Genentech: Publications

January 1, 2014

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

Nature, ISSN: 14764687 00280836

Rajkumar Noubade; Kit Wong; Naruhisa Ota; Sascha Rutz; Celine Eidenschenk; Patricia A. Valdez; Jiabing Ding; Ivan Peng; Andrew Sebrell; Patrick Caplazi; Jason Devoss; Robert Soriano; Tao Sai; Rongze Lu; Zora Modrusan; Jason A. Hackney; Wenjun Ouyang

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January 1, 2014

Targeting protein-protein interaction by small molecules

Annual Review of Pharmacology and Toxicology, ISSN: 15454304 03621642

Lingyan Jin; Weiru Wang; Guowei Fang

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January 1, 2014

Qualification and application of a liquid chromatography-tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction

Archives of Pharmacal Research, ISSN: 19763786 02536269

Young G. Shin; Lee Hamm; Stanley Murakami; Kenji Buirst; Michael H. Buonarati; April Cox; Kelly Regal; Kevin W. Hunt; Kimberly Scearce-Levie; Ryan J. Watts; Xingrong Liu

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January 1, 2014

Macular epiretinal brachytherapy in treated age-related macular degeneration (meritage): Month 24 safety and efficacy results

Retina, ISSN: 15392864 0275004X

Robert Petrarca; Pravin U. Dugel; Michael Bennett; Adiel Barak; Dov Weinberger; Jeffrey Nau; Timothy L. Jackson

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January 1, 2014

Role of IL-22 in microbial host defense

Current Topics in Microbiology and Immunology, ISSN: 21969965 0070217X

Celine Eidenschenk; Sascha Rutz; Oliver Liesenfeld; Wenjun Ouyang

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January 1, 2014

Rational selection of alternative, environmentally compatible surfactants for biotechnological production of pharmaceuticals-A step toward green biotechnology

Environmental Toxicology and Chemistry, ISSN: 15528618 07307268

Jürg Oliver Straub; Russel Shearer; Martin Studer

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January 1, 2014

Safety and tolerability of double-dose and duration oseltamivir regimens in patients with H1N1pdm09

Infectious Diseases in Clinical Practice, ISSN: 15369943 10569103

Lisa Cupelli; Mohammed Bailony; Tracy Burgess; Regina Dutkowski

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January 1, 2014

Intracellular effects of the hepatitis c virus nucleoside polymerase inhibitor ro5855 (mericitabine parent) and ribavirin in combination

Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804

Ma; Sophie Le Pogam; Fletcher; Hinojosa-Kirschenbaum; Javanbakht; Yan; Jiang; Inocencio; Klumpp; Nájera

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January 1, 2014

Molecular and cellular heterogeneity in the Rheumatoid Arthritis synovium: Clinical correlates of synovitis

Best Practice and Research: Clinical Rheumatology, ISSN: 15321770 15216942

Michael J. Townsend

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January 1, 2014

Ocular toxicity in BRAF mutant cutaneous melanoma patients treated with vemurafenib

American Journal of Ophthalmology, ISSN: 18791891 00029394

Christina H. Choe; McArthur; Ivor Caro; John H. Kempen; Ravi K. Amaravadi

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January 1, 2014

Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions

New England Journal of Medicine, ISSN: 15334406 00284793

Valentin Goede; Kirsten Fischer; Raymonde Busch; Anja Engelke; Barbara Eichhorst; Clemens M. Wendtner; Tatiana Chagorova; Javier De La Serna; Marie-Sarah Dilhuydy; Thomas Illmer; Stephen Opat; Carolyn J. Owen; Olga Samoylova; Karl-Anton Kreuzer; Stephan Stilgenbauer; Hartmut Doḧner; Anton W. Langerak; Matthias Ritgen; Kneba; Elina Asikanius; Kathryn Humphrey; Michael Wenger; Michael Hallek

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January 1, 2014

Treatment practice in the elderly patient with chronic lymphocytic leukemia - Analysis of the combined SEER and Medicare database

Annals of Hematology, ISSN: 14320584 09395555

Sacha Satram-Hoang; Carolina Reyes; Khang Q. Hoang; Faiyaz Momin; Sandra Skettino

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January 1, 2014

A phase I study of PRO131921, a novel anti-CD20 monoclonal antibody in patients with relapsed/refractory CD20+ indolent NHL: Correlation between clinical responses and AUC pharmacokinetics

Clinical Immunology, ISSN: 15217035 15216616

Carla Casulo; Julie Vose; William Y. Ho; Brad Kahl; Mark Brunvand; Andre Goy; Yvette Kasamon; Bruce D. Cheson; Jonathan W. Friedberg

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January 1, 2014

Apoptosis initiation through the cell-extrinsic pathway

Methods in Enzymology, ISSN: 15577988 00766879

Pradeep Nair; Min Lu; Sean Petersen; Avi Ashkenazi

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January 1, 2014

Identification and cost of adverse events in metastatic breast cancer in taxane and capecitabine based regimens

SpringerPlus, ISSN: 21931801

Ryan N. Hansen; Scott D. Ramsey; Deepa Lalla; Anthony Masaquel; Tripthi V. Kamath; Melissa Brammer; Sara A. Hurvitz; Sean D. Sullivan

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January 1, 2014

A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study)

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Gerd R. Burmester; Rubbert-Roth; Alain Cantagrel; Stephen Hall; Piotr Leszczynski; Daniel Feldman; Madura J. Rangaraj; Georgia Roane; Charles Ludivico; Peng Lu; Lucy Rowell; Bao; Eduardo F. Mysler

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January 1, 2014

Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice

Journal of Vascular Surgery, ISSN: 10976809 07415214

Junji Moriya; Xiumin Wu; Jose Zavala-Solorio; Ross; Xiao Huan Liang; Napoleone Ferrara

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January 1, 2014

Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: Quo vadis?

Drug Discovery Today, ISSN: 18785832 13596446

Andreas Baumann; Dietrich Tuerck; Saileta Prabhu; Leslie Dickmann; Jennifer Sims

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January 1, 2014

STAT3 activation in tumor cell-free lymph nodes predicts a poor prognosis for gastric cancer

International Journal of Clinical and Experimental Pathology, ISSN: 19362625

Li-Jun Wu; Hai-Xia Li; Xiao-Ting Luo; Rongze Lu; Yun-Fang Ma; Rui Wang; Jun Zhang; Dong-Qin Yang; Hua Yu; Jie Liu

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January 1, 2014

A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III)

International Journal of Stroke, ISSN: 17474949 17474930

Wendy C. Ziai; Stanley Tuhrim; Karen Lane; Nichol Mcbee; Kennedy Lees; Jesse Dawson; Kenneth Butcher; Paul Vespa; David W. Wright; Penelope M. Keyl; A. David Mendelow; Carlos Kase; Christine Wijman; Marc Lapointe; Sayona John; Richard Thompson; Carol Thompson; Steven Mayo; Pat Reilly; Scott Janis; Issam Awad; Daniel F. Hanley

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January 1, 2014

T-bet regulates immunity to Francisella tularensis live vaccine strain infection, particularly in lungs

Infection and Immunity, ISSN: 10985522 00199567

Amanda A. Melillo; Oded Foreman; Catharine M. Bosio; Karen L. Elkins

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January 1, 2014

Erratum to "Doubling down on the PI3K-AKTmTOR pathway enhances the antitumor efficacy of parp inhibitor in triple negative breast cancer model beyond BRCA-ness" [Neoplasia 16 (2014) 43-72]

Neoplasia (United States), ISSN: 14765586 15228002

Pradip De; Yuling Sun; Jennifer H. Carlson; Lori S. Friedman; Brian R. Leyland-Jones; Nandini Dey

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January 1, 2014

Investigators' Experience With Expedited Safety Reports Prior to the FDA's Final IND Safety Reporting Rule

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

Judith M. Kramer; David Vock; Howard E. Greenberg; Cheri Janning; Lynda Szczech; Miklos Salgo; Suzanne Gagnon; Susan Ellenberg

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January 1, 2014

An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins

mAbs, ISSN: 19420862 19420870

Meredith Hazen; Sunil Bhakta; Rajesh Vij; Steven Randle; Dara Y. Kallop; Vicki Chiang; Isidro Htzel; Bijay S. Jaiswal; Karen E. Ervin; Bing Li; Robby M. Weimer; Paul G. Polakis; Richard H. Scheller; Jagath R. Junutula; Hongo

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January 1, 2014

Special Focus on Investigative Techniques

Veterinary Pathology, ISSN: 03009858 15442217

Ramos-Vara; Webster

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January 1, 2014

Targeting IgE to facilitate oral immunotherapy for food allergy: A potential new role for anti-IgE therapy?

