Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6251 - 6300 OF 16428 RESULTS

January 15, 2016

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Wendy B. Young; Jim Barbosa; Peter Blomgren; Meire C. Bremer; James J. Crawford; Donna M. Dambach; Eigenbrot; Steven L. Gallion; Adam R. Johnson; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Daniel F. Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Christine Yu; Zhongdong Zhao; Kevin S. Currie

January 15, 2016

α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Vishal A. Verma; Daniel G. Shore; Huifen Chen; Jun Chen; Steven Do; David Hackos; Aleksandr Kolesnikov; Joseph P. Lyssikatos; Suzanne Tay; Lan Wang; Anthony A. Estrada

January 15, 2016

Complex regulation of ADAR-mediated RNA-editing across tissues

BMC Genomics, ISSN: 14712164

Melanie A. Huntley; Melanie Lou; Leonard D. Goldstein; Michael Lawrence; Gerrit J. P. Dijkgraaf; Joshua S. Kaminker; Robert Gentleman

January 15, 2016

4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Emily J. Hanan; Matthew Baumgardner; Marian C. Bryan; Yuan Chen; Eigenbrot; Peter W. Fan; Xiao-Hui Gu; Hank La; Shiva Malek; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Steve Sideris; Ivana Yen; Christine Yu; Timothy P. Heffron

January 14, 2016

Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease

Cell, ISSN: 10974172 00928674

Chiao-Wen Yang; Caroline D Hojer; Meijuan Zhou; Xiumin Wu; Arthur Wuster; Wyne P. Lee; Brian L. Yaspan; Andrew A. Chan

January 14, 2016

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR

ACS Medicinal Chemistry Letters, ISSN: 19485875

Marian C. Bryan; Burdick; Bryan K. Chan; Yuan Chen; Saundra Clausen; Jennafer Dotson; Eigenbrot; Richard Elliott; Emily J. Hanan; Robert Heald; Philip Jackson; Hank La; Michael Lainchbury; Shiva Malek; Sam E. Mann; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Shumei Wang; Ivana Yen; Christine Yu; Timothy P. Heffron

January 11, 2016

Mericitabine and either boceprevir or telaprevir in combination with peginterferon ALFA-2a plus ribavirin for patients with chronic hepatitis c genotype 1 infection and prior null response: The randomized DYNAMO 1 and DYNAMO 2 studies

PLoS ONE, ISSN: 19326203

Heiner Wedemeyer; Xavier Forns; Christophe Hézode; Samuel S. Lee; Astrid Scalori; Athina Voulgari; Sophie Le Pogam; Nájera; James A. Thommes

January 11, 2016

A quantitative investigation of linker histone interactions with nucleosomes and chromatin

Scientific Reports, ISSN: 20452322

Alison E. White; Aaron R. Hieb; Karolin Luger

January 11, 2016

Ubiquitin in the activation and attenuation of innate antiviral immunity

Journal of Experimental Medicine, ISSN: 15409538 00221007

Steven M. Heaton; Natalie A. Borg; Vishva M. Dixit

January 7, 2016

Randomized phase 2 study of obinutuzumab monotherapy in symptomatic, Previously untreated chronic lymphocytic leukemia

Blood, ISSN: 15280020 00064971

John C. Byrd; Joseph M. Flynn; Thomas J. Kipps; Michael Boxer; Kathryn S. Kolibaba; David J. Carlile; Guenter Fingerle-Rowson; Nicola Tyson; Jamie Hirata; Jeff P. Sharman

January 7, 2016

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

Nature, ISSN: 14764687 00280836

Elaine E. Storm; Durinck; Felipe de Sousa e Melo; Jarrod Tremayne; Noelyn Kljavin; Christine Tan; Ye; Cecilia Chiu; Thinh Q. Pham; Hongo; Travis W. Bainbridge; Ron Firestein; Elizabeth M. Blackwood; Ciara Metcalfe; Eric Stawiski; Robert Yauch; Yan Wu; Frederic J. De Sauvage

January 6, 2016

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

Neuron, ISSN: 10974199 08966273

Y. Joy Yu Zuchero; Xiaocheng Chen; Nga Bien-Ly; Daniela Bumbaca; Raymond K. Tong; Xiaoying Gao; Shuo Zhang; Kwame Hoyte; Wilman Luk; Melanie A. Huntley; Lilian Phu; Christine Tan; Dara Y. Kallop; Robby M. Weimer; Yanmei Lu; Donald S. Kirkpatrick; James A. Ernst; Ben Chih; Dennis; Ryan J. Watts

