Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6751 - 6800 OF 15394 RESULTS

Long-term outcomes of ranibizumab therapy for diabetic macular edema: The 36-month results from two phase III trials: RISE and RIDE
Ophthalmology, ISSN: 01616420 15494713
David M. Brown; Quan Dong Nguyen; Dennis Marcus; David S. Boyer; Sunil Patel; Leonard Feiner; Patricio G. Schlottmann; Amy Chen Rundle; Jiameng Zhang; Roman G. Rubio; Anthony P. Adamis; Jason S. Ehrlich; J. Jill Hopkins
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Hepatitis C virus therapy is associated with lower health care costs not only in noncirrhotic patients but also in patients with end-stage liver disease
Alimentary Pharmacology and Therapeutics, ISSN: 02692813 13652036
Gordon; Hamzeh; Pockros; Hoop; Buikema; Korner; Terrault
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Mass spectrometry of antibody-drug conjugates in plasma and tissue in drug development
Characterization of Protein Therapeutics using Mass Spectrometry,
Surinder Kaur; Keyang Xu; Ola M. Saad; Luna Liu; Tim Slattery; Randall Dere
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A high-throughput functional complementation assay for classification of BRCA1 missense variants
Cancer Discovery, ISSN: 21598274 21598290
Peter Bouwman; Hanneke van der Gulden; Ingrid van der Heijden; Rinske Drost; Christiaan N. Klijn; Pramudita Prasetyanti; Mark Pieterse; Ellen Wientjens; Jost Seibler; Frans B.L. Hogervorst; Jos Jonkers
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The anatomy of successful computational biology software
Nature Biotechnology, ISSN: 10870156 15461696
Stephen Altschul; Barry Demchak; Richard Durbin; Robert Gentleman; Martin Krzywinski; Heng Li; Anton Nekrutenko; James Robinson; Wayne Rasband; James Taylor; Cole Trapnell
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Pak and Rac GTPases promote oncogenic KIT-induced neoplasms
Journal of Clinical Investigation, ISSN: 00219738 15588238
Holly Martin; Raghuveer Singh Mali; Peilin Ma; Anindya Chatterjee; Baskar Ramdas; Emily Sims; Veerendra Munugalavadla; Joydeep Ghosh; Matringly; Valeria Visconte; Ramon V. Tiu; Cornelis P. Vlaar; Suranganie Dharmawardhane; Reuben Kapur
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Spray Drying of Monoclonal Antibodies: Investigating Powder-Based Biologic Drug Substance Bulk Storage
Drying Technology, ISSN: 07373937 15322300
Mayumi Bowen; Robert Turok; Maa
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Considerations for the successful co-development of targeted cancer therapies and companion diagnostics
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Jane Fridlyand; Richard M. Simon; Jessica C. Walrath; Roach; Richard Buller; David P. Schenkein; Keith Flaherty; Jeff D. Allen; Ellen V. Sigal; Scher
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Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins
PLoS Pathogens, ISSN: 15537366 15537374
Wouter L. W. Hazenbos; Kimberly K. Kajihara; Richard L. Vandlen; J. Hiroshi Morisaki; Sophie M. Lehar; Mark J. Kwakkenbos; Tim Beaumont; Arjen Q. Bakker; Qui Phung; Lee R. Swem; Satish Ramakrishnan; Janice Kim; Min Xu; Ishita M. Shah; Binh An Diep; Tao Sai; Andrew Sebrell; Yana Khalfin; Angela Oh; Christopher M. Koth; S. Jack Lin; Byoung-Chul Lee; Magnus Strandh; Klaus Koefoed; Peter S. Andersen; Hergen Spits; Eric J. Brown; Man-Wah Tan; Sanjeev Mariathasan
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SUMOylation is essential for sex-specific assembly and function of the Caenorhabditis elegans dosage compensation complex on X chromosomes
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Rebecca R. Pferdehirt; Barbara J. Meyer
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A dual host vector for Fab phage display and expression of native IgG in mammalian cells
Protein Engineering, Design and Selection, ISSN: 17410126 17410134
Devin B. Tesar; Isidro Hötzel
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Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Elizabeth M. Blackwood; Jennifer A. Epler; Ivana Yen; Michael Flagella; Thomas O'Brien; Marie Evangelista; Stephen Schmidt; Yang Xiao; Jonathan Choi; Kaska Kowanetz; Judi Ramiscal; Kenton Wong; Diana Jakubiak; Sharon Fong Yee; Cain; Lewis Gazzard; Karen Williams; Jason S Halladay; Peter K Jackson; Shiva Malek
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New paradigms for process validation: A practical approach
