Genentech: Publications

January 29, 2013

An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Stefan L. Oliver; Jennifer J. Brady; Marvin H. Sommer; Mike Reichelt; Phillip Sung; Helen M. Blau; Ann M. Arvin

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January 25, 2013

Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Steffan Vartanian; Carolyn Bentley; Matthew J. Brauer; Li Li; Senji Shirasawa; Takehiko Sasazuki; Jung-Sik Kim; Matthias Peter; Eric Stawiski; Zora Modrusan; Todd Waldman; David Stokoe

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January 24, 2013

Neuroscience: Strength in numbers

Nature, ISSN: 00280836 14764687

Morgan Sheng; Roberto Malinow; Richard Huganir

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January 18, 2013

Development of a scalable strategy for the synthesis of PI3Kδ inhibitors: Selective and efficient functionalization of purine derivatives

Organic Process Research and Development, ISSN: 10836160 1520586X

Diane Carrera; Peijue Sheng; Brian S. Safina; Jun Li; Remy Angelaud

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January 18, 2013

Cyanide anion as a leaving group in nucleophilic aromatic substitution: Synthesis of quaternary centers at azine heterocycles

Journal of Organic Chemistry, ISSN: 00223263 15206904

Alexander D. Thompson; Malcolm P. Huestis

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January 18, 2013

A practical synthesis of a PI3K inhibitor under noncryogenic conditions via functionalization of a lithium triarylmagnesiate intermediate

Organic Process Research and Development, ISSN: 10836160 1520586X

Qingping Tian; Zhigang Cheng; Herbert M. Yajima; Scott Savage; Keena L. Green; Theresa Humphries; Mark E. Reynolds; Srinivasan Babu; Francis Gosselin; David Askin; Isao Kurimoto; Norihiko Hirata; Mitsuhiro Iwasaki; Yasuharu Shimasaki; Takashi Miki

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January 17, 2013

Screening Reactive Metabolites: Role of Liquid Chromatography-High-Resolution Mass Spectrometry in Combination with "Intelligent" Data Mining Tools

Mass Spectrometry for Drug Discovery and Drug Development,

Shuguang Ma; Swapan K. Chowdhury

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January 17, 2013

Mass Spectrometry of siRNA

Mass Spectrometry for Drug Discovery and Drug Development,

Mark T. Cancilla; W. Michael Flanagan

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January 17, 2013

Conditional activation of Pik3ca H1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations

Oncogene, ISSN: 09509232 14765594

Yuan; Eric Stawiski; Vasantharajan Janakiraman; Emily Chan; Durinck; Kyle A. Edgar; Noelyn Kljavin; Rivers; Florian Gnad; Merone Roose-Girma; Matthias Peter; Grazyna Fedorowicz; Sherry Heldens; Robert Soriano; Zemin Zhang; Jeffery J. Wallin; Johnson; Mark Merchant; Zora Modrusan; Howard M. Stern; Somasekar Seshagiri

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January 17, 2013

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the sonic hedgehog pathway via cAMP signaling

Cell, ISSN: 10974172 00928674

Saikat Mukhopadhyay; Xiaohui Wen; Navneet Ratti; Alexander V. Loktev; Linda Rangell; Suzie J. Scales; Peter K Jackson

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January 16, 2013

Efficient syntheses of 2-fluoroalkylbenzimidazoles and -benzothiazoles

Tetrahedron Letters, ISSN: 00404039 18733581

Olivier René; Alexandra Souverneva; Steven Magnuson; Benjamin P. Fauber

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January 15, 2013

Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma

Cancer, ISSN: 10970142 0008543X

Han Chong Toh; Pei-Jer Chen; Brian I. Carr; Jennifer J. Knox; Sharlene Gill; Peter Ansell; Evelyn M. McKeegan; Barry Dowell; Michelle Pedersen; Qin Qin; Jiang Qian; Frank A. Scappaticci; Justin L. Ricker; Dawn M. Carlson; Wei Peng Yong

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January 15, 2013

Recommendations for including multiple symptoms as endpoints in cancer clinical trials: A report from the ASCPRO (Assessing the Symptoms of Cancer Using Patient-Reported Outcomes) Multisymptom Task Force

