Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6401 - 6450 OF 15390 RESULTS

Pathology in drug discovery and development
Journal of Pathology, ISSN: 00223417 10969896
Adrian M. Jubb; Koeppen; Jorge S. Reis-Filho
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Population pharmacokinetics and exposure-response analyses of trastuzumab in patients with advanced gastric or gastroesophageal junction cancer
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Valérie F. Cosson; Vivian W. Ng; Michaela Lehle; Bert L. Lum
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Effect of adjuvant capecitabine or fluorouracil, with or without oxaliplatin, on survival outcomes in stage III colon cancer and the effect of oxaliplatin on post-relapse survival: A pooled analysis of individual patient data from four randomised controlled trials
The Lancet Oncology, ISSN: 14745488 14702045
Hans-Joachim Schmoll; Chris Twelves; Sun; Michael J O'Connell; Cartwright; Edward McKenna; Muhammad Saif; Lee; Greg Yothers; Daniel Haller
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Protein crystallization image classification with elastic net
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, ISSN: 16057422
Jeffrey Hung; John Collins; Mehari Weldetsion; Oliver Newland; Eric Chiang; Steve Guerrero; Kazunori Okada
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Profiling cancer genemutations in clinical formalin-fixed, paraffin-embedded colorectal tumor specimens using targeted next-generation sequencing
Oncologist, ISSN: 1549490X 10837159
Liangxuan Zhang; Liangjing Chen; Sachin Sah; Gary J. Latham; Rajesh Patel; Qinghua Song; Koeppen; Rachel Tam; Erica Schleifman; Haider Mashhedi; Sreedevi Chalasani; Ling Fu; Teiko Sumiyoshi; Rajiv Raja; William F. Forrest; Garret M. Hampton; Lackner; Priti Hegde; Shidong Jia
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Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: A randomized trial
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Erika H. De Boever; Claire Ashman; Anthony P. Cahn; Nicholas W. Locantore; Phil Overend; Isabelle J. Pouliquen; Adrian P. Serone; Tracey J. Wright; Mair M. Jenkins; Inderpal S. Panesar; Sivayogan S. Thiagarajah; Sally E. Wenzel
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Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake
Science China Life Sciences, ISSN: 16747305
LiLi Qian; ChangZu Cai; PengFei Yuan; Sun-Young Jeong; XiaoZhou Yang; Venita I. DeAlmeida; James A. Ernst; Michael Costa; Stanley N. Cohen; WenSheng Wei
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A new player on the psoriasis block: IL-17A- and IL-22-producing innate lymphoid cells
Journal of Investigative Dermatology, ISSN: 15231747 0022202X
Nicole L. Ward; Dale T. Umetsu
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AKT-induced tamoxifen resistance is overturned by RRM2 inhibition
Molecular Cancer Research, ISSN: 15573125 15417786
Khyati N. Shah; Kshama R. Mehta; David Peterson; Marie Evangelista; John C. Livesey; Jesika S. Faridi
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Phase 1b study of safety, tolerability and efficacy of R1507, a monoclonal antibody to IGF-1R in combination with multiple standard oncology regimens in patients with advanced solid malignancies
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Daruka Mahadevan; Gregory Ryan Sutton; Rafael Arteta-Bulos; Chris J. Bowden; Paul J. E. Miller; Rachel Elizabeth Swart; Mark S. Walker; Paul Haluska; Pamela N. Münster; John Marshall; Omid Hamid; Razelle Kurzrock
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Interrogation of in vivo protein-protein interactions using transgenic mouse models and stable isotope labeling
Methods in Molecular Biology, ISSN: 10643745
Anwesha Dey; Jiansheng Wu; Donald S. Kirkpatrick
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IAP family of cell death and signaling regulators
Methods in Enzymology, ISSN: 15577988 00766879
John Silke; Domagoj Vucic
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Comparison of treatment patterns and economic outcomes in metastatic breast cancer patients initiated on trastuzumab versus lapatinib: A retrospective analysis
