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Publications

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DISPLAYING 7201 - 7250 OF 15486 RESULTS

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity
ACS Chemical Biology, ISSN: 15548937 15548929
Toru Okamoto; Zobel; Anna V. Fedorova; Quan; Hong Yang; Wayne J. Fairbrother; David C.S. Huang; Brian J. Smith; Deshayes; Czabotar
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Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Conor J. Kearney; Clare Sheridan; Sean P. Cullen; Graham A. Tynan; Susan E. Logue; Inna S. Afonina; Domagoj Vucic; Ed C. Lavelle; Seamus J. Martin
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Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas
Clinical Cancer Research, ISSN: 10780432 15573265
Mark L. McCleland; Adam S. Adler; Laura Deming; Ely Cosino; Leslie Lee; Elizabeth M. Blackwood; Margaret Solon; Janet Tao; Li Li; David S. Shames; Erica L. Jackson; William F. Forrest; Ron Firestein
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High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening
Rapid Communications in Mass Spectrometry, ISSN: 09514198 10970231
Xiao Ding; Hesham Ghobarah; Xiaolin Zhang; Allan Jaochico; Xingrong Liu; Gauri Deshmukh; Bianca M. Liederer; Cornelis E. Hop; Brian J. Dean
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A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3
Cell Cycle, ISSN: 15514005 15384101
Jenni Lahtela; Laura B. Corson; Annabrita Hemmes; Matthew J. Brauer; Sonja Koopal; James Lee; Thomas Hunsaker; Peter K Jackson; Emmy W. Verschuren
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A direct and melanopsin-dependent fetal light response regulates mouse eye development
Nature, ISSN: 00280836 14764687
Sujata Rao; Christina Chun; Jieqing Fan; J. Matthew Kofron; Michael B. Yang; Rashmi S. Hegde; Napoleone Ferrara; David R. Copenhagen; Richard Lang
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Application of a new wall-less plate technology to complex multistep cell-based investigations using suspension cells
Blood, ISSN: 15280020 00064971
Gabriel Quinones; Travis I. Moore; Nicholes; Hyunjae Lee; Sudong Kim; Laura Sun; Noo Li Jeon; Jean-Philippe Stephan
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Targeted and Untargeted Fusion Proteins: Current Approaches to Cancer Immunotherapy
Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges,
Leslie A. Khawli; Peisheng Hu; Alan L. Epstein
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CRIg mediates early kupffer cell responses to adenovirus
Journal of Leukocyte Biology, ISSN: 07415400 19383673
Jeannie Q. He; Kenneth J. Katschke Jr.; Gribling; Eric Suto; Wyne P. Lee; Laurie Diehl; Jeffrey Eastham-Anderson; Anusha Ponakala; László Kömüves; Jackson G. Egen; Menno Van Lookeren Campagne
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HectDI E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Hoanh Tran; Daisy J. Bustos; Ronald Yeh; Bonnee Rubinfeld; Cynthia Lam; Stephanie K. Shriver; Inna Zilberleyb; Michelle W. Lee; Lilian Phu; Anjali A. Sarkar; Irene E. Zohn; Ingrid E. Wertz; Donald S. Kirkpatrick; Paul G. Polakis
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LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance
Blood, ISSN: 15280020 00064971
Sung-Uk Lee; Manami Maeda; Yuichi Ishikawa; Sierra Min Li; Anne Wilson; Adrian M. Jubb; Nagisa Sakurai; Lihong Weng; Emma Fiorini; Freddy Radtke; Minhong Yan; H. Robson MacDonald; Ching-Cheng Chen; Takahiro Maeda
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Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice
PLoS ONE, ISSN: 19326203
Ghanashyam Sarikonda; Sowbarnika Sachithanantham; Yulia Manenkova; Tinalyn Kupfer; Amanda Posgai; Clive Wasserfall; Philip Bernstein; Laura Straub; Philippe P. Pagni; Darius Schneider; Teresa Rodriguez Calvo; Marilyne Coulombe; Kevan Herold; Ronald G. Gill; Mark Atkinson; Gerald Nepom; Mario Ehlers; Teodora Staeva; Hideki Garren; Lawrence Steinman; Andrew A. Chan; Matthias von Herrath
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Small-molecule inducer of β cell proliferation identified by high-throughput screening
Journal of the American Chemical Society, ISSN: 15205126 00027863