Cancer, ISSN: 0008543X 10970142

Charles S. Cleeland; Jeff A. Sloan; Cella; Connie Chen; Amylou Dueck; Nora A. Janjan; Astra M. Liepa; Rajiv Mallick; Ann O'Mara; Jay D. Pearson; Yasuhiro Torigoe; Xin Shelley Wang; Loretta A. Williams; Jeanie F. Woodruff

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January 15, 2013

Results from AMBER, a randomized phase 2 study of bevacizumab and bortezomib versus bortezomib in relapsed or refractory multiple myeloma

Cancer, ISSN: 0008543X 10970142

Darrell White; Adetola Kassim; Birbal Bhaskar; Jing Yi; Karen Wamstad; Virginia Paton

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January 15, 2013

So, what's it really like to work in biotech?

Molecular Biology of the Cell, ISSN: 10591524 19394586

Lisa D. Belmont

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January 15, 2013

Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer

Cancer Research, ISSN: 00085472 15387445

Kyle David Proffitt; Babita Madan; Zhiyuan Ke; Vishal Pendharkar; Lijun Ding; May Ann Lee; Rami N. Hannoush; David M. Virshup

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January 14, 2013

The role of amino acid sequence in the self-association of therapeutic monoclonal antibodies: Insights from coarse-grained modeling

Journal of Physical Chemistry B, ISSN: 15205207 15206106

Anuj Chaudhri; Isidro E. Zarraga; Sandeep Yadav; Thomas W. Patapoff; Steven J. Shire; Gregory A. Voth

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January 11, 2013

Improving pH gradient cation-exchange chromatography of monoclonal antibodies by controlling ionic strength

Journal of Chromatography A, ISSN: 00219673 18733778

Liangyi Zhang; Thomas W. Patapoff; Dell Farnan; Boyan Zhang

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January 10, 2013

Discovery and biological profiling of potent and selective mTOR inhibitor GDC-0349

ACS Medicinal Chemistry Letters, ISSN: 19485875

Zhonghua Pei; Elizabeth M. Blackwood; Lichuan Liu; Shiva Malek; Marcia Belvin; Michael F. T. Koehler; Daniel F. Ortwine; Huifen Chen; Frederick Cohen; Jane R. Kenny; Philippe Bergeron; Kevin Lau; Cuong Q. Ly; Xianrui Zhao; Anthony A. Estrada; Tom Truong; Jennifer A. Epler; Jim Nonomiya; Lan Trinh; Steve Sideris; John Lesnick; Linda Bao; Ulka Vijapurkar; Sophie Mukadam; Suzanne Tay; Gauri Deshmukh; Yunghsiang Chen; Xiao Ding; Lori S. Friedman; Joseph P. Lyssikatos

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January 10, 2013

Discovery of a highly selective, brain-penetrant aminopyrazole LRRK2 inhibitor

ACS Medicinal Chemistry Letters, ISSN: 19485875

Bryan K. Chan; Anthony A. Estrada; Huifen Chen; John Atherall; Charles Baker-Glenn; Alan Beresford; Burdick; Mark Chambers; Sara L. Dominguez; Jason H. Drummond; Andrew Gill; Tracy L. Kleinheinz; Claire E. Le Pichon; Andrew D. Medhurst; Xingrong Liu; John Moffat; Kevin Nash; Kimberly Scearce-Levie; Zejuan Sheng; Daniel G. Shore; Hervé Van De Poël; Shuo Zhang; Haitao Zhu; Zachary K. Sweeney

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January 8, 2013

The Akt DUBbed inAktive

Science Signaling, ISSN: 19450877 19379145

Kui Lin

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January 7, 2013

Role of surface exposed tryptophan as substrate generators for the antibody catalyzed water oxidation pathway

Molecular Pharmaceutics, ISSN: 15438384 15438392

Alavattam Sreedhara; Kimberly Lau; Charlene Li; Brian Hosken; Frank D. Macchi; Dejin Zhan; Amy Shen; Daniel Steinmann; Christian Schöneich; Yvonne Lentz

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January 5, 2013

Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection

Virology, ISSN: 00426822 10960341

Michael B.A. Oldstone; John R. Teijaro; Kevin B. Walsh; Hugh Rosen

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January 4, 2013

Development of a native nanoelectrospray mass spectrometry method for determination of the drug-to-antibody ratio of antibody-drug conjugates

