Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6901 - 6950 OF 15390 RESULTS

July 1, 2013

Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies

Clinical Cancer Research, ISSN: 10780432 15573265

Matthew J. Brauer; Guanglei Zhuang; Maike Schmidt; Jenny Yao; Xiumin Wu; Joshua S. Kaminker; Stefanie S. Jurinka; Ganesh Kolumam; Alicia S Chung; Adrian M. Jubb; Zora Modrusan; Tomoko Ozawa; C. David James; Phillips; Benjamin Haley; Rachel Tam; Anne C. Clermont; Jason H. Cheng; Sherry X. Yang; Sandra M. Swain; Daniel S. Chen; Stefan J. Scherer; Koeppen; Ru-Fang Yeh; Peng Yue; Jean-Philippe Stephan; Priti Hegde; Napoleone Ferrara; Mallika Singh; Carlos Bais

July 1, 2013

Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processings

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Xingrong Liu; Harvey Wong; Kimberly Scearce-Levie; Ryan J. Watts; Melis Coraggio; Young G. Shin; Kun Peng; Kristin R. Wildsmith; Jasvinder K. Atwal; Jason Mango; Stephen P. Schauer; Kelly Regal; Kevin W. Hunt; Allen A. Thomas; Michael Siu; Joseph P. Lyssikatos; Gauri Deshmukh; Cornelis E. Hop

July 1, 2013

Assessment of granulation technologies for an API with poor physical properties

Drug Development and Industrial Pharmacy, ISSN: 03639045 15205762

Gena Dalziel; Ewa Nauka; Feng Zhang; Sanjeev Kothari; Minli Xie

July 1, 2013

Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG

mAbs, ISSN: 19420862 19420870

Xiangdan Wang; Quarmby; Carl Ng; Anan Chuntharapai; Theresa Shek; Eigenbrot; Robert F. Kelley; Steven Shia; Krista McCutcheon; John Lowe; Cecilia Leddy; Kyle Coachman; Cain; Felix Chu; Isidro Hötzel; Mauricio Maia; Eric Wakshull; Yang

July 1, 2013

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response

PLoS Pathogens, ISSN: 15537366 15537374

Lee Kozakiewicz; Yong Chen; Jiayong Xu; Yanhua Wang; Kyri Dunussi-Joannopoulos; Qinglin Ou; JoAnne L. Flynn; Steven A. Porcelli; William R. Jacobs Jr.; John Chan

July 1, 2013

Pre-existing biotherapeutic-reactive antibodies: Survey results within the american association of pharmaceutical scientists

AAPS Journal, ISSN: 15507416

Li Xue; Michele Fiscella; Manoj Rajadhyaksha; Jaya Goyal; Claire Holland; Boris Gorovits; Alyssa M. Morimoto

July 1, 2013

Pilot of peer assessment within experiential teaching and learning

Currents in Pharmacy Teaching and Learning, ISSN: 18771297

Craig D. Cox; Michael J. Peeters; Brad L. Stanford; Charles F. Seifert

July 1, 2013

Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: The ITC evidence-based position

Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535

Kalvass; Polli; Bourdet; Bo Feng; Huang; Xingrong Liu; Smith; Zhang; Zamek-Gliszczynski

July 1, 2013

Photodegradation of human growth hormone: A novel backbone cleavage between Glu-88 and Pro-89

Molecular Pharmaceutics, ISSN: 15438384 15438392

Daniel Steinmann; Junyan A. Ji; Y. John Wang; Christian Schöneich

June 28, 2013

AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes

Nature, ISSN: 00280836 14764687

Ritu Kumar; Lauren Dimenna; Nadine Schrode; Ting-Chun Liu; Philipp Franck; Silvia Muñoz-Descalzo; Anna-Katerina Hadjantonakis; Ali A. Zarrin; Jayanta Chaudhuri; Olivier Elemento; Todd Evans

June 28, 2013

T Cell Receptor (TCR) and Transforming Growth Factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Chaoran Li; Peter J. R. Ebert; Qi-Jing Li

June 27, 2013

Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Xiaozhang Zheng; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Jian Lin; Dominic J. Reynolds; Geeta Sharma; Chase C. Smith; Zhongguo Wang; Peter Dragovich; Angela Oh; Weiru Wang; Mark Zak; Janet Gunzner; Guiling Zhao; Po-Wai Yuen; Kenneth W. Bair

June 26, 2013

Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor

Journal of Molecular Biology, ISSN: 10898638 00222836

Xiaolei Ma; Pierre A. Barthelemy; Lionel Rouge; Wiesmann; Sachdev S. Sidhu

June 24, 2013

Therapeutic protein drug-drug interactions: Navigating the knowledge gaps-highlights from the 2012 AAPS NBC roundtable and IQ Consortium/FDA workshop

AAPS Journal, ISSN: 15507416

Jane R. Kenny; Maggie M. Liu; Andrew T. Chow; Justin C. Earp; Raymond Evers; J. Greg Slatter; Diane D. Wang; Lei Zhang; Honghui Zhou

June 24, 2013

Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain

PLoS ONE, ISSN: 19326203

Rebecca A. Helmer; Oded Foreman; Janet S. Dertien; Marlyn Panchoo; Suhani M. Bhakta; Beverly S. Chilton

June 20, 2013

Characterization of the guinea pig CMV gH/gL/GP129/GP131/GP133 complex in infection and spread

Virology, ISSN: 00426822 10960341

Marcy Auerbach; Donghong Yan; Ashley Fouts; Min Xu; Alberto Estevez; Cary D. Austin; Fernando Bazan; Becket Feierbach

June 18, 2013

Population pharmacokinetics of cyclosporine in transplant recipients

AAPS Journal, ISSN: 15507416

Kelong Han; Venkateswaran C. Pillai; Raman Venkataramanan

June 18, 2013

Adherence to dornase alfa treatment among commercially insured patients with cystic fibrosis

Journal of Medical Economics, ISSN: 13696998 1941837X

Samya Z. Nasr; Will Chou; Kathleen F. Villa; Eunice Chang; Michael S. Broder

June 18, 2013

Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

eLife, ISSN: 2050084X

Ling Luo; Hironori Uehara; Xiaohui Zhang; Subrata K. Das; Thomas Olsen; Derick Holt; Jacquelyn M. Simonis; Kyle Jackman; Nirbhai Singh; Tadashi R. Miya; Wei Huang; Faisal Ahmed; Ana Bastos-Carvalho; Yun Zheng Le; Christina Mamalis; Vince A. Chiodo; William W. Hauswirth; Judit Z. Baffi; Pedro M. Lacal; Angela Orecchia; Napoleone Ferrara; Guangping Gao; Kim Young-hee; Yingbin Fu; Leah Owen; Romulo J. C. Albuquerque; Wolfgang Baehr; Kirk Thomas; Dean Y. Li; Kakarla V. Chalam; Masabumi Shibuya; Salvatore Grisanti; David J. Wilson; Jayakrishna Ambati; Balamurali K. Ambati

June 15, 2013

Previous myocardial infarction as a risk factor for in-hospital cardiovascular outcomes (from the National Registry of Myocardial Infarction 4 and 5)

American Journal of Cardiology, ISSN: 00029149 18791913

Quang T. Bui; Vanessa S. Reddy; Joan R. Jacobs; Susan M. Begelman; Paul D. Frederick; Dave P. Miller; William J. French

June 15, 2013

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Christopher A. Hurley; Wade S. Blair; Richard J. Bull; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Hazel J. Dyke; Rina Fong; Nico Ghilardi; Paul Gibbons; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Robert J. Maxey; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Savita Ubhayakar; Anne Van Abbema; Stuart I. Ward; Bohdan Waszkowycz; Mark Zak

June 15, 2013

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells

Cancer Research, ISSN: 00085472 15387445

Luis E. Arias-Romero; Olga Villamar-Cruz; Min Huang; Klaus P. Hoeflich; Jonathan Chernoff

June 15, 2013

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Janet Gunzner; Guiling Zhao; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bang Fu; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Sophie Mukadam; Thomas O'Brien; Angela Oh; Dominic J. Reynolds; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jasleen K. Sodhi; Weiru Wang; Zhongguo Wang; Yang Xiao; Po-Wai Yuen; Mark Zak; Lei Zhang; Xiaozhang Zheng; Kenneth W. Bair; Peter Dragovich

June 13, 2013

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Jun Liang; Anne Van Abbema; Mercedesz Balazs; Kathy Barrett; Leo Berezhkovsky; Wade S. Blair; Christine Chang; Donnie Delarosa; Jason Devoss; James Driscoll; Eigenbrot; Nico Ghilardi; Paul Gibbons; Jason S Halladay; Adam R. Johnson; Pawan Bir Kohli; Yingjie Lai; Yanzhou Liu; Joseph P. Lyssikatos; Priscilla Mantik; Kapil Menghrajani; Jeremy Murray; Ivan Peng; Amy Sambrone; Steven Shia; Young G. Shin; Jan Smith; Sue J. Sohn; Vickie Tsui; Ultsch; Lawren C. Wu; Yisong Xiao; Wenqian Yang; Judy Young; Birong Zhang; Bing-Yan Zhu; Steven Magnuson

June 13, 2013

Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d ][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2- methylpropanamide (GDC-0032): A β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Chudi O. Ndubaku; Timothy P. Heffron; Steven T. Staben; Matthew Baumgardner; Nicole Blaquiere; Erin K. Bradley; Richard J. Bull; Steven Do; Jennafer Dotson; Danette Dudley; Kyle A. Edgar; Lori S. Friedman; Richard Goldsmith; Robert Heald; Aleksandr Kolesnikov; Leslie Lee; Lewis; Michelle Nannini; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Jeffery J. Wallin; Lan Wang; Binqing Wei; Deepak Sampath; Alan G. Olivero

June 13, 2013

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Mark Zak; Christopher A. Hurley; Stuart I. Ward; Philippe Bergeron; Kathy Barrett; Mercedesz Balazs; Wade S. Blair; Richard J. Bull; Paroma Chakravarty; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Jason Devoss; Peter Dragovich; Eigenbrot; Charles Ellwood; Simon Gaines; Nico Ghilardi; Paul Gibbons; Stefan Gradl; Gribling; Chris Hamman; Eric Harstad; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Michael F. T. Koehler; Pawan Bir Kohli; Sharada Labadie; Wyne P. Lee; Jiangpeng Liao; Marya Liimatta; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Austin Reeve; Scott Savage; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Ignacio Aliagas; Barbara Avitabile-Woo; Yisong Xiao; Jing Yang; Janusz J. Kulagowski

June 13, 2013

Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria

New England Journal of Medicine, ISSN: 15334406 00284793

Marcus Maurer; Karin Rosén; Hsin-Ju Hsieh; Sarbjit S. Saini; Clive E. Grattan; Ana Gimenéz-Arnau; Sunil Agarwal; Ramona Doyle; Janice Canvin; Allen P. Kaplan; Thomas B. Casale

June 12, 2013

Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies

Journal of Molecular Biology, ISSN: 10898638 00222836

Homer Pantua; Jingyu Diao; Ultsch; Meredith Hazen; Mary Mathieu; Krista McCutcheon; Kentaro Takeda; Shailesh V. Date; Tommy K. Cheung; Qui Phung; Hass; David Arnott; Hongo; Matthews; Alex Brown; Arvind H. Patel; Robert F. Kelley; Eigenbrot; Sharookh B. Kapadia

June 11, 2013

Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant

Chemical Communications, ISSN: 1364548X 13597345

Laura M. Dornan; Qun Cao; James C.A. Flanagan; James J. Crawford; Matthew J. Cook; Mark J. Muldoon

June 11, 2013

miR-221/222 Targets Adiponectin Receptor 1 to Promote the Epithelial-to-Mesenchymal Transition in Breast Cancer

PLoS ONE, ISSN: 19326203

Michael S. Hwang; Nancy Yu; Susanna Y. Stinson; Peng Yue; Robert J. Newman; Bernard B. Allan; David Dornan

June 10, 2013

Evaluation of tumor-size response metrics to predict overall survival in Western and Chinese patients with first-line metastatic colorectal cancer

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Laurent Claret; Manish Gupta; Kelong Han; Amita Joshi; Nenad Sarapa; Jing He; Bob Powell; Rene Bruno

June 6, 2013

The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD41 T-cell recovery: A randomized trial

Blood, ISSN: 15280020 00064971

Peter W. Hunt; Nancy Shulman; Timothy L. Hayes; Viktor Dahl; Ma Somsouk; Nicholas T. Funderburg; Bridget McLaughlin; Alan L. Landay; Oluwatoyin Adeyemi; Lee E. Gilman; Brian Clagett; Benigno Rodriguez; Jeffrey N. Martin; Timothy W. Schacker; Barbara L. Shacklett; Sarah Palmer; Michael M. Lederman; Steven G. Deeks

June 4, 2013

Early effects of tocilizumab in the treatment of moderate to severe active rheumatoid arthritis: A one-week sub-study of a randomised controlled trial (Rapid Onset and Systemic Efficacy [ROSE] Study)

Clinical and Experimental Rheumatology, ISSN: 0392856X 1593098X

Yazici; Jeffrey R. Curtis; Ince; Baraf; Lepley; Jenny Devenport; Arthur Kavanaugh

June 3, 2013

Turning on lanthanide luminescence via nanoencapsulation

Inorganic Chemistry, ISSN: 00201669 1520510X

Boris Makhinson; Alexandra K. Duncan; Ashley R. Elam; Ana De Bettencourt-Dias; Colin D. Medley; Joshua E. Smith; Eric J. Werner

June 1, 2013

Ranibizumab treatment outcomes in phakic versus pseudophakic eyes: An individual patient data analysis of 2 phase 3 trials

Ophthalmology, ISSN: 01616420 15494713

David V. Weinberg; Howard Shapiro; Jason S. Ehrlich

June 1, 2013

HGF as a circulating biomarker of onartuzumab treatment in patients with advanced solid tumors

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Elicia M. Penuel; Congfen Li; Vaishali Parab; Luciana Burton; Kyra J. Cowan; Mark Merchant; Robert Yauch; Premal Patel; Amy Peterson; Garret M. Hampton; Lackner; Priti Hegde

June 1, 2013

Bispecific antibodies for delivery into the brain

Current Opinion in Chemical Biology, ISSN: 13675931 18790402

Ryan J. Watts; Dennis

June 1, 2013

Two-in-One antibodies with dual action Fabs

Current Opinion in Chemical Biology, ISSN: 13675931 18790402

Eigenbrot; Fuh

June 1, 2013

Application of in vitro-in vivo extrapolation (IVIVE) and physiologically based pharmacokinetic (PBPK) modelling to investigate the impact of the CYP2C8 polymorphism on rosiglitazone exposure

European Journal of Clinical Pharmacology, ISSN: 00316970 14321041

Karen Rowland-Yeo; Jane R. Kenny; Amin Rostami-Hodjegan

June 1, 2013

Kif3a is necessary for initiation and maintenance of medulloblastoma

Carcinogenesis, ISSN: 01433334 14602180

Monique T. Barakat; Eric W. Humke; Matthew P. Scott

June 1, 2013

Bcl-2/Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic tumor models

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Nguyen Tan; Maureen Wong; Michelle Nannini; Rebecca Hong; Leslie Lee; Stephen Price; Karen Williams; Pierre Pascal Savy; Peng Yue; Deepak Sampath; Jeffrey Settleman; Wayne J. Fairbrother; Lisa D. Belmont

June 1, 2013

Phenotypical differences in connective tissue cells emerging from microvascular pericytes in response to overexpression of PDGF-B and TGF-β1 in normal skin in vivo

American Journal of Pathology, ISSN: 00029440 15252191

Alejandro Rodriguez; Tomas Friman; Marcin Kowanetz; Tijs Van Wieringen; Renata Gustafsson; Christian Sundberg

June 1, 2013

A requirement for wild-type Ras isoforms in mutant KRas-driven signaling and transformation

Biochemical Journal, ISSN: 02646021 14708728

Carolyn Bentley; Stefanie S. Jurinka; Noelyn Kljavin; Steffan Vartanian; Sree R. Ramani; Lino C. Gonzalez Jr.; Kebing Yu; Zora Modrusan; Pan Du; Richard Bourgon; Richard M. Neve; David Stokoe

June 1, 2013

Pharmaceutical toxicology: Designing studies to reduce animal use, while maximizing human translation

Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295

Kathryn Chapman; Henry Holzgrefe; Lauren E. Black; Marilyn Brown; Gary Chellman; Christine Copeman; Jessica A. Couch; Stuart Creton; Sean Gehen; Alan M. Hoberman; Lewis B. Kinter; Stephen Madden; Charles Mattis; Hugh A. Stemple; Stephen Wilson

June 1, 2013

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Xiaojing Wang; Steven Magnuson; Richard Pastor; Eric Fan; Huiyong Hu; Vickie Tsui; Wei Deng; Jeremy Murray; Micah Steffek; Heidi J. A. Wallweber; John Moffat; Jason H. Drummond; Grace Chan; Eric Harstad; Allen Ebens

June 1, 2013

GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior

Neuropsychopharmacology, ISSN: 0893133X 1740634X

Jesse E. Hanson; Martin Weber; William J. Meilandt; Tiffany Wu; Tom Luu; Lunbin Deng; Mehrdad Shamloo; Morgan Sheng; Kimberly Scearce-Levie; Qiang Zhou

June 1, 2013

Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas

Cancer Letters, ISSN: 03043835 18727980

Nadia Lounnas; Célia Rosilio; Marielle Nebout; Didier Mary; Emmanuel Griessinger; Zouhour Neffati; Johanna Chiche; Hergen Spits; Thijs Hagenbeek; Vahid Asnafi; Sally-Ann Poulsen; Claudiu T. Supuran; Jean-François Peyron; Véronique Imbert

June 1, 2013

Structure-guided design of a selective BCL-XL inhibitor

Nature Chemical Biology, ISSN: 15524450 15524469

Guillaume Lessene; Czabotar; Brad E Sleebs; Zobel; Kym N Lowes; Jerry M Adams; Jonathan B Baell; Colman; Deshayes; Wayne J. Fairbrother; Flygare; Paul Gibbons; Wilhelmus J A Kersten; Sanji Kulasegaram; Rebecca M Moss; John P Parisot; Brian J. Smith; Ian P Street; Hong Yang; David C.S. Huang; Keith G Watson

June 1, 2013

Next generation therapeutics

Current Opinion in Chemical Biology, ISSN: 13675931 18790402

Paul J. Carter; Daria Hazuda; James A. Wells

June 1, 2013

Evaluation of food effect on pharmacokinetics of vismodegib in advanced solid tumor patients

Clinical Cancer Research, ISSN: 10780432 15573265

Manish R. Sharma; Theodore G. Karrison; Bethany Kell; Kehua Wu; Michelle Turcich; David Geary; S. Peter Kang; Naoko Takebe; Richard A. Graham; Michael Maitland; Richard L. Schilsky; Ratain; Ezra E W Cohen

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