Scientists / Publications

Publications

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DISPLAYING 6951 - 7000 OF 15394 RESULTS

Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas
Cancer Letters, ISSN: 03043835 18727980
Nadia Lounnas; Célia Rosilio; Marielle Nebout; Didier Mary; Emmanuel Griessinger; Zouhour Neffati; Johanna Chiche; Hergen Spits; Thijs Hagenbeek; Vahid Asnafi; Sally-Ann Poulsen; Claudiu T. Supuran; Jean-François Peyron; Véronique Imbert
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Structure-guided design of a selective BCL-XL inhibitor
Nature Chemical Biology, ISSN: 15524450 15524469
Guillaume Lessene; Czabotar; Brad E Sleebs; Zobel; Kym N Lowes; Jerry M Adams; Jonathan B Baell; Colman; Deshayes; Wayne J. Fairbrother; Flygare; Paul Gibbons; Wilhelmus J A Kersten; Sanji Kulasegaram; Rebecca M Moss; John P Parisot; Brian J. Smith; Ian P Street; Hong Yang; David C.S. Huang; Keith G Watson
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Next generation therapeutics
Current Opinion in Chemical Biology, ISSN: 13675931 18790402
Paul J. Carter; Daria Hazuda; James A. Wells
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Evaluation of food effect on pharmacokinetics of vismodegib in advanced solid tumor patients
Clinical Cancer Research, ISSN: 10780432 15573265
Manish R. Sharma; Theodore G. Karrison; Bethany Kell; Kehua Wu; Michelle Turcich; David Geary; S. Peter Kang; Naoko Takebe; Richard A. Graham; Michael Maitland; Richard L. Schilsky; Ratain; Ezra E W Cohen
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The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
Nature Reviews Cancer, ISSN: 1474175X 14741768
Morgan O'Hayre; José Vázquez-Prado; Irina Kufareva; Eric Stawiski; Tracy M. Handel; Somasekar Seshagiri; J. Silvio Gutkind
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Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations
Molecular Cancer Research, ISSN: 15417786 15573125
Sato; Larsen; Woochang Lee; Han Sun; David S. Shames; Maithili P. Dalvi; Ruben D. Ramirez; Hao Tang; John Michael DiMaio; Boning Gao; Yang Xie; Ignacio I. Wistuba; Adi Gazdar; Jerry W. Shay; Minna
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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Peter Dragovich; Benjamin P. Fauber; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Yichin Liu; Shiva Malek; Borlan Pan; David Peterson; Keith Pitts; Hans E. Purkey; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang
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Anti-inflammatory strategies for plaque stabilization after acute coronary syndromes topical collection on vascular biology
Current Atherosclerosis Reports, ISSN: 15346242 15233804
Amos Baruch; Nicholas Van Bruggen; Juyong Brian Kim; Joshua E. Lehrer-Graiwer
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Assessment and significance of protein-protein interactions during development of protein biopharmaceuticals
Biophysical Reviews, ISSN: 18672469 18672450
Sandeep Yadav; Jun Liu; Thomas M. Scherer; Yatin Gokarn; Barthélemy Demeule; Sonoko Kanai; Andya; Steven J. Shire
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On assay robustness: the importance of early determination and science-driven decision-making
Bioanalysis, ISSN: 17576180 17576199
Kyra J. Cowan
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Drug products for biological medicines: Novel delivery devices, challenging formulations, and combination products, part 2
BioProcess International, ISSN: 15426319
Mire-Sluis; Donna French; Jennifer Mercer; Gerd Kleemann; John Dougherty
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MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
Journal of Experimental Medicine, ISSN: 00221007 15409538
Jaehak Oh; Nan Wu; Günther Baravalle; Benjamin Cohn; Jessica K. Ma; Bryan Lo; Ira Mellman; Satoshi Ishido; Mark S. Anderson; Jeoung-Sook Shin
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Monoclonal antibody self-association, cluster formation, and rheology at high concentrations
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Wayne G. Lilyestrom; Sandeep Yadav; Steven J. Shire; Thomas M. Scherer
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Antagonists of IAP proteins as cancer therapeutics
Cancer Letters, ISSN: 18727980 03043835
Jasmin N. Dynek; Domagoj Vucic
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Pharmacological brake-release of mRNA translation enhances cognitive memory
eLife, ISSN: 2050084X
Carmela Sidrauski; Diego Acosta-Alvear; Arkady Khoutorsky; Punitha Vedantham; Brian R. Hearn; Han Li; Karine Gamache; Ciara M. Gallagher; Kenny K.-H. Ang; Chris Wilson; Voytek Okreglak; Avi Ashkenazi; Byron Hann; Karim Nader; Michelle R. Arkin; Adam R. Renslo; Nahum Sonenberg; Peter Walter
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Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christian Bowman-Colin; Bing Xia; Samuel Bunting; Christiaan N. Klijn; Rinske Drost; Peter Bouwman; Laura Fineman; Xixi Chen; Aedin C. Culhane; Hong Cai; Scott J. Rodig; Roderick T. Bronson; Jos Jonkers; Andre Nussenzweig; Chryssa Kanellopoulou; David M. Livingston
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Characterization of antibody-polyol interactions by static light scattering: Implications for physical stability of protein formulations
International Journal of Pharmaceutics, ISSN: 03785173 18733476
Shermeen A. Abbas; Vikas Sharma; Thomas W. Patapoff; Devendra S. Kalonia
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Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex
Nature Communications, ISSN: 20411723
Bridget E. Lamonica; Jan H. Lui; David V. Hansen; Arnold R. Kriegstein
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A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays
PLoS ONE, ISSN: 19326203
Grace Chan; Tracy L. Kleinheinz; David Peterson; John Moffat
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Total antibody quantification for MMAE-conjugated antibody-drug conjugates: Impact of assay format and reagents
Bioconjugate Chemistry, ISSN: 15204812 10431802
Katherine R. Kozak; Siao Ping Tsai; Aimee Fourie-O'Donohue; Josefa Dela Cruz Chuh; Roth; Ryan Cook; Elton Chan; Pamela Chan; Martine Darwish; Rachana Ohri; Helga Raab; Crystal Zhang; Kedan Lin; Wai Lee T. Wong
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A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth
Cancer Research, ISSN: 00085472 15387445
Ted Lau; Emily Chan; Marinella G. Callow; Jo Waaler; Jason Boggs; Robert A. Blake; Steven Magnuson; Amy Sambrone; Melissa Schutten; Ron Firestein; Ondrej Machon; Vladimir Korinek; Edna F. Choo; Dolores Diaz; Mark Merchant; Paul G. Polakis; Daniel D. Holsworth; Stefan Krauss; Michael Costa
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Analysis of Tumor Heterogeneity and Cancer Gene Networks Using Deep Sequencing of MMTV-Induced Mouse Mammary Tumors
PLoS ONE, ISSN: 19326203
Christiaan N. Klijn; Marco J. Koudijs; Jaap Kool; Jelle ten Hoeve; Mandy Boer; Joost de Moes; Waseem Akhtar; Martine van Miltenburg; Annabel Vendel-Zwaagstra; Marcel J. T. Reinders; David J. Adams; Maarten van Lohuizen; John Hilkens; Lodewyk F. A. Wessels; Jos Jonkers
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Oncogenic ERBB3 Mutations in Human Cancers
Cancer Cell, ISSN: 18783686 15356108
Bijay S. Jaiswal; Noelyn Kljavin; Eric Stawiski; Emily Chan; Chaitali Parikh; Durinck; Subhra Chaudhuri; Kanan Pujara; Joseph Guillory; Kyle A. Edgar; Vasantharajan Janakiraman; Rolf-Peter Scholz; Krista K. Bowman; Maria N. Lorenzo; Hong Li; Jiansheng Wu; Yuan; Brock A. Peters; Zhengyan Kan; Stinson; Michelle Mak; Zora Modrusan; Eigenbrot; Ron Firestein; Howard M. Stern; Krishnaraj Rajalingam; Gabriele Schaefer; Mark Merchant; Mark X. Sliwkowski; FredericJ. deSauvage; Somasekar Seshagiri
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Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Kerstin Trunzer; Anna Pavlick; Lynn Schuchter; Rene Gonzalez; McArthur; Thomas E. Hutson; Stergios J. Moschos; Keith Flaherty; Kevin B. Kim; Jeffrey S. Weber; Peter Hersey; Georgina V. Long; Donald Lawrence; Patrick A. Ott; Ravi K. Amaravadi; Karl Lewis; Igor Puzanov; Roger S. Lo; Astrid Koehler; Mark Kockx; Olivia Spleiss; Annette Schell-Steven; Houston N. Gilbert; Louise Cockey; Gideon Bollag; Richard J. Lee; Andrew K. Joe; Jeffrey A. Sosman; Antoni Ribas
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G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Hong Xin; Rongze Lu; Heehyoung Lee; Wang Zhang; Chunyan Zhang; Jiehui Deng; Yong Liu; Shudan Shen; Kay-Uwe Wagner; Stephen Forman; Richard Jove; Hua Yu