Weijun Shen; Matthew S. Tremblay; Vishal A. Deshmukh; Weidong Wang; Christophe Filippi; George Harb; You-Qing Zhang; Anwesh Kamireddy; Janine E Baaten; Qihui Jin; Tom Wu; Jonathan G. Swoboda; Charles Y. Cho; Jing Li; Bryan A. Laffitte; Peter McNamara; Richard Glynne; Xu Wu; Ann E. Herman; Peter G. Schultz
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Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer
Science Translational Medicine, ISSN: 19466234 19466242
Ganapati V. Hegde; Cecile C. de la Cruz; Cecilia Chiu; Navneet Alag; Gabriele Schaefer; Lisa Crocker; Ross; David Goldenberg; Mark Merchant; Janet Y. Tien; Lily Shao; Roth; Siao Ping Tsai; Scott Stawicki; Zhaoyu Jin; Shelby K. Wyatt; Richard A. D. Carano; Yanyan Zheng; E. Alejandro Sweet-Cordero; Yan Wu; Erica L. Jackson
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Comparison of Sequencing Platforms for Single Nucleotide Variant Calls in a Human Sample
PLoS ONE, ISSN: 19326203
Aakrosh Ratan; Webb Miller; Joseph Guillory; Stinson; Somasekar Seshagiri; Stephan C. Schuster
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Metal-catalyzed oxidation of protein methionine residues in human parathyroid hormone (1-34): Formation of homocysteine and a novel methionine-dependent hydrolysis reaction
Molecular Pharmaceutics, ISSN: 15438384 15438392
Olivier Mozziconacci; Junyan A. Ji; Y. John Wang; Christian Schöneich
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Regulation of Neurod1 Contributes to the Lineage Potential of Neurogenin3+ Endocrine Precursor Cells in the Pancreas
PLoS Genetics, ISSN: 15537390 15537404
Teresa L. Mastracci; Keith R. Anderson; James B. Papizan; Lori Sussel
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Response to "drug interactions produced by proton pump inhibitors: Not simply a ph effect"
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Nageshwar Budha; Leslie Z. Benet; Joseph A. Ware
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Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung
PLoS Genetics, ISSN: 15537390 15537404
Carla Calvi; Megan Podowski; Armando Lopez-Mercado; Shana Metzger; Kaori Misono; Alla Malinina; Dustin Dikeman; Hataya Poonyagariyon; Leslie Ynalvez; Roshanak Derakhshandeh; Anne Le; Mark Merchant; Ralph H. Schwall; Enid R. Neptune
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Absolute and relative contraindications to pegylated-interferon or ribavirin in the US general patient population with chronic hepatitis C: Results from a US database of over 45 000 HCV-infected, evaluated patients
Alimentary Pharmacology and Therapeutics, ISSN: 02692813 13652036
Talal; Joanne Lafleur; Hoop; Prashant K. Pandya; Martin; Ira M. Jacobson; Jian Han; Korner
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Evaluation of metabolism and disposition of GDC-0152 in rats using 14C labeling strategy at two different positions: A novel formation of hippuric acid from 4-phenyl-5-amino-1,2,3-thiadiazoles
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Qin Yue; Teresa Mulder; Patrick J. Rudewicz; Eric G. Solon; Nageshwar Budha; Joseph A. Ware; Joseph P. Lyssikatos; Cornelis E. Hop; Harvey Wong; S. Cyrus Khojasteh
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The burden of faulty proofreading in colon cancer
Nature Genetics, ISSN: 10614036 15461718
Somasekar Seshagiri
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Systematic analysis and validation of differential gene expression in ovarian serous adenocarcinomas and normal ovary
Journal of Cancer Research and Clinical Oncology, ISSN: 01715216 14321335
Dirk Bauerschlag; Karen Bräutigam; Roland Moll; Jalid Sehouli; Alexander Mustea; Darius Salehin; Maryla Krajewska; John C. Reed; Nicolai Maass; Garret M. Hampton; Ivo Meinhold-Heerlein
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Response to Deng et al.'s LRRK2 patent review
Expert Opinion on Therapeutic Patents, ISSN: 13543776 17447674
Burdick
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Integrated and translational nonclinical in vivo cardiovascular risk assessment: Gaps and opportunities
Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295
Brian R. Berridge; Peter K. Hoffmann; James R. Turk; Frank W Sellke; Gary Gintant; Gerald Hirkaler; Kevin Dreher; A. Eric Schultze; Dana Walker; Nick Edmunds; Wendy Halpern; James Falls; Marty Sanders; Syril D. Pettit
