard H. Scheller; Paul G. Polakis; Mark X. Sliwkowski; Flygare; Jagath R. Junutula

October 9, 2014

Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo

Blood, ISSN: 15280020 00064971

Asif J. Iqbal; Eileen McNeill; Theodore S. Kapellos; Daniel Regan-Komito; Sophie Norman; Sarah Burd; Nicola Smart; Daniel E. W. Machemer; Elena Stylianou; Helen McShane; Keith M. Channon; Ajay Chawla; David R. Greaves

October 9, 2014

Discovery of a potent and selective BCL-XLinhibitor with in vivo activity

ACS Medicinal Chemistry Letters, ISSN: 19485875

Zhi-Fu Tao; Lisa Hasvold; Le Wang; Xilu Wang; Andrew M. Petros; Chang H. Park; Erwin R. Boghaert; Nathaniel D. Catron; Jun Chen; Colman; Czabotar; Deshayes; Wayne J. Fairbrother; Flygare; Sarah G. Hymowitz; Sha Jin; Russell A. Judge; Michael F. T. Koehler; Peter J. Kovar; Guillaume Lessene; Michael J. Mitten; Chudi O. Ndubaku; Paul M. Nimmer; Hans E. Purkey; Anatol Oleksijew; Darren C. Phillips; Brad E Sleebs; Brian J. Smith; Morey L. Smith; Stephen K. Tahir; Keith G Watson; Yu Xiao; John Xue; Haichao Zhang; Zobel; Saul H. Rosenberg; Chris Tse; Joel D. Leverson; Steven W. Elmore; Andrew J. Souers

October 9, 2014

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

Nature, ISSN: 14764687 00280836

Xiaoting Wang; Naruhisa Ota; Paolo Manzanillo; Lance Kates; Jose Zavala-Solorio; Celine Eidenschenk; Juan Zhang; Justin Lesch; Wyne P. Lee; Ross; Laurie Diehl; Nicholas Van Bruggen; Ganesh Kolumam; Wenjun Ouyang

October 7, 2014

Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Rui Pedro Galvao; Anita Kasina; Robert S. McNeill; Jordan E. Harbin; Oded Foreman; Roel G.W. Verhaak; Akiko Nishiyama; Ryan Miller; Hui Zong

October 7, 2014

Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy

Cell Metabolism, ISSN: 19327420 15504131

Amy N. Dubinsky; Somasish Ghosh Dastidar; Cynthia L. Hsu; Rabaab Zahra; Stevan N. Djakovic; Sonia Duarte; Christine C. Esau; Brian Spencer; Travis D. Ashe; Kimberlee M. Fischer; Deidre A. Mackenna; Bryce L. Sopher; Eliezer Masliah; Terry Gaasterland; B. Nelson Chau; Luis Pereira De Almeida; Bradley E. Morrison; Albert R. La Spada

October 7, 2014

Recombinant antibody color resulting from advanced glycation end product modifications

Analytical Chemistry, ISSN: 15206882 00032700

Margaret Butko; Hilary Pallat; Cordoba; X. Christopher Yu

October 6, 2014

Structural basis for resistance to diverse classes of NAMPT inhibitors

PLoS ONE, ISSN: 19326203

Weiru Wang; Kristi Elkins; Angela Oh; Yen-Ching Ho; Jiansheng Wu; Hong Li; Yang Xiao; Mandy Kwong; Mary Coons; Bobby Brillantes; Eric Cheng; Lisa Crocker; Peter Dragovich; Deepak Sampath; Xiaozhang Zheng; Kenneth W. Bair; Thomas O'Brien; Lisa D. Belmont

October 6, 2014

Comparison of binding characteristics and in vitro activities of three inhibitors of vascular endothelial growth factor A

Molecular Pharmaceutics, ISSN: 15438392 15438384

Yang; Xiangdan Wang; Fuh; Lanlan Yu; Eric Wakshull; Mehraban Khosraviani; Eric S. Day; Barthélemy Demeule; Jun Liu; Steven J. Shire; Napoleone Ferrara; Sandeep Yadav

