Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6151 - 6200 OF 15390 RESULTS

August 1, 2014

Analytical strategies for genotoxic impurities in the pharmaceutical industry

American Pharmaceutical Review, ISSN: 10998012

Venkatramani; Mohammad Al-Sayah

July 17, 2014

PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia

Blood, ISSN: 15280020 00064971

Martin Weisser; Ru-Fang Yeh; Guillemette Duchateau-Nguyen; Palermo; Tri Quang Nguyen; Xiaoyan Shi; Susanna Y. Stinson; Nancy Yu; Annika Dufour; Tadeusz Robak; Galina Salogub; Anna Dmoszynska; Philippe Solal-Celigny; Krzysztof Warzocha; Javier Loscertales; John Catalano; Loree Larratt; Viktor A. Rossiev; Isabelle Bence-Bruckler; Christian H. Geisler; Marco Montillo; Kirsten Fischer; Anna-Maria Fink; Michael Hallek; Johannes Bloehdorn; Raymonde Busch; Axel Benner; Hartmut Doḧner; Nancy Valente; Michael Wenger; Stephan Stilgenbauer; David Dornan

July 16, 2014

Statistical modeling of the drug load distribution on trastuzumab emtansine (Kadcyla), a lysine-linked antibody drug conjugate

Bioconjugate Chemistry, ISSN: 15204812 10431802

Michael Kim; Yan Chen; Joseph C. Marhoul; Fred Jacobson

July 16, 2014

Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains

PLoS ONE, ISSN: 19326203

Travis W. Bainbridge; Venita I. DeAlmeida; Anita Izrael-Tomasevic; Cecile Chalouni; Borlan Pan; Joshua Goldsmith; Alia P. Schoen; Gabriel Quinones; Ryan Kelly; Jennie R. Lill; Wendy N. Sandoval; Michael Costa; Paul G. Polakis; David Arnott; Bonnee Rubinfeld; James A. Ernst

July 16, 2014

Activity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons

Neuron, ISSN: 10974199 08966273

Yelin Chen; Yuanyuan Wang; Ali Ertürk; Dara Y. Kallop; Zhiyu Jiang; Robby M. Weimer; Joshua S. Kaminker; Morgan Sheng

July 15, 2014

Cellular mechanisms for response heterogeneity among L2/3 pyramidal cells in whisker somatosensory cortex

Journal of Neurophysiology, ISSN: 15221598 00223077

Justin Elstrott; Kelly B. Clancy; Haani Jafri; Igor Akimenko; Daniel E. Feldman

July 15, 2014

MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein

Genes and Development, ISSN: 15495477 08909369

Monica S. Guo; Taylor B. Updegrove; Emily Gogol; Svetlana A. Shabalina; Carol A. Gross; Gisela Storz

July 15, 2014

VariantAnnotation: A Bioconductor package for exploration and annotation of genetic variants

Bioinformatics, ISSN: 14602059 13674803

Valerie Obenchain; Michael Lawrence; Vincent J. Carey; Stephanie M. Gogarten; Paul Shannon; Martin Morgan

July 15, 2014

PILRα negatively regulates mouse inflammatory arthritis

Journal of Immunology, ISSN: 15506606 00221767

Yonglian Sun; Patrick Caplazi; Juan Zhang; Anita Mazloom; Sarah K. Kummerfeld; Gabriel Quinones; Kate Senger; Justin Lesch; Ivan Peng; Andrew Sebrell; Wilman Luk; Yanmei Lu; Zhonghua Lin; Kai H. Barck; Judy Young; Mariela Del Rio; Sophie M. Lehar; Vida Asghari; Wei Yu Lin; Sanjeev Mariathasan; Jason Devoss; Shahram Misaghi; Mercedesz Balazs; Tao Sai; Benjamin Haley; Hass; Min Xu; Wenjun Ouyang; Flavius Martin; Wyne P. Lee; Ali A. Zarrin

July 10, 2014

Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible t-cell kinase inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Jason D. Burch; Kevin Lau; John J. Barker; Frederick A. Brookfield; Yong Chen; Yuan Chen; Eigenbrot; Claire Ellebrandt; Moulay Hicham Alaoui Ismaili; Adam R. Johnson; Daniel Kordt; Colin H. Mackinnon; Paul A. McEwan; Daniel F. Ortwine; Daniel B. Stein; Xiaolu Wang; Dirk Winkler; Po-Wai Yuen; Yamin Zhang; Ali A. Zarrin; Zhonghua Pei