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Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: A commentary on why they are still necessary
Xenobiotica, ISSN: 00498254 13665928
Ronald E. White; David C. Evans; Cornelis E. Hop; David J. Moore; Chandra Prakash; Sekhar Surapaneni; Francis L. S. Tse
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Unexpected hematologic effects of biotherapeutics in nonclinical species and in humans
Toxicologic Pathology, ISSN: 01926233 15331601
Nancy E. Everds; Jacqueline M. Tarrant
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Regional radiographic damage and functional limitations in patients with ankylosing spondylitis: Differences in early and late disease
Arthritis Care and Research, ISSN: 2151464X 21514658
Michael M. Ward; Thomas J. Learch; Lianne S. Gensler; John C. Davis; John D. Reveille; Michael H. Weisman
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Discussion of 'Small-sample behavior of novel phase i cancer trial designs' by Assaf P Oron and Peter D Hoff
Clinical Trials, ISSN: 17407745 17407753
Bradley P. Carlin; Wei Zhong; Joseph S. Koopmeiners
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Personalizing medicine for autoimmune and inflammatory diseases
Nature Immunology, ISSN: 15292908 15292916
Andrew A. Chan; Timothy W. Behrens
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The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic isletss
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103
Xiaoyan Nina Li; James Herrington; Aleksandr Petrov; Lan Ge; George Eiermann; Yusheng Xiong; Mette V. Jensen; Hans E. Hohmeier; Christopher B. Newgard; Maria L. Garcia; Michael Wagner; Bei B. Zhang; Nancy A. Thornberry; Andrew D. Howard; Gregory J. Kaczorowski; Yun-Ping Zhou
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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Nature Medicine, ISSN: 10788956 1546170X
Andrew J. Souers; Joel D. Leverson; Erwin R. Boghaert; Scott L. Ackler; Nathaniel D. Catron; Jun Chen; Brian D. Dayton; Hong Ding; Sari H. Enschede; Wayne J. Fairbrother; David C.S. Huang; Sarah G. Hymowitz; Sha Jin; Seong Lin Khaw; Peter J. Kovar; Lloyd T. Lam; Jackie Lee; Heather Maecker; Kennan C. Marsh; Kylie D. Mason; Michael J. Mitten; Paul M. Nimmer; Anatol Oleksijew; Chang H. Park; Cheol-Min Park; Darren C. Phillips; Andrew W. Roberts; Deepak Sampath; John F. Seymour; Morey L. Smith; Gerard M. Sullivan; Stephen K. Tahir; Chris Tse; Michael D. Wendt; Yu Xiao; John Xue; Haichao Zhang; Rod A. Humerickhouse; Saul H. Rosenberg; Steven W. Elmore
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Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interactions
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103
Toshiko Nishimura; Yajing Hu; Manhong Wu; Edward Pham; Hiroshi Suemizu; Menashe Elazar; Michael Liu; Ramazan Idilman; Cihan Yurdaydin; Peter Angus; Catherine Stedman; Brian Murphy; Jeffrey Glenn; Masato Nakamura; Tatsuji Nomura; Yuan Chen; Ming Zheng; William L. Fitch; Gary Peltz
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Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steven T. Staben; Nicole Blaquiere; Vickie Tsui; Aleksandr Kolesnikov; Steven Do; Erin K. Bradley; Jennafer Dotson; Richard Goldsmith; Timothy P. Heffron; John Lesnick; Lewis; Jeremy Murray; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Lionel Rouge; Laurent Salphati; Binqing Wei; Wiesmann; Ping Wu
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A potent combination of the novel PI3K inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: Long-lasting responses after treatment withdrawal
Clinical Cancer Research, ISSN: 10780432 15573265
Giuseppe Floris; Agnieszka Wozniak; Raf Sciot; Haifu Li; Lori S. Friedman; Thomas Van Looy; Jasmien Wellens; Peter Vermaelen; Christophe M. Deroose; Jonathan A. Fletcher; Maria Debiec-Rychter; Patrick Schöffski
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Novel benzoxazole inhibitors of mPGES-1
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Natasha Kablaoui; Snahel Patel; Jay Shao; Douglas Demian; Keith Hoffmaster; Francioise Berlioz; Michael L. Vazquez; William M. Moore; Richard A. Nugent
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Predictive impact of circulating vascular endothelial growth factor in four phase III trials evaluating bevacizumab