SpringerPlus, ISSN: 21931801
Annie Guérin; Deepa Lalla; Geneviève Gauthier; Amy Styles; Eric Q. Wu; Anthony Masaquel; Melissa Brammer
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Investigation of adverse-event-related costs for patients with metastatic breast cancer in a real-world setting
Oncologist, ISSN: 1549490X 10837159
Sara A. Hurvitz; Annie Guérin; Melissa Brammer; Ellie Guardino; Zheng-Yi Zhou; Dominick Latremouille Viau; Eric Q. Wu; Deepa Lalla
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Tailoring small molecules for an allosteric site on procaspase-6
ChemMedChem, ISSN: 18607179 18607187
Jeremy Murray; Anthony M. Giannetti; Micah Steffek; Paul Gibbons; Brian R. Hearn; Frederick Cohen; Christine Tam; Christine D. Pozniak; Brandon Bravo; Joe Lewcock; Priyadarshini Jaishankar; Cuong Q. Ly; Xianrui Zhao; Yinyan Tang; Preeti Chugha; Michelle R. Arkin; Flygare; Adam R. Renslo
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Immunomodulation and lymphoma in humans
Journal of Immunotoxicology, ISSN: 1547691X
Rafael Ponce; Thomas R. Gelzleichter; Helen G. Haggerty; Shawn Heidel; Matthew S. Holdren; Herve Lebrec; R. Daniel Mellon; Marc Pallardy
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In vivo antigen-driven plasmablast enrichment in combination with antigen-specific cell sorting to facilitate the isolation of rare monoclonal antibodies from human B cells
Nature Protocols, ISSN: 17502799 17542189
Zhonghua Lin; Nancy Y. Chiang; Ning Chai; Dhaya Seshasayee; Wyne P. Lee; Mercedesz Balazs; Nakamura; Lee R. Swem
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Amphiregulin and pten evoke a multimodal mechanism of acquired resistance to PI3k inhibition
Genes and Cancer, ISSN: 19476027 19476019
Kyle A. Edgar; Lisa Crocker; Eric Cheng; Marie-Claire Wagle; Matthew Wongchenko; Yibing Yan; Wilson; Nicholas A. Dompe; Richard M. Neve; Marcia Belvin; Deepak Sampath; Lori S. Friedman; Jeffery J. Wallin
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Genetic markers of bevacizumab-induced hypertension
Angiogenesis, ISSN: 15737209 09696970
Diether Lambrechts; Matthieu Moisse; Paul Delmar; David W. Miles; Natasha Leighl; Bernard Escudier; Eric Van Cutsem; Aruna T. Bansal; Peter Carmeliet; Stefan J. Scherer; Sanne De Haas; Celine Pallaud
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Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized fab-antigen complexes
mAbs, ISSN: 19420870 19420862
Sherry L. La Porte; Eigenbrot; Ultsch; Ho; Davide Foletti; Alison Forgie; Kevin C. Lindquist; David L. Shelton; Jaume Pons
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Complete knockout of the lactate dehydrogenase A gene is lethal in pyruvate dehydrogenase kinase 1, 2, 3 down-regulated CHO cells
Molecular Biotechnology, ISSN: 15590305 10736085
Shirley S. M. Yip; Meixia Zhou; John C. Joly; Snedecor; Amy Shen; Yongping Crawford
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Population pharmacokinetic and covariate analysis of pertuzumab, a HER2-targeted monoclonal antibody, and evaluation of a fixed, non-weight-based dose in patients with a variety of solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Amit Garg; Angelica Quartino; Jing Li; Jin Y. Jin; D. Russell Wada; Hanbin Li; Javier Cortés; Virginia McNally; Graham Ross; Jennifer Visich; Bert L. Lum
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Geographic atrophy: Clinical features and potential therapeutic approaches
Ophthalmology, ISSN: 15494713 01616420
Frank G. Holz; Erich C. Strauss; Steffen Schmitz-Valckenberg; Menno Van Lookeren Campagne
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Bispecific therapeutics for ophthalmic indications: Target selection and the optimal molecular format
Expert Review of Ophthalmology, ISSN: 17469902 17469899
Jennifer Le Couter; Justin M. Scheer
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Intraocular pressure in eyes receiving monthly ranibizumab in 2 pivotal age-related macular degeneration clinical trials
Ophthalmology, ISSN: 15494713 01616420