July 7, 2014

Imaging cleared intact biological systems at a cellular level by 3DISCO

Journal of Visualized Experiments, ISSN: 1940087X

Ali Ertürk; Daniel Lafkas; Cecile Chalouni

July 3, 2014

Comparative efficacy of biologics as monotherapy and in combination with methotrexate on patient reported outcomes (PROs) in rheumatoid arthritis patients with an inadequate response to conventional DMARDs - a systematic review and network meta-analysis

Health and Quality of Life Outcomes, ISSN: 14777525

Jeroen P. Jansen; Felicity Buckley; Fred Dejonckheere; Sarika Ogale

July 3, 2014

Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides

Organic Letters, ISSN: 15237052 15237060

Olivier René; Benjamin P. Fauber; Sushant Malhotra; Herbert M. Yajima

July 2, 2014

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

Science Translational Medicine, ISSN: 19466242 19466234

Gauvreau; Harris; Boulet; Heleen Scheerens; Fitzgerald; Wendy Putnam; Cockcroft; Davis; Richard Leigh; Zheng; Barbro Dahlén; Yehong Wang; Romeo MacIuca; Mayers; X. Charlene Liao; Lawren C. Wu; Matthews; O'Byrne

July 1, 2014

The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation

Cancer Research, ISSN: 15387445 00085472

Debasish Raha; Wilson; Jing Peng; David Peterson; Peng Yue; Marie Evangelista; Catherine Wilson; Mark Merchant; Jeffrey Settleman

July 1, 2014

Rituximab and three dexamethasone cycles provide responses similar to splenectomy in women and those with immune thrombocytopenia of less than two years duration

Haematologica, ISSN: 15928721 03906078

James B. Bussel; Christina S. Lee; Caroline Seery; Allison A. Imahiyerobo; Michaela V. Thompson; Diane Catellier; Ithamar G. Turenne; Vivek L. Patel; Paul A. Basciano; Rebecca Elstrom; Waleed Ghanima

July 1, 2014

Treatment emergent suicidal ideation and behavior

Suicide: Phenomenology and Neurobiology,

Sian Ratcliffe; Phillip B. Chappell; Janel Boyce-Rustay; Svetlana Gloukhova; Denise M. Oleske

July 1, 2014

Endogenously expressed IL-13Rα2 attenuates IL-13- mediated responses but does not activate signaling in human lung fibroblasts

Journal of Immunology, ISSN: 15506606 00221767

Sanjay Chandriani; Daryle J. DePianto; Elsa N. N'Diaye; Abbas Alexander; Janet Jackman; Jack Bevers; Vladimir Ramirez-Carrozzi; Rajita Pappu; Steven E. Kauder; Toy; Connie Ha; Zora Modrusan; Lawren C. Wu; Harold R. Collard; Paul J. Wolters; Jackson G. Egen; Joseph R. Arron

July 1, 2014

Predicting Discontinuation of Pegylated Interferon as a Result of Lack of Efficacy in United States Veterans With Chronic Hepatitis C on Dual Therapy

Annals of Pharmacotherapy, ISSN: 15426270 10600280

Richard E. Nelson; Hoop; Korner; Scott L. Duvall; Candace Hayden; Kristin Knippenberg; Timothy Morgan; Prashant K. Pandya; Jian Han; Joanne Lafleur

July 1, 2014

Balancing benefit and risk of medicines: A systematic review and classification of available methodologies

Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569

Shahrul Mt-Isa; Christine Hallgreen; Nan Wang; Georgy Genov; Ian Hirsch; Davide Luciani; Lawrence D. Phillips; George Quartey; Sinan B. Sarac; Isabelle Stoeckert; Ioanna Tzoulaki; Alain Micaleff; Deborah Ashby; Billy Amzal; Simon Ashworth; Alex Asiimwe; Johan Bring; Torbjorn Callreus; Edmond Kakit Chan; Christoph Dierig; Gerald Downey; David Gelb; Alesia Goginsky; Richard Hermann; Steve Hobbiger; Kimberley S. Hockley; Diana Hughes; Juhaeri Juhaeri; Silvia Kuhls; Alfons Lieftucht; Marilyn Metcalf; Jeremiah Mwangi; Richard Nixon; Rebecca Noel; John Pears; Ruth Peters; Lawrence Phillips; Susan Shepherd; Elizabeth Swain J.; Andrew Thomson; Laurence Titeux; Rianne van den Ham; Tjeerd van Staa; Edward Waddingham; Lesley Wise

July 1, 2014

Asymmetric stereodivergent strategy towards aminocyclitols

Chemistry - A European Journal, ISSN: 15213765 09476539

Barry M. Trost; Sushant Malhotra

July 1, 2014

Development of a comprehensive near infrared spectroscopy calibration model for rapid measurements of moisture content in multiple pharmaceutical products

