Scientists / Publications

Publications

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DISPLAYING 6751 - 6800 OF 15477 RESULTS

Placental transfer of Fc-containing biopharmaceuticals across species, an industry survey analysis
Birth Defects Research Part B - Developmental and Reproductive Toxicology, ISSN: 15429733 15429741
Christopher J. Bowman; William J. Breslin; Anu V. Connor; Pauline L. Martin; Graeme J. Moffat; Lakshmi Sivaraman; M. Belen Tornesi; Simon Chivers
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Learning and confirming with preclinical studies: Modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Harvey Wong; Stephen Gould; Nageshwar Budha; Darbonne; Edward E. Kadel III; Hank La; Bruno Alicke; Jason S Halladay; Rebecca Erickson; Chia C. Portera; Anthony W. Tolcher; Jeffery R. Infante; Michael Mamounas; Flygare; Cornelis E. Hop; Wayne J. Fairbrother
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Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability
Toxicology and Applied Pharmacology, ISSN: 0041008X 10960333
Kirsten Achilles Poon; Kelly Flagella; Joseph Beyer; Jay Tibbitts; Surinder Kaur; Ola M. Saad; Joo-Hee Yi; Sandhya Girish; Noel Dybdal; Theresa Reynolds
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Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Colin H. Mackinnon; Kevin Lau; Jason D. Burch; Yuan Chen; Jonathon Dines; Xiao Ding; Eigenbrot; Alexander Heifetz; Allan Jaochico; Adam R. Johnson; Joachim Kraemer; Susanne Kruger; Thomas M. Krülle; Marya Liimatta; Justin Ly; Rosemary Maghames; Christian A.G.N. Montalbetti; Daniel F. Ortwine; Yolanda Pérez-Fuertes; Steven Shia; Daniel B. Stein; Giancarlo Trani; Darshan G. Vaidya; Xiaolu Wang; Steven M. Bromidge; Lawren C. Wu; Zhonghua Pei
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Erratum: Anti-inflammatory strategies for plaque stabilization after acute coronary syndromes (Current Atherosclerosis Reports (2013) 15:6 (327) DOI: 10.1007/s11883-013-0327-7)
Current Atherosclerosis Reports, ISSN: 15233804 15346242
Amos Baruch; Nicholas Van Bruggen; Juyong Brian Kim; Joshua E. Lehrer-Graiwer
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IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity
Journal of Experimental Medicine, ISSN: 00221007 15409538
Giorgia Simonetti; Amanda Carette; Kathryn Silva; Haowei Wang; Nilushi S. De Silva; Nicole Heise; Christian W. Siebel; Mark J. Shlomchik; Ulf Klein
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Regulation of deubiquitinase proteolytic activity
Current Opinion in Structural Biology, ISSN: 0959440X 1879033X
Oscar W Huang; Andrea G Cochran
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Allosteric inhibition of BACE1 by an exosite-binding antibody
Current Opinion in Structural Biology, ISSN: 0959440X 1879033X
Weiru Wang; Yichin Liu; Lazarus
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The role of ubiquitination in TWEAK-stimulated signaling
Frontiers in Immunology, ISSN: 16643224
Domagoj Vucic
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Modulating caspase activity: Beyond the active site
Current Opinion in Structural Biology, ISSN: 0959440X 1879033X
Jeremy Murray; Adam R. Renslo
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Patterns of delivery of chemoimmunotherapy to patients with follicular lymphoma in the United States: Results of the National LymphoCare Study
Cancer, ISSN: 0008543X 10970142
Peter Martin; Michelle Byrtek; Keith Dawson; Ryan Ziemiecki; Jonathan W. Friedberg; James R. Cerhan; Christopher R. Flowers; Brian K. Link
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2013 White Paper on recent issues in bioanalysis: 'Hybrid' - The best of LBA and LCMS
Bioanalysis, ISSN: 17576180 17576199
Lauren Stevenson; Fabio Garofolo; Binodh DeSilva; Isabelle Dumont; Suzanne Martinez; Mario Rocci; Lakshmi Amaravadi; Margarete Brudny-Kloeppel; Adrien Musuku; Brian Booth; Catherine Dicaire; Laura Wright; Laurence Mayrand-Provencher; Mike Losauro; Dominique Gouty; Mark Arnold; Surendra Bansal; Sherri Dudal; Dawn Dufield; Jeff Duggan; Christopher Evans; Eric Fluhler; Stephanie Fraser; Boris Gorovits; Sam Haidar; Roger Hayes; Stacy Ho; Richard Houghton; Rafiqul Islam; Rand Jenkins; Noriko Katori; Surinder Kaur; Marian Kelley; Magnus Knutsson; Jean W. Lee; Hanlan Liu; Steve Lowes; Mark Ma; Alvydas Mikulskis; Heather Myler; Bob Nicholson; Timothy Olah; Eric Ormsby; Shefali Patel; Vincenzo Pucci; Chad Ray; Gary Schultz; Judy Shih; Ronald Shoup; Craig Simon; An Song; João Tavares Neto; Valerie Theobald; Theingi Thway; Jason Wakelin-Smith; Jian Wang; Laixin Wang; Jan Welink; Emma Whale; Eric Woolf; Raymond Xu