October 1, 2014

Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells

Cancer Research, ISSN: 15387445 00085472

Teemu T. Junttila; Ji Li; Jennifer A. Johnston; Maria Hristopoulos; Robyn Clark; Diego Ellerman; Bu-Er Wang; Yijin Li; Mary Mathieu; Guangmin Li; Judy Young; Luis; Gail L. Phillips; Stefanich; Christoph Spiess; Andrew G. Polson; Bryan Irving; Justin M. Scheer; Melissa Junttila; Dennis; Robert F. Kelley; Klara Totpal; Allen Ebens

October 1, 2014

Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Kirk D. Robarge; Wendy Lee; Eigenbrot; Ultsch; Wiesmann; Robert Heald; Steve Price; Joanne F. M. Hewitt; Philip Jackson; Pascal P. A. Savy; Brenda Burton; Edna F. Choo; Jodie Pang; Jason Boggs; April Yang; Yang Xiao; Matthew Baumgardner

October 1, 2014

The pharmaceutical development of rhDNase (Dornase Alpha) for the treatment of cystic fibrosis

Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies,

Steven J. Shire; Thomas M. Scherer

October 1, 2014

Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Fiona Sewell; Kathryn Chapman; Paul Baldrick; David Brewster; Alan Broadmeadow; Paul Brown; Leigh Ann Burns-Naas; Janet Clarke; Alex Constan; Jessica A. Couch; Oliver Czupalla; Andy Danks; Joseph DeGeorge; Lolke de Haan; Klaudia Hettinger; Marilyn Hill; Matthias Festag; Abby Jacobs; David Jacobson-Kram; Stephan J. Kopytek; Helga Lorenz; Sophia Gry Moesgaard; Emma Moore; Markku Pasanen; Rick Perry; Ian Ragan; Sally Robinson; Petra M. Schmitt; Brian Short; Beatriz Silva Lima; Diane Smith; Sue Sparrow; Yvette van Bekkum; David Jones

October 1, 2014

Rituximab extended schedule or re-treatment trial for low-tumor burden follicular lymphoma: Eastern cooperative oncology group protocol E4402

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Brad Kahl; Fangxin Hong; Marna Williams; Randy D. Gascoyne; Lynne I. Wagner; John C. Krauss; Thomas M. Habermann; Lode J. Swinnen; Stephen J. Schuster; Christopher G. Peterson; Mark D. Sborov; S. Eric Martin; Matthias Weiss; W. Christopher Ehmann; Sandra J. Horning

October 1, 2014

Impact of betaine HCl on the absorption of orally administered drugs

Advances in Medicine and Biology,

Marc R. Yago; Joseph A. Ware; Leslie Z. Benet

October 1, 2014

GATA-3 dose-dependent checkpoints in early T cell commitment

Journal of Immunology, ISSN: 15506606 00221767

Deirdre D. Scripture-Adams; Sagar S. Damle; Long Li; Koorosh J. Elihu; Shuyang Qin; Alexandra M. Arias; Robert R. Butler; Ameya Champhekar; Jingli A. Zhang; Ellen V. Rothenberg

October 1, 2014

Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma

Human Genetics, ISSN: 14321203 03406717

Jessica Cooke Bailey; Brian L. Yaspan; Louis R. Pasquale; Michael A. Hauser; Jae H. Kang; Stephanie J. Loomis; Murray Brilliant; Donald L. Budenz; Christen; John Fingert; Douglas Gaasterland; Terry Gaasterland; Peter Kraft; Richard K. Lee; Paul R. Lichter; Yutao Liu; Catherine A. McCarty; Sayoko E. Moroi; Julia E. Richards; Tony Realini; Schuman; William K. Scott; Kuldev Singh; Arthur J. Sit; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Kang Zhang; Brian W. Kunkle; R. Rand Allingham; Robert N. Weinreb; Jonathan L. Haines; Janey L. Wiggs

October 1, 2014

Type i IFN induces IL-10 production in an IL-27-Independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in mycobacterium tuberculosis-infected macrophages

Journal of Immunology, ISSN: 15506606 00221767

Finlay W. McNab; John Ewbank; Ashleigh Howes; Lucia Moreira-Teixeira; Anna Martirosyan; Nico Ghilardi; Margarida Saraiva; Anne O'Garra

October 1, 2014

Genetic variability of VEGF pathway genes in six randomized phase III trials assessing the addition of bevacizumab to standard therapy

