Genentech: Publications

January 1, 2013

High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

William W. Busse; Sheldon Spector; Karin Rosén; Yan Wang; Oral Alpan

January 1, 2013

Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity

mAbs, ISSN: 19420870 19420862

Whitney Shatz; Shan Chung; Bing Li; Brett Marshall; Max L. Tejada; Wilson Phung; Wendy N. Sandoval; Robert F. Kelley; Justin M. Scheer

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January 1, 2013

Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies

Nature Biotechnology, ISSN: 15461696 10870156

Christoph Spiess; Mark Merchant; Arthur Huang; Zhong Zheng; Nai-Ying Yang; Jing Peng; Diego Ellerman; Whitney Shatz; Dorothea Reilly; Yansura; Justin M. Scheer

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January 1, 2013

High shear rheology and anisotropy in concentrated solutions of monoclonal antibodies

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Isidro E. Zarraga; Rosalynn Taing; Jonathan Zarzar; Jacob Luoma; Jenny Hsiung; Ankit Patel; Fred Lim

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January 1, 2013

Trehalose limits BSA aggregation in spray-dried formulations at high temperatures: Implications in preparing polymer implants for long-term protein delivery

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Karthikan Rajagopal; Joseph Wood; Benjamin Tran; Thomas W. Patapoff; Thierry Nivaggioli

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January 1, 2013

Efficacy of remission-induction regimens for ANCA-associated vasculitis

New England Journal of Medicine, ISSN: 15334406 00284793

Specks; Merkel; Seo; Spiera; Langford; Hoffman; Cees Kallenberg; St.clair; Barri J. Fessler; Linna Ding; Viviano; Tchao; Deborah J. Phippard; Adam Asare; Noha Lim; Iklé; Brett Jepson; Paul Brunetta; Allen; Fervenza; Duvuru Geetha; Keogh; Kissin; Monach; Peikert; Stegeman; Steven R. Ytterberg; Mark Mueller; Lourdes P. Sejismundo; Kathleen Mieras; John H. Stone

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January 1, 2013

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Nature, ISSN: 14764687 00280836

Georgia Hatzivassiliou; Jacob R. Haling; Huifen Chen; Kyung Song; Steve Price; Robert Heald; Joanne F. M. Hewitt; Mark Zak; Ariana Peck; Christine Orr; Mark Merchant; Klaus P. Hoeflich; Jocelyn Chan; Shiuh-Ming Luoh; Daniel J Anderson; Mary J. C. Ludlam; Wiesmann; Ultsch; Lori S. Friedman; Shiva Malek; Marcia Belvin

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January 1, 2013

NMR study to identify a ligand-binding pocket in ras

Enzymes, ISSN: 18746047

Till Maurer; Weiru Wang

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January 1, 2013

Lead identification of novel and selective TYK2 inhibitors

European Journal of Medicinal Chemistry, ISSN: 17683254 02235234

Jun Liang; Vickie Tsui; Anne Van Abbema; Liang Bao; Kathy Barrett; Beresini; Leonid M. Berezhkovskiy; Wade S. Blair; Christine Chang; James Driscoll; Eigenbrot; Nico Ghilardi; Paul Gibbons; Jason S Halladay; Adam R. Johnson; Pawan Bir Kohli; Yingjie Lai; Marya Liimatta; Priscilla Mantik; Kapil Menghrajani; Jeremy Murray; Amy Sambrone; Yisong Xiao; Steven Shia; Young G. Shin; Jan Smith; Sue J. Sohn; Mark S. Stanley; Ultsch; Birong Zhang; Lawren C. Wu; Steven Magnuson

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January 1, 2013

A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation

Pain, ISSN: 18726623 03043959

Lynn Webster; Sunita Dhar; Michael Eldon; Lorianne Masuoka; Jaakko Lappalainen; Mark Sostek

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January 1, 2013

Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes

Journal of Inherited Metabolic Disease, ISSN: 15732665 01418955

Derek G. Burke; Ahad A. Rahim; Simon N. Waddington; Stefan Karlsson; Ida Enquist; Kailash Bhatia; Atul Mehta; Ashok Vellodi; Simon Heales

