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Publications

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DISPLAYING 6701 - 6750 OF 15394 RESULTS

Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development
Molecular Pharmaceutics, ISSN: 15438384 15438392
Gillian S. Smelick; Timothy P. Heffron; Laura Chu; Brian J. Dean; David A. West; Scott L. Duvall; Bert L. Lum; Nageshwar Budha; Scott N. Holden; Leslie Z. Benet; Adam Frymoyer; Mark J. Dresser; Joseph A. Ware
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Investigation of the rat model for preclinical evaluation of pH-dependent oral absorption in humans
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph W. Lubach; Jacob Z. Chen; Jonathan Hau; Jose Imperio; Melis Coraggio; Lichuan Liu; Harvey Wong
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Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria
Molecular Pharmaceutics, ISSN: 15438384 15438392
Marc R. Yago; Adam Frymoyer; Gillian S. Smelick; Lynda A. Frassetto; Nageshwar Budha; Mark J. Dresser; Joseph A. Ware; Leslie Z. Benet
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Absolute bioavailability and effect of formulation change, food, or elevated pH with rabeprazole on cobimetinib absorption in healthy subjects
Molecular Pharmaceutics, ISSN: 15438384 15438392
Luna Musib; Edna F. Choo; Yuzhong Deng; Stephen M. Eppler; Isabelle Rooney; Iris Chan; Mark J. Dresser
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Characterization of a water-solid interaction in a partially ordered system
Molecular Pharmaceutics, ISSN: 15438384 15438392
Paroma Chakravarty; Joseph W. Lubach
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Systemic concentrations can limit the oral absorption of poorly soluble drugs: An investigation of non-sink permeation using physiologically based pharmacokinetic modeling
Molecular Pharmaceutics, ISSN: 15438384 15438392
Po-Chang Chiang; Hank La; Haiming Zhang; Harvey Wong
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Two-dimensional HPLC in pharmaceutical analysis
American Pharmaceutical Review, ISSN: 10998012
Kelly Zhang; Jennifer Wang; Midco Tsang; Larry Wigman; Nik P. Chetwyn
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Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Nature Neuroscience, ISSN: 10976256 15461726
David V. Hansen; Jan H. Lui; Pierre Flandin; Kazuaki Yoshikawa; John L. R. Rubenstein; Arturo Alvarez-Buylla; Arnold R. Kriegstein
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Vehicle selection for nonclinical oral safety studies
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607
Evan A Thackaberry
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Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Sharada Labadie; Kathy Barrett; Wade S. Blair; Christine Chang; Gauri Deshmukh; Eigenbrot; Paul Gibbons; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Marya Liimatta; Patrick J. Lupardus; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Mark Zak
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Purification of antibodies by precipitating impurities using Polyethylene Glycol to enable a two chromatography step process
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X
Glen Giese; Adam Myrold; Gorrell; Josefine Persson
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Exposure-response analysis of pertuzumab in HER2-positive metastatic breast cancer: Absence of effect on QTc prolongation and other ECG parameters
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Amit Garg; Jing Li; Emma Clark; Adam Knott; Timothy J. Carrothers; Jean-François Marier; Javier Cortés; Michael Brewster; Jennifer Visich; Bert L. Lum
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ATLAS: Randomized, double-blind, placebo-controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib, after completion of chemotherapy, with bevacizumab for first-line treatment of advanced non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Bruce E. Johnson; Fairooz F. Kabbinavar; Louis Fehrenbacher; John Hainsworth; Saifuddin Kasubhai; Bruce Kressel; Chin-Yu Lin; Thomas Marsland; Taral Patel; Jonathan Polikoff; Mark Rubin; Leonard White; James Chih-Hsin Yang; Chris J. Bowden; Vincent A. Miller