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Evaluation of UGT protein interactions in human hepatocytes: Effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes
Archives of Biochemistry and Biophysics, ISSN: 00039861 10960384
Camille M. Konopnicki; Leslie Dickmann; Jeffrey M. Tracy; Robert H. Tukey; Larry C. Wienkers; Robert S. Foti
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Drug delivery across the blood-brain barrier
Molecular Pharmaceutics, ISSN: 15438392 15438384
Leslie A. Khawli; Saileta Prabhu
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Vascular physiology and protein disposition in a preclinical model of neurodegeneration
Molecular Pharmaceutics, ISSN: 15438384 15438392
C. Andrew Boswell; Eduardo E. Mundo; Bernadette Johnstone; Sheila Ulufatu; Michelle G. Schweiger; Daniela Bumbaca; Fielder; Saileta Prabhu; Leslie A. Khawli
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Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation
Journal of Experimental Medicine, ISSN: 15409538 00221007
Lillian Cohn; Bithi Chatterjee; Filipp Esselborn; Anna Smed-Sörensen; Norihiro Nakamura; Cecile Chalouni; Byoung-Chul Lee; Richard L. Vandlen; Tibor Keler; Peter Lauer; Dirk Brockstedt; Ira Mellman; Lélia Delamarre
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Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients
Blood, ISSN: 15280020 00064971
Annika Dufour; Palermo; Evelyn Zellmeier; Gudrun Mellert; Guillemette Duchateau-Nguyen; Stephanie Schneider; Tobias Benthaus; Purvi M. Kakadia; Karsten Spiekermann; Wolfgang Hiddemann; Jan Braess; Sim Truong; Nancy Patten; Lin Wu; Sabine Lohmann; David Dornan; Debraj GuhaThakurta; Ru-Fang Yeh; Galina Salogub; Philippe Solal-Celigny; Anna Dmoszynska; Tadeusz Robak; Marco Montillo; John Catalano; Christian H. Geisler; Martin Weisser; Stefan K. Bohlander
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Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: Correlative analysis from a large North American cooperative group trial
Blood, ISSN: 15280020 00064971
Jennifer A. Kanakry; Hailun Li; Lan L. Gellert; M. Victor Lemas; Wen-Son Hsieh; Fangxin Hong; King L. Tan; Randy D. Gascoyne; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Patrick J. Stiff; Bruce D. Cheson; Ranjana H. Advani; Thomas P. Miller; Brad Kahl; Sandra J. Horning; Richard F. Ambinder
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Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: Correlative analysis from a large North American cooperative group trial
Blood, ISSN: 15280020 00064971
Jennifer A. Kanakry; Hailun Li; Lan L. Gellert; M. Victor Lemas; Wen-Son Hsieh; Fangxin Hong; King L. Tan; Randy D. Gascoyne; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Patrick J. Stiff; Bruce D. Cheson; Ranjana H. Advani; Thomas P. Miller; Wojciech Jurczak; Sandra J. Horning; Richard F. Ambinder
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GPU-accelerated nonparametric kinetic analysis of DCE-MRI data from glioblastoma patients treated with bevacizumab
Magnetic Resonance Imaging, ISSN: 0730725X 18735894
Yu-Han H. Hsu; Gregory Z. Ferl; Chee Ng
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Strategies to address drug interaction potential for antibody-drug conjugates in clinical development
Bioanalysis, ISSN: 17576180 17576199
Dan Lu; Srikumar Sahasranaman; Yi Zhang; Sandhya Girish
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Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier
Science Translational Medicine, ISSN: 19466234 19466242
Jessica A. Couch; Y. Joy Yu; Yin Zhang; Jacqueline M. Tarrant; Reina N. Fuji; William J. Meilandt; Hilda Solanoy; Raymond K. Tong; Kwame Hoyte; Wilman Luk; Yanmei Lu; Kapil Gadkar; Saileta Prabhu; Benjamin A. Ordonia; Quyen Nguyen; Yuwen L. Lin; Zhonghua Lin; Mercedesz Balazs; Kimberly Scearce-Levie; James A. Ernst; Dennis; Ryan J. Watts
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Recapitulating human cancer in a mouse
Nature Biotechnology, ISSN: 10870156 15461696
Lynda Chin; Frederic J. De Sauvage; Mikala Egeblad; Kenneth P. Olive; David Tuveson; William Weiss