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January 1, 2013

Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Michael Noonan; Phillip Korenblat; Mosesova; Heleen Scheerens; Joseph R. Arron; Zheng; Wendy Putnam; Merdad V. Parsey; Sean P. Bohen; Matthews

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January 1, 2013

Critical review of preclinical approaches to investigate cytochrome P450-mediated therapeutic protein drug-drug interactions and recommendations for best practices: A white paper

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Raymond Evers; Shannon Dallas; Leslie Dickmann; Odette A. Fahmi; Jane R. Kenny; Eugenia Kraynov; Theresa Nguyen; Aarti H. Patel; J. Greg Slatter; Lei Zhang

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January 1, 2013

Bevacizumab plus chemotherapy continued beyond first progression in patients withmetastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings

Annals of Oncology, ISSN: 15698041 09237534

Stefan Kubicka; Greil; André; Bennouna; Sastre; Eric Van Cutsem; Von Moos; Österlund; Reyes-Rivera; Thomas Müller; Makrutzki; Arnold; Andel; Balcke; Benedicic; Eisterer; Fridrik; Jagdt; Keil; Kretschmer; Krippl; Oexle; Pecherstorfer; Samonigg; Schmid; Thaler; Tinchon; Weiss; Arts; De Man; Demolin; Janssens; Polus; Benczikova; Melichar; Prausova; Vitek; Andersen; Jensen; Keldsen; Østerlind; Vistisen; Elme; Magi; Ojamaa; Ristamäki; Salminen; Ben Abdelghani; Bouche; Borg; Bouhier-Leporrier; Breysacher; Chone; Clavero Fabri; Deplanque; Desseigne; Dourthe; Ezenfis; Faroux; François; Garnier; Gaspard; Hebbar; Illory; Kaminsky; Lecomte; Legoux; Levache; Lobry; Lotz; Mabro; Manet-Lacombe; Manfredi; Matysiak Budnik; Miglianico; Mineur; Moullet; Naman; Nouyrigat; Oziel-Taieb; Perrier; Pezet; Philip; Pottier; Porneuf; Ramdani; Re; Rinaldi; Spaeth; Taieb; Terrebonne; Texereau; Thirot Bidault; Tournigand; Tubiana-Mathieu; Vantelon; Viret; Ychou; Bangerter; Bertram; Bohnsteen; Brinkmann; Caca; Constantin; Cordes; Dietrich; Eggert; Engel; Fahlke; Fensterer; Florschütz; Folprecht; Forstbauer; Freier; Freund; Frickhofen; Gäbele; Geißler; Gieseler; Göhler; Graeven; Groschek; Grundeis; Hacker; Hagen; Hebart; Hegewisch-Becker; Heike; Herrmann; Hildebrandt; Höffkes; Hübner; Hübner; Kettner; Kneba; Kohnke; Kojouharoff; König; Kretzschmar; Kröning; Kürner; Lammert; Lerchenmüller; Lück; Meiler; Mergenthaler; Müller; Müller-Naendrup; Nusch; Papke; Porschen; Rädle; Reddemann; Ridwelski; Riera-Knorrenschild; Rudi; Schmalenberger; Schimanski; Schlegel; Schlichting; Schmidt; Schmiegel; Schmitz; Schulze-Bergkamen; Schwaner; Schwarzer; Schwerdtfeger; Selbach; Sieber; Jürgen Siebler; Staib; Stauch; Steffens; Stübs; Tischendorf; Trarbach; Tummes; Valdix; Vogel; Von Wichert; Walther; Welslau; Wilhelm; Wobster; Wolf; Zeigenhagen; Zomorodbaksch; Batman; Bloemendal; Kehrer; Guren; Indrebø; Kersten; Soerbye; Fragoso; Fragoso; Mellidez; Sa; Aljobran; Darwish; Alonso-Orduna; Aparicio; Aranda; Bosch; Galan-Brotons; Busquier Hernandez; Camara; Campos Cervera; Carlos Garcia Giron; Del Prado; Donnay; Escudero; Falco; Gallego Plazas; Garcia Alfonso; Gonzalez Flores; Gravalos; Guardeno; Juárez; Lopez Ladron; Losa Gaspa; MaVicent Vergé; Marcuello Gaspar; Massuti Sureda; Molina; Montero; Muñoa; Naranjo; Oruezabal Moreno; Pachón Olmos; Pericay; Reina Zoilo; Rivera; Ruiz Casado; Safont; Salud Salvia; Tobena; Toral; Valenti; Valladares Ayerbes; Vieitez; Vera; Vieitez; Berglund; Fernebro; Hess-Umbricht; Miklos Pless; Popescu; Winterhalder