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Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
Journal of Experimental Medicine, ISSN: 00221007 15409538
Christine D. Pozniak; Arundhati Sengupta Ghosh; Alvin Gogineni; Jesse E. Hanson; Seung-Hye Lee; Jessica L. Larson; Hilda Solanoy; Daisy J. Bustos; Hong Li; Hai Ngu; Adrian M. Jubb; Gai Ayalon; Jiansheng Wu; Kimberly Scearce-Levie; Qiang Zhou; Robby M. Weimer; Donald S. Kirkpatrick; Joe Lewcock
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Maximizing kinetic performance in supercritical fluid chromatography using state-of-the-art instruments
Journal of Chromatography A, ISSN: 18733778 00219673
Alexandre Grand-Guillaume Perrenoud; Chris Hamman; Meenakshi Goel; Jean-Luc Veuthey; Davy Guillarme; Szabolcs Fekete
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Porcine circovirus (PCV) removal by Q sepharose fast flow chromatography
Biotechnology Progress, ISSN: 87567938 15206033
Bin Yang; Hua Wang; Cintia Ho; Philip M. Lester; Qi Chen; Florian Neske; Sally A. Baylis; Johannes Blümel
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Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells
Acta Neuropathologica, ISSN: 00016322 14320533
Annegret Kathagen; Alexander Schulte; Gerd Balcke; Phillips; Tobias Martens; Jakob Matschke; Hauke S. Günther; Robert Soriano; Zora Modrusan; Thomas Sandmann; Carsten Kuhl; Alain Tissier; Mareike Holz; Lutz A. Krawinkel; Markus Glatzel; Manfred Westphal; Katrin Lamszus
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Absence of pharmacokinetic drug-drug interaction of pertuzumab with trastuzumab and docetaxel
Anti-Cancer Drugs, ISSN: 09594973 14735741
Javier Cortés; Sandra M. Swain; Iveta Kudaba; Maik Hauschild; Taral Patel; Elza Grincuka; Norikazu Masuda; Virginia McNally; Graham Ross; Michael Brewster; Jean-François Marier; My My Trinh; Amit Garg; Ihsan Nijem; Jennifer Visich; Bert L. Lum; Baselga
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Sample size and threshold estimation for clinical trials with predictive biomarkers
Contemporary Clinical Trials, ISSN: 15517144 15592030
Howard M. Mackey; Thomas Bengtsson
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Population pharmacokinetic analysis from phase i and phase ii studies of the humanized monovalent antibody, onartuzumab (metmab), in patients with advanced solid tumors
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Yan Xin; Denise Jin; Stephen M. Eppler; Lisa A. Damico; Amita Joshi; John Davis; Surinder Kaur; Ihsan Nijem; John Bothos; Amy Peterson; Premal Patel; Shuang Bai
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Using registries to identify adverse events in rheumatic diseases
Pediatrics, ISSN: 00314005 10984275
Geraldina Lionetti; Yukiko Kimura; Laura E. Schanberg; Timothy Beukelman; Carol A. Wallace; Norman T. Ilowite; Jane Winsor; Kathleen Fox; Marc Natter; John S. Sundy; Eric Brodsky; Jeffrey R. Curtis; Vincent Del Gaizo; Solomon Iyasu; Angelika Jahreis; Ann Meeker-O'connell; Barbara B. Mittleman; Bernard M. Murphy; Eric D. Peterson; Sandra C. Raymond; Soko Setoguchi; Jeffrey N. Siegel; Rachel E. Sobel; Daniel Solomon; Taunton R. Southwood; Richard Vesely; Patience H. White; Nico M. Wulffraat; Christy I. Sandborg
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A two-stage Bayesian design with sample size reestimation and subgroup analysis for phase II binary response trials
Contemporary Clinical Trials, ISSN: 15517144 15592030
Wei Zhong; Joseph S. Koopmeiners; Bradley P. Carlin
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Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Bradley J. Newhouse; Steve Wenglowsky; Jonas Grina; Ellen R. Laird; Walter C. Voegtli; Li Ren; Kateri Ahrendt; Alexandre J. Buckmelter; Susan L. Gloor; Nathalie Klopfenstein; Joachim Rudolph; Zhaoyang Wen; Xianfeng Li; Bainian Feng
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Age distribution of patients with advanced non-melanoma skin cancer in the United States
Archives of Dermatological Research, ISSN: 03403696 1432069X
Stacey Dacosta Byfield; Diana M. Chen; Yeun Mi Yim; Carolina Reyes