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X

Dipak Mainali; Jane Li; Peter M. Yehl; Nicholas Chetwyn

July 1, 2014

The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation

Cancer Research, ISSN: 15387445 00085472

Debasish Raha; Wilson; Jing Peng; David Peterson; Peng Yue; Marie Evangelista; Catherine Wilson; Mark Merchant; Jeffrey Settleman

June 30, 2014

Estimated cases of blindness and visual impairment from neovascular age-related macular degeneration avoided in Australia by ranibizumab treatment

PLoS ONE, ISSN: 19326203

Paul Mitchell; Neil M. Bressler; Quan V. Doan; Chantal M. Dolan; Alberto Ferreira; Aaron Osborne; Elena Rochtchina; Mark Danese; Shoshana Colman; Andrew K. Wong

June 25, 2014

Direct reprogramming of human fibroblasts to hepatocyte-like cells by synthetic modified mRNAs

PLoS ONE, ISSN: 19326203

Kamen P. Simeonov; Hirdesh Uppal

June 20, 2014

Development of a semi-automated high throughput transient transfection system

Journal of Biotechnology, ISSN: 18734863 01681656

Aaron B. Bos; Joseph N. Duque; Sunil Bhakta; Farzam Farahi; Lindsay A. Chirdon; Jagath R. Junutula; Peter D. Harms; Athena W. Wong

June 19, 2014

From cancer genomics to precision oncology - Tissue's still an issue

Cell, ISSN: 10974172 00928674

Robert L. Cohen; Jeffrey Settleman

June 19, 2014

E-Cadherin Couples Death Receptors to the Cytoskeleton to Regulate Apoptosis

Molecular Cell, ISSN: 10974164 10972765

Min Lu; Scot A. Marsters; Ye; Luis; Lino C. Gonzalez Jr.; Avi Ashkenazi

June 19, 2014

Designer proteins to trigger cell death

Cell, ISSN: 10974172 00928674

Wayne J. Fairbrother; Avi Ashkenazi

June 19, 2014

Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis

PLoS ONE, ISSN: 19326203

Sarah L. May; Qing Zhou; Mitzi Lewellen; Cristan M. Carter; David Coffey; Steven L. Highfill; Christoph M. Bucher; Ilze Matise; Herbert C. Morse Iii; M. Gerard O'Sullivan; Melissa Schutten; Charles Johnson; Donald Bellgrau; Bruce R. Blazar; Jaime F. Modiano

June 18, 2014

β-Amyloid inhibits E-S potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition

Neuron, ISSN: 10974199 08966273

Adrienne L. Orr; Jesse E. Hanson; Dong Li; Adam Klotz; Sarah Wright; Dale Schenk; Peter Seubert; Daniel V. Madison

June 16, 2014

B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas

Cancer Cell, ISSN: 18783686 15356108

Nesrine I. Affara; Brian Ruffell; Terry R. Medler; Andrew J. Gunderson; Magnus Johansson; Sophia Bornstein; Emily Bergsland; Martin Steinhoff; Yijin Li; Qian Gong; Ma; Jane F. Wiesen; Melissa H. Wong; Molly Kulesz-Martin; Bryan Irving; Lisa Coussens

June 15, 2014

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

James F. Blake; John J. Gaudino; Jason De Meese; Peter Mohr; Mark Chicarelli; Hongqi Tian; Rustam Garrey; Allen A. Thomas; Christopher S. Siedem; Michael Welch; Gabrielle Kolakowski; Robert Kaus; Michael Burkard; Matthew Martinson; Huifen Chen; Brian J. Dean; Danette Dudley; Stephen Gould; Patricia Pacheco; Sheerin Shahidi-Latham; Weiru Wang; Kristina West; Jianping Yin; John Moffat; Jacob B. Schwarz

June 15, 2014

The use and effectiveness of rituximab maintenance in patients with follicular lymphoma diagnosed between 2004 and 2007 in the United States

Cancer, ISSN: 10970142 0008543X

Loretta J. Nastoupil; Sinha; Michelle Byrtek; Zhou; Taylor; Jonathan W. Friedberg; Brian K. Link; James R. Cerhan; Keith Dawson; Christopher R. Flowers

June 12, 2014

Structure-guided rescaffolding of selective antagonists of BCL-X L

ACS Medicinal Chemistry Letters, ISSN: 19485875

Michael F. T. Koehler; Philippe Bergeron; Edna F. Choo; Kevin Lau; Chudi O. Ndubaku; Danette Dudley; Paul Gibbons; Brad E Sleebs; Carl S. Rye; George Nikolakopoulos; Chinh Bui; Sanji Kulasegaram; Wilhelmus J A Kersten; Brian J. Smith; Czabotar; Colman; David C.S. Huang; Jonathan B Baell; Keith G Watson; Lisa Hasvold; Zhi-Fu Tao; Le Wang; Andrew J. Souers; Steven W. Elmore; Flygare; Wayne J. Fairbrother; Guillaume Lessene

