Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6501 - 6550 OF 15477 RESULTS

January 1, 2014

Tailoring small molecules for an allosteric site on procaspase-6

ChemMedChem, ISSN: 18607179 18607187

Jeremy Murray; Anthony M. Giannetti; Micah Steffek; Paul Gibbons; Brian R. Hearn; Frederick Cohen; Christine Tam; Christine D. Pozniak; Brandon Bravo; Joe Lewcock; Priyadarshini Jaishankar; Cuong Q. Ly; Xianrui Zhao; Yinyan Tang; Preeti Chugha; Michelle R. Arkin; Flygare; Adam R. Renslo

January 1, 2014

Immunomodulation and lymphoma in humans

Journal of Immunotoxicology, ISSN: 1547691X

Rafael Ponce; Thomas R. Gelzleichter; Helen G. Haggerty; Shawn Heidel; Matthew S. Holdren; Herve Lebrec; R. Daniel Mellon; Marc Pallardy

January 1, 2014

In vivo antigen-driven plasmablast enrichment in combination with antigen-specific cell sorting to facilitate the isolation of rare monoclonal antibodies from human B cells

Nature Protocols, ISSN: 17502799 17542189

Zhonghua Lin; Nancy Y. Chiang; Ning Chai; Dhaya Seshasayee; Wyne P. Lee; Mercedesz Balazs; Nakamura; Lee R. Swem

January 1, 2014

Amphiregulin and pten evoke a multimodal mechanism of acquired resistance to PI3k inhibition

Genes and Cancer, ISSN: 19476027 19476019

Kyle A. Edgar; Lisa Crocker; Eric Cheng; Marie-Claire Wagle; Matthew Wongchenko; Yibing Yan; Wilson; Nicholas A. Dompe; Richard M. Neve; Marcia Belvin; Deepak Sampath; Lori S. Friedman; Jeffery J. Wallin

January 1, 2014

Genetic markers of bevacizumab-induced hypertension

Angiogenesis, ISSN: 15737209 09696970

Diether Lambrechts; Matthieu Moisse; Paul Delmar; David W. Miles; Natasha Leighl; Bernard Escudier; Eric Van Cutsem; Aruna T. Bansal; Peter Carmeliet; Stefan J. Scherer; Sanne De Haas; Celine Pallaud

January 1, 2014

Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized fab-antigen complexes

mAbs, ISSN: 19420870 19420862

Sherry L. La Porte; Eigenbrot; Ultsch; Ho; Davide Foletti; Alison Forgie; Kevin C. Lindquist; David L. Shelton; Jaume Pons

January 1, 2014

Complete knockout of the lactate dehydrogenase A gene is lethal in pyruvate dehydrogenase kinase 1, 2, 3 down-regulated CHO cells

Molecular Biotechnology, ISSN: 15590305 10736085

Shirley S. M. Yip; Meixia Zhou; John C. Joly; Snedecor; Amy Shen; Yongping Crawford

January 1, 2014

Population pharmacokinetic and covariate analysis of pertuzumab, a HER2-targeted monoclonal antibody, and evaluation of a fixed, non-weight-based dose in patients with a variety of solid tumors

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Amit Garg; Angelica Quartino; Jing Li; Jin Y. Jin; D. Russell Wada; Hanbin Li; Javier Cortés; Virginia McNally; Graham Ross; Jennifer Visich; Bert L. Lum

January 1, 2014

Geographic atrophy: Clinical features and potential therapeutic approaches

Ophthalmology, ISSN: 15494713 01616420

Frank G. Holz; Erich C. Strauss; Steffen Schmitz-Valckenberg; Menno Van Lookeren Campagne

January 1, 2014

Bispecific therapeutics for ophthalmic indications: Target selection and the optimal molecular format

Expert Review of Ophthalmology, ISSN: 17469902 17469899

Jennifer Le Couter; Justin M. Scheer

January 1, 2014

Intraocular pressure in eyes receiving monthly ranibizumab in 2 pivotal age-related macular degeneration clinical trials

Ophthalmology, ISSN: 15494713 01616420

Sophie J. Bakri; Darius M. Moshfeghi; Steve Francom; Amy Chen Rundle; Daniel S. Reshef; Paul P. Lee; Carol Schaeffer; Roman G. Rubio; Phillip Lai