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Composite indices using 3 or 4 components of the core data set have similar predictive ability to measure disease activity in RA: Evidence from the DANCER and REFLEX studies
Autoimmune Diseases, ISSN: 20900430
Martin J. Bergman; William Reiss; Carol Y. Chung; Pamela Wong; Adam Turpcu
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Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma
Annals of the American Thoracic Society, ISSN: 23256621
Joseph R. Arron; David F. Choy; Heleen Scheerens; Matthews
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Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1
Nature Immunology, ISSN: 15292908 15292916
Chauncey J. Spooner; Justin Lesch; Donghong Yan; Aly A. Khan; Abbas Alexander; Vladimir Ramirez-Carrozzi; Meijuan Zhou; Robert Soriano; Jeffrey Eastham-Anderson; Laurie Diehl; Wyne P. Lee; Zora Modrusan; Rajita Pappu; Min Xu; Jason Devoss; Harinder Singh
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Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse
Developmental Biology, ISSN: 1095564X 00121606
Idella F. Yamben; Rivka A. Rachel; Shalini Shatadal; Neal G. Copeland; Nancy A. Jenkins; Søren Warming; Anne E. Griep
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Use of optimized aminotransferase methods in regulated preclinical studies
Veterinary Clinical Pathology, ISSN: 02756382 1939165X
Jacqueline M. Tarrant; Denny Meyer; Paula Katavolos
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Association of cyp2c9*2 with bosentan-induced liver injury
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Markova; Teresa De Marco; Bendjilali; Kobashigawa; Mefford; Jasleen K. Sodhi; Hoa Le; Chenghong Zhang; Jason S Halladay; Rettie; S. Cyrus Khojasteh; McGlothlin; Wu; Hsueh; Witte; Schwartz; Deanna L. Kroetz
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Systematic evaluation of spliced alignment programs for RNA-seq data
Nature Methods, ISSN: 15487091 15487105
Pär G. Engström; Tamara Steijger; Botond Sipos; Gregory R. Grant; André Kahles; Gunnar Rätsch; Nick Goldman; Tim J. Hubbard; Jennifer Harrow; Roderic Guigó; Paul Bertone; Tyler Alioto; Jonas Behr; Regina Bohnert; Davide Campagna; Carrie A. Davis; Alexander Dobin; Thomas R. Gingeras; Géraldine Jean; Peter Kosarev; Sheng Li; Jinze Liu; Christopher E Mason; Vladimir Molodtsov; Zemin Ning; Hannes Ponstingl; Jan F. Prins; Paolo Ribeca; Igor Seledtsov; Victor Solovyev; Giorgio Valle; Nicola Vitulo; Kai Wang; Thomas D Wu; Georg Zeller
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Assessment of transcript reconstruction methods for RNA-seq
Nature Methods, ISSN: 15487091 15487105
Tamara Steijger; Josep F. Abril; Pär G. Engström; Felix Kokocinski; Martin Akerman; Tyler Alioto; Giovanna Ambrosini; Stylianos E. Antonarakis; Jonas Behr; Paul Bertone; Regina Bohnert; Philipp Bucher; Nicole Cloonan; Thomas Derrien; Sarah Djebali; Jiang Du; Sandrine Dudoit; Mark Gerstein; Thomas R. Gingeras; David Gonzalez; Sean M. Grimmond; Roderic Guigó; Lukas Habegger; Jennifer Harrow; Tim J. Hubbard; Christian Iseli; Géraldine Jean; André Kahles; Julien Lagarde; Jing Leng; Gregory Lefebvre; Suzanna E. Lewis; Ali Mortazavi; Peter Niermann; Gunnar Rätsch; Alexandre Reymond; Paolo Ribeca; Hugues Richard; Jacques Rougemont; Joel Rozowsky; Michael Sammeth; Andrea Sboner; Marcel H. Schulz; Steven M. J. Searle; Naryttza Diaz Solorzano; Victor Solovyev; Mario Stanke; Brian J. Stevenson; Heinz Stockinger; Armand Valsesia; David Weese; Simon White; Barbara J. Wold; Jie Wu; Thomas D Wu; Georg Zeller; Daniel Zerbino; Michael Q. Zhang
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Process lifecycle validation: Applying risk management
BioPharm International, ISSN: 1542166X 19391862
Anurag S. Rathore; Scott Bozzone; A. Hamid Mollah
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Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Nandini C. Patel; Jacob B. Schwarz; Xinjun J. Hou; Dennis J. Hoover; Longfei Xie; Anton J. Fliri; Randall J. Gallaschun; John T. Lazzaro; Dianne K. Bryce; William E. Hoffmann; Ashley N. Hanks; Dina F. McGinnis; Eric S. Marr; Justin L. Gazard; Mihály Hajós; Renato J. Scialis; Raymond S. Hurst; Christopher L. Shaffer; Jayvardhan Pandit; Christopher J. O'Donnell
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Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Donald S. Kirkpatrick; Daisy J. Bustos; Taner Dogan; Jocelyn Chan; Lilian Phu; Amy Young; Lori S. Friedman; Marcia Belvin; Qinghua Song; Corey Bakalarski; Klaus P. Hoeflich
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A Nobel Prize for membrane traffic: Vesicles find their journey's end
Journal of Cell Biology, ISSN: 00219525 15408140
Ira Mellman; Scott D. Emr
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RASIP1 regulates vertebrate vascular endothelial junction stability through EPAC1-RAP1 signaling
Blood, ISSN: 15280020 00064971
Christopher W. Wilson; Leon Parker; Christopher J. Hall; Tanya Smyczek; Judy Mak; Ailey Crow; George Posthuma; Ann De Mazière; Meredith Sagolla; Cecile Chalouni; Philip Vitorino; Merone Roose-Girma; Søren Warming; Judith Klumperman; Philip S. Crosier; Weilan Ye
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Subcutaneous versus intravenous administration of rituximab: Pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys
PLoS ONE, ISSN: 19326203
Cheng-Ping Mao; Martin R. Brovarney; Karim Dabbagh; Herbert F. Birnböck; Wolfgang F. Richter; Christopher J. Del Nagro
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C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christian S. Lobsiger; Severine Boillée; Christine Pozniake; Amir M. Khan; Melissa McAlonis-Downes; Joe Lewcock; Don W. Cleveland
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Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 15277755
David Spigel; Thomas J. Ervin; Rodryg Ramlau; Davey B Daniel; Jerome H Goldschmidt; George R. Blumenschein; Maciej J Krzakowski; Gilles Robinet; Benoit Godbert; Fabrice Barlesi; Ramaswamy Govindan; Taral Patel; Sergey Orlov; Michael Wertheim; Wei Yu; Jiping Zha; Robert Yauch; Premal Patel; See Phan; Amy Peterson
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Improved crystallographic structures using extensive combinatorial refinement
Structure, ISSN: 09692126 18784186
Jerome C. Nwachukwu; Mark R. Southern; James R. Kiefer; Pavel V. Afonine; Paul D. Adams; Thomas C. Terwilliger; Kendall W. Nettles
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Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs - Reversing the effect of elevated gastric pH with betaine HCl
Molecular Pharmaceutics, ISSN: 15438384 15438392
Jodie Pang; Gena Dalziel; Brian J. Dean; Joseph A. Ware; Laurent Salphati
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Impact of food and the proton pump inhibitor rabeprazole on the pharmacokinetics of GDC-0941 in healthy volunteers: Bench to bedside investigation of pH-dependent solubility
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph A. Ware; Gena Dalziel; Jin Y. Jin; Jackson D. Pellett; Gillian S. Smelick; David A. West; Laurent Salphati; Xiao Ding; Rebecca Sutton; Jane Fridyland; Mark J. Dresser; Glenn Morrisson; Scott N. Holden
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Physical chemical drug-drug interactions from drug discovery to registration: New opportunities for the pharmaceutical scientist to impact drug development
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph A. Ware; Gena Dalziel
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Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development
Molecular Pharmaceutics, ISSN: 15438384 15438392
Gillian S. Smelick; Timothy P. Heffron; Laura Chu; Brian J. Dean; David A. West; Scott L. Duvall; Bert L. Lum; Nageshwar Budha; Scott N. Holden; Leslie Z. Benet; Adam Frymoyer; Mark J. Dresser; Joseph A. Ware
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Investigation of the rat model for preclinical evaluation of pH-dependent oral absorption in humans
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph W. Lubach; Jacob Z. Chen; Jonathan Hau; Jose Imperio; Melis Coraggio; Lichuan Liu; Harvey Wong
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Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria
Molecular Pharmaceutics, ISSN: 15438384 15438392
Marc R. Yago; Adam Frymoyer; Gillian S. Smelick; Lynda A. Frassetto; Nageshwar Budha; Mark J. Dresser; Joseph A. Ware; Leslie Z. Benet
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Absolute bioavailability and effect of formulation change, food, or elevated pH with rabeprazole on cobimetinib absorption in healthy subjects
Molecular Pharmaceutics, ISSN: 15438384 15438392
Luna Musib; Edna F. Choo; Yuzhong Deng; Stephen M. Eppler; Isabelle Rooney; Iris Chan; Mark J. Dresser
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Characterization of a water-solid interaction in a partially ordered system
Molecular Pharmaceutics, ISSN: 15438384 15438392
Paroma Chakravarty; Joseph W. Lubach
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Systemic concentrations can limit the oral absorption of poorly soluble drugs: An investigation of non-sink permeation using physiologically based pharmacokinetic modeling
Molecular Pharmaceutics, ISSN: 15438384 15438392
Po-Chang Chiang; Hank La; Haiming Zhang; Harvey Wong
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Two-dimensional HPLC in pharmaceutical analysis
American Pharmaceutical Review, ISSN: 10998012
Kelly Zhang; Jennifer Wang; Midco Tsang; Larry Wigman; Nik P. Chetwyn
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Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Nature Neuroscience, ISSN: 10976256 15461726
David V. Hansen; Jan H. Lui; Pierre Flandin; Kazuaki Yoshikawa; John L. R. Rubenstein; Arturo Alvarez-Buylla; Arnold R. Kriegstein
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Vehicle selection for nonclinical oral safety studies
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607
Evan A Thackaberry
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Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Sharada Labadie; Kathy Barrett; Wade S. Blair; Christine Chang; Gauri Deshmukh; Eigenbrot; Paul Gibbons; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Marya Liimatta; Patrick J. Lupardus; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Mark Zak
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Purification of antibodies by precipitating impurities using Polyethylene Glycol to enable a two chromatography step process
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X
Glen Giese; Adam Myrold; Gorrell; Josefine Persson
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Exposure-response analysis of pertuzumab in HER2-positive metastatic breast cancer: Absence of effect on QTc prolongation and other ECG parameters
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Amit Garg; Jing Li; Emma Clark; Adam Knott; Timothy J. Carrothers; Jean-François Marier; Javier Cortés; Michael Brewster; Jennifer Visich; Bert L. Lum
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ATLAS: Randomized, double-blind, placebo-controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib, after completion of chemotherapy, with bevacizumab for first-line treatment of advanced non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Bruce E. Johnson; Fairooz F. Kabbinavar; Louis Fehrenbacher; John Hainsworth; Saifuddin Kasubhai; Bruce Kressel; Chin-Yu Lin; Thomas Marsland; Taral Patel; Jonathan Polikoff; Mark Rubin; Leonard White; James Chih-Hsin Yang; Chris J. Bowden; Vincent A. Miller
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Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
Journal of Experimental Medicine, ISSN: 00221007 15409538
Christine D. Pozniak; Arundhati Sengupta Ghosh; Alvin Gogineni; Jesse E. Hanson; Seung-Hye Lee; Jessica L. Larson; Hilda Solanoy; Daisy J. Bustos; Hong Li; Hai Ngu; Adrian M. Jubb; Gai Ayalon; Jiansheng Wu; Kimberly Scearce-Levie; Qiang Zhou; Robby M. Weimer; Donald S. Kirkpatrick; Joe Lewcock
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Maximizing kinetic performance in supercritical fluid chromatography using state-of-the-art instruments
Journal of Chromatography A, ISSN: 18733778 00219673
Alexandre Grand-Guillaume Perrenoud; Chris Hamman; Meenakshi Goel; Jean-Luc Veuthey; Davy Guillarme; Szabolcs Fekete
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Porcine circovirus (PCV) removal by Q sepharose fast flow chromatography
Biotechnology Progress, ISSN: 87567938 15206033
Bin Yang; Hua Wang; Cintia Ho; Philip M. Lester; Qi Chen; Florian Neske; Sally A. Baylis; Johannes Blümel
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Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells
Acta Neuropathologica, ISSN: 00016322 14320533
Annegret Kathagen; Alexander Schulte; Gerd Balcke; Phillips; Tobias Martens; Jakob Matschke; Hauke S. Günther; Robert Soriano; Zora Modrusan; Thomas Sandmann; Carsten Kuhl; Alain Tissier; Mareike Holz; Lutz A. Krawinkel; Markus Glatzel; Manfred Westphal; Katrin Lamszus
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Absence of pharmacokinetic drug-drug interaction of pertuzumab with trastuzumab and docetaxel
Anti-Cancer Drugs, ISSN: 09594973 14735741
Javier Cortés; Sandra M. Swain; Iveta Kudaba; Maik Hauschild; Taral Patel; Elza Grincuka; Norikazu Masuda; Virginia McNally; Graham Ross; Michael Brewster; Jean-François Marier; My My Trinh; Amit Garg; Ihsan Nijem; Jennifer Visich; Bert L. Lum; Baselga
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