Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7351 - 7400 OF 15394 RESULTS

Studying dissolution with a model integrating solid-liquid interface kinetics and diffusion kinetics
Analytical Chemistry, ISSN: 00032700 15206882
Jeff Y. Gao
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Mutation Scanning Using MUT-MAP, a High-Throughput, Microfluidic Chip-Based, Multi-Analyte Panel
PLoS ONE, ISSN: 19326203
Rajesh Patel; Alison Tsan; Rachel Tam; Rupal Desai; Nancy Schoenbrunner; Thomas W. Myers; Keith Bauer; Edward Smith; Rajiv Raja
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miR-451 regulates dendritic cell cytokine responses to influenza infection
Journal of Immunology, ISSN: 00221767 15506606
Carrie M. Rosenberger; Rebecca L. Podyminogin; Garnet Navarro; Guo-Wei Zhao; Peter S. Askovich; Mitchell J. Weiss; Alan Aderem
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Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Sharada Labadie; Peter Dragovich; Kathy Barrett; Wade S. Blair; Philippe Bergeron; Christine Chang; Gauri Deshmukh; Eigenbrot; Nico Ghilardi; Paul Gibbons; Christopher A. Hurley; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Rohan Mendonca; Jeremy Murray; Rebecca Pulk; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Mark Zak
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Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models
Clinical Cancer Research, ISSN: 10780432 15573265
Jill M. Spoerke; Carol O'Brien; Huw; Koeppen; Jane Fridlyand; Rainer Brachmann; Matthias Peter; Ajay Pandita; Sankar Mohan; Deepak Sampath; Lori S. Friedman; Berry; Garret M. Hampton; Lukas Amler; David S. Shames; Lackner
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The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma
International Journal of Cancer, ISSN: 00207136 10970215
Momen Elshazley; Sato; Tetsunari Hase; Ryo Yamashita; Kenya Yoshida; Shinya Toyokuni; Futoshi Ishiguro; Hirotaka Osada; Yoshitaka Sekido; Kohei Yokoi; Noriyasu Usami; David S. Shames; Masashi Kondo; Adi Gazdar; Minna; Yoshinori Hasegawa
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Molecular pathways: Next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1
Clinical Cancer Research, ISSN: 10780432 15573265
Daniel S. Chen; Bryan Irving; F. Stephen Hodi
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Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria
Immunity, ISSN: 10747613 10974180
Rajatava Basu; Darrell B. O'Quinn; Daniel J. Silberger; Trenton R. Schoeb; Lynette Fouser; Wenjun Ouyang; Robin D. Hatton; Casey T. Weaver
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Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
PLoS ONE, ISSN: 19326203
Christopher E. Heise; Jeremy Murray; Katherine E. Augustyn; Brandon Bravo; Preeti Chugha; Frederick Cohen; Anthony M. Giannetti; Paul Gibbons; Rami N. Hannoush; Brian R. Hearn; Priyadarshini Jaishankar; Cuong Q. Ly; Kinjalkumar Shah; Karen Stanger; Micah Steffek; Yinyan Tang; Xianrui Zhao; Joe Lewcock; Adam R. Renslo; Flygare; Michelle R. Arkin
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A caspase cascade regulating developmental axon degeneration
Journal of Neuroscience, ISSN: 02706474 15292401
David J. Simon; Robby M. Weimer; Todd McLaughlin; Dara Y. Kallop; Karen Stanger; Jing Yang; Dennis D.M. O'Leary; Rami N. Hannoush; Marc Tessier-Lavigne
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An update on the genomic landscape of breast cancer: New opportunity for personalized therapy?
Translational Cancer Research, ISSN: 22196803 2218676X
Anneleen Daemen
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Open Reconcile: A practical open-sourced ontology-driven webservice
Proceedings of the 2012 IEEE 16th International Enterprise Distributed Object Computing Conference Workshops, EDOCW 2012,
Rebecca Lawler; Hui Yang; Kathryn Woods; Joshua S. Kaminker
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GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling
Nature Neuroscience, ISSN: 10976256 15461726
Seung Min Shin; Nanyan Zhang; Jonathan Hansen; Nashaat Z. Gerges; Daniel T. S. Pak; Morgan Sheng; Sang H. Lee
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Multiple courses of rituximab produce sustained clinical and radiographic efficacy and safety in patients with rheumatoid arthritis and an inadequate response to 1 or more tumor necrosis factor inhibitors: 5-Year data from the REFLEX study
Journal of Rheumatology, ISSN: 0315162X 14992752
Edward Keystone; Stanley B. Cohen; Paul Emery; Joel M. Kremer; Maxime Dougados; James E. Loveless; Carol Y. Chung; Pamela Wong; Lehane; Helen Tyrrell
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Advanced microscale bioreactor system: A representative scale-down model for bench-top bioreactors
Cytotechnology, ISSN: 09209069 15730778
Wei-Ting Hsu; Rigzen P. S. Aulakh; Donald L. Traul; Inn H. Yuk
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Factors associated with gastrointestinal perforation in a cohort of patients with rheumatoid arthritis
Arthritis Care and Research, ISSN: 2151464X 21514658
Jeffrey R. Curtis; Angel Lanas; Ani John; David A. Johnson; Kathy L. Schulman
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A phase 1 study of weekly dosing of trastuzumab emtansine (T-DM1) in patients with advanced human epidermal growth factor 2-positive breast cancer
Cancer, ISSN: 0008543X 10970142
Muralidhar Beeram; Ian E. Krop; Howard A. Burris; Sandhya Girish; Wei Yu; Michael W. Lu; Scott N. Holden; Shanu Modi
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Mouse mammary tumor virus suppresses apoptosis of mammary epithelial cells through ITAM-mediated signaling
Journal of Virology, ISSN: 0022538X 10985514
Hyoung H. Kim; Shannon M. Grande; John G. Monroe; Susan R. Ross
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A new scale-down membrane adsorber device for process development and validation
BioPharm International, ISSN: 1542166X 19391862
Nathalie Frau; Martin Leuthold; Amit Mehta; Kome Shomglin; Rene Faber
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Cost-effectiveness of rituximab as maintenance therapy in patients with follicular non-Hodgkin lymphoma after responding to first-line rituximab plus chemotherapy
Leukemia and Lymphoma, ISSN: 10428194 10292403
John Hornberger; Rebecca Chien; Mark Friedmann; Leona Han; Ashwini Shewade; Sacha Satram-Hoang; Carolina Reyes
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Erratum: Phase i clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma (Investigational New Drugs DOI 10.1007/s10637-011-9765-7)
Investigational New Drugs, ISSN: 01676997 15730646
Jason Konner; Rachel N. Grisham; Jae Park; Owen A. O'Connor; Gillian Cropp; Robert Johnson; Alison L. Hannah; Martee L. Hensley; Paul Sabbatini; Svetlana Mironov; Samuel Danishefsky; David Hyman; David R. Spriggs; Jakob Dupont; Carol Aghajanian
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Phase Ib study of drozitumab combined with first-line mFOLFOX6 plus bevacizumab in patients with metastatic colorectal cancer
Cancer Investigation, ISSN: 07357907 15324192
Caio M. Rocha Lima; Soley Bayraktar; Aurea M. Flores; Jessica MacIntyre; Alberto Montero; Joaquina C. Baranda; John Wallmark; Chia C. Portera; Rajiv Raja; Howard M. Stern; Stephanie Royer-Joo; Lukas Amler
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Population pharmacokinetics of rituximab in patients with chronic lymphocytic leukemia
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Jing Li; Jianguo Zhi; Michael Wenger; Nancy Valente; Anna Dmoszynska; Tadeusz Robak; Ranvir Mangat; Amita Joshi; Jennifer Visich
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Adult asthma and risk of coronary heart disease, cerebrovascular disease, and heart failure: A prospective study of 2 matched cohorts
American Journal of Epidemiology, ISSN: 00029262 14766256
Carlos Iribarren; Irina V. Tolstykh; Mary K. Miller; Erica Sobel; Mark D. Eisner
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Risk of Mortality, Fatal Infection, and Fatal Malignancy Related to Use of Anti-Tumor Necrosis Factor-α Biologics by Rheumatoid Arthritis Patients
Seminars in Arthritis and Rheumatism, ISSN: 00490172 1532866X
Veena Thyagarajan; Heather Norman; Kimberly Alexander; Pavel Napalkov; Cheryl Enger
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Survival outcomes of bevacizumab beyond progression in metastatic colorectal cancer patients treated in us community oncology
Clinical Colorectal Cancer, ISSN: 15330028 19380674
Cartwright; Yeun Mi Yim; Elaine B. Yu; Hsingwen Chung; Melissa Halm; Michael Forsyth
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Computerized extraction of electrocardiograms from continuous 12-lead holter recordings reduces measurement variability in a thorough QT study
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Samuel George; Ignacio Rodriguez; David Ipe; Philip T. Sager; Ihor Gussak; Branislav Vajdic
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Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events
Genome Research, ISSN: 10889051 15495469
Jinfeng Liu; William Lee; Zhaoshi Jiang; Zhongqiang Chen; Suchit Jhunjhunwala; Matthias Peter; Florian Gnad; Yinghui Guan; Houston N. Gilbert; Stinson; Christiaan N. Klijn; Joseph Guillory; Deepali Bhatt; Steffan Vartanian; Kimberly Walter; Jocelyn Chan; Thomas Holcomb; Gerrit J. P. Dijkgraaf; Stephanie Johnson; Julie Koeman; Minna; Adi Gazdar; Howard M. Stern; Klaus P. Hoeflich; Thomas D Wu; Jeffrey Settleman; Frederic J. De Sauvage; Robert Gentleman; Richard M. Neve; David Stokoe; Zora Modrusan; Somasekar Seshagiri; David S. Shames; Zemin Zhang
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Prostate cancer- a biomarker perspective
Frontiers in Endocrinology, ISSN: 16642392
Yanqiu Liu; Priti Hegde; Fengmin Zhang; Garret M. Hampton; Shidong Jia
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Adjuvant trials of targeted agents: The newest battleground in the war on cancer
Current Topics in Microbiology and Immunology, ISSN: 0070217X
Robert L. Cohen
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Project execution risk management in the biopharmaceutical industry - A life cycle approach
AACE International Transactions, ISSN: 15287106
Britton L. Wolf
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A case of semantic variant primary progressive aphasia with severe insular atrophy
Neurocase, ISSN: 13554794 14653656
Tiffany Chow; Links; Masterman; Mendez; Harry V. Vinters
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Pooled analysis of individual patient data from capecitabine monotherapy clinical trials in locally advanced or metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Blum; Carlos H. Barrios; Nancy Feldman; Sunil Verma; Edward McKenna; Lee; Nana Scotto; Julie Gralow
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Fixed monthly versus less frequent ranibizumab dosing and predictors of visual response in exudative age-related macular degeneration
Journal of Ophthalmology, ISSN: 2090004X 20900058
Seenu M. Hariprasad; Lawrence S. Morse; Howard Shapiro; Pamela Wong; Lisa Tuomi
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GWASTools: An R/Bioconductor package for quality control and analysis of genome-wide association studies
Bioinformatics, ISSN: 13674803 14602059
Stephanie M. Gogarten; Tushar Bhangale; Matthew P. Conomos; Cecelia A. Laurie; Caitlin P. McHugh; Ian Painter; Xiuwen Zheng; David R. Crosslin; David Levine; Thomas Lumley; Sarah C. Nelson; Kenneth Rice; Jess Shen; Rohit Swarnkar; Bruce S. Weir; Cathy C. Laurie
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A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission
Clinical Cancer Research, ISSN: 10780432 15573265
Stanley B. Kaye; Louis Fehrenbacher; Robert Holloway; Amnon Amit; Beth Karlan; Brian Slomovitz; Paul Sabbatini; Ling Fu; Robert Yauch; Ilsung Chang; Josina C. Reddy
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Phosphoproteome of Pristionchus pacificus provides insights into architecture of signaling networks in nematode models
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Nadine Borchert; Karsten Krug; Florian Gnad; Amit Sinha; Ralf J. Sommer; Boris Macek
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Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
Journal of Cell Biology, ISSN: 00219525 15408140
Bryan Lo; Geraldine Strasser; Meredith Sagolla; Cary D. Austin; Melissa Junttila; Ira Mellman
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Microwave-assisted protein staining, destaining, and in-gel/in-solution digestion of proteins
Methods in Molecular Biology, ISSN: 10643745
Jennie R. Lill; Victor J. Nesatyy