Clinical Cancer Research, ISSN: 15573265 10780432
Priti Hegde; Adrian M. Jubb; Dafeng Chen; Nicole F. Li; Meng; Coen A. Bernaards; Rebecca Elliott; Stefan J. Scherer; Daniel S. Chen
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Immunohistochemistry and fluorescence in situ hybridization assessment of HER2 in clinical trials of adjuvant therapy for breast cancer (NCCTG N9831, BCIRG 006, and BCIRG 005)
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Edith A. Perez; Michael F. Press; Amylou Dueck; Robert B. Jenkins; Chungyeul Kim; Beiyun Chen; Ivonne Villalobos; Soonmyung Paik; Marc Buyse; Anne E. Wiktor; Reid Meyer; Melanie Finnigan; Joanne Zujewski; Mona Shing; Howard M. Stern; Wilma L. Lingle; Monica M. Reinholz; Dennis J. Slamon
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Lgr5-Expressing Cells Are Sufficient And Necessary for Postnatal Mammary Gland Organogenesis
Cell Reports, ISSN: 22111247
Vicki Plaks; Audrey Brenot; Devon A. Lawson; Jelena R. Linnemann; Eline C. Van Kappel; Karren C. Wong; Frederic J. De Sauvage; Ophir D. Klein; Zena Werb
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Evaluation of semi-homogeneous assay formats for dual-specificity antibodies
Journal of Immunological Methods, ISSN: 00221759 18727905
Guoying Jiang; Chung W. Lee; Wong; Hélène Gazzano-Santoro
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Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach
PLoS ONE, ISSN: 19326203
Ka Young Chung; Peter W. Day; Gisselle Vélez-Ruiz; Roger K. Sunahara; Brian K. Kobilka
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An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Stefan L. Oliver; Jennifer J. Brady; Marvin H. Sommer; Mike Reichelt; Phillip Sung; Helen M. Blau; Ann M. Arvin
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Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Steffan Vartanian; Carolyn Bentley; Matthew J. Brauer; Li Li; Senji Shirasawa; Takehiko Sasazuki; Jung-Sik Kim; Matthias Peter; Eric Stawiski; Zora Modrusan; Todd Waldman; David Stokoe
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Neuroscience: Strength in numbers
Nature, ISSN: 00280836 14764687
Morgan Sheng; Roberto Malinow; Richard Huganir
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A practical synthesis of a PI3K inhibitor under noncryogenic conditions via functionalization of a lithium triarylmagnesiate intermediate
Organic Process Research and Development, ISSN: 10836160 1520586X
Qingping Tian; Zhigang Cheng; Herbert M. Yajima; Scott Savage; Keena L. Green; Theresa Humphries; Mark E. Reynolds; Srinivasan Babu; Francis Gosselin; David Askin; Isao Kurimoto; Norihiko Hirata; Mitsuhiro Iwasaki; Yasuharu Shimasaki; Takashi Miki
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Cyanide anion as a leaving group in nucleophilic aromatic substitution: Synthesis of quaternary centers at azine heterocycles
Journal of Organic Chemistry, ISSN: 00223263 15206904
Alexander D. Thompson; Malcolm P. Huestis
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Development of a scalable strategy for the synthesis of PI3Kδ inhibitors: Selective and efficient functionalization of purine derivatives
Organic Process Research and Development, ISSN: 10836160 1520586X
Diane Carrera; Peijue Sheng; Brian S. Safina; Jun Li; Remy Angelaud
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The ciliary G-protein-coupled receptor Gpr161 negatively regulates the sonic hedgehog pathway via cAMP signaling
Cell, ISSN: 10974172 00928674
Saikat Mukhopadhyay; Xiaohui Wen; Navneet Ratti; Alexander V. Loktev; Linda Rangell; Suzie J. Scales; Peter K Jackson
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Conditional activation of Pik3ca H1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations
Oncogene, ISSN: 09509232 14765594
Yuan; Eric Stawiski; Vasantharajan Janakiraman; Emily Chan; Durinck; Kyle A. Edgar; Noelyn Kljavin; Rivers; Florian Gnad; Merone Roose-Girma; Matthias Peter; Grazyna Fedorowicz; Sherry Heldens; Robert Soriano; Zemin Zhang; Jeffery J. Wallin; Johnson; Mark Merchant; Zora Modrusan; Howard M. Stern; Somasekar Seshagiri
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Mass Spectrometry of siRNA
Mass Spectrometry for Drug Discovery and Drug Development,
Mark T. Cancilla; W. Michael Flanagan
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