January 1, 2014

The effect of mild to moderate renal impairment on the pharmacokinetics of the nucleoside analog hepatitis C virus polymerase inhibitor mericitabine

Drug Development Research, ISSN: 10982299 02724391

Joshua Haznedar; Sebastian A. Moreira; Thomas Marbury; Richard Robson; William Smith; Rohit Kulkarni; Marie L. Munson; James A. Thommes; Annabelle Lemenuel-Diot; Carla Washington; Patrick F. Smith; Ya-Chi Chen

January 1, 2014

Treatment patterns and clinical outcomes for patients with de novo versus recurrent HER2-positive metastatic breast cancer

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Denise A. Yardley; Peter A. Kaufman; Adam Brufsky; Marianne Ulcickas Yood; Hope S. Rugo; Musa Mayer; Quah; Bongin Yoo; Debasish Tripathy

January 1, 2014

Internal virus polarization model for virus retention by the Ultipor® VF Grade DV20 membrane

Biotechnology Progress, ISSN: 15206033 87567938

Nigel B. Jackson; Meisam Bakhshayeshi; Andrew Zydney; Amit Mehta; Robert Van Reis; Ralf Kuriyel

January 1, 2014

Homozygosity of the autosomal dominant alzheimer disease presenilin 1 E280A mutation

Neurology, ISSN: 1526632X 00283878

Kenneth S. Kosik; Claudia Muñoz; Liliana Lopez; Mary Luz Arcila; Gloria García; Lucía Madrigal; Sonia Moreno; Silvia Ríos Romenets; Hugo Lopez; Madelyn Gutierrez; Jessica B. Langbaum; William Cho; Shehnaaz Suliman; Pierre N. Tariot; Carole Ho; Eric M. Reiman; Francisco Lopera

January 1, 2014

Real-time asthma outreach reduces excessive short-acting β2-agonist use: A randomized study

Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198

Robert S. Zeiger; Michael Schatz; Qiaowu Li; Paul G. Solari; James L. Zazzali; Wansu Chen

January 1, 2014

Systematic review of vismodegib toxicity profile in the treatment of advanced basal cell carcinomas compared to other systemic therapies in dermatology

Journal of Drugs in Dermatology, ISSN: 15459616

Margit L. W. Juhász; Ellen S. Marmur

January 1, 2014

Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy

Journal of Virology, ISSN: 10985514 0022538X

Kevin B. Walsh; John R. Teijaro; Linda G. Brock; Daniel M. Fremgen; Peter L. Collins; Hugh Rosen; Michael B.A. Oldstone

January 1, 2014

Prediction of overall survival or progression free survival by disease control rate at week 8 is independent of ethnicity: Western versus Chinese patients with first-line non-small cell lung cancer treated with chemotherapy with or without bevacizumab

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Laurent Claret; Manish Gupta; Kelong Han; Amita Joshi; Nenad Sarapa; Jing He; Bob Powell; Rene Bruno

January 1, 2014

Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib

Journal of the American Academy of Dermatology, ISSN: 01909622 10976787

Anne Lynn S. Chang; James A. Solomon; John Hainsworth; Leonard Goldberg; Edward McKenna; Bann-Mo Day; Diana M. Chen; Glen J. Weiss

January 1, 2014

The use of FDG-PET in diffuse large B cell lymphoma (DLBCL): Predicting outcome following first line therapy

Cancer Imaging, ISSN: 14707330

Monica Coughlan; Rebecca Elstrom

January 1, 2014

1-Aminobenzotriazole coincubated with (s)-warfarin results in potent inactivation of CYP2C9s

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Jasleen K. Sodhi; Kevin A. Ford; Sophie Mukadam; Susan C. Wong; Cornelis E. Hop; S. Cyrus Khojasteh; Jason S Halladay

January 1, 2014

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Laurent Salphati; Xiaoyan Chu; Liangfu Chen; Bhagwat Prasad; Shannon Dallas; Raymond Evers; Donna Mamaril-Fishman; Ethan G. Geier; Jonathan Kehler; Jeevan Kunta; Mario Mezler; Loic Laplanche; Jodie Pang; Anja Rode; Matthew G. Soars; Jashvant D. Unadkat; Robert A. B. Van Waterschoot; Jocelyn Yabut; Alfred H. Schinkel; Nico Scheer