Sophie J. Bakri; Darius M. Moshfeghi; Steve Francom; Amy Chen Rundle; Daniel S. Reshef; Paul P. Lee; Carol Schaeffer; Roman G. Rubio; Phillip Lai
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The effect of mild to moderate renal impairment on the pharmacokinetics of the nucleoside analog hepatitis C virus polymerase inhibitor mericitabine
Drug Development Research, ISSN: 10982299 02724391
Joshua Haznedar; Sebastian A. Moreira; Thomas Marbury; Richard Robson; William Smith; Rohit Kulkarni; Marie L. Munson; James A. Thommes; Annabelle Lemenuel-Diot; Carla Washington; Patrick F. Smith; Ya-Chi Chen
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Treatment patterns and clinical outcomes for patients with de novo versus recurrent HER2-positive metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Denise A. Yardley; Peter A. Kaufman; Adam Brufsky; Marianne Ulcickas Yood; Hope S. Rugo; Musa Mayer; Quah; Bongin Yoo; Debasish Tripathy
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Internal virus polarization model for virus retention by the Ultipor® VF Grade DV20 membrane
Biotechnology Progress, ISSN: 15206033 87567938
Nigel B. Jackson; Meisam Bakhshayeshi; Andrew Zydney; Amit Mehta; Robert Van Reis; Ralf Kuriyel
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Homozygosity of the autosomal dominant alzheimer disease presenilin 1 E280A mutation
Neurology, ISSN: 1526632X 00283878
Kenneth S. Kosik; Claudia Muñoz; Liliana Lopez; Mary Luz Arcila; Gloria García; Lucía Madrigal; Sonia Moreno; Silvia Ríos Romenets; Hugo Lopez; Madelyn Gutierrez; Jessica B. Langbaum; William Cho; Shehnaaz Suliman; Pierre N. Tariot; Carole Ho; Eric M. Reiman; Francisco Lopera
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Real-time asthma outreach reduces excessive short-acting β2-agonist use: A randomized study
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Robert S. Zeiger; Michael Schatz; Qiaowu Li; Paul G. Solari; James L. Zazzali; Wansu Chen
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Systematic review of vismodegib toxicity profile in the treatment of advanced basal cell carcinomas compared to other systemic therapies in dermatology
Journal of Drugs in Dermatology, ISSN: 15459616
Margit L. W. Juhász; Ellen S. Marmur
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Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy
Journal of Virology, ISSN: 10985514 0022538X
Kevin B. Walsh; John R. Teijaro; Linda G. Brock; Daniel M. Fremgen; Peter L. Collins; Hugh Rosen; Michael B.A. Oldstone
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Prediction of overall survival or progression free survival by disease control rate at week 8 is independent of ethnicity: Western versus Chinese patients with first-line non-small cell lung cancer treated with chemotherapy with or without bevacizumab
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Laurent Claret; Manish Gupta; Kelong Han; Amita Joshi; Nenad Sarapa; Jing He; Bob Powell; Rene Bruno
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Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib
Journal of the American Academy of Dermatology, ISSN: 01909622 10976787
Anne Lynn S. Chang; James A. Solomon; John Hainsworth; Leonard Goldberg; Edward McKenna; Bann-Mo Day; Diana M. Chen; Glen J. Weiss
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The use of FDG-PET in diffuse large B cell lymphoma (DLBCL): Predicting outcome following first line therapy
Cancer Imaging, ISSN: 14707330
Monica Coughlan; Rebecca Elstrom
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1-Aminobenzotriazole coincubated with (s)-warfarin results in potent inactivation of CYP2C9s
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Jasleen K. Sodhi; Kevin A. Ford; Sophie Mukadam; Susan C. Wong; Cornelis E. Hop; S. Cyrus Khojasteh; Jason S Halladay
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Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Laurent Salphati; Xiaoyan Chu; Liangfu Chen; Bhagwat Prasad; Shannon Dallas; Raymond Evers; Donna Mamaril-Fishman; Ethan G. Geier; Jonathan Kehler; Jeevan Kunta; Mario Mezler; Loic Laplanche; Jodie Pang; Anja Rode; Matthew G. Soars; Jashvant D. Unadkat; Robert A. B. Van Waterschoot; Jocelyn Yabut; Alfred H. Schinkel; Nico Scheer