January 5, 2016

Clinical and economic burden of idiopathic pulmonary fibrosis: A retrospective cohort study

BMC Pulmonary Medicine, ISSN: 14712466

Karina Raimundo; Eunice Chang; Michael S. Broder; Kimberly Alexander; James L. Zazzali; Jeffrey J. Swigris

January 5, 2016

Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling

Structure, ISSN: 18784186 09692126

Cameron Noland; Sarah Gierke; Paul D. Schnier; Jeremy Murray; Wendy N. Sandoval; Meredith Sagolla; Anwesha Dey; Rami N. Hannoush; Wayne J. Fairbrother; Christian N. Cunningham

January 5, 2016

Chemical de-conjugation for investigating the stability of small molecule drugs in antibody-drug conjugates

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Tao Chen; Dian Su; Jason Gruenhagen; Christine Gu; Yi Li; Peter M. Yehl; Nik P. Chetwyn; Colin D. Medley

January 5, 2016

Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

eLife, ISSN: 2050084X

Andrew R. Conery; Richard C. Centore; Adrianne Neiss; Patricia J. Keller; Shivangi Joshi; Kerry L. Spillane; Peter Sandy; Charlie Hatton; Eneida Pardo; Laura E. Zawadzke; Archana Bommi-Reddy; Karen Gascoigne; Barbara M. Bryant; Jennifer A. Mertz; Robert J. Sims

January 2, 2016

Optimized method for murine bone marrow collection, fixation and staining for microscopic evaluation

Journal of Histotechnology, ISSN: 20460236 01478885

Marjie Van Hoy; Monika Larson; Victor Nunez; Angela Martzall; Laurie Leong; Oded Foreman; Paula Katavolos

January 1, 2016

Short-Term Efficacy Reliably Predicts Long-Term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-Based Meta-Analysis

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Yehong Wang; Rui Zhu; Jim J. Xiao; John C. Davis; Jaap W. Mandema; Jin Y. Jin; Meina Tao Tang

January 1, 2016

Preexisting antibodies to an F(ab′)2 Antibody therapeutic and novel method for immunogenicity assessment

Journal of Immunology Research, ISSN: 23147156 23148861

Jane Ruppel; Ann Brady; Rebecca Elliott; Cecilia Leddy; Marco Palencia; Daniel A. Coleman; Jessica A. Couch; Eric Wakshull

January 1, 2016

De novo guanine biosynthesis but not the riboswitch-regulated purine salvage pathway is required for Staphylococcus aureus infection in vivo

Journal of Bacteriology, ISSN: 10985530 00219193

Eric M. Kofoed; Donghong Yan; Anand K. Katakam; Mike Reichelt; Baiwei Lin; Janice Kim; Summer Park; Shailesh V. Date; Ian R. Monk; Min Xu; Cary D. Austin; Till Maurer; Man-Wah Tan

January 1, 2016

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Wendy Lee; James J. Crawford; Ignacio Aliagas; Lesley J. Murray; Suzanne Tay; Weiru Wang; Christopher E. Heise; Klaus P. Hoeflich; Hank La; Simon Mathieu; Robert Mintzer; Sreemathy Ramaswamy; Lionel Rouge; Joachim Rudolph

January 1, 2016

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Jun Liang; Birong Zhang; Sharada Labadie; Daniel F. Ortwine; Maia Vinogradova; James R. Kiefer; Victor S Gehling; Jean-Christophe Harmange; Richard T Cummings; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Yichin Liu; Amy Gustafson; Erica Vanderporten; Weifeng Mao; Bianca M. Liederer; Gauri Deshmukh; Marie Classon; Patrick Trojer; Peter Dragovich; Lesley J. Murray

January 1, 2016

Identification of potent, selective KDM5 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Victor S Gehling; Steve Bellon; Jean-Christophe Harmange; Yves Leblanc; Florence Poy; Shobu Odate; Shane Buker; Fei Lan; Shilpi Arora; Kaylyn E Williamson; Peter Sandy; Richard T Cummings; Christopher Bailey; Louise Bergeron; Weifeng Mao; Amy Gustafson; Yichin Liu; Erica Vanderporten; James E. Audia; Patrick Trojer; Brian K Albrecht

January 1, 2016

Assessment of placental transfer and the effect on embryo-fetal development of a humanized monoclonal antibody targeting lymphotoxin-alpha in non-human primates