June 9, 2014

Pannexin-1 is blocked by its C-terminus through a delocalized non-specific interaction surface

PLoS ONE, ISSN: 19326203

Michelle Dourado; Evera Wong; David Hackos

June 6, 2014

Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics

Molecular Neurodegeneration, ISSN: 17501326

Kristin R. Wildsmith; Stephen P. Schauer; Ashley Smith; David Arnott; Yuda Zhu; Joshua Haznedar; Surinder Kaur; W Rodney Mathews; Lee Honigberg

June 4, 2014

Genomic characterization of Salmonella Cerro ST367, an emerging Salmonella subtype in cattle in the United States

BMC Genomics, ISSN: 14712164

Lorraine D. Rodriguez-Rivera; Andrea I. Moreno Switt; Lovorka Degoricija; Rixun Fang; Craig A. Cummings; Manohar Furtado; Martin Wiedmann; Henk C. Den Bakker

June 4, 2014

AB3 building blocks for the synthesis of polyester dendrimers

Tetrahedron Letters, ISSN: 18733581 00404039

Jean-D'Amour K. Twibanire; Malcolm P. Huestis; T. Bruce Grindley

June 3, 2014

Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Ashley Fouts; Laetitia Comps-Agrar; Katharina F. Stengel; Diego Ellerman; Allyn J. Schoeffler; Søren Warming; Dan L. Eaton; Becket Feierbach

June 3, 2014

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Patrick J. Lupardus; Ultsch; Heidi J. A. Wallweber; Pawan Bir Kohli; Adam R. Johnson; Eigenbrot

June 1, 2014

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Richard Pastor; Jason D. Burch; Steven Magnuson; Daniel F. Ortwine; Yuan Chen; Kelly De La Torre; Xiao Ding; Eigenbrot; Adam R. Johnson; Marya Liimatta; Yichin Liu; Steven Shia; Xiaolu Wang; Lawren C. Wu; Zhonghua Pei

June 1, 2014

Comparative oncogenomics identifies psmb4 and shmt2 as potential cancer driver genes

Cancer Research, ISSN: 15387445 00085472

Genee Y. Lee; Matthias Peter; Li Li; Noelyn Kljavin; Richard Bourgon; James Lee; Howard M. Stern; Zora Modrusan; Somasekar Seshagiri; Zemin Zhang; David P. Davis; David Stokoe; Jeffrey Settleman; Frederic J. De Sauvage; Richard M. Neve

June 1, 2014

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Matthew Volgraf; Lina Chan; Malcolm P. Huestis; Hans E. Purkey; Michael Burkard; Mary K. Geck Do; Julie Harris; Kevin W. Hunt; Xingrong Liu; Joseph P. Lyssikatos; Sumeet Rana; Allen A. Thomas; Guy Vigers; Michael Siu

May 26, 2014

Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase

ChemBioChem, ISSN: 14397633 14394227

Angela Oh; Yen-Ching Ho; Mark Zak; Yongbo Liu; Xukun Chen; Po-Wai Yuen; Xiaozhang Zheng; Yichin Liu; Peter Dragovich; Weiru Wang

May 24, 2014

Safety of infusing rituximab at a more rapid rate in patients with rheumatoid arthritis: Results from the RATE-RA study

BMC Musculoskeletal Disorders, ISSN: 14712474

Charles H Pritchard; Maria Greenwald; Joel M. Kremer; Norman B. Gaylis; William F. Rigby; Steve Zlotnick; Carol Y. Chung; Birgit Jaber; William Reiss

May 23, 2014

Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: A randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer

Breast Cancer Research, ISSN: 1465542X 14655411

Edith A. Perez; Sara A. Hurvitz; Lukas Amler; Kirsten E. Mundt; Vivian W. Ng; Ellie Guardino; Luca Gianni

May 22, 2014

Mechanisms and functions of inflammasomes

Cell, ISSN: 10974172 00928674

Lamkanfi; Vishva M. Dixit

May 21, 2014

Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation

F1000Research, ISSN: 1759796X 20461402

Chih-Cheng Yang; Alicia S Chung; Chia-Yu Ku; Laurence M. Brill; Roy Williams; Dieter A. Wolf

May 20, 2014

Characterization of oxidative carbonylation on recombinant monoclonal antibodies

Analytical Chemistry, ISSN: 15206882 00032700

Yi Yang; Cinzia Stella; Weiru Wang; Christian Schöneich; Lynn Gennaro

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