BioProcess International, ISSN: 15426319
Mire-Sluis; Vijay Chiruvolu; Kelley; Linda Ng; Reb Russell; Chiang Syin; Victor Vinci; Mats Welin; Nathan McKnight; Bob Kuhn; Christian Klock; Ranjit Deshmukh; Siddharth Advant
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The structure and regulation of magnesium selective ion channels
Biochimica et Biophysica Acta - Biomembranes, ISSN: 00052736 18792642
Jian Payandeh; Roland Pfoh; Emil F. Pai
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The RosettaCon 2012 Special Collection: Code Writ on Water, Documentation Writ in Stone
PLoS ONE, ISSN: 19326203
Ingemar André; Jacob E. Corn
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Influence of tumour micro-environment heterogeneity on therapeutic response
Nature, ISSN: 00280836 14764687
Melissa Junttila; Frederic J. De Sauvage
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Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Shahram Misaghi; Kate Senger; Tao Sai; Yan Qu; Yonglian Sun; Kajal Hamidzadeh; Allen Nguyen; Zhaoyu Jin; Meijuan Zhou; Donghong Yan; Wei Yu Lin; Zhonghua Lin; Maria N. Lorenzo; Andrew Sebrell; Jiabing Ding; Min Xu; Patrick Caplazi; Cary D. Austin; Mercedesz Balazs; Merone Roose-Girma; Laura DeForge; Søren Warming; Wyne P. Lee; Vishva M. Dixit; Ali A. Zarrin
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Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control
BMC Genomics, ISSN: 14712164
Emanuele De Rinaldis; Patrycja Gazinska; Anca Mera; Zora Modrusan; Grazyna Fedorowicz; Brian Burford; Cheryl Gillett; Pierfrancesco Marra; Anita Grigoriadis; David Dornan; Lars Holmberg; Sarah Pinder; Andrew Tutt
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Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies
Journal of Experimental Medicine, ISSN: 00221007 15409538
Kim; Avi Ashkenazi
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Differential Host Response, Rather Than Early Viral Replication Efficiency, Correlates with Pathogenicity Caused by Influenza Viruses
PLoS ONE, ISSN: 19326203
Peter S. Askovich; Catherine J. Sanders; Carrie M. Rosenberger; Alan H. Diercks; Pradyot Dash; Garnet Navarro; Peter Vogel; Peter C. Doherty; Paul G. Thomas; Alan Aderem
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Using glucaminium-based ionic liquids for improving the separation of 2-aminopyrimidine-5-ylboronic acid and its pinacol ester by high performance liquid chromatography
Journal of Chromatography A, ISSN: 00219673 18733778
Manishkumar D. Joshi; Tianhao Li; Qiqing Zhong; Jared L. Anderson
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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
Journal of Cell Biology, ISSN: 00219525 15408140
Sarah Huntwork-Rodriguez; Bei Wang; Trent A. Watkins; Arundhati Sengupta Ghosh; Christine D. Pozniak; Daisy J. Bustos; Kim Newton; Donald S. Kirkpatrick; Joe Lewcock
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Peripherally induced Tregs-role in immune homeostasis and autoimmunity
Frontiers in Immunology, ISSN: 16643224
Mahesh Yadav; Stephen Stephan; Jeffrey A. Bluestone
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Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells
Nature Immunology, ISSN: 15292908 15292916
Kamalakannan Rajasekaran; Pawan Kumar; Kristina M. Schuldt; Erik J. Peterson; Bart Vanhaesebroeck; Vishva M. Dixit; Monica S. Thakar; Subramaniam Malarkannan
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Structural and biophysical insights into the role of CD4 and CD8 in T cell activation
Frontiers in Immunology, ISSN: 16643224
Yili Li; Yiyuan Yin; Roy A. Mariuzza
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Onartuzumab (MetMab): Using nonclinical pharmacokinetic and concentration-effect data to support clinical development
Clinical Cancer Research, ISSN: 10780432 15573265
Hong Xiang; Brendan C. Bender; Arthur Reyes; Mark Merchant; Nelson L. Shasha Jumbe; Mally Romero; Teresa Davancaze; Ihsan Nijem; Elaine Mai; Judy Young; Amy Peterson; Lisa A. Damico
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A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Wendy Lee; Daniel F. Ortwine; Philippe Bergeron; Kevin Lau; Lichuan Liu; Shiva Malek; Jim Nonomiya; Zhonghua Pei; Kirk D. Robarge; Stephen Schmidt; Steve Sideris; Joseph P. Lyssikatos
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SIR-nucleosome interactions: Structure-function relationships in yeast silent chromatin
