Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7051 - 7100 OF 15394 RESULTS

April 1, 2013

Drug products for biological medicines

BioProcess International, ISSN: 15426319

Mire-Sluis; Donna French; Jennifer Mercer; Gerd Kleemann; John Dougherty

April 1, 2013

The efficacy and tolerability of adriamycin, bleomycin, vinblastine, dacarbazine and Stanford V in older Hodgkin lymphoma patients: A comprehensive analysis from the North American intergroup trial E2496

British Journal of Haematology, ISSN: 00071048 13652141

Andrew M. Evens; Fangxin Hong; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Joseph M. Connors; Randy D. Gascoyne; Henry Wagner; Mary Gospodarowicz; Bruce D. Cheson; Patrick J. Stiff; Ranjana H. Advani; Thomas P. Miller; Richard T. Hoppe; Wojciech Jurczak; Sandra J. Horning

April 1, 2013

Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models

Clinical Cancer Research, ISSN: 10780432 15573265

Jie Lin; Deepak Sampath; Michelle Nannini; Brian B. Lee; Michael Degtyarev; Jason Oeh; Heidi Savage; Zhengyu Guan; Rebecca Hong; Robert Kassees; Leslie Lee; Tyler Risom; Stefan Gross; Bianca M. Liederer; Koeppen; Nicholas J. Skelton; Jeffery J. Wallin; Marcia Belvin; Elizabeth A. Punnoose; Lori S. Friedman; Kui Lin

April 1, 2013

Development of advanced fermentor control applications for use in an industrial automation environment

Journal of Laboratory Automation, ISSN: 22110690 22110682

Ryan Hamilton; Krishna Tamminana; John Boyd; Gen Sasaki; Alex Toda; Sid Haskell; Elizabeth Danbe

April 1, 2013

A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer

Biopharmaceutics and Drug Disposition, ISSN: 01422782 1099081X

Sravanthi Cheeti; Nageshwar Budha; Sharmila Rajan; Mark J. Dresser; Jin Y. Jin

March 30, 2013

A sequential testing approach to detecting multiple change points in the proportional hazards model

Statistics in Medicine, ISSN: 02776715 10970258

Pei He; Liang Fang; Zheng Su

March 29, 2013

Generation of tumor-targeted antibody-CpG conjugates

Journal of Immunological Methods, ISSN: 00221759 18727905

Zhongjun Li; Julie K. Jang; Melissa G. Lechner; Peisheng Hu; Leslie A. Khawli; Christopher A. Scannell; Alan L. Epstein

March 23, 2013

Development of a robust flow cytometry-based pharmacodynamic assay to detect phospho-protein signals for phosphatidylinositol 3-kinase inhibitors in multiple myeloma

Journal of Translational Medicine, ISSN: 14795876

Congfen Li; Chikara Takahashi; Liangxuan Zhang; Mahrukh Huseni; Basha Stankovich; Haider Mashhedi; Joanna Y. Lee; French; Jeffrey Eastham-Anderson; Doris Kim; Howell; Matthew J. Brauer; Marcin Kowanetz; Yibing Yan; Eric W. Humke; Allen Ebens; Garret M. Hampton; Lackner; Priti Hegde; Shidong Jia

March 22, 2013

Phosphorylation of dishevelled by protein kinase RIPK4 regulates Wnt signaling

Science, ISSN: 10959203 00368075

Xiaodong Huang; James C. McGann; Bob Y. Liu; Rami N. Hannoush; Jennie R. Lill; Victoria Pham; Kim Newton; Michael Kakunda; Jinfeng Liu; Christine Yu; Sarah G. Hymowitz; Hongo; Anthony Wynshaw-Boris; Paul G. Polakis; Richard M. Harland; Vishva M. Dixit

March 21, 2013

A safe synthesis of 1,5-disubstituted 3-amino-1 H-1,2,4-triazoles from 1,3,4-oxadiazolium hexafluorophosphates

Synthesis (Germany), ISSN: 00397881 1437210X

Brian Wong; Andreas Stumpf; Diane Carrera; Christine Gu; Haiming Zhang

March 21, 2013

Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8+ T Cell Responses in the Lymph Node

Immunity, ISSN: 10747613 10974180

Wolfgang Kastenmüller; Marlene Brandes; Ze Wang; Jasmin Herz; Jackson G. Egen; Ronald N. Germain

March 19, 2013

Biomarker results from the AVADO phase 3 trial of first-line bevacizumab plus docetaxel for HER2-negative metastatic breast cancer

British Journal of Cancer, ISSN: 00070920 15321827

David W. Miles; Sanne De Haas; Luc Dirix; Romieu; Chan; Pivot; Tomczak; Provencher; Javier Cortés; Paul Delmar; Stefan J. Scherer

March 15, 2013

Future Perspectives

Pharmacogenomics of Human Drug Transporters: Clinical Impacts,

Toshihisa Ishikawa; Joseph A. Ware

March 14, 2013

Discovery and optimization of a novel series of potent mutant B-Raf V600E selective kinase inhibitors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Melissa M. Vasbinder; Brian Aquila; Martin Augustin; Huawei Chen; Tony Cheung; Donald Cook; Lisa Drew; Benjamin P. Fauber; Steve Glossop; Michael Grondine; Edward Hennessy; Jeffrey Johannes; Stephen Lee; Paul Lyne; Mario Mörtl; Charles Omer; Sangeetha Palakurthi; Timothy Pontz; Jon Read; Li Sha; Minhui Shen; Stefan Steinbacher; Haixia Wang; Allan Wu; Minwei Ye

March 11, 2013

A Major Epigenetic Programming Mechanism Guided by piRNAs

Developmental Cell, ISSN: 15345807 18781551

Xiao A. Huang; Hang Yin; Sarah Sweeney; Debasish Raha; Michael Snyder; Haifan Lin

March 8, 2013

Biomarkers of Residual Disease, Disseminated Tumor Cells, and Metastases in the MMTV-PyMT Breast Cancer Model

PLoS ONE, ISSN: 19326203

Christian Franci; Jenny Zhou; Zhaoshi Jiang; Zora Modrusan; Zinaida Good; Erica L. Jackson; Hosein Kouros-Mehr

March 8, 2013

One resin, multiple products: A green approach to purification

ACS Symposium Series, ISSN: 19475918 00976156

Ekta Mahajan; Jay Werber; Kapil Kothary; Tina M. Larson

March 6, 2013

Treatment satisfaction is associated with improved quality of life in patients treated with inhaled treprostinil for pulmonary arterial hypertension

Health and Quality of Life Outcomes, ISSN: 14777525

Hubert Chen; Erika B. Rosenzweig; S Karl Gotzkowsky; Carl Arneson; Andrew C. Nelsen; Robert C. Bourge

March 6, 2013

Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria

EMBO Journal, ISSN: 02614189 14602075

Coenraad Kuijl; Manohar Pilli; Suresh K. Alahari; Hans Janssen; Poh-Sim Khoo; Karen E. Ervin; Monica Calero; Sobhanaditya Jonnalagadda; Richard H. Scheller; Jacques Neefjes; Jagath R. Junutula

March 5, 2013

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Trent A. Watkins; Bei Wang; Sarah Huntwork-Rodriguez; Jing Yang; Zhiyu Jiang; Jeffrey Eastham-Anderson; Zora Modrusan; Joshua S. Kaminker; Marc Tessier-Lavigne; Joe Lewcock

March 1, 2013

Markers of response for the antiangiogenic agent bevacizumab

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Diether Lambrechts; Heinz-Josef Lenz; Sanne De Haas; Peter Carmeliet; Stefan J. Scherer

March 1, 2013

Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Sara A. Hurvitz; Luc Dirix; Judit Kocsis; Giulia V. Bianchi; Janice Lu; Jeferson Vinholes; Ellie Guardino; Chunyan Song; Barbara Tong; Vivian W. Ng; Yu-Waye Chu; Edith A. Perez

March 1, 2013

Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver

Xenobiotica, ISSN: 00498254 13665928

Hoa Le; Kevin A. Ford; S. Cyrus Khojasteh; Peter W. Fan

March 1, 2013

Characterization of the long-term pharmacokinetics of bevacizumab following last dose in patients with resected stage II and III carcinoma of the colon

Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843

Jing Li; Manish Gupta; Denise Jin; Yan Xin; Jennifer Visich; David E. Allison

March 1, 2013

Antibody-drug conjugates for the treatment of B-cell non-Hodgkin's lymphoma and leukemia

Future Oncology, ISSN: 14796694 17448301

Yu-Waye Chu; Andrew G. Polson

March 1, 2013

PAR-1 contributes to the innate immune response during viral infection

Journal of Clinical Investigation, ISSN: 00219738 15588238

Silvio Antoniak; A. Phillip Owens III; Martin Baunacke; Julie C. Williams; Rebecca D. Lee; Alice Weithäuser; Patricia A. Sheridan; Ronny Malz; James P. Luyendyk; Denise A. Esserman; Jo Ann Trejo; Daniel Kirchhofer; Burns C. Blaxall; Rafal Pawlinski; Melinda A. Beck; Ursula Rauch; Nigel Mackman

March 1, 2013

Antimalarial chemoprophylaxis and the risk of neuropsychiatric disorders

Travel Medicine and Infectious Disease, ISSN: 14778939 18730442

Cornelia Schneider; Miriam Adamcova; Susan S. Jick; Patricia Schlagenhauf; Mary K. Miller; Hans-Georg Rhein; Christoph R. Meier

March 1, 2013

Meeting report - Workshop on virus removal by filtration: Trends and new developments

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124

Hannelore Willkommen; Johannes Blümel; Kurt Brorson; Dayue Chen; Qi Chen; Albrecht Gröner; Thomas R. Kreil; James S. Robertson; Michel Ruffing; Sol Ruiz

March 1, 2013

Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice

Arthritis and Rheumatism, ISSN: 00043591 15290131

Rajasekaran; Nan Wang; Phi Truong; Rinderknecht; Macaubas; Beilhack; Shizuru; Mellins

March 1, 2013

Analysis of dermatologic events in vemurafenib-treated patients with melanoma

Oncologist, ISSN: 10837159 1549490X

Mario E. Lacouture; Madeleine Duvic; Axel Hauschild; Victor G. Prieto; Caroline Robert; Dirk Schadendorf; Caroline C. Kim; Christopher J. McCormack; Patricia L. Myskowski; Olivia Spleiss; Kerstin Trunzer; Fei Su; Betty Nelson; Keith B. Nolop; Joseph F. Grippo; Richard J. Lee; Matthew J. Klimek; James L. Troy; Andrew K. Joe

March 1, 2013

Cardiac tolerability of pertuzumab plus trastuzumab plus docetaxel in patients with HER2-positive metastatic breast cancer in CLEOPATRA: A randomized, double-blind, placebo-controlled phase III study

Oncologist, ISSN: 10837159 1549490X

Sandra M. Swain; Michael S. Ewer; Javier Cortés; Dino Amadori; David W. Miles; Adam Knott; Emma Clark; Benyunes; Graham Ross; Baselga

March 1, 2013

Freely turning over palmitate in erythrocyte membrane proteins is not responsible for the anchoring of lipid rafts to the spectrin skeleton: A study with bio-orthogonal chemical probes

Biochimica et Biophysica Acta - Biomembranes, ISSN: 00052736 18792642

Annarita Ciana; Cesare Achilli; Rami N. Hannoush; Angela Risso; Cesare Balduini; Giampaolo Minetti

March 1, 2013

Meeting report: PDA virus and TSE safety forum

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124

Hannelore Willkommen; Johannes Blümel; Kurt Brorson; Dayue Chen; Qi Chen; Albrecht Gröner; Thomas R. Kreil; James S. Robertson; Michel Ruffing; Sol Ruiz

March 1, 2013

Quality of life of young adult survivors of hematologic malignancies

Cancer Nursing, ISSN: 0162220X 15389804

Marlana R. Mattson; Regan K. Demshar; Barbara J. Daly

March 1, 2013

Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

mAbs, ISSN: 19420862 19420870

Ekaterine Kortkhonjia; Relly Brandman; Joe Zhongxiang Zhou; Vincent A. Voelz; Ilya Chorny; Bruce Kabakoff; Thomas W. Patapoff; Ken A. Dill; Trevor E. Swartz

March 1, 2013

Evaluating the impact of bevacizumab maintenance therapy on overall survival in advanced non-small-cell lung cancer

Clinical Lung Cancer, ISSN: 15257304 19380690

George Dranitsaris; Nancy Beegle; Arliene Ravelo; Traci Kalberer; Elaine B. Yu; Sachdev Thomas

March 1, 2013

Comparative Effectiveness of Chemotherapy in Elderly Patients with Metastatic Colorectal Cancer

Journal of Gastrointestinal Cancer, ISSN: 19416636 19416628

Sacha Satram-Hoang; Lee; Shui Yu; Sridhar R. Guduru; Ashokvardhan R. Gunuganti; Carolina Reyes; Edward McKenna

March 1, 2013

The degrabase: A database of proteolysis in healthy and apoptotic human cells

Molecular and Cellular Proteomics, ISSN: 15359476 15359484

Emily D. Crawford; Julia E. Seaman; Nick Agard; Gerald W. Hsu; Olivier Julien; Sami Mahrus; Huy Nguyen; Kazutaka Shimbo; Hikari A.I. Yoshihara; Min Zhuang; Robert J. Chalkley; James A. Wells

March 1, 2013

PI3K/AKT Activation and Response in Phase IB: AKT Inhibitor GDC-0068 with Docetaxel (D) Or MFOLFOX6 (F) in Refractory Solid Tumors

Annals of Oncology, ISSN: 15698041 09237534

Meng; Molife; De Mattos-Arruda; Antoine Hollebecque; Isakoff; Roda; Yan; Andrés Cervantes; Jean-Charles Soria; Mateo; Guillem Argiles; Bendell

March 1, 2013

PI3K/AKT Activation and Response in Phase IB: AKT Inhibitor GDC-0068 with Docetaxel (D) Or MFOLFOX6 (F) in Refractory Solid Tumors

Annals of Oncology, ISSN: 15698041 09237534

Raymond D. Meng; Molife; De Mattos-Arruda; Antoine Hollebecque; Isakoff; Desamparados Roda; Yan; Andrés Cervantes; Jean-Charles Soria; Mateo; Guillem Argiles; Bendell

March 1, 2013

IL-22, not simply a Th17 cytokine

Immunological Reviews, ISSN: 01052896 1600065X

Sascha Rutz; Celine Eidenschenk; Wenjun Ouyang

March 1, 2013

Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels

Journal of Cell Biology, ISSN: 00219525 15408140

Nathalie Jurisch-Yaksi; Applonia J. Rose; Huiqi Lu; Tim Raemaekers; Sebastian Munck; Pieter Baatsen; Veerle Baert; Wendy Vermeire; Suzie J. Scales; Daphne Verleyen; Roel Vandepoel; Przemko Tylzanowski; Emre Yaksi; Thomy de Ravel; H. Joseph Yost; Guy Froyen; Cammon B. Arrington; Wim Annaert

March 1, 2013

Thermodynamic and structural characterization of an antibody gel

mAbs, ISSN: 19420862 19420870

Osigwe Esue; Anna X. Xie; Tim J. Kamerzell; Thomas W. Patapoff

March 1, 2013

Analysis of early hypertension and clinical outcome with bevacizumab: Results from seven phase III studies

Oncologist, ISSN: 10837159 1549490X

Herbert Hurwitz; Pamela Douglas; John P. Middleton; George W. Sledge; David H. Johnson; David A. Reardon; Dafeng Chen; Oliver Rosen

February 28, 2013

High Heregulin Expression Is Associated with Activated HER3 and May Define an Actionable Biomarker in Patients with Squamous Cell Carcinomas of the Head and Neck

PLoS ONE, ISSN: 19326203

David S. Shames; Juliet Carbon; Kimberly Walter; Adrian M. Jubb; Cleopatra Kozlowski; Thomas Januario; An Do; Ling Fu; Yuanyuan Xiao; Rajiv Raja; Brittany Jiang; Ashi Malekafzali; Howard M. Stern; Jeffrey Settleman; Wilson; Garret M. Hampton; Robert Yauch; Andrea Pirzkall; Lukas Amler

February 28, 2013

Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma

Cell, ISSN: 10974172 00928674

Matija Snuderl; Ana Batista; Nathaniel D. Kirkpatrick; Carmen Ruiz de Almodovar; Lars Riedemann; Elisa C. Walsh; Rachel Anolik; Yuhui Huang; John D. Martin; Walid Kamoun; Ellen Knevels; Thomas Schmidt; Christian T. Farrar; Benjamin J. Vakoc; Nishant Mohan; Euiheon Chung; Sylvie Roberge; Teresa Peterson; Carlos Bais; Boryana H. Zhelyazkova; Stephen Yip; Martin Hasselblatt; Claudia Rossig; Elisabeth Niemeyer; Napoleone Ferrara; Michael Klagsbrun; Dan G. Duda; Dai Fukumura; Lei Xu; Peter Carmeliet; Rakesh K. Jain

February 28, 2013

Cosolute effects on the chemical potential and interactions of an IgG1 monoclonal antibody at high concentrations

Journal of Physical Chemistry B, ISSN: 15205207 15206106

Thomas M. Scherer

February 26, 2013

EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells

PLoS ONE, ISSN: 19326203

Eugene Y. Chiang; Robert J. Johnston; Jane L. Grogan

February 26, 2013

Particle shape enhances specificity of antibody-displaying nanoparticles

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Sutapa Barua; Jin-Wook Yoo; Poornima Kolhar; Aditya A. Wakankar; Yatin Gokarn; Samir Mitragotri

February 22, 2013

Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia

PLoS ONE, ISSN: 19326203

Ai-Luen Wu; Bo Feng; Mark Chen; Ganesh Kolumam; Jose Zavala-Solorio; Shelby K. Wyatt; Vineela D. Gandham; Richard A. D. Carano; Junichiro Sonoda

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