Analytical Chemistry, ISSN: 15206882 00032700

Jia Chen; Sheng Yin; Yongjian Wu; Jun Ouyang

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January 4, 2013

The chromosome-centric human proteome project: A call to action

Journal of Proteome Research, ISSN: 15353893 15353907

Andreas F. R. Hühmer; Aran Paulus; Leroy B. Martin; Kevin Millis; Tasha Agreste; Julian Saba; Jennie R. Lill; Steven M. Fischer; William Dracup; Paddy Laver

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January 1, 2013

The molecular choreography of IRF4 and IRF8 with immune system partners

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Harinder Singh; Elke Glasmacher; Abraham B. Chang; Bryan Vander Lugt

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January 1, 2013

EGFR mutation testing for squamous cell lung carcinoma (2)

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Larry Leon; Bann-Mo Day; Hu

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January 1, 2013

Retrospective analysis of first-line anti-vascular endothelial growth factor treatment patterns in wet age-related macular degeneration

Advances in Therapy, ISSN: 18658652 0741238X

Stephen S. Johnston; Kathleen Wilson; Alice Huang; David Smith; Helen Varker; Adam Turpcu

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January 1, 2013

Treatment effect of capecitabine and docetaxel or docetaxel alone byoestrogen receptor status in patients with metastatic breast cancer: Results of an exploratory analysis

Breast, ISSN: 15323080 09609776

Glück; Russell; O'Shaughnessy; Edward McKenna; Hu; Odom; Blum

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January 1, 2013

Anti-vascular endothelial growth factor therapy for diabetic macular edema

Therapeutic Advances in Endocrinology and Metabolism, ISSN: 20420196 20420188

David S. Boyer; J. Jill Hopkins; Jonathan Sorof; Jason S. Ehrlich

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January 1, 2013

P21-Activated Kinase Inhibitors

Enzymes, ISSN: 18746047

Joachim Rudolph; James J. Crawford; Klaus P. Hoeflich; Jonathan Chernoff

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January 1, 2013

First-line bevacizumab in combination with chemotherapy for HER2-negative metastatic breast cancer: Pooled and subgroup analyses of data from 2447 patients

Annals of Oncology, ISSN: 15698041 09237534

David W. Miles; Diéras; Javier Cortés; Duenne; Joo-Hee Yi; O'Shaughnessy

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January 1, 2013

Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

Chemical Engineering Research and Design, ISSN: 02638762

Alvin W. Nienow; William H. Scott; Christopher J. Hewitt; Colin R. Thomas; Gareth Lewis; Ashraf Amanullah; Robert Kiss; Steven Meier

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January 1, 2013

Mapping in vivo tumor oxygenation within viable tumor by 19F-MRI and multispectral analysis

Neoplasia (United States), ISSN: 14765586 15228002

Yunzhou Shi; Jason Oeh; Jeffrey Eastham-Anderson; Sharon Fong Yee; David Finkle; Franklin V. Peale Jr.; Ross; Maj Hedehus; Nicholas Van Bruggen; Rayna Venook; Ross; Deepak Sampath; Richard A. D. Carano

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January 1, 2013

The effects of membrane filters used in biopharmaceutical processes on the concentration and composition of polysorbate 20

Biotechnology Progress, ISSN: 15206033 87567938

Ming Lei; Daniel Hewitt; Christopher Cornell; Ken Skidmore; Kao; Jimmy Sugahara; Diane Beane; Junyan A. Ji

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January 1, 2013

CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Kit W. Tam; Wei Zhang; Junichi Soh; Victor Stastny; Min Chen; Han Sun; Kelsie Thu; Jonathan J. Rios; Chenchen Yang; Crystal N. Marconett; Suhaida. A. Selamat; Ite A. Laird-Offringa; Ayumu Taguchi; Samir Hanash; David S. Shames; Xiaotu Ma; Michael Q. Zhang; Wan L. Lam; Adi Gazdar

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January 1, 2013

Health-related quality of life in patients with advanced nonsquamous non-small-cell lung cancer receiving bevacizumab or bevacizumab-plus-pemetrexed maintenance therapy in AVAPERL (MO22089)

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Achim Rittmeyer; Vera Gorbunova; Anders Vikström; Arnaud Scherpereel; Joo-Hang Kim; Myung-Ju Ahn; Antonio Chella; Christos Chouaid; Alicyn K. Campbell; Fabrice Barlesi

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January 1, 2013

Assessment of computational methods for predicting the effects of missense mutations in human cancers.