Angiogenesis, ISSN: 15737209 09696970

Sanne De Haas; Paul Delmar; Aruna T. Bansal; Matthieu Moisse; David W. Miles; Natasha Leighl; Bernard Escudier; Eric Van Cutsem; Peter Carmeliet; Stefan J. Scherer; Celine Pallaud; Diether Lambrechts

October 1, 2014

Development and validation of the diabetes medication system rating questionnaire-short form

Diabetic Medicine, ISSN: 14645491 07423071

Peyrot; Yaping Xu; Rubin

October 1, 2014

Phase III safety study of rituximab administered as a 90-minute infusion in patients with previously untreated diffuse large B-cell and follicular lymphoma

Leukemia and Lymphoma, ISSN: 10292403 10428194

Shaker R. Dakhil; Robert Hermann; Marshall T. Schreeder; Stephanie A. Gregory; Marc Monte; Kevin S. Windsor; Deborah Hurst; Akiko Chai; Michael Brewster; Paul Richards

October 1, 2014

Response to Becher and Strohner comment regarding Baker DL et al. Evaluation of two commercial omalizumab/free IgE immunoassays: Implications of use during therapy. CMRO 2014;30:913-22

Current Medical Research and Opinion, ISSN: 14734877 03007995

Baker; Kun Peng; Melissa Cheu; Saloumeh Kadkhodayan Fischer

October 1, 2014

Myelinating cocultures of purified oligodendrocyte lineage cells and retinal ganglion cells

Cold Spring Harbor Protocols, ISSN: 15596095 19403402

Trent A. Watkins; Anja R. Scholze

October 1, 2014

Prognostic implications of creatine kinase-MB measurements in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention

American Heart Journal, ISSN: 10976744 00028703

Akshay Bagai; Phillip J. Schulte; Christopher B. Granger; Kenneth W. Mahaffey; Robert H. Christenson; Gregory Bell; Renato D. Lopes; Cynthia L. Green; A. Michael Lincoff; Paul W. Armstrong; Matthew T. Roe

October 1, 2014

The impact of second-generation antipsychotic adherence on positive and negative symptoms in recent-onset schizophrenia

Schizophrenia Research, ISSN: 15732509 09209964

Kenneth L. Subotnik; Joseph Ventura; Denise Gretchen-Doorly; Gerhard S. Hellemann; Elisha R. Agee; Laurie R. Casaus; John S. Luo; Kathleen F. Villa; Keith H. Nuechterlein

October 1, 2014

Myelinating cocultures of rat retinal ganglion cell reaggregates and optic nerve oligodendrocyte precursor cells

Cold Spring Harbor Protocols, ISSN: 15596095 19403402

Trent A. Watkins; Anja R. Scholze

October 1, 2014

Rituximab extended schedule or re-treatment trial for low-tumor burden follicular lymphoma: Eastern cooperative oncology group protocol E4402

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Wojciech Jurczak; Fangxin Hong; Marna Williams; Randy D. Gascoyne; Lynne I. Wagner; John C. Krauss; Thomas M. Habermann; Lode J. Swinnen; Stephen J. Schuster; Christopher G. Peterson; Mark D. Sborov; S. Eric Martin; Matthias Weiss; W. Christopher Ehmann; Sandra J. Horning

September 30, 2014

Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132Hglioma

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Ruihuan Chen; Merry C. Nishimura; Samir Kharbanda; Franklin V. Peale Jr.; Yuzhong Deng; Anneleen Daemen; William F. Forrest; Mandy Kwong; Maj Hedehus; Georgia Hatzivassiliou; Lori S. Friedman; Phillips

September 26, 2014

Determination of trace level genotoxic impurities in small molecule drug substances using conventional headspace gas chromatography with contemporary ionic liquid diluents and electron capture detection

Journal of Chromatography A, ISSN: 18733778 00219673

Tien Ho; Peter M. Yehl; Nik P. Chetwyn; Jin Wang; Jared L. Anderson; Qiqing Zhong

September 25, 2014

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia

Nature, ISSN: 14764687 00280836

Monique Dail; Jason Wong; Jessica Lawrence; Daniel O'Connor; Joy Nakitandwe; Shann-Ching Chen; Jin Xu; Leslie Lee; Keiko Akagi; Qing Li; Jon C. Aster; Warren S. Pear; James R. Downing; Deepak Sampath; Kevin Shannon

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