Reproductive Toxicology, ISSN: 18731708 08906238

Hong Wang; Chris Schuetz; Akihiro Arima; Yutaka Chihaya; Gerhard F. Weinbauer; Gunnar Habermann; Jim J. Xiao; Cynthia Woods; Jane L. Grogan; Thomas R. Gelzleichter; Cain

January 1, 2016

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

Oncotarget, ISSN: 19492553

Sonja C. Lueck; Annika C. Russ; Ursula Botzenhardt; Richard F. Schlenk; Zobel; Deshayes; Domagoj Vucic; Hartmut Doḧner; Konstanze Döhner; Fulda; Lars Bullinger

January 1, 2016

In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats

Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782

Karen E. Parrish; Jialin Mao; Jacob Z. Chen; Allan Jaochico; Justin Ly; Quynh Ho; Sophie Mukadam; Matthew Wright

January 1, 2016

Evaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) based macrocyclic chelator for 89Zr4+ and its use for immunoPET imaging of HER2 positive model of ovarian carcinoma in mice

Theranostics, ISSN: 18387640

Jeff N. Tinianow; Darpan N. Pandya; Sylvie L. Pailloux; Annie Ogasawara; Alexander N. Vanderbilt; Herman S. Gill; Simon P. Williams; Thaddeus J. Wadas; Darren Magda; Jan Marik

January 1, 2016

HER2-targeted polyinosine/polycytosine therapy inhibits tumor growth and modulates the tumor immune microenvironment

Cancer immunology research, ISSN: 23266074 23266066

Maya Zigler; Alexei Shir; Salim Joubran; Anna Sagalov; Shoshana Klein; Nufar Edinger; Jeffrey Lau; Shang-Fan Yu; Gabriel Mizraji; Anat Globerson Levin; Mark X. Sliwkowski; Alexander Levitzki

January 1, 2016

Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development

Journal of Immunology Research, ISSN: 23147156 23148861

Yanmei Lu; Leslie A. Khawli; Shobha Purushothama; Frank-Peter Theil; Michael A. Partridge

January 1, 2016

Knockout and humanised animal models to study membrane transporters in drug development

RSC Drug Discovery Series, ISSN: 20413211 20413203

Nico Scheer; Xiaoyan Chu; Laurent Salphati; Zamek-Gliszczynski

January 1, 2016

Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies

Journal of Immunology Research, ISSN: 23147156 23148861

Michael A. Partridge; Shobha Purushothama; Chinnasamy Elango; Yanmei Lu

January 1, 2016

Malignancy rates in patients with rheumatoid arthritis treated with tocilizumab

RMD Open, ISSN: 20565933

Rubbert-Roth; Anthony Sebba; Laura Brockwell; Ariella Kelman; Benjamin Porter-Brown; Jennifer Pulley; Pavel Napalkov; Ronald Van Vollenhoven

January 1, 2016

Application of LCMS in small-molecule drug development

European Pharmaceutical Review, ISSN: 13608606

Chunang Gu; David J. Russell; Peter M. Yehl

January 1, 2016

Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody–drug conjugates

Bioorganic and Medicinal Chemistry, ISSN: 14643391 09680896

Anna C. Giddens; Ho H. Lee; Guo-Liang Lu; Christian K. Miller; Jun Guo; Gail L. Phillips; Thomas H. Pillow; Moana Tercel

January 1, 2016

Single-step synthesis of 3-hydroxycarbazoles by annulation of electron-rich anilines and quinones

Tetrahedron Letters, ISSN: 18733581 00404039

Eugenia Pushkarskaya; Brian Wong; Chong Han; Simona S. Capomolla; Christine Gu; Brian M. Stoltz; Haiming Zhang

January 1, 2016

Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma

Oncotarget, ISSN: 19492553

Anne Lynn S. Chang; Karl Lewis; Sarah T. Arron; Michael R. Migden; James A. Solomon; Simon Yoo; Bann-Mo Day; Edward McKenna; Aleksandar Sekulic

January 1, 2016

Human monoclonal antibody 81.39a effectively neutralizes emerging influenza A viruses of group 1 and 2 hemagglutinins

Journal of Virology, ISSN: 10985514 0022538X

Henju Marjuki; Vasiliy P. Mishin; Ning Chai; Man-Wah Tan; Elizabeth Newton; John Tegeris; Karl Erlandson; Melissa Willis; Joyce Jones; Todd Davis; James Stevens; Larisa V. Gubareva