Gene, ISSN: 03781119 18790038
Mariano Oppikofer; Stephanie Kueng; Susan M. Gasser
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Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Christoph Spiess; Jack Bevers; Janet Jackman; Nancy Y. Chiang; Nakamura; Michael Dillon; Hongbin Liu; Patricia Molina; J. Michael Elliott; Whitney Shatz; Justin M. Scheer; Glen Giese; Josefine Persson; Yin Zhang; Dennis; James Giulianotti; Prateek Gupta; Dorothea Reilly; Enzo Palma; Jianyong Wang; Stefanich; Heleen Scheerens; Fuh; Lawren C. Wu
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GPR3 Stimulates Aβ Production via Interactions with APP and β-Arrestin2
PLoS ONE, ISSN: 19326203
Nelson; Morgan Sheng
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Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Song-Hua Lee; Rui-Rui Wong; Chui-Yoke Chin; Tian-Yeh Lim; Su-Anne Eng; Cin Kong; Nur Afifah Ijap; Ming-Seong Lau; Mei-Perng Lim; Yunn-Hwen Gan; Fang-Lian He; Man-Wah Tan; Sheila Nathan
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Multicenter Intestinal Current Measurements in Rectal Biopsies from CF and Non-CF Subjects to Monitor CFTR Function
PLoS ONE, ISSN: 19326203
John P. Clancy; Rhonda D. Szczesniak; Melissa A. Ashlock; Sarah E. Ernst; Lijuan Fan; Douglas B. Hornick; Philip H. Karp; Umer Khan; James Lymp; Alicia J. Ostmann; Amir Rezayat; Timothy D. Starner; Shajan P. Sugandha; Hongtao Sun; Nancy Quinney; Scott H. Donaldson; Steven M. Rowe; Sherif E. Gabriel
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Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region
Journal of Molecular Biology, ISSN: 10898638 00222836
Kittichoat Tiyanont; Thomas E. Wales; Christian W. Siebel; John R. Engen; Stephen C. Blacklow
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Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Cancer Cell, ISSN: 18783686 15356108
Krishna P.L. Bhat; Veerakumar Balasubramaniyan; Brian Vaillant; Ravesanker Ezhilarasan; Karlijn Hummelink; Faith Hollingsworth; Khalida Wani; Lindsey Heathcock; Johanna D. James; Lindsey D. Goodman; Siobhan Conroy; Lihong Long; Nina Lelic; Suzhen Wang; Joy Gumin; Divya Raj; Yoshinori Kodama; Aditya Raghunathan; Adriana Olar; Kaushal Joshi; Christopher E. Pelloski; Amy Heimberger; SeHoon Kim; Daniel P. Cahill; Ganesh Rao; Wilfred F. A. DenDunnen; Hendrikus W.G.M. Boddeke; Phillips; Ichiro Nakano; Frederick F. Lang; Howard Colman; Erik P. Sulman; Kenneth D. Aldape
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A Role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway
Cell Stem Cell, ISSN: 19345909 18759777
Kai Kessenbrock; Gerrit J. P. Dijkgraaf; Devon A. Lawson; Laurie E. Littlepage; Payam Shahi; Ursula Pieper; Zena Werb
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CD8+ T-cell epitope mapping for pneumonia virus of mice in H-2b mice
Journal of Virology, ISSN: 0022538X 10985514
Kevin B. Walsh; John Sidney; Megan J. Welch; Daniel M. Fremgen; Alessandro Sette; Michael B.A. Oldstone
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A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb
Journal of General Physiology, ISSN: 00221295 15407748
Tamer M. Gamal El-Din; Gilbert Q. Martinez; Jian Payandeh; Todd Scheuer; William A. Catterall
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Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy
Journal of Clinical Investigation, ISSN: 15588238 00219738
Leisa Johnson; Mahrukh Huseni; Tanya Smyczek; Anthony Lima; Stacey Yeung; Jason H. Cheng; Rafael Molina; David Kan; Ann De Mazière; Judith Klumperman; Ian Kasman; Yin Zhang; Dennis; Jeffrey Eastham-Anderson; Adrian M. Jubb; Olivia Hwang; Rupal Desai; Maike Schmidt; Michelle Nannini; Kai H. Barck; Richard A. D. Carano; William F. Forrest; Qinghua Song; Daniel S. Chen; Louie Naumovski; Mallika Singh; Weilan Ye; Priti Hegde
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NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition
Oncogenesis, ISSN: 21579024
Osborne; Larsen; Gonzales; David S. Shames; Sato; Ignacio I. Wistuba; Girard; Minna; Cobb
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Protein microarrays for identification of novel extracellular protein-protein interactions
Current protocols in protein science / editorial board, John E. Coligan ... [et al.], ISSN: 19343655 19343663
Irene Tom; Nicholas Lewin-Koh; Sree R. Ramani; Lino C. Gonzalez Jr.