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Newer developments in HPLC impacting pharmaceutical analysis: A brief review
American Pharmaceutical Review, ISSN: 10998012
Michael W. Dong; Davy Guillarme
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Data acquisition and data mining techniques for metabolite identification using LC coupled to high-resolution MS
Bioanalysis, ISSN: 17576180 17576199
Shuguang Ma; Swapan K. Chowdhury
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Bioanalysis of antibody-drug conjugates: American Association of Pharmaceutical Scientists Antibody-Drug Conjugate Working Group position paper
Bioanalysis, ISSN: 17576180 17576199
Boris Gorovits; Stephen C. Alley; Sanela Bilic; Brian Booth; Surinder Kaur; Phillip Oldfield; Shobha Purushothama; Chetana Rao; Stacy Shord; Patricia Siguenza
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Bioanalysis special focus issue on antibody-drug conjugates
Bioanalysis, ISSN: 17576180 17576199
Surinder Kaur
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Development of a new bioprocess scheme using frozen seed train intermediates to initiate CHO cell culture manufacturing campaigns
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Gargi Seth; Robert W. Hamilton; Stapp; Lisa Zheng; Angela Meier; Krista Petty; Stephenie Leung; Srikanth Chary
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Dr. Keystone, et al, reply
Journal of Rheumatology, ISSN: 0315162X 14992752
Edward Keystone; Stanley B. Cohen; Paul Emery; Joel M. Kremer; Maxime Dougados; James E. Loveless; Carol Y. Chung; Pamela Wong; Lehane; Helen Tyrrell
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Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
The Lancet Oncology, ISSN: 14702045 14745488
Sandra M. Swain; Sung-Bae Kim; Javier Cortés; Jungsil Ro; Vladimir Semiglazov; Mario Campone; Eva Ciruelos; Jean-Marc Ferrero; Andreas Schneeweiss; Adam Knott; Emma Clark; Graham Ross; Benyunes; Baselga
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Safety of rituximab in combination with other biologic disease-modifying antirheumatic drugs in rheumatoid arthritis: An open-label study
Journal of Rheumatology, ISSN: 0315162X 14992752
William F. Rigby; Philip J. Mease; Ewa Olech; Ashby; Swati Tole
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Predictive value in retinal vein occlusions of early versus late or incomplete ranibizumab response defined by optical coherence tomography
Ophthalmology, ISSN: 01616420 15494713
Robert B. Bhisitkul; Peter A. Campochiaro; Howard Shapiro; Roman G. Rubio
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8th annual european antibody congress 2012: November 27-28, 2012, Geneva, Switzerland
mAbs, ISSN: 19420862 19420870
Alain Beck; Paul J. Carter; Hans-Peter Gerber; Alexey A. Lugovskoy; Thierry Wurch; Jagath R. Junutula; Roland Kontermann; Robert Mabry
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A likelihood and resampling based approach to dichotomizing a continuous biomarker in medical research
Journal of Biopharmaceutical Statistics, ISSN: 10543406 15205711
Min Su; Liang Fang; Zheng Su
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Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steven T. Staben; Chudi O. Ndubaku; Nicole Blaquiere; Marcia Belvin; Richard J. Bull; Danette Dudley; Kyle A. Edgar; Daniel C. Gray; Robert Heald; Timothy P. Heffron; Graham Jones; Mark Jones; Aleksandr Kolesnikov; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Neville J. McLean; Jim Nonomiya; Alan G. Olivero; Rachel Ord; Jodie Pang; Stephen Price; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Jeffery J. Wallin; Lan Wang; Binqing Wei; Christian Weismann; Ping Wu
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Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Inna Y. Gong; Wendy A. Teft; Justin Ly; Yunghsiang Chen; Bruno Alicke; Richard B. Kim; Edna F. Choo
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Characterization of the drug-to-antibody ratio distribution for antibody-drug conjugates in plasma/serum
Bioanalysis, ISSN: 17576180 17576199
Keyang Xu; Luna Liu; Randall Dere; Elaine Mai; Rebecca Erickson; Angela Hendricks; Kedan Lin; Jagath R. Junutula; Surinder Kaur
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