January 1, 2016

The Medicinal Chemistry and Commercial Manufacturing behind the Discovery and Development of the Hedgehog Inhibitor Vismodegib

ACS Symposium Series, ISSN: 19475918 00976156

Remy Angelaud; Daniel P. Sutherlin; Mark E. Reynolds; Scott Savage; Andreas Stumpf

January 1, 2016

The Discovery and Process Chemistry Development of GDC-0084, a Brain Penetrating Inhibitor of PI3K and mTOR

ACS Symposium Series, ISSN: 19475918 00976156

Timothy P. Heffron; Andrew McClory; Andreas Stumpf

January 1, 2016

Discovery and Process Development of Class i PI3K and Class i PI3K/mTOR Inhibitors GDC-0941 and GDC-0980

ACS Symposium Series, ISSN: 19475918 00976156

Srinivasan Babu; Francis Gosselin; Theresa Humphries; Alan G. Olivero; Daniel P. Sutherlin; Qingping Tian

January 1, 2016

Periostin levels and eosinophilic inflammation in poorly-controlled asthma

BMC Pulmonary Medicine, ISSN: 14712466

Jodie L. Simpson; Ian A. Yang; John W. Upham; Paul N. Reynolds; Sandra Hodge; Alan L. James; Christine Jenkins; Matthew J. Peters; Guiquan Jia; Cécile T.J. Holweg; Peter G. Gibson

January 1, 2016

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Chemical Science, ISSN: 20416539 20416520

Thomas H. Pillow; Jack D. Sadowsky; Donglu Zhang; Shang-Fan Yu; Geoffrey Del Rosario; Keyang Xu; Jintang He; Sunil Bhakta; Rachana Ohri; Katherine R. Kozak; Edward Ha; Jagath R. Junutula; Flygare

January 1, 2016

Bitpacking techniques for indexing genomes: II. Enhanced suffix arrays

Algorithms for Molecular Biology, ISSN: 17487188

Thomas D Wu

January 1, 2016

Bitpacking techniques for indexing genomes: I. Hash tables

Algorithms for Molecular Biology, ISSN: 17487188

Thomas D Wu

January 1, 2016

Natural killer cell granules converge to avoid collateral damage

Journal of Cell Biology, ISSN: 15408140 00219525

Alex T. Ritter; Ira Mellman

January 1, 2016

Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-An Industry Perspective

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Tonika Bohnert; Aarti H. Patel; Ian E. Templeton; Yuan Chen; Chuang Lu; George Lai; Louis Leung; Susanna Tse; Heidi J. Einolf; Ying-Hong Wang; Michael Sinz; Ralph Stearns; Robert L. Walsky; Wanping Geng; Sirimas Sudsakorn; David J. Moore; Ling He; Jan Wahlstrom; Jim Keirns; Rangaraj Narayanan; Dieter Lang; Xiaoqing Yang

January 1, 2016

Impact of vial capping on residual seal force and container closure integrity

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Roman Mathaes; Hanns-Christian Mahler; Yves Roggo; Robert Ovadia; Philippe Lam; Oliver B. Stauch; Martin Vogt; Holger Roehl; Joerg Huwyler; Silke Mohl; Alexander Streubel

January 1, 2016

De-risking immunotherapy: Report of a consensus workshop of the cancer immunotherapy consortium of the cancer research institute

Cancer immunology research, ISSN: 23266074 23266066

Ira Mellman; Vanessa M. Hubbard-Lucey; Matthew J. Tontonoz; Michael D. Kalos; Daniel S. Chen; James P. Allison; Charles G. Drake; Hy Levitsky; Nils Lonberg; Sjoerd H. van der Burg; Douglas T. Fearon; E. John Wherry; Israel Lowy; Robert Hvonderheide; Patrick Hwu

January 1, 2016

Process analytical technology for high shear wet granulation: Wet mass consistency reported by in-line: Drag flow force sensor is consistent with powder rheology measured by at-line FT4 powder Rheometer®

Particle Technology Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting,

Tim Freeman; Ajit S. Narang; Valery Sheverev; Douglas Both; Vadim Stapaniuk; Doug Millington-Smith; Kevin Macias; Ganeshkumar Subramanian; Michael Delancy

January 1, 2016

The Use of Genetically Modified Animals in Discovery Toxicology

Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers,

Dolores Diaz; Jonathan M. Maher

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