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January 1, 2013

Operationalization of Global Alzheimer's Disease Trials

Global Clinical Trials for Alzheimer's Disease: Design, Implementation, and Standardization,

Lynne Hughes; Spencer Guthrie

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January 1, 2013

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys

mAbs, ISSN: 19420870 19420862

Maya Leabman; Meng; Robert F. Kelley; Laura DeForge; Kyra J. Cowan; Suhasini Iyer

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January 1, 2013

Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor

International Journal of Pharmaceutics, ISSN: 18733476 03785173

Yong Cui; Po-Chang Chiang; Edna F. Choo; Jason Boggs; Joachim Rudolph; Jonas Grina; Steve Wenglowsky; Yingqing Ran

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January 1, 2013

Randomized controlled trial of danoprevir plus peginterferon alfa-2a and ribavirin in treatment-naïve patients with hepatitis c virus genotype 1 infection

Gastroenterology, ISSN: 15280012 00165085

Marcellin; Curtis Cooper; Luis Balart; Dominique Larrey; Terry Box; Eric Yoshida; Eric Lawitz; Peter Buggisch; Peter Ferenci; Martin D. Weltman; Emily Labriola-Tompkins; Sophie Le Pogam; Nájera; Denise Thomas; Gregory J. Hooper; Nancy Shulman; Ying Zhang; Mercidita T. Navarro; Chin Yin Lim; Michael Brunda; Terrault; Ellen S. Yetzer

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January 1, 2013

Independent radiologic reviewof the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer

Gynecologic Oncology, ISSN: 10956859 00908258

Robert. A. Burger; Mark F. Brady; Joon Rhee; Mika A. Sovak; George Kong; Hoa P. Nguyen; Michael A. Bookman

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January 1, 2013

An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Donna M. Dambach; Dylan H. Hartley; Kevin A. Ford; Frank-Peter Theil; Eric Harstad; Jason S Halladay; Edna F. Choo; Jason Boggs; Bianca M. Liederer; Brian J. Dean; Dolores Diaz

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January 1, 2013

Probability of treatment following acute decline in lung function in children with cystic fibrosis is related to baseline pulmonary function

Journal of Pediatrics, ISSN: 10976833 00223476

Morgan; Wagener; Ashley Yegin; David J. Pasta; Stefanie J. Millar; Michael W. Konstan

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January 1, 2013

Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models

Neoplasia (United States), ISSN: 14765586 15228002

Thomas O'Brien; Jason Oeh; Yang Xiao; Xiaorong Liang; Alexander N. Vanderbilt; Ann R. Qin; Lulu Yang; Leslie Lee; Justin Ly; Ely Cosino; Jennifer A. Lacap; Annie Ogasawara; Simon P. Williams; Michelle Nannini; Bianca M. Liederer; Peter K Jackson; Peter Dragovich; Deepak Sampath

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January 1, 2013

Assessment of computational methods for predicting the effects of missense mutations in human cancers.