Expert Review of Clinical Immunology, ISSN: 17448409 1744666X

Dale T. Umetsu

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January 1, 2014

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

Nature, ISSN: 14764687 00280836

Norihiro Nakamura; Jennie R. Lill; Qui Phung; Zhaoshi Jiang; Corey Bakalarski; Ann De Mazière; Judith Klumperman; Megan Schlatter; Lélia Delamarre; Ira Mellman

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January 1, 2014

Antiviral treatment of influenza in children: A retrospective cohort study

Advances in Therapy, ISSN: 18658652 0741238X

Lizheng Shi; Mark Loveless; Philip Spagnuolo; Mengxi Zhang; Shuqian Liu; Jinan Liu; Yaping Xu; Er Chen; Jian Han

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January 1, 2014

Pharmacokinetics and pharmacodynamics of CD4-anchoring Bi-functional fusion inhibitor in monkeys

Pharmaceutical Research, ISSN: 1573904X 07248741

Xingrong Liu; Ying C. Ou; Jun Zhang; Ago Ahene; Douglas Clark; Su-Chun Hsieh; Matthew Cooper; Changhua Ji

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January 1, 2014

A tiered approach to address regulatory drug metabolite-related issues in drug development

Bioanalysis, ISSN: 17576199 17576180

Shuguang Ma; Swapan K. Chowdhury

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January 1, 2014

Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases

Current Topics in Medicinal Chemistry, ISSN: 18734294 15680266

Flygare; Michelle R. Arkin

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January 1, 2014

Implementing high-temperature short-time media treatment in commercial-scale cell culture manufacturing processes

Applied Microbiology and Biotechnology, ISSN: 14320614 01757598

Michael Pohlscheidt; Salim Charaniya; Fikret Kulenovic; Mahalia Corrales; Masaru Shiratori; Justin Bourret; Steven Meier; Eric Fallon; Robert Kiss

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January 1, 2014

Combination of PIM and JAK2 inhibitors synergistically suppresses MPN cell proliferation and overcomes drug resistance

Oncotarget, ISSN: 19492553

Shih-Min A. Huang; Anlai Wang; Rita Greco; Zhifang Li; Claude Barberis; Michel Tabart; Vinod Patel; Laurent Schio; Raelene Hurley; Hong Cheng; Christoph Lengauer; Jack Pollard; James Watters; Carlos Garcia-Echeverria; Dmitri Wiederschain; Francisco Adrian; JingXin Zhang

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January 1, 2014

Genomic landscape of metastatic colorectal cancer

Nature Communications, ISSN: 20411723

Josien C. Haan; Mariette Labots; Christian Rausch; Miriam Koopman; Jolien Tol; Leonie J. M. Mekenkamp; Mark A. Van De Wiel; Danielle Israeli; Hendrik F. Van Essen; Nicole C. T. Van Grieken; Quirinus J. M. Voorham; Linda J. W. Bosch; Xueping Qu; Omar Kabbarah; Henk M. W. Verheul; Iris D. Nagtegaal; Cornelis J. A. Punt; Bauke Ylstra; Gerrit A. Meijer

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January 1, 2014

Phase I dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies

Clinical Cancer Research, ISSN: 15573265 10780432

Ravi Salgia; Premal Patel; John Bothos; Wei Yu; Stephen M. Eppler; Priti Hegde; Shuang Bai; Surinder Kaur; Ihsan Nijem; Daniel V.T. Catenacci; Amy Peterson; Ratain; Blase Polite; Janice M. Mehnert; Rebecca A. Moss

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January 1, 2014

Use of anti-malarial drugs and the risk of developing eye disorders

Travel Medicine and Infectious Disease, ISSN: 14778939 18730442

Cornelia Schneider; Miriam Adamcova; Susan S. Jick; Patricia Schlagenhauf; Mary K. Miller; Hans-Georg Rhein; Christoph R. Meier

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January 1, 2014

A Homozygous PDE6D Mutation in Joubert Syndrome Impairs Targeting of Farnesylated INPP5E Protein to the Primary Cilium

Human Mutation, ISSN: 10597794 10981004

Sophie Thomas; Kevin J. Wright; Stéphanie Le Corre; Alessia Micalizzi; Marta Romani; Avinash Abhyankar; Julien Saada; Isabelle Perrault; Jeanne Amiel; Julie Litzler; Emilie Filhol; Nadia Elkhartoufi; Mandy Kwong; Jean-Laurent Casanova; Nathalie Boddaert; Wolfgang Baehr; Stanislas Lyonnet; Arnold Munnich; Lydie Burglen; Nicolas Chassaing; Ferechté Encha-Ravazi; Michel Vekemans; Joseph G. Gleeson; Enza Maria Valente; Peter K Jackson; Iain A. Drummond; Sophie Saunier; Tania Attié-Bitach

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January 1, 2014

The effect of rifampicin, a prototypical CYP3A4 inducer, on erlotinib pharmacokinetics in healthy subjects

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Marta Hamilton; Julie Wolf; Drolet; Scott Fettner; Ashok Rakhit; Karsten Witt; Bert L. Lum

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January 1, 2014

Effect of meal and antisecretory agents on the pharmacokinetics of danoprevir/ritonavir in healthy volunteers

Journal of Pharmacy and Pharmacology, ISSN: 00223573 20427158

Peter N. Morcos; Sebastian A. Moreira; Mercidita T. Navarro; Núria Bech; Amanda Quatkemeyer; Patrick F. Smith; Barbara J. Brennan

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January 1, 2014

Risk of hospitalized bacterial infections associated with biologic treatment among US veterans with rheumatoid arthritis

Arthritis Care and Research, ISSN: 21514658 2151464X

Jeffrey R. Curtis; Yang; Patkar; Chen; Jasvinder A. Singh; Cannon; Ted R. Mikuls; Delzell; Saag; Safford; Scott L. Duvall; Kimberly Alexander; Pavel Napalkov; Kevin L. Winthrop; Burton; Kamauu; Baddley

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January 1, 2014

Budesonide nebulization added to systemic prednisolone in the treatment of acute asthma in children: A double-blind, randomized, controlled trial

Chest, ISSN: 19313543 00123692

Abdullah A. Alangari; Nidal Malhis; Mohamed Mubasher; Najwa Al-Ghamedi; Mohamad Al-Tannir; Muhammad Riaz; Dale T. Umetsu; Saleh Al-Tamimi

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January 1, 2014

Changes in PIK3CA mutation status are not associated with recurrence, metastatic disease or progression in endocrine-treated breast cancer

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Arthur; Turnbull; Renshaw; Keys; Thomas; Wilson; Lackner; Sims; Dixon

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January 1, 2014

Whole-Slide Imaging and Automated Image Analysis: Considerations and Opportunities in the Practice of Pathology

Veterinary Pathology, ISSN: 03009858 15442217

Webster; Dunstan

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January 1, 2014

Emerging technologies in extracellular vesicle-based molecular diagnostics

Expert Review of Molecular Diagnostics, ISSN: 17448352 14737159

Shidong Jia; Davide Zocco; Michael L. Samuels; Michael F. Chou; Roger Chammas; Johan Skog; Natasa Zarovni; Fatemeh Momen-Heravi; Winston Patrick Kuo

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January 1, 2014

Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: Reciprocal suppression with VEGF

Journal of Cellular Physiology, ISSN: 10974652 00219541

Jikui Shen; David F. Choy; Tsunehiko Yoshida; Takeshi Iwase; Gulnar Hafiz; Bing Xie; Sean F. Hackett; Joseph R. Arron; Peter A. Campochiaro

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January 1, 2014

Progression-free survival as a surrogate endpoint for overall survival in glioblastoma: A literature-based meta-analysis from 91 trials

Neuro-Oncology, ISSN: 15235866 15228517

Kelong Han; Melanie Ren; Wick; Lauren E. Abrey; Asha Das; Jin Y. Jin; David A. Reardon

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January 1, 2014

The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling

Molecular and Cellular Biology, ISSN: 10985549 02707306

Bo Cen; Ying Xiong; Jin H. Song; Sandeep Mahajan; Rachel DuPont; Kristen McEachern; Daniel J. DeAngelo; Jorge E. Cortes; Mark D. Minden; Allen Ebens; Alice Mims; Amanda LaRue; Andrew S. Kraft

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January 1, 2014

Using RNAi screening technologies to interrogate the extrinsic apoptosis pathway

Methods in Enzymology, ISSN: 15577988 00766879

Jean-Philippe Stephan

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January 1, 2014

New challenges and opportunities in nonclinical safety testing of biologics

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Andreas Baumann; Kelly Flagella; Roy Forster; Lolke de Haan; Sven Kronenberg; Mathias Locher; Wolfgang F. Richter; Frank-Peter Theil; Marque Todd

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January 1, 2014