Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7101 - 7150 OF 15394 RESULTS

February 21, 2013

Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner

Oncogene, ISSN: 09509232 14765594

Wagner; Marschall; Karl; Cristofanon; Zobel; Deshayes; Domagoj Vucic; Debatin; Fulda

February 20, 2013

Cells is defined by positive feedback loop between CIP2A and E2F1

Cancer Discovery, ISSN: 21598274 21598290

Anni Laine; Harri Sihto; Christophe Come; Mathias T. Rcsenfeldt; Aleksandra Zwolinska; Minna Niemelä; Anchit Khanna; Edward K. Chan; Veli-Matti Kähäri; Pirkko-Liisa Kellokumpu-Lehtinen; Owen J. Sansom; Gerard I. Evan; Melissa Junttila; Kevin M. Ryan; Jean-Christophe Marine; Heikki Joensuu; Jukka Westermarck

February 20, 2013

Noncovalent wild-type-sparing inhibitors of EGFR T790M

Cancer Discovery, ISSN: 21598274 21598290

Ho-June Lee; Gabriele Schaefer; Timothy P. Heffron; Lily Shao; Ye; Steve Sideris; Shiva Malek; Emily Chan; Mark Merchant; Hank La; Savita Ubhayakar; Robert Yauch; Valentina Pirazzoli; Katerina Politi; Jeffrey Settleman

February 20, 2013

Specific Trans-synaptic interaction with inhibitory interneuronal neurexin underlies differential ability of neuroligins to induce functional inhibitory synapses

Journal of Neuroscience, ISSN: 02706474 15292401

Kensuke Futai; Christopher D. Doty; Brian Baek; Jubin Ryu; Morgan Sheng

February 19, 2013

Do clustering monoclonal antibody solutions really have a concentration dependence of viscosity?

Biophysical Journal, ISSN: 00063495 15420086

Jai A. Pathak; Rumi R. Sologuren; Rojaramani Narwal

February 19, 2013

Intricate interplay between astrocytes and motor neurons in ALS

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Hemali P. Phatnani; Paolo Guarnieri; Brad A. Friedman; Monica A. Carrasco; Michael Muratet; Sean O'Keeffe; Chiamaka Nwakeze; Florencia Pauli-Behn; Kimberly M. Newberry; Sarah K. Meadows; Juan Carlos Tapia; Richard M. Myers; Tom Maniatis

February 18, 2013

Critical role of activation induced cytidine deaminase in Experimental Autoimmune Encephalomyelitis

Autoimmunity, ISSN: 08916934 1607842X

Yonglian Sun; Ivan Peng; Kate Senger; Kajal Hamidzadeh; Mike Reichelt; Miriam Baca; Ronald Yeh; Maria N. Lorenzo; Andrew Sebrell; Christopher Dela Cruz; Lucinda Tam; Corpuz; Jiansheng Wu; Tao Sai; Merone Roose-Girma; Søren Warming; Mercedesz Balazs; Lino C. Gonzalez Jr.; Patrick Caplazi; Flavius Martin; Jason Devoss; Ali A. Zarrin

February 18, 2013

Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta

Genome Biology, ISSN: 1474760X 14747596

Stephen R. Fairclough; Zehua Chen; Eric Kramer; Qiandong Zeng; Sarah Young; Hugh M. Robertson; Emina Begovic; Daniel J. Richter; Carsten Russ; M Jody Westbrook; Gerard Manning; B Franz Lang; Brian Haas; Chad Nusbaum; Nicole King

February 15, 2013

Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the eubacterium Rhodopirellula baltica

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Phildrich G. Teh; Mark J. Chen; James L. Engel; Carolyn A. Worby; Gerard Manning; Jack E. Dixon; Ji Zhang

February 15, 2013

A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3

Cell Cycle, ISSN: 15514005 15384101

Jenni Lahtela; Laura B. Corson; Annabrita Hemmes; Matthew J. Brauer; Sonja Koopal; James Lee; Thomas Hunsaker; Peter K Jackson; Emmy W. Verschuren

February 15, 2013

High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening

Rapid Communications in Mass Spectrometry, ISSN: 09514198 10970231

Xiao Ding; Hesham Ghobarah; Xiaolin Zhang; Allan Jaochico; Xingrong Liu; Gauri Deshmukh; Bianca M. Liederer; Cornelis E. Hop; Brian J. Dean

February 15, 2013

Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas

Clinical Cancer Research, ISSN: 10780432 15573265

Mark L. McCleland; Adam S. Adler; Laura Deming; Ely Cosino; Leslie Lee; Elizabeth M. Blackwood; Margaret Solon; Janet Tao; Li Li; David S. Shames; Erica L. Jackson; William F. Forrest; Ron Firestein

February 15, 2013

Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Conor J. Kearney; Clare Sheridan; Sean P. Cullen; Graham A. Tynan; Susan E. Logue; Inna S. Afonina; Domagoj Vucic; Ed C. Lavelle; Seamus J. Martin

February 15, 2013

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity

ACS Chemical Biology, ISSN: 15548937 15548929

Toru Okamoto; Zobel; Anna V. Fedorova; Quan; Hong Yang; Wayne J. Fairbrother; David C.S. Huang; Brian J. Smith; Deshayes; Czabotar

February 14, 2013

Application of a new wall-less plate technology to complex multistep cell-based investigations using suspension cells

Blood, ISSN: 15280020 00064971

Gabriel Quinones; Travis I. Moore; Nicholes; Hyunjae Lee; Sudong Kim; Laura Sun; Noo Li Jeon; Jean-Philippe Stephan

February 14, 2013

A direct and melanopsin-dependent fetal light response regulates mouse eye development

Nature, ISSN: 00280836 14764687

Sujata Rao; Christina Chun; Jieqing Fan; J. Matthew Kofron; Michael B. Yang; Rashmi S. Hegde; Napoleone Ferrara; David R. Copenhagen; Richard Lang

February 12, 2013

Targeted and Untargeted Fusion Proteins: Current Approaches to Cancer Immunotherapy

Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges,

Leslie A. Khawli; Peisheng Hu; Alan L. Epstein

February 8, 2013

HectDI E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Hoanh Tran; Daisy J. Bustos; Ronald Yeh; Bonnee Rubinfeld; Cynthia Lam; Stephanie K. Shriver; Inna Zilberleyb; Michelle W. Lee; Lilian Phu; Anjali A. Sarkar; Irene E. Zohn; Ingrid E. Wertz; Donald S. Kirkpatrick; Paul G. Polakis

February 8, 2013

CRIg mediates early kupffer cell responses to adenovirus

Journal of Leukocyte Biology, ISSN: 07415400 19383673

Jeannie Q. He; Kenneth J. Katschke Jr.; Gribling; Eric Suto; Wyne P. Lee; Laurie Diehl; Jeffrey Eastham-Anderson; Anusha Ponakala; László Kömüves; Jackson G. Egen; Menno Van Lookeren Campagne

February 7, 2013

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

Blood, ISSN: 15280020 00064971

Sung-Uk Lee; Manami Maeda; Yuichi Ishikawa; Sierra Min Li; Anne Wilson; Adrian M. Jubb; Nagisa Sakurai; Lihong Weng; Emma Fiorini; Freddy Radtke; Minhong Yan; H. Robson MacDonald; Ching-Cheng Chen; Takahiro Maeda

February 6, 2013

Comparison of Sequencing Platforms for Single Nucleotide Variant Calls in a Human Sample

PLoS ONE, ISSN: 19326203

Aakrosh Ratan; Webb Miller; Joseph Guillory; Stinson; Somasekar Seshagiri; Stephan C. Schuster

February 6, 2013

Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer

Science Translational Medicine, ISSN: 19466234 19466242

Ganapati V. Hegde; Cecile C. de la Cruz; Cecilia Chiu; Navneet Alag; Gabriele Schaefer; Lisa Crocker; Ross; David Goldenberg; Mark Merchant; Janet Y. Tien; Lily Shao; Roth; Siao Ping Tsai; Scott Stawicki; Zhaoyu Jin; Shelby K. Wyatt; Richard A. D. Carano; Yanyan Zheng; E. Alejandro Sweet-Cordero; Yan Wu; Erica L. Jackson

February 6, 2013

Small-molecule inducer of β cell proliferation identified by high-throughput screening

Journal of the American Chemical Society, ISSN: 15205126 00027863

Weijun Shen; Matthew S. Tremblay; Vishal A. Deshmukh; Weidong Wang; Christophe Filippi; George Harb; You-Qing Zhang; Anwesh Kamireddy; Janine E Baaten; Qihui Jin; Tom Wu; Jonathan G. Swoboda; Charles Y. Cho; Jing Li; Bryan A. Laffitte; Peter McNamara; Richard Glynne; Xu Wu; Ann E. Herman; Peter G. Schultz

February 6, 2013

Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice

PLoS ONE, ISSN: 19326203

Ghanashyam Sarikonda; Sowbarnika Sachithanantham; Yulia Manenkova; Tinalyn Kupfer; Amanda Posgai; Clive Wasserfall; Philip Bernstein; Laura Straub; Philippe P. Pagni; Darius Schneider; Teresa Rodriguez Calvo; Marilyne Coulombe; Kevan Herold; Ronald G. Gill; Mark Atkinson; Gerald Nepom; Mario Ehlers; Teodora Staeva; Hideki Garren; Lawrence Steinman; Andrew A. Chan; Matthias von Herrath

February 4, 2013

Metal-catalyzed oxidation of protein methionine residues in human parathyroid hormone (1-34): Formation of homocysteine and a novel methionine-dependent hydrolysis reaction

Molecular Pharmaceutics, ISSN: 15438384 15438392

Olivier Mozziconacci; Junyan A. Ji; Y. John Wang; Christian Schöneich

February 1, 2013

Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung

PLoS Genetics, ISSN: 15537390 15537404

Carla Calvi; Megan Podowski; Armando Lopez-Mercado; Shana Metzger; Kaori Misono; Alla Malinina; Dustin Dikeman; Hataya Poonyagariyon; Leslie Ynalvez; Roshanak Derakhshandeh; Anne Le; Mark Merchant; Ralph H. Schwall; Enid R. Neptune

February 1, 2013

Response to "drug interactions produced by proton pump inhibitors: Not simply a ph effect"

Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535

Nageshwar Budha; Leslie Z. Benet; Joseph A. Ware

February 1, 2013

Regulation of Neurod1 Contributes to the Lineage Potential of Neurogenin3+ Endocrine Precursor Cells in the Pancreas

PLoS Genetics, ISSN: 15537390 15537404

Teresa L. Mastracci; Keith R. Anderson; James B. Papizan; Lori Sussel

February 1, 2013

Immunohistochemistry and fluorescence in situ hybridization assessment of HER2 in clinical trials of adjuvant therapy for breast cancer (NCCTG N9831, BCIRG 006, and BCIRG 005)

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Edith A. Perez; Michael F. Press; Amylou Dueck; Robert B. Jenkins; Chungyeul Kim; Beiyun Chen; Ivonne Villalobos; Soonmyung Paik; Marc Buyse; Anne E. Wiktor; Reid Meyer; Melanie Finnigan; Joanne Zujewski; Mona Shing; Howard M. Stern; Wilma L. Lingle; Monica M. Reinholz; Dennis J. Slamon

February 1, 2013

Predictive impact of circulating vascular endothelial growth factor in four phase III trials evaluating bevacizumab

Clinical Cancer Research, ISSN: 15573265 10780432

Priti Hegde; Adrian M. Jubb; Dafeng Chen; Nicole F. Li; Meng; Coen A. Bernaards; Rebecca Elliott; Stefan J. Scherer; Daniel S. Chen

February 1, 2013

Novel benzoxazole inhibitors of mPGES-1

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Natasha Kablaoui; Snahel Patel; Jay Shao; Douglas Demian; Keith Hoffmaster; Francioise Berlioz; Michael L. Vazquez; William M. Moore; Richard A. Nugent

February 1, 2013

A potent combination of the novel PI3K inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: Long-lasting responses after treatment withdrawal

Clinical Cancer Research, ISSN: 10780432 15573265

Giuseppe Floris; Agnieszka Wozniak; Raf Sciot; Haifu Li; Lori S. Friedman; Thomas Van Looy; Jasmien Wellens; Peter Vermaelen; Christophe M. Deroose; Jonathan A. Fletcher; Maria Debiec-Rychter; Patrick Schöffski

February 1, 2013

Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Steven T. Staben; Nicole Blaquiere; Vickie Tsui; Aleksandr Kolesnikov; Steven Do; Erin K. Bradley; Jennafer Dotson; Richard Goldsmith; Timothy P. Heffron; John Lesnick; Lewis; Jeremy Murray; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Lionel Rouge; Laurent Salphati; Binqing Wei; Wiesmann; Ping Wu

February 1, 2013

Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interactions

Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103

Toshiko Nishimura; Yajing Hu; Manhong Wu; Edward Pham; Hiroshi Suemizu; Menashe Elazar; Michael Liu; Ramazan Idilman; Cihan Yurdaydin; Peter Angus; Catherine Stedman; Brian Murphy; Jeffrey Glenn; Masato Nakamura; Tatsuji Nomura; Yuan Chen; Ming Zheng; William L. Fitch; Gary Peltz

February 1, 2013

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Nature Medicine, ISSN: 10788956 1546170X

Andrew J. Souers; Joel D. Leverson; Erwin R. Boghaert; Scott L. Ackler; Nathaniel D. Catron; Jun Chen; Brian D. Dayton; Hong Ding; Sari H. Enschede; Wayne J. Fairbrother; David C.S. Huang; Sarah G. Hymowitz; Sha Jin; Seong Lin Khaw; Peter J. Kovar; Lloyd T. Lam; Jackie Lee; Heather Maecker; Kennan C. Marsh; Kylie D. Mason; Michael J. Mitten; Paul M. Nimmer; Anatol Oleksijew; Chang H. Park; Cheol-Min Park; Darren C. Phillips; Andrew W. Roberts; Deepak Sampath; John F. Seymour; Morey L. Smith; Gerard M. Sullivan; Stephen K. Tahir; Chris Tse; Michael D. Wendt; Yu Xiao; John Xue; Haichao Zhang; Rod A. Humerickhouse; Saul H. Rosenberg; Steven W. Elmore

February 1, 2013

The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic isletss

Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103

Xiaoyan Nina Li; James Herrington; Aleksandr Petrov; Lan Ge; George Eiermann; Yusheng Xiong; Mette V. Jensen; Hans E. Hohmeier; Christopher B. Newgard; Maria L. Garcia; Michael Wagner; Bei B. Zhang; Nancy A. Thornberry; Andrew D. Howard; Gregory J. Kaczorowski; Yun-Ping Zhou

February 1, 2013

Personalizing medicine for autoimmune and inflammatory diseases

Nature Immunology, ISSN: 15292908 15292916

Andrew A. Chan; Timothy W. Behrens

February 1, 2013

Discussion of 'Small-sample behavior of novel phase i cancer trial designs' by Assaf P Oron and Peter D Hoff

Clinical Trials, ISSN: 17407745 17407753

Bradley P. Carlin; Wei Zhong; Joseph S. Koopmeiners

February 1, 2013

Regional radiographic damage and functional limitations in patients with ankylosing spondylitis: Differences in early and late disease

Arthritis Care and Research, ISSN: 2151464X 21514658

Michael M. Ward; Thomas J. Learch; Lianne S. Gensler; John C. Davis; John D. Reveille; Michael H. Weisman

February 1, 2013

Unexpected hematologic effects of biotherapeutics in nonclinical species and in humans

Toxicologic Pathology, ISSN: 01926233 15331601

Nancy E. Everds; Jacqueline M. Tarrant

February 1, 2013

Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: A commentary on why they are still necessary

Xenobiotica, ISSN: 00498254 13665928

Ronald E. White; David C. Evans; Cornelis E. Hop; David J. Moore; Chandra Prakash; Sekhar Surapaneni; Francis L. S. Tse

February 1, 2013

Integrated and translational nonclinical in vivo cardiovascular risk assessment: Gaps and opportunities

Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295

Brian R. Berridge; Peter K. Hoffmann; James R. Turk; Frank W Sellke; Gary Gintant; Gerald Hirkaler; Kevin Dreher; A. Eric Schultze; Dana Walker; Nick Edmunds; Wendy Halpern; James Falls; Marty Sanders; Syril D. Pettit

February 1, 2013

Response to Deng et al.'s LRRK2 patent review

Expert Opinion on Therapeutic Patents, ISSN: 13543776 17447674

Burdick

February 1, 2013

Systematic analysis and validation of differential gene expression in ovarian serous adenocarcinomas and normal ovary

Journal of Cancer Research and Clinical Oncology, ISSN: 01715216 14321335

Dirk Bauerschlag; Karen Bräutigam; Roland Moll; Jalid Sehouli; Alexander Mustea; Darius Salehin; Maryla Krajewska; John C. Reed; Nicolai Maass; Garret M. Hampton; Ivo Meinhold-Heerlein

February 1, 2013

The burden of faulty proofreading in colon cancer

Nature Genetics, ISSN: 10614036 15461718

Somasekar Seshagiri

February 1, 2013

Evaluation of metabolism and disposition of GDC-0152 in rats using 14C labeling strategy at two different positions: A novel formation of hippuric acid from 4-phenyl-5-amino-1,2,3-thiadiazoles

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Qin Yue; Teresa Mulder; Patrick J. Rudewicz; Eric G. Solon; Nageshwar Budha; Joseph A. Ware; Joseph P. Lyssikatos; Cornelis E. Hop; Harvey Wong; S. Cyrus Khojasteh

February 1, 2013

Absolute and relative contraindications to pegylated-interferon or ribavirin in the US general patient population with chronic hepatitis C: Results from a US database of over 45 000 HCV-infected, evaluated patients

Alimentary Pharmacology and Therapeutics, ISSN: 02692813 13652036

Talal; Joanne Lafleur; Hoop; Prashant K. Pandya; Martin; Ira M. Jacobson; Jian Han; Korner

January 31, 2013

Evaluation of semi-homogeneous assay formats for dual-specificity antibodies

Journal of Immunological Methods, ISSN: 00221759 18727905

Guoying Jiang; Chung W. Lee; Wong; Hélène Gazzano-Santoro

January 31, 2013

Lgr5-Expressing Cells Are Sufficient And Necessary for Postnatal Mammary Gland Organogenesis

Cell Reports, ISSN: 22111247

Vicki Plaks; Audrey Brenot; Devon A. Lawson; Jelena R. Linnemann; Eline C. Van Kappel; Karren C. Wong; Frederic J. De Sauvage; Ophir D. Klein; Zena Werb

January 30, 2013

Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach

PLoS ONE, ISSN: 19326203

Ka Young Chung; Peter W. Day; Gisselle Vélez-Ruiz; Roger K. Sunahara; Brian K. Kobilka

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