BMC Genomics, ISSN: 14712164

Florian Gnad; Albion Baucom; Kiran Mukhyala; Gerard Manning; Zemin Zhang

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January 1, 2013

Health-related quality of life in patients with advanced nonsquamous non-small-cell lung cancer receiving bevacizumab or bevacizumab-plus-pemetrexed maintenance therapy in AVAPERL (MO22089)

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Achim Rittmeyer; Vera Gorbunova; Anders Vikström; Arnaud Scherpereel; Joo-Hang Kim; Myung-Ju Ahn; Antonio Chella; Christos Chouaid; Alicyn K. Campbell; Fabrice Barlesi

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January 1, 2013

CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Kit W. Tam; Wei Zhang; Junichi Soh; Victor Stastny; Min Chen; Han Sun; Kelsie Thu; Jonathan J. Rios; Chenchen Yang; Crystal N. Marconett; Suhaida. A. Selamat; Ite A. Laird-Offringa; Ayumu Taguchi; Samir Hanash; David S. Shames; Xiaotu Ma; Michael Q. Zhang; Wan L. Lam; Adi Gazdar

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January 1, 2013

The effects of membrane filters used in biopharmaceutical processes on the concentration and composition of polysorbate 20

Biotechnology Progress, ISSN: 15206033 87567938

Ming Lei; Daniel Hewitt; Christopher Cornell; Ken Skidmore; Kao; Jimmy Sugahara; Diane Beane; Junyan A. Ji

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January 1, 2013

Mapping in vivo tumor oxygenation within viable tumor by 19F-MRI and multispectral analysis

Neoplasia (United States), ISSN: 14765586 15228002

Yunzhou Shi; Jason Oeh; Jeffrey Eastham-Anderson; Sharon Fong Yee; David Finkle; Franklin V. Peale Jr.; Ross; Maj Hedehus; Nicholas Van Bruggen; Rayna Venook; Ross; Deepak Sampath; Richard A. D. Carano

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January 1, 2013

Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

Chemical Engineering Research and Design, ISSN: 02638762

Alvin W. Nienow; William H. Scott; Christopher J. Hewitt; Colin R. Thomas; Gareth Lewis; Ashraf Amanullah; Robert Kiss; Steven Meier

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January 1, 2013

First-line bevacizumab in combination with chemotherapy for HER2-negative metastatic breast cancer: Pooled and subgroup analyses of data from 2447 patients

Annals of Oncology, ISSN: 15698041 09237534

David W. Miles; Diéras; Javier Cortés; Duenne; Joo-Hee Yi; O'Shaughnessy

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January 1, 2013

P21-Activated Kinase Inhibitors

Enzymes, ISSN: 18746047

Joachim Rudolph; James J. Crawford; Klaus P. Hoeflich; Jonathan Chernoff

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January 1, 2013

Anti-vascular endothelial growth factor therapy for diabetic macular edema

Therapeutic Advances in Endocrinology and Metabolism, ISSN: 20420196 20420188

David S. Boyer; J. Jill Hopkins; Jonathan Sorof; Jason S. Ehrlich

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January 1, 2013

Treatment effect of capecitabine and docetaxel or docetaxel alone byoestrogen receptor status in patients with metastatic breast cancer: Results of an exploratory analysis

Breast, ISSN: 15323080 09609776

Glück; Russell; O'Shaughnessy; Edward McKenna; Hu; Odom; Blum

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January 1, 2013

Retrospective analysis of first-line anti-vascular endothelial growth factor treatment patterns in wet age-related macular degeneration

Advances in Therapy, ISSN: 18658652 0741238X

Stephen S. Johnston; Kathleen Wilson; Alice Huang; David Smith; Helen Varker; Adam Turpcu

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January 1, 2013

EGFR mutation testing for squamous cell lung carcinoma (2)

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Larry Leon; Bann-Mo Day; Hu

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January 1, 2013

The molecular choreography of IRF4 and IRF8 with immune system partners

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Harinder Singh; Elke Glasmacher; Abraham B. Chang; Bryan Vander Lugt

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January 1, 2013

Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

Journal of Clinical Investigation, ISSN: 15588238 00219738

Tiffany Chang; Kimberly Krisman; Emily Harding Theobald; Jin Xu; Jon Akutagawa; Jennifer O. Lauchle; Scott Kogan; Benjamin S. Braun; Kevin Shannon

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January 1, 2013

Lupus nephritis: Induction therapy in severe lupus nephritis-should MMF be considered the drug of choice?