BMC Genomics, ISSN: 14712164

Florian Gnad; Albion Baucom; Kiran Mukhyala; Gerard Manning; Zemin Zhang

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January 1, 2013

Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models

Neoplasia (United States), ISSN: 14765586 15228002

Thomas O'Brien; Jason Oeh; Yang Xiao; Xiaorong Liang; Alexander N. Vanderbilt; Ann R. Qin; Lulu Yang; Leslie Lee; Justin Ly; Ely Cosino; Jennifer A. Lacap; Annie Ogasawara; Simon P. Williams; Michelle Nannini; Bianca M. Liederer; Peter K Jackson; Peter Dragovich; Deepak Sampath

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January 1, 2013

Probability of treatment following acute decline in lung function in children with cystic fibrosis is related to baseline pulmonary function

Journal of Pediatrics, ISSN: 10976833 00223476

Morgan; Wagener; Ashley Yegin; David J. Pasta; Stefanie J. Millar; Michael W. Konstan

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January 1, 2013

An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Donna M. Dambach; Dylan H. Hartley; Kevin A. Ford; Frank-Peter Theil; Eric Harstad; Jason S Halladay; Edna F. Choo; Jason Boggs; Bianca M. Liederer; Brian J. Dean; Dolores Diaz

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January 1, 2013

Independent radiologic reviewof the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer

Gynecologic Oncology, ISSN: 10956859 00908258

Robert. A. Burger; Mark F. Brady; Joon Rhee; Mika A. Sovak; George Kong; Hoa P. Nguyen; Michael A. Bookman

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January 1, 2013

Randomized controlled trial of danoprevir plus peginterferon alfa-2a and ribavirin in treatment-naïve patients with hepatitis c virus genotype 1 infection

Gastroenterology, ISSN: 15280012 00165085

Marcellin; Curtis Cooper; Luis Balart; Dominique Larrey; Terry Box; Eric Yoshida; Eric Lawitz; Peter Buggisch; Peter Ferenci; Martin D. Weltman; Emily Labriola-Tompkins; Sophie Le Pogam; Nájera; Denise Thomas; Gregory J. Hooper; Nancy Shulman; Ying Zhang; Mercidita T. Navarro; Chin Yin Lim; Michael Brunda; Terrault; Ellen S. Yetzer

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January 1, 2013

Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor

International Journal of Pharmaceutics, ISSN: 18733476 03785173

Yong Cui; Po-Chang Chiang; Edna F. Choo; Jason Boggs; Joachim Rudolph; Jonas Grina; Steve Wenglowsky; Yingqing Ran

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January 1, 2013

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys

mAbs, ISSN: 19420870 19420862

Maya Leabman; Meng; Robert F. Kelley; Laura DeForge; Kyra J. Cowan; Suhasini Iyer

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January 1, 2013

Operationalization of Global Alzheimer's Disease Trials

Global Clinical Trials for Alzheimer's Disease: Design, Implementation, and Standardization,

Lynne Hughes; Spencer Guthrie

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January 1, 2013

Bevacizumab plus chemotherapy continued beyond first progression in patients withmetastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings

Annals of Oncology, ISSN: 15698041 09237534

Stefan Kubicka; Greil; André; Bennouna; Sastre; Eric Van Cutsem; Von Moos; Österlund; Reyes-Rivera; Thomas Müller; Makrutzki; Arnold; Andel; Balcke; Benedicic; Eisterer; Fridrik; Jagdt; Keil; Kretschmer; Krippl; Oexle; Pecherstorfer; Samonigg; Schmid; Thaler; Tinchon; Weiss; Arts; De Man; Demolin; Janssens; Polus; Benczikova; Melichar; Prausova; Vitek; Andersen; Jensen; Keldsen; Østerlind; Vistisen; Elme; Magi; Ojamaa; Ristamäki; Salminen; Ben Abdelghani; Bouche; Borg; Bouhier-Leporrier; Breysacher; Chone; Clavero Fabri; Deplanque; Desseigne; Dourthe; Ezenfis; Faroux; François; Garnier; Gaspard; Hebbar; Illory; Kaminsky; Lecomte; Legoux; Levache; Lobry; Lotz; Mabro; Manet-Lacombe; Manfredi; Matysiak Budnik; Miglianico; Mineur; Moullet; Naman; Nouyrigat; Oziel-Taieb; Perrier; Pezet; Philip; Pottier; Porneuf; Ramdani; Re; Rinaldi; Spaeth; Taieb; Terrebonne; Texereau; Thirot Bidault; Tournigand; Tubiana-Mathieu; Vantelon; Viret; Ychou; Bangerter; Bertram; Bohnsteen; Brinkmann; Caca; Constantin; Cordes; Dietrich; Eggert; Engel; Fahlke; Fensterer; Florschütz; Folprecht; Forstbauer; Freier; Freund; Frickhofen; Gäbele; Geißler; Gieseler; Göhler; Graeven; Groschek; Grundeis; Hacker; Hagen; Hebart; Hegewisch-Becker; Heike; Herrmann; Hildebrandt; Höffkes; Hübner; Hübner; Kettner; Kneba; Kohnke; Kojouharoff; König; Kretzschmar; Kröning; Kürner; Lammert; Lerchenmüller; Lück; Meiler; Mergenthaler; Müller; Müller-Naendrup; Nusch; Papke; Porschen; Rädle; Reddemann; Ridwelski; Riera-Knorrenschild; Rudi; Schmalenberger; Schimanski; Schlegel; Schlichting; Schmidt; Schmiegel; Schmitz; Schulze-Bergkamen; Schwaner; Schwarzer; Schwerdtfeger; Selbach; Sieber; Jürgen Siebler; Staib; Stauch; Steffens; Stübs; Tischendorf; Trarbach; Tummes; Valdix; Vogel; Von Wichert; Walther; Welslau; Wilhelm; Wobster; Wolf; Zeigenhagen; Zomorodbaksch; Batman; Bloemendal; Kehrer; Guren; Indrebø; Kersten; Soerbye; Fragoso; Fragoso; Mellidez; Sa; Aljobran; Darwish; Alonso-Orduna; Aparicio; Aranda; Bosch; Galan-Brotons; Busquier Hernandez; Camara; Campos Cervera; Carlos Garcia Giron; Del Prado; Donnay; Escudero; Falco; Gallego Plazas; Garcia Alfonso; Gonzalez Flores; Gravalos; Guardeno; Juárez; Lopez Ladron; Losa Gaspa; MaVicent Vergé; Marcuello Gaspar; Massuti Sureda; Molina; Montero; Muñoa; Naranjo; Oruezabal Moreno; Pachón Olmos; Pericay; Reina Zoilo; Rivera; Ruiz Casado; Safont; Salud Salvia; Tobena; Toral; Valenti; Valladares Ayerbes; Vieitez; Vera; Vieitez; Berglund; Fernebro; Hess-Umbricht; Miklos Pless; Popescu; Winterhalder

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January 1, 2013

Critical review of preclinical approaches to investigate cytochrome P450-mediated therapeutic protein drug-drug interactions and recommendations for best practices: A white paper

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Raymond Evers; Shannon Dallas; Leslie Dickmann; Odette A. Fahmi; Jane R. Kenny; Eugenia Kraynov; Theresa Nguyen; Aarti H. Patel; J. Greg Slatter; Lei Zhang

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January 1, 2013

Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Michael Noonan; Phillip Korenblat; Mosesova; Heleen Scheerens; Joseph R. Arron; Zheng; Wendy Putnam; Merdad V. Parsey; Sean P. Bohen; Matthews

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January 1, 2013

Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes

Journal of Inherited Metabolic Disease, ISSN: 15732665 01418955

Derek G. Burke; Ahad A. Rahim; Simon N. Waddington; Stefan Karlsson; Ida Enquist; Kailash Bhatia; Atul Mehta; Ashok Vellodi; Simon Heales

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