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A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail
European Journal of Clinical Pharmacology, ISSN: 00316970 14321041
Peter N. Morcos; Linda Chang; Rohit Kulkarni; Mylene Giraudon; Nancy Shulman; Barbara J. Brennan; Patrick F. Smith; Jonathan Q. Tran
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Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct
Developmental Dynamics, ISSN: 10588388 10970177
Yoko Inès Nozawa; Erica Yao; Chuwen Lin; Jehn-Hsiahn Yang; Christopher W. Wilson; Rhodora Gacayan; Pao-Tien Chuang
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Erratum: Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes (Journal of Inherited Metabolic Disease DOI: 10.1007/s10545-012-9561-3)
Journal of Inherited Metabolic Disease, ISSN: 01418955 15732665
Derek G. Burke; Ahad A. Rahim; Simon N. Waddington; Stefan Karlsson; Ida Enquist; Kailash Bhatia; Atul Mehta; Ashok Vellodi; Simon Heales
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Clinical applications of palifermin: Amelioration of oral mucositis and other potential indications
Journal of Cellular and Molecular Medicine, ISSN: 15821838
Saroj Vadhan-Raj; Jenna D. Goldberg; Miguel-Angel Perales; Dietmar P. Berger; Marcel R.M. van den Brink
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Strategy for selecting disposable bags for cell culture media applications based on a root-cause investigation
Biotechnology Progress, ISSN: 87567938 15206033
Joseph Wood; Ekta Mahajan; Masaru Shiratori
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More myths in ultrahigh-pressure liquid chromatography
LC-GC Europe, ISSN: 14716577
Michael W. Dong
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Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Journal of Experimental Medicine, ISSN: 00221007 15409538
Omar Abdel-Wahab; Jie Gao; Mazhar Adli; Anwesha Dey; Thomas Trimarchi; Young Rock Chung; Cem Kuscu; Todd Hricik; Delphine Ndiaye-Lobry; Lindsay M. LaFave; Richard Koche; Alan H. Shih; Olga A. Guryanova; Eunhee Kim; Sheng Li; Suveg Pandey; Joseph Y. Shin; Leon Telis; Jinfeng Liu; Parva K. Bhatt; Sebastien Monette; Xinyang Zhao; Christopher E Mason; Christopher Y. Park; Bradley E. Bernstein; Iannis Aifantis; Ross L. Levine
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IL-2 Immunotherapy Reveals Potential for Innate Beta Cell Regeneration in the Non-Obese Diabetic Mouse Model of Autoimmune Diabetes
PLoS ONE, ISSN: 19326203
Yaiza Diaz-de-Durana; Janet Lau; Deborah Knee; Christophe Filippi; Marco Londei; Peter McNamara; Marc Nasoff; Michael Didonato; Richard Glynne; Ann E. Herman
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Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)
Tetrahedron Letters, ISSN: 00404039 18733581
Malcolm P. Huestis; Wendy Liu; Matthew Volgraf; Hans E. Purkey; Christine Yu; Weiru Wang; Darin Smith; Guy Vigers; Darrin Dutcher; Kevin W. Hunt; Michael Siu
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Methylglyoxal Evokes Pain by Stimulating TRPA1
PLoS ONE, ISSN: 19326203
David A. Andersson; Clive Gentry; Emily Light; Nisha Vastani; Julie Vallortigara; Angelika Bierhaus; Thomas Fleming; Stuart Bevan
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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
Journal of Experimental Medicine, ISSN: 00221007 15409538
Adriana Soler; Helena Serra; Wayne Pearce; Ana Angulo; Julie Guillermet-Guibert; Lori S. Friedman; Francesc Viñals; Holger Gerhardt; Oriol Casanovas; Mariona Graupera; Bart Vanhaesebroeck
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Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells
Journal of Cell Science, ISSN: 00219533 14779137
Abitha Jacob; Jian Jing; James Lee; Pepper Schedin; Simon M. Gilbert; Andrew A. Peden; Jagath R. Junutula; Rytis Prekeris
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Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism
Journal of Experimental Medicine, ISSN: 00221007 15409538
Nathan E. Welty; Christopher Staley; Nico Ghilardi; Michael J. Sadowsky; Botond Z. Igyártó; Daniel H. Kaplan
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Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