Clinical Journal of the American Society of Nephrology, ISSN: 1555905X 15559041

Brad H. Rovin; Samir V. Parikh; Lee A. Hebert; Tak Mao Chan; Chi Chiu Mok; Ginzler; Lai Seong Hooi; Paul Brunetta; Romeo MacIuca; Neil Solomons

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December 31, 2012

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

Journal of Biotechnology, ISSN: 18734863 01681656

Huong Le; Santosh Kabbur; Luciano Pollastrini; Ziran Sun; Mills; Kevin Johnson; George Karypis; Hu

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December 31, 2012

Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-Bevacizumab or FOLFIRI-bevacizumab: Results from ARIES, a bevacizumab observational cohort study

Oncologist, ISSN: 10837159 1549490X

Bendell; Bekaii-Saab; Cohn; Herbert Hurwitz; Kozloff; Haluk Tezcan; Roach; Yong Mun; Susan Fish; E. Dawn Flick; Darshan Dalal; Grothey

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December 30, 2012

MTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations

Cancer Letters, ISSN: 03043835 18727980

Ulka Vijapurkar; Liliane Robillard; Siqun Zhou; Michael Degtyarev; Kui Lin; Tom Truong; Jarrod Tremayne; Berry; Zhonghua Pei; Lori S. Friedman; Elizabeth M. Blackwood; Marcia Belvin

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December 28, 2012

Development of capillary size exclusion chromatography for the analysis of monoclonal antibody fragments extracted from human vitreous humor

Journal of Chromatography A, ISSN: 00219673 18733778

Jennifer C. Rea; Yun Lou; Joel Cuzzi; Yuhua Hu; Isabella de Jong; Yajun Jennifer Wang; Dell Farnan

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December 28, 2012

TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer

Molecular Cell, ISSN: 10972765 10974164

François Gonzalvez; David Lawrence; Becky Yang; Sharon Fong Yee; Pitti; Scot A. Marsters; Victoria Pham; Jean-Philippe Stephan; Jennie R. Lill; Avi Ashkenazi

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December 27, 2012

Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Michael F. T. Koehler; Philippe Bergeron; Elizabeth M. Blackwood; Krista K. Bowman; Yunghsiang Chen; Gauri Deshmukh; Xiao Ding; Jennifer A. Epler; Kevin Lau; Leslie Lee; Lichuan Liu; Cuong Q. Ly; Shiva Malek; Jim Nonomiya; Jason Oeh; Daniel F. Ortwine; Deepak Sampath; Steve Sideris; Lan Trinh; Tom Truong; Jiansheng Wu; Zhonghua Pei; Joseph P. Lyssikatos

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December 21, 2012

LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Bernd Wranik; Erin Christensen; Gabriele Schaefer; Janet Jackman; Andrew C. Vendel; Dan L. Eaton

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December 21, 2012

The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily

Biochemistry, ISSN: 15204995 00062960

Goetz Parsiegla; Christophe Noguere; Santell; Lazarus; Yves Bourne

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December 21, 2012

Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Michael T. Lipari; Wei Li; Paul Moran; Monica Kong-Beltran; Tao Sai; Joyce Lai; S. Jack Lin; Ganesh Kolumam; Jose Zavala-Solorio; Anita Izrael-Tomasevic; David Arnott; Jianyong Wang; Andrew S. Peterson; Daniel Kirchhofer

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December 20, 2012

A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments

Statistics in Medicine, ISSN: 02776715 10970258

Kingshuk Roy Choudhury; Finbarr O'Sullivan; Ian Kasman; Greg D. Plowman

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December 20, 2012

Dynamic randomization and a randomization model for clinical trials data

Statistics in Medicine, ISSN: 02776715 10970258

Lee D. Kaiser

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December 20, 2012