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Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: A proof-of-principle
Annals of Oncology, ISSN: 15698041 09237534
De Mattos-Arruda; Weigelt; Javier Cortés; Won; Ng; Nuciforo; Bidard; Aura; Saura; Peg; Piscuoglio; Oliveira; Smolders; Premal Patel; Norton; Tabernero; Berger; Seoane; Jorge S. Reis-Filho
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Incidence and relevance of proteinuria in bevacizumab-treated patients: Pooled analysis from randomized controlled trials
American Journal of Nephrology, ISSN: 14219670 02508095
Richard A. Lafayette; Bruce Mccall; Nicole F. Li; Laura Chu; Patricia Werner; Asha Das; Richard Glassock
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Online integrity monitoring in the Protein A step of mAb Production Processes-increasing reliability and process robustness
Biotechnology Progress, ISSN: 15206033 87567938
Christopher Bork; Sarah Holdridge; Mark Walter; Eric Fallon; Michael Pohlscheidt
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Structural basis for Ca2+ selectivity of a voltage-gated calcium channel
Nature, ISSN: 00280836 14764687
Lin Tang; Tamer M. Gamal El-Din; Jian Payandeh; Gilbert Q. Martinez; Teresa M. Heard; Todd Scheuer; Ning Zheng; William A. Catterall
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A multiplexed hybrid LC-MS/MS pharmacokinetic assay to measure two co-administered monoclonal antibodies in a clinical study
Bioanalysis, ISSN: 17576199 17576180
Keyang Xu; Luna Liu; Mauricio Maia; Jenny Li; John Lowe; An Song; Surinder Kaur
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DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid
Inflammatory Bowel Diseases, ISSN: 15364844 10780998
Tammie S. MacFie; Richard Poulsom; Alexandra Parker; Gary Warnes; Tatjana Boitsova; Anke Nijhuis; Nirosha Suraweera; Angela Poehlmann; Jaroslaw Szary; Roger Feakins; Rosemary Jeffery; Richart W. Harper; Adrian M. Jubb; James O. Lindsay; Andrew Silver
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Neutralization of vascular endothelial growth factor slows progression of retinal nonperfusion in patients with diabetic macular edema
Ophthalmology, ISSN: 15494713 01616420
Peter A. Campochiaro; Charles C. Wykoff; Howard Shapiro; Roman G. Rubio; Jason S. Ehrlich
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Maximum likelihood estimation of GEVD: Applications in bioinformatics
IEEE/ACM Transactions on Computational Biology and Bioinformatics, ISSN: 15455963
Minta Thomas; Anneleen Daemen; Bart De Moor
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Dendritic cell-targeted vaccines
Frontiers in Immunology, ISSN: 16643224
Lillian Cohn; Lélia Delamarre
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Comparison of hospital length of stay, costs, and readmissions of alteplase versus catheter replacement among patients with occluded central venous catheters
Journal of Hospital Medicine, ISSN: 15535606 15535592
Frank R. Ernst; Er Chen; Craig Lipkin; Darren Tayama; Alpesh N. Amin
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The use of phase 2 interim analysis to expedite drug development decisions
Contemporary Clinical Trials, ISSN: 15592030 15517144
Jie Huang; Asha Das; Hans Ulrich Burger; Wei Zhong; Wenwen Zhang; Lieberman
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Impact of age on viral kinetics of peginterferon alfa-2a/ribavirin in chronic hepatitis C: Final analysis from the PROPHESYS cohort
Journal of Viral Hepatitis, ISSN: 13652893 13520504
Aronsohn; Ancuta; Caruntu; Coppola; Delic; Digiacomo; Dusheiko; Lengyel; Marcellin; Orlandini; Pruthi; Silva; Tallarico; Schmitz; Tatsch; Korner; Cheinquer
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Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Aidan Long; Abdelkader Rahmaoui; Kenneth J. Rothman; Eva Guinan; Mark D. Eisner; Mary S. Bradley; Carlos Iribarren; Hubert Chen; Gillis Carrigan; Karin Rosén; Stanley J. Szefler
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