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Analysis of pharmaceutical impurities using multi-heartcutting 2D LC coupled with UV-charged aerosol MS detection
Journal of Separation Science, ISSN: 16159306 16159314
Kelly Zhang; Yi Li; Midco Tsang; Nik P. Chetwyn
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Pharmacokinetics of a three-way drug interaction between danoprevir, ritonavir and the organic anion transporting polypeptide (OATP) inhibitor ciclosporin
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Barbara J. Brennan; Sebastian A. Moreira; Peter N. Morcos; Mercidita T. Navarro; Jiney Asthappan; Petra Goelzer; Paul Weigl; Patrick F. Smith
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Effect of cell culture medium components on color of formulated monoclonal antibody drug substance
Biotechnology Progress, ISSN: 87567938 15206033
Natarajan Vijayasankaran; Sharat Varma; Yi Yang; Melissa Mun; Silvana Arevalo; Martin Gawlitzek; Trevor E. Swartz; Lim; Feng Li; Boyan Zhang; Steven Meier; Robert Kiss
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Pharmaco-economic analysis of direct medical costs of metastatic colorectal cancer therapy with XELOX or modified FOLFOX-6 regimens: Implications for health-care utilization in Australia
Asia-Pacific Journal of Clinical Oncology, ISSN: 17437555 17437563
Giao Tran; Stephen P. Hack; Annette Kerr; Leanne Stokes; Peter Gibbs; Timothy Price; Carlene Todd
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Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined φC31 integrase and CRE-Lox technologies
Biotechnology Progress, ISSN: 87567938 15206033
Yongping Crawford; Michelle Zhou; Zhilan Hu; John C. Joly; Snedecor; Amy Shen; Albert Gao
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Demonstrating measurement equivalence of the electronic and paper formats of the urticaria patient daily diary in patients with chronic idiopathic urticaria
Patient, ISSN: 11781653 11781661
Emuella M. Flood; James L. Zazzali; Jennifer Devlen
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Assessing the potential cost-effectiveness of retesting IHC0, IHC1+, or FISH-negative early stage breast cancer patients for HER2 status
Cancer, ISSN: 0008543X 10970142
Louis P. Garrison Jr.; Deepa Lalla; Melissa Brammer; Joseph B. Babigumira; Bruce Wang; Edith A. Perez
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High resolution reversed phase analysis of recombinant monoclonal antibodies by ultra-high pressure liquid chromatography column coupling
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X
Szabolcs Fekete; Michael W. Dong; Taylor Zhang; Davy Guillarme
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Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death
Nature Chemical Biology, ISSN: 15524450 15524469
Paola Magnaghi; Roberto D'Alessio; Barbara Valsasina; Nilla Avanzi; Simona Rizzi; Daniela Asa; Fabio Gasparri; Liviana Cozzi; Ulisse Cucchi; Christian Orrenius; Paolo Polucci; Dario Ballinari; Claudia Perrera; Antonella Leone; Giovanni Cervi; Elena Casale; Yang Xiao; Wong; Daniel J Anderson; Arturo Galvani; Daniele Donati; Thomas O'Brien; Peter K Jackson; Antonella Isacchi
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A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors
Journal of Immunology, ISSN: 00221767 15506606
Sue J. Sohn; Kathy Barrett; Anne Van Abbema; Christine Chang; Pawan Bir Kohli; Hidenobu Kanda; Janice Smith; Yingjie Lai; Aihe Zhou; Birong Zhang; Wenqian Yang; Karen Williams; Calum Macleod; Christopher A. Hurley; Janusz J. Kulagowski; Nicholas Lewin-Koh; Hart S. Dengler; Adam R. Johnson; Nico Ghilardi; Mark Zak; Jun Liang; Wade S. Blair; Steven Magnuson; Lawren C. Wu
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