C. Andrew Boswell; Jan Marik; Michael J. Elowson; Noe A. Reyes; Sheila Ulufatu; Daniela Bumbaca; Victor Yip; Eduardo E. Mundo; Nicholas Majidy; Marjie Van Hoy; Saritha N. Goriparthi; Anthony Trias; Herman S. Gill; Simon P. Williams; Jagath R. Junutula; Fielder; Leslie A. Khawli
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IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis
BMJ Open, ISSN: 20446055
Jianmei Wang; Adam Platt; Ruchi Upmanyu; Søren Germer; Guiyuan Lei; Christina Rabe; Ryma Benayed; Andrew Kenwright; Andrew Hemmings; Mitchell Martin; Olivier Harari
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Managing technologies in a global drug substance biotech manufacturing network - A case study
Pharmaceutical Outsourcing, ISSN: 19453337
Michael Pohlscheidt; Eric Fallon; David Chang; Dan Stark; Frank Trach
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Investigation into temperature-induced aggregation of an antibody drug conjugate
Bioconjugate Chemistry, ISSN: 15204812 10431802
Nia S. Beckley; Kathlyn P. Lazzareschi; Hung-Wei Chih; Vikas Sharma; Heather Flores
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Dynamical modelling of phenotypes in a genome-wide RNAi live-cell imaging assay
BMC Bioinformatics, ISSN: 14712105
Gregoire Pau; Thomas Walter; Beate Neumann; Jean-Karim Hériché; Jan Ellenberg; Wolfgang Huber
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Incidence of catheter-related complications in patients with central venous or hemodialysis catheters: A health care claims database analysis
BMC Cardiovascular Disorders, ISSN: 14712261
Pavel Napalkov; Diana M. Felici; Laura Chu; Joan R. Jacobs; Susan M. Begelman
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Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5- carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Xiaozhang Zheng; Kenneth W. Bair; Paul Bauer; Timm Baumeister; Krista K. Bowman; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Yezhen Feng; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Hong Li; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Justin Ly; Thomas O'Brien; Jason Oeh; Angela Oh; Dominic J. Reynolds; Deepak Sampath; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jarrod Tremayne; Leslie Wang; Weiru Wang; Zhongguo Wang; Hongxing Wu; Jiansheng Wu; Yang Xiao; Guangxing Yang; Po-Wai Yuen; Mark Zak; Peter Dragovich
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Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Benjamin P. Fauber; Peter Dragovich; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Yichin Liu; Yingchun Liu; Shiva Malek; David Peterson; Keith Pitts; Steve Sideris; Ultsch; Erica Vanderporten; Jing Wang; Binqing Wei; Ivana Yen; Qin Yue
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EGFR-activating mutations correlate with a fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity
Cancer Research, ISSN: 00085472 15387445
Heike N. Pfaäffle; Meng Wang; Liliana Gheorghiu; Natalie Ferraiolo; Patricia Greninger; Kerstin Borgmann; Jeffrey Settleman; Cyril H. Benes; Lecia V. Sequist; Lee Zou; Henning Willers
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B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes
Clinical and Experimental Immunology, ISSN: 00099104 13652249
Rajasekaran; Nan Wang; Hang; Macaubas; Rinderknecht; Beilhack; Shizuru; Mellins
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In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release
Nature Medicine, ISSN: 10788956 1546170X
Richard H. Scheller
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Bevacizumab confers additional advantage to the combination of trastuzumab plus pertuzumab in trastuzumab-refractory breast cancer model
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Yuliang Sun; Nandini Dey; Melissa Brammer; Pradip De; Brian R. Leyland-Jones
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Racial disparities in treatment patterns and clinical outcomes in patients with HER2-positive metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Hope S. Rugo; Adam Brufsky; Marianne Ulcickas Yood; Debasish Tripathy; Peter A. Kaufman; Musa Mayer; Bongin Yoo; Oyewale Abidoye; Denise A. Yardley
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