Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7401 - 7450 OF 15486 RESULTS

A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation
Pain, ISSN: 18726623 03043959
Lynn Webster; Sunita Dhar; Michael Eldon; Lorianne Masuoka; Jaakko Lappalainen; Mark Sostek
View on Scopus
Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes
Journal of Inherited Metabolic Disease, ISSN: 15732665 01418955
Derek G. Burke; Ahad A. Rahim; Simon N. Waddington; Stefan Karlsson; Ida Enquist; Kailash Bhatia; Atul Mehta; Ashok Vellodi; Simon Heales
View on Scopus
Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Michael Noonan; Phillip Korenblat; Mosesova; Heleen Scheerens; Joseph R. Arron; Zheng; Wendy Putnam; Merdad V. Parsey; Sean P. Bohen; Matthews
View on Scopus
Critical review of preclinical approaches to investigate cytochrome P450-mediated therapeutic protein drug-drug interactions and recommendations for best practices: A white paper
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Raymond Evers; Shannon Dallas; Leslie Dickmann; Odette A. Fahmi; Jane R. Kenny; Eugenia Kraynov; Theresa Nguyen; Aarti H. Patel; J. Greg Slatter; Lei Zhang
View on Scopus
Bevacizumab plus chemotherapy continued beyond first progression in patients withmetastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings
Annals of Oncology, ISSN: 15698041 09237534
Stefan Kubicka; Greil; André; Bennouna; Sastre; Eric Van Cutsem; Von Moos; Österlund; Reyes-Rivera; Thomas Müller; Makrutzki; Arnold; Andel; Balcke; Benedicic; Eisterer; Fridrik; Jagdt; Keil; Kretschmer; Krippl; Oexle; Pecherstorfer; Samonigg; Schmid; Thaler; Tinchon; Weiss; Arts; De Man; Demolin; Janssens; Polus; Benczikova; Melichar; Prausova; Vitek; Andersen; Jensen; Keldsen; Østerlind; Vistisen; Elme; Magi; Ojamaa; Ristamäki; Salminen; Ben Abdelghani; Bouche; Borg; Bouhier-Leporrier; Breysacher; Chone; Clavero Fabri; Deplanque; Desseigne; Dourthe; Ezenfis; Faroux; François; Garnier; Gaspard; Hebbar; Illory; Kaminsky; Lecomte; Legoux; Levache; Lobry; Lotz; Mabro; Manet-Lacombe; Manfredi; Matysiak Budnik; Miglianico; Mineur; Moullet; Naman; Nouyrigat; Oziel-Taieb; Perrier; Pezet; Philip; Pottier; Porneuf; Ramdani; Re; Rinaldi; Spaeth; Taieb; Terrebonne; Texereau; Thirot Bidault; Tournigand; Tubiana-Mathieu; Vantelon; Viret; Ychou; Bangerter; Bertram; Bohnsteen; Brinkmann; Caca; Constantin; Cordes; Dietrich; Eggert; Engel; Fahlke; Fensterer; Florschütz; Folprecht; Forstbauer; Freier; Freund; Frickhofen; Gäbele; Geißler; Gieseler; Göhler; Graeven; Groschek; Grundeis; Hacker; Hagen; Hebart; Hegewisch-Becker; Heike; Herrmann; Hildebrandt; Höffkes; Hübner; Hübner; Kettner; Kneba; Kohnke; Kojouharoff; König; Kretzschmar; Kröning; Kürner; Lammert; Lerchenmüller; Lück; Meiler; Mergenthaler; Müller; Müller-Naendrup; Nusch; Papke; Porschen; Rädle; Reddemann; Ridwelski; Riera-Knorrenschild; Rudi; Schmalenberger; Schimanski; Schlegel; Schlichting; Schmidt; Schmiegel; Schmitz; Schulze-Bergkamen; Schwaner; Schwarzer; Schwerdtfeger; Selbach; Sieber; Jürgen Siebler; Staib; Stauch; Steffens; Stübs; Tischendorf; Trarbach; Tummes; Valdix; Vogel; Von Wichert; Walther; Welslau; Wilhelm; Wobster; Wolf; Zeigenhagen; Zomorodbaksch; Batman; Bloemendal; Kehrer; Guren; Indrebø; Kersten; Soerbye; Fragoso; Fragoso; Mellidez; Sa; Aljobran; Darwish; Alonso-Orduna; Aparicio; Aranda; Bosch; Galan-Brotons; Busquier Hernandez; Camara; Campos Cervera; Carlos Garcia Giron; Del Prado; Donnay; Escudero; Falco; Gallego Plazas; Garcia Alfonso; Gonzalez Flores; Gravalos; Guardeno; Juárez; Lopez Ladron; Losa Gaspa; MaVicent Vergé; Marcuello Gaspar; Massuti Sureda; Molina; Montero; Muñoa; Naranjo; Oruezabal Moreno; Pachón Olmos; Pericay; Reina Zoilo; Rivera; Ruiz Casado; Safont; Salud Salvia; Tobena; Toral; Valenti; Valladares Ayerbes; Vieitez; Vera; Vieitez; Berglund; Fernebro; Hess-Umbricht; Miklos Pless; Popescu; Winterhalder
View on Scopus
Operationalization of Global Alzheimer's Disease Trials
Global Clinical Trials for Alzheimer's Disease: Design, Implementation, and Standardization,
Lynne Hughes; Spencer Guthrie
View on Scopus
Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys
mAbs, ISSN: 19420870 19420862
Maya Leabman; Meng; Robert F. Kelley; Laura DeForge; Kyra J. Cowan; Suhasini Iyer
View on Scopus
Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor
International Journal of Pharmaceutics, ISSN: 18733476 03785173
Yong Cui; Po-Chang Chiang; Edna F. Choo; Jason Boggs; Joachim Rudolph; Jonas Grina; Steