Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6901 - 6950 OF 15394 RESULTS

Estimating the survival functions for right-censored and interval-censored data with piecewise constant hazard functions
Contemporary Clinical Trials, ISSN: 15517144 15592030
Pei He; George Kong; Zheng Su
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Challenges of trial design for extended drug delivery: A virtual round table with industry
Retina Today, ISSN: 18250572
Ken Green; Yehia Hashad; Roman G. Rubio
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A novel visuospatial priming task for rats with relevance to Tourette syndrome and modulation of dopamine levels
Neuroscience and Biobehavioral Reviews, ISSN: 01497634 18737528
Nurith Amitai; Martin Weber; Neal R. Swerdlow; Richard F. Sharp; Michelle R. Breier; Adam L. Halberstadt; Jared W. Young
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Developing Therapeutic Antibodies for Neurodegenerative Disease
Neurotherapeutics, ISSN: 19337213 18787479
Y. Joy Yu; Ryan J. Watts
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Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies
Clinical Cancer Research, ISSN: 10780432 15573265
Matthew J. Brauer; Guanglei Zhuang; Maike Schmidt; Jenny Yao; Xiumin Wu; Joshua S. Kaminker; Stefanie S. Jurinka; Ganesh Kolumam; Alicia S Chung; Adrian M. Jubb; Zora Modrusan; Tomoko Ozawa; C. David James; Phillips; Benjamin Haley; Rachel Tam; Anne C. Clermont; Jason H. Cheng; Sherry X. Yang; Sandra M. Swain; Daniel S. Chen; Stefan J. Scherer; Koeppen; Ru-Fang Yeh; Peng Yue; Jean-Philippe Stephan; Priti Hegde; Napoleone Ferrara; Mallika Singh; Carlos Bais
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Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processings
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Xingrong Liu; Harvey Wong; Kimberly Scearce-Levie; Ryan J. Watts; Melis Coraggio; Young G. Shin; Kun Peng; Kristin R. Wildsmith; Jasvinder K. Atwal; Jason Mango; Stephen P. Schauer; Kelly Regal; Kevin W. Hunt; Allen A. Thomas; Michael Siu; Joseph P. Lyssikatos; Gauri Deshmukh; Cornelis E. Hop
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Assessment of granulation technologies for an API with poor physical properties
Drug Development and Industrial Pharmacy, ISSN: 03639045 15205762
Gena Dalziel; Ewa Nauka; Feng Zhang; Sanjeev Kothari; Minli Xie
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Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG
mAbs, ISSN: 19420862 19420870
Xiangdan Wang; Quarmby; Carl Ng; Anan Chuntharapai; Theresa Shek; Eigenbrot; Robert F. Kelley; Steven Shia; Krista McCutcheon; John Lowe; Cecilia Leddy; Kyle Coachman; Cain; Felix Chu; Isidro Hötzel; Mauricio Maia; Eric Wakshull; Yang
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B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response
PLoS Pathogens, ISSN: 15537366 15537374
Lee Kozakiewicz; Yong Chen; Jiayong Xu; Yanhua Wang; Kyri Dunussi-Joannopoulos; Qinglin Ou; JoAnne L. Flynn; Steven A. Porcelli; William R. Jacobs Jr.; John Chan
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Pre-existing biotherapeutic-reactive antibodies: Survey results within the american association of pharmaceutical scientists
AAPS Journal, ISSN: 15507416
Li Xue; Michele Fiscella; Manoj Rajadhyaksha; Jaya Goyal; Claire Holland; Boris Gorovits; Alyssa M. Morimoto
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Pilot of peer assessment within experiential teaching and learning
Currents in Pharmacy Teaching and Learning, ISSN: 18771297
Craig D. Cox; Michael J. Peeters; Brad L. Stanford; Charles F. Seifert
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Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: The ITC evidence-based position
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Kalvass; Polli; Bourdet; Bo Feng; Huang; Xingrong Liu; Smith; Zhang; Zamek-Gliszczynski
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Photodegradation of human growth hormone: A novel backbone cleavage between Glu-88 and Pro-89
Molecular Pharmaceutics, ISSN: 15438384 15438392
Daniel Steinmann; Junyan A. Ji; Y. John Wang; Christian Schöneich
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AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes
Nature, ISSN: 00280836 14764687
Ritu Kumar; Lauren Dimenna; Nadine Schrode; Ting-Chun Liu; Philipp Franck; Silvia Muñoz-Descalzo; Anna-Katerina Hadjantonakis; Ali A. Zarrin; Jayanta Chaudhuri; Olivier Elemento; Todd Evans
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T Cell Receptor (TCR) and Transforming Growth Factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Chaoran Li; Peter J. R. Ebert; Qi-Jing Li
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Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Xiaozhang Zheng; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Jian Lin; Dominic J. Reynolds; Geeta Sharma; Chase C. Smith; Zhongguo Wang; Peter Dragovich; Angela Oh; Weiru Wang; Mark Zak; Janet Gunzner; Guiling Zhao; Po-Wai Yuen; Kenneth W. Bair
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Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor
Journal of Molecular Biology, ISSN: 10898638 00222836
Xiaolei Ma; Pierre A. Barthelemy; Lionel Rouge; Wiesmann; Sachdev S. Sidhu
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Therapeutic protein drug-drug interactions: Navigating the knowledge gaps-highlights from the 2012 AAPS NBC roundtable and IQ Consortium/FDA workshop
AAPS Journal, ISSN: 15507416
Jane R. Kenny; Maggie M. Liu; Andrew T. Chow; Justin C. Earp; Raymond Evers; J. Greg Slatter; Diane D. Wang; Lei Zhang; Honghui Zhou
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Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain
PLoS ONE, ISSN: 19326203
Rebecca A. Helmer; Oded Foreman; Janet S. Dertien; Marlyn Panchoo; Suhani M. Bhakta; Beverly S. Chilton
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Characterization of the guinea pig CMV gH/gL/GP129/GP131/GP133 complex in infection and spread
Virology, ISSN: 00426822 10960341
Marcy Auerbach; Donghong Yan; Ashley Fouts; Min Xu; Alberto Estevez; Cary D. Austin; Fernando Bazan; Becket Feierbach
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Population pharmacokinetics of cyclosporine in transplant recipients
AAPS Journal, ISSN: 15507416
Kelong Han; Venkateswaran C. Pillai; Raman Venkataramanan
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Adherence to dornase alfa treatment among commercially insured patients with cystic fibrosis
Journal of Medical Economics, ISSN: 13696998 1941837X
Samya Z. Nasr; Will Chou; Kathleen F. Villa; Eunice Chang; Michael S. Broder
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Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1
eLife, ISSN: 2050084X
Ling Luo; Hironori Uehara; Xiaohui Zhang; Subrata K. Das; Thomas Olsen; Derick Holt; Jacquelyn M. Simonis; Kyle Jackman; Nirbhai Singh; Tadashi R. Miya; Wei Huang; Faisal Ahmed; Ana Bastos-Carvalho; Yun Zheng Le; Christina Mamalis; Vince A. Chiodo; William W. Hauswirth; Judit Z. Baffi; Pedro M. Lacal; Angela Orecchia; Napoleone Ferrara; Guangping Gao; Kim Young-hee; Yingbin Fu; Leah Owen; Romulo J. C. Albuquerque; Wolfgang Baehr; Kirk Thomas; Dean Y. Li; Kakarla V. Chalam; Masabumi Shibuya; Salvatore Grisanti; David J. Wilson; Jayakrishna Ambati; Balamurali K. Ambati
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Previous myocardial infarction as a risk factor for in-hospital cardiovascular outcomes (from the National Registry of Myocardial Infarction 4 and 5)
American Journal of Cardiology, ISSN: 00029149 18791913
Quang T. Bui; Vanessa S. Reddy; Joan R. Jacobs; Susan M. Begelman; Paul D. Frederick; Dave P. Miller; William J. French
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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Christopher A. Hurley; Wade S. Blair; Richard J. Bull; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Hazel J. Dyke; Rina Fong; Nico Ghilardi; Paul Gibbons; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Robert J. Maxey; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Savita Ubhayakar; Anne Van Abbema; Stuart I. Ward; Bohdan Waszkowycz; Mark Zak
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Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells
Cancer Research, ISSN: 00085472 15387445
Luis E. Arias-Romero; Olga Villamar-Cruz; Min Huang; Klaus P. Hoeflich; Jonathan Chernoff
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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Janet Gunzner; Guiling Zhao; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bang Fu; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Sophie Mukadam; Thomas O'Brien; Angela Oh; Dominic J. Reynolds; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jasleen K. Sodhi; Weiru Wang; Zhongguo Wang; Yang Xiao; Po-Wai Yuen; Mark Zak; Lei Zhang; Xiaozhang Zheng; Kenneth W. Bair; Peter Dragovich
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Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Jun Liang; Anne Van Abbema; Mercedesz Balazs; Kathy Barrett; Leo Berezhkovsky; Wade S. Blair; Christine Chang; Donnie Delarosa; Jason Devoss; James Driscoll; Eigenbrot; Nico Ghilardi; Paul Gibbons; Jason S Halladay; Adam R. Johnson; Pawan Bir Kohli; Yingjie Lai; Yanzhou Liu; Joseph P. Lyssikatos; Priscilla Mantik; Kapil Menghrajani; Jeremy Murray; Ivan Peng; Amy Sambrone; Steven Shia; Young G. Shin; Jan Smith; Sue J. Sohn; Vickie Tsui; Ultsch; Lawren C. Wu; Yisong Xiao; Wenqian Yang; Judy Young; Birong Zhang; Bing-Yan Zhu; Steven Magnuson
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Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d ][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2- methylpropanamide (GDC-0032): A β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Chudi O. Ndubaku; Timothy P. Heffron; Steven T. Staben; Matthew Baumgardner; Nicole Blaquiere; Erin K. Bradley; Richard J. Bull; Steven Do; Jennafer Dotson; Danette Dudley; Kyle A. Edgar; Lori S. Friedman; Richard Goldsmith; Robert Heald; Aleksandr Kolesnikov; Leslie Lee; Lewis; Michelle Nannini; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Jeffery J. Wallin; Lan Wang; Binqing Wei; Deepak Sampath; Alan G. Olivero
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Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Mark Zak; Christopher A. Hurley; Stuart I. Ward; Philippe Bergeron; Kathy Barrett; Mercedesz Balazs; Wade S. Blair; Richard J. Bull; Paroma Chakravarty; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Jason Devoss; Peter Dragovich; Eigenbrot; Charles Ellwood; Simon Gaines; Nico Ghilardi; Paul Gibbons; Stefan Gradl; Gribling; Chris Hamman; Eric Harstad; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Michael F. T. Koehler; Pawan Bir Kohli; Sharada Labadie; Wyne P. Lee; Jiangpeng Liao; Marya Liimatta; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Austin Reeve; Scott Savage; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Ignacio Aliagas; Barbara Avitabile-Woo; Yisong Xiao; Jing Yang; Janusz J. Kulagowski
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Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria
New England Journal of Medicine, ISSN: 15334406 00284793
Marcus Maurer; Karin Rosén; Hsin-Ju Hsieh; Sarbjit S. Saini; Clive E. Grattan; Ana Gimenéz-Arnau; Sunil Agarwal; Ramona Doyle; Janice Canvin; Allen P. Kaplan; Thomas B. Casale
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Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies
Journal of Molecular Biology, ISSN: 10898638 00222836
Homer Pantua; Jingyu Diao; Ultsch; Meredith Hazen; Mary Mathieu; Krista McCutcheon; Kentaro Takeda; Shailesh V. Date; Tommy K. Cheung; Qui Phung; Hass; David Arnott; Hongo; Matthews; Alex Brown; Arvind H. Patel; Robert F. Kelley; Eigenbrot; Sharookh B. Kapadia
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Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant
Chemical Communications, ISSN: 1364548X 13597345
Laura M. Dornan; Qun Cao; James C.A. Flanagan; James J. Crawford; Matthew J. Cook; Mark J. Muldoon
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miR-221/222 Targets Adiponectin Receptor 1 to Promote the Epithelial-to-Mesenchymal Transition in Breast Cancer
PLoS ONE, ISSN: 19326203
Michael S. Hwang; Nancy Yu; Susanna Y. Stinson; Peng Yue; Robert J. Newman; Bernard B. Allan; David Dornan
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Evaluation of tumor-size response metrics to predict overall survival in Western and Chinese patients with first-line metastatic colorectal cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Laurent Claret; Manish Gupta; Kelong Han; Amita Joshi; Nenad Sarapa; Jing He; Bob Powell; Rene Bruno
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The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD41 T-cell recovery: A randomized trial
Blood, ISSN: 15280020 00064971
Peter W. Hunt; Nancy Shulman; Timothy L. Hayes; Viktor Dahl; Ma Somsouk; Nicholas T. Funderburg; Bridget McLaughlin; Alan L. Landay; Oluwatoyin Adeyemi; Lee E. Gilman; Brian Clagett; Benigno Rodriguez; Jeffrey N. Martin; Timothy W. Schacker; Barbara L. Shacklett; Sarah Palmer; Michael M. Lederman; Steven G. Deeks
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Early effects of tocilizumab in the treatment of moderate to severe active rheumatoid arthritis: A one-week sub-study of a randomised controlled trial (Rapid Onset and Systemic Efficacy [ROSE] Study)
Clinical and Experimental Rheumatology, ISSN: 0392856X 1593098X
Yazici; Jeffrey R. Curtis; Ince; Baraf; Lepley; Jenny Devenport; Arthur Kavanaugh
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Turning on lanthanide luminescence via nanoencapsulation
Inorganic Chemistry, ISSN: 00201669 1520510X
Boris Makhinson; Alexandra K. Duncan; Ashley R. Elam; Ana De Bettencourt-Dias; Colin D. Medley; Joshua E. Smith; Eric J. Werner
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Ranibizumab treatment outcomes in phakic versus pseudophakic eyes: An individual patient data analysis of 2 phase 3 trials
Ophthalmology, ISSN: 01616420 15494713
David V. Weinberg; Howard Shapiro; Jason S. Ehrlich
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HGF as a circulating biomarker of onartuzumab treatment in patients with advanced solid tumors
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Elicia M. Penuel; Congfen Li; Vaishali Parab; Luciana Burton; Kyra J. Cowan; Mark Merchant; Robert Yauch; Premal Patel; Amy Peterson; Garret M. Hampton; Lackner; Priti Hegde
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Bispecific antibodies for delivery into the brain
Current Opinion in Chemical Biology, ISSN: 13675931 18790402
Ryan J. Watts; Dennis
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Two-in-One antibodies with dual action Fabs
Current Opinion in Chemical Biology, ISSN: 13675931 18790402
Eigenbrot; Fuh
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Application of in vitro-in vivo extrapolation (IVIVE) and physiologically based pharmacokinetic (PBPK) modelling to investigate the impact of the CYP2C8 polymorphism on rosiglitazone exposure
European Journal of Clinical Pharmacology, ISSN: 00316970 14321041
Karen Rowland-Yeo; Jane R. Kenny; Amin Rostami-Hodjegan
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Kif3a is necessary for initiation and maintenance of medulloblastoma
Carcinogenesis, ISSN: 01433334 14602180
Monique T. Barakat; Eric W. Humke; Matthew P. Scott
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Bcl-2/Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic tumor models
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Nguyen Tan; Maureen Wong; Michelle Nannini; Rebecca Hong; Leslie Lee; Stephen Price; Karen Williams; Pierre Pascal Savy; Peng Yue; Deepak Sampath; Jeffrey Settleman; Wayne J. Fairbrother; Lisa D. Belmont
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Phenotypical differences in connective tissue cells emerging from microvascular pericytes in response to overexpression of PDGF-B and TGF-β1 in normal skin in vivo
American Journal of Pathology, ISSN: 00029440 15252191
Alejandro Rodriguez; Tomas Friman; Marcin Kowanetz; Tijs Van Wieringen; Renata Gustafsson; Christian Sundberg
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A requirement for wild-type Ras isoforms in mutant KRas-driven signaling and transformation
Biochemical Journal, ISSN: 02646021 14708728
Carolyn Bentley; Stefanie S. Jurinka; Noelyn Kljavin; Steffan Vartanian; Sree R. Ramani; Lino C. Gonzalez Jr.; Kebing Yu; Zora Modrusan; Pan Du; Richard Bourgon; Richard M. Neve; David Stokoe
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Pharmaceutical toxicology: Designing studies to reduce animal use, while maximizing human translation
Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295
Kathryn Chapman; Henry Holzgrefe; Lauren E. Black; Marilyn Brown; Gary Chellman; Christine Copeman; Jessica A. Couch; Stuart Creton; Sean Gehen; Alan M. Hoberman; Lewis B. Kinter; Stephen Madden; Charles Mattis; Hugh A. Stemple; Stephen Wilson
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Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Xiaojing Wang; Steven Magnuson; Richard Pastor; Eric Fan; Huiyong Hu; Vickie Tsui; Wei Deng; Jeremy Murray; Micah Steffek; Heidi J. A. Wallweber; John Moffat; Jason H. Drummond; Grace Chan; Eric Harstad; Allen Ebens
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GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior
Neuropsychopharmacology, ISSN: 0893133X 1740634X
Jesse E. Hanson; Martin Weber; William J. Meilandt; Tiffany Wu; Tom Luu; Lunbin Deng; Mehrdad Shamloo; Morgan Sheng; Kimberly Scearce-Levie; Qiang Zhou
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