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Characterizing ubiquitination sites by peptide-based immunoaffinity enrichment
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Daisy J. Bustos; Corey Bakalarski; Yanling Yang; Junmin Peng; Donald S. Kirkpatrick
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Author response: Validation of the national eye institute visual function questionnaire-25 (NEIVFQ-25) in age-related macular degeneration
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Peggy Orr; Anne M. Rentz; Mary Kay Margolis; Dennis A. Revicki; Chantal M. Dolan; Shoshana Colman; Jennifer T. Fine; Neil M. Bressler
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Development of an ELISA based bridging assay as a surrogate measure of ADCC
Journal of Immunological Methods, ISSN: 00221759 18727905
Aaron S. Miller; Max L. Tejada; Hélène Gazzano-Santoro
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Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Gordon J. King; Jacqueline Stöckli; Shu-Hong Hu; Brit Winnen; Wilko G. A. Duprez; Christopher C. Meoli; Jagath R. Junutula; Russell J. Jarrott; David E. James; Andrew E. Whitten; Jennifer L. Martin
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Early development gmps for small-molecule specifications
Pharmaceutical Technology, ISSN: 15432521 21507376
Michael Coutant; Zhihong Ge; James S. McElvain; Scott A. Miller; Dennis O'Connor; Frank Swanek; Michael Szulc; Mark D. Trone; Kirby Wong-Moon; Mehran Yazdanian; Peter M. Yehl; Shuhong Zhang
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Early development GMPs for drug-product manufacturing of small molecules: An industry perspective (Part III)
Pharmaceutical Technology, ISSN: 15432521 21507376
Richard Creekmore; Eleni Dokou; Amnon Eylath; Dennis Joiner; Michael Lovdahl; Jackson D. Pellett; Eric Schmitt; John W. Skoug
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Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Anthony A. Estrada; Xingrong Liu; Charles Baker-Glenn; Alan Beresford; Burdick; Mark Chambers; Bryan K. Chan; Huifen Chen; Xiao Ding; Antonio G. DiPasquale; Sara L. Dominguez; Jennafer Dotson; Jason H. Drummond; Michael Flagella; Sean Flynn; Reina N. Fuji; Andrew Gill; Janet Gunzner; Seth F. Harris; Timothy P. Heffron; Tracy L. Kleinheinz; Donna W. Lee; Claire E. Le Pichon; Joseph P. Lyssikatos; Andrew D. Medhurst; John Moffat; Susmith Mukund; Kevin Nash; Kimberly Scearce-Levie; Zejuan Sheng; Daniel G. Shore; Thuy Tran; Naimisha Trivedi; Shumei Wang; Shuo Zhang; Xiaolin Zhang; Guiling Zhao; Haitao Zhu; Zachary K. Sweeney
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Discovery of potent and selective pyrazolopyrimidine Janus kinase 2 inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Emily J. Hanan; Anne Van Abbema; Kathy Barrett; Wade S. Blair; Jeff Blaney; Christine Chang; Eigenbrot; Sean Flynn; Paul Gibbons; Christopher A. Hurley; Jane R. Kenny; Janusz J. Kulagowski; Leslie Lee; Steven Magnuson; Claire Morris; Jeremy Murray; Richard Pastor; Thomas E. Rawson; Michael Siu; Ultsch; Aihe Zhou; Deepak Sampath; Joseph P. Lyssikatos
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14-3-3 Proteins Regulate a Cell-Intrinsic Switch from Sonic Hedgehog-Mediated Commissural Axon Attraction to Repulsion after Midline Crossing
Neuron, ISSN: 08966273 10974199
Patricia T. Yam; Christopher B. Kent; Steves Morin; W. Todd Farmer; Ricardo Alchini; Léa Lepelletier; David R. Colman; Marc Tessier-Lavigne; Alyson E. Fournier; Frédéric Charron
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Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Chaitali Parikh; Vasantharajan Janakiraman; Wen-I. Wu; Catherine K. Foo; Noelyn Kljavin; Subhra Chaudhuri; Eric Stawiski; Brian Lee; Jie Lin; Hong Li; Maria N. Lorenzo; Yuan; Joseph Guillory; Marlena Jackson; Jesus Rondon; Yvonne Franke; Krista K. Bowman; Meredith Sagolla; Stinson; Thomas D Wu; Jiansheng Wu; David Stokoe; Howard M. Stern; Barbara J. Brandhuber; Kui Lin; Nicholas J. Skelton; Somasekar Seshagiri
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Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Chaitali Parikh; Vasantharajan Janakiraman; Wen-I. Wu; Catherine K. Foo; Noelyn Kljavin; Subhra Chaudhuri; Eric Stawiski; Brian B. Lee; Jie Lin; Hong Li; Maria N. Lorenzo; Yuan; Joseph Guillory; Marlena Jackson; Jesus Rondon; Yvonne Franke; Krista K. Bowman; Meredith Sagolla; Stinson; Thomas D Wu; Jiansheng Wu; David Stokoe; Howard M. Stern; Barbara J. Brandhuber; Kui Lin; Nicholas J. Skelton; Somasekar Seshagiri
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