January 1, 2014

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: A proof-of-principle

Annals of Oncology, ISSN: 15698041 09237534

De Mattos-Arruda; Weigelt; Javier Cortés; Won; Ng; Nuciforo; Bidard; Aura; Saura; Peg; Piscuoglio; Oliveira; Smolders; Premal Patel; Norton; Tabernero; Berger; Seoane; Jorge S. Reis-Filho

January 1, 2014

Incidence and relevance of proteinuria in bevacizumab-treated patients: Pooled analysis from randomized controlled trials

American Journal of Nephrology, ISSN: 14219670 02508095

Richard A. Lafayette; Bruce Mccall; Nicole F. Li; Laura Chu; Patricia Werner; Asha Das; Richard Glassock

January 1, 2014

Online integrity monitoring in the Protein A step of mAb Production Processes-increasing reliability and process robustness

Biotechnology Progress, ISSN: 15206033 87567938

Christopher Bork; Sarah Holdridge; Mark Walter; Eric Fallon; Michael Pohlscheidt

January 1, 2014

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

Nature, ISSN: 00280836 14764687

Lin Tang; Tamer M. Gamal El-Din; Jian Payandeh; Gilbert Q. Martinez; Teresa M. Heard; Todd Scheuer; Ning Zheng; William A. Catterall

January 1, 2014

A multiplexed hybrid LC-MS/MS pharmacokinetic assay to measure two co-administered monoclonal antibodies in a clinical study

Bioanalysis, ISSN: 17576199 17576180

Keyang Xu; Luna Liu; Mauricio Maia; Jenny Li; John Lowe; An Song; Surinder Kaur

January 1, 2014

DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid

Inflammatory Bowel Diseases, ISSN: 15364844 10780998

Tammie S. MacFie; Richard Poulsom; Alexandra Parker; Gary Warnes; Tatjana Boitsova; Anke Nijhuis; Nirosha Suraweera; Angela Poehlmann; Jaroslaw Szary; Roger Feakins; Rosemary Jeffery; Richart W. Harper; Adrian M. Jubb; James O. Lindsay; Andrew Silver

January 1, 2014

Neutralization of vascular endothelial growth factor slows progression of retinal nonperfusion in patients with diabetic macular edema

Ophthalmology, ISSN: 15494713 01616420

Peter A. Campochiaro; Charles C. Wykoff; Howard Shapiro; Roman G. Rubio; Jason S. Ehrlich

January 1, 2014

Maximum likelihood estimation of GEVD: Applications in bioinformatics

IEEE/ACM Transactions on Computational Biology and Bioinformatics, ISSN: 15455963

Minta Thomas; Anneleen Daemen; Bart De Moor

January 1, 2014

Dendritic cell-targeted vaccines

Frontiers in Immunology, ISSN: 16643224

Lillian Cohn; Lélia Delamarre

January 1, 2014

Comparison of hospital length of stay, costs, and readmissions of alteplase versus catheter replacement among patients with occluded central venous catheters

Journal of Hospital Medicine, ISSN: 15535606 15535592

Frank R. Ernst; Er Chen; Craig Lipkin; Darren Tayama; Alpesh N. Amin

January 1, 2014

The use of phase 2 interim analysis to expedite drug development decisions

Contemporary Clinical Trials, ISSN: 15592030 15517144

Jie Huang; Asha Das; Hans Ulrich Burger; Wei Zhong; Wenwen Zhang; Lieberman

January 1, 2014

Impact of age on viral kinetics of peginterferon alfa-2a/ribavirin in chronic hepatitis C: Final analysis from the PROPHESYS cohort

Journal of Viral Hepatitis, ISSN: 13652893 13520504

Aronsohn; Ancuta; Caruntu; Coppola; Delic; Digiacomo; Dusheiko; Lengyel; Marcellin; Orlandini; Pruthi; Silva; Tallarico; Schmitz; Tatsch; Korner; Cheinquer

January 1, 2014

Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Aidan Long; Abdelkader Rahmaoui; Kenneth J. Rothman; Eva Guinan; Mark D. Eisner; Mary S. Bradley; Carlos Iribarren; Hubert Chen; Gillis Carrigan; Karin Rosén; Stanley J. Szefler

January 1, 2014

Superficially porous particles: Perspectives, practices, and trends

LCGC North America, ISSN: 15275949

Michael W. Dong; Szabolcs Fekete; Davy Guillarme

January 1, 2014

HPLC for characterization and quality control of therapeutic monoclonal antibodies

LC-GC Europe, ISSN: 14716577

Taylor Zhang; Quan; Michael W. Dong

January 1, 2014

Effect of ritonavir-boosted danoprevir, a potent hepatitis C virus protease inhibitor, on the pharmacokinetics of methadone in healthy subjects undergoing methadone maintenance therapy

Pharmacotherapy, ISSN: 02770008

Sebastian A. Moreira; Peter N. Morcos; Mercidita T. Navarro; Núria Bech; Patrick F. Smith; Barbara J. Brennan

January 1, 2014

Sex-specific control of central nervous system autoimmunity by p38 mitogen-activated protein kinase signaling in myeloid cells

Annals of Neurology, ISSN: 03645134 15318249

Dimitry N. Krementsov; Rajkumar Noubade; Julie A. Dragon; Kinya Otsu; Mercedes Rincon; Cory Teuscher

January 1, 2014

The effects of tocilizumab on osteitis, synovitis and erosion progression in rheumatoid arthritis: Results from the ACT-RAY MRI substudy

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Philip G. Conaghan; Charles G. Peterfy; Ewa Olech; Jeffrey Kaine; David Ridley; Julie DiCarlo; Josh Friedman; Jenny Devenport; Orrin Troum

January 1, 2014

Viral clearance using traditional, well-understood unit operations (session I): Low-pH inactivation

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124

Qi Chen

January 1, 2014

Resource utilization and cost in a commercially insured population with schizophrenia

American Health and Drug Benefits, ISSN: 19422970 19422962

Kathryn Fitch; Kosuke Iwasaki; Kathleen F. Villa

January 1, 2014

Development of a tripartite solvent blend for sustainable chromatography

Green Chemistry, ISSN: 14639270 14639262

Florence M. Chardon; Nicole Blaquiere; Georgette M. Castanedo; Stefan G. Koenig

January 1, 2014

Patients' willingness to trade off between the duration and frequency of rheumatoid arthritis treatments

Arthritis Care and Research, ISSN: 21514658 2151464X

Christine Poulos; A. Brett Hauber; Juan Marcos González; Adam Turpcu

January 1, 2014

A comparison of health-related quality of life in idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis

Chest, ISSN: 19313543 00123692

Molly Lubin; Hubert Chen; Brett Elicker; Kirk D. Jones; Harold R. Collard; Joyce S. Lee

January 1, 2014

Combinatorial approach for large-scale identification of linked peptides from tandem mass spectrometry spectra

Molecular and Cellular Proteomics, ISSN: 15359484 15359476

Jian Wang; Veronica G. Anania; Jeff Knott; John Rush; Jennie R. Lill; Philip E. Bourne; Nuno Bandeira

January 1, 2014

Assessing health-related quality of life for advanced basal cell carcinoma and basal cell carcinoma nevus syndrome development of the first disease-specific patient-reported outcome questionnaires

JAMA Dermatology, ISSN: 21686068

Susan D. Mathias; Mary-Margaret Chren; Hilary H. Colwell; Yeun Mi Yim; Carolina Reyes; Diana M. Chen; Scott W. Fosko

January 1, 2014

OX40L blockade and allergen-induced airway responses in subjects with mild asthma

Clinical and Experimental Allergy, ISSN: 09547894 13652222

Gauvreau; Boulet; Cockcroft; Fitzgerald; Mayers; Carlsten; Laviolette; Killian; Davis; Larché; Kipling; Dua; Mosesova; Wendy Putnam; Zheng; Heleen Scheerens; Mcclintock; Matthews; O'Byrne

January 1, 2014

Distribution of the phosphatidylinositol 3-kinase inhibitors pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models - Assessment by matrix-assisted laser desorption ionization imaging

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Laurent Salphati; Sheerin Shahidi-Latham; Cristine Quiason; Kai H. Barck; Merry C. Nishimura; Bruno Alicke; Jodie Pang; Richard A. D. Carano; Alan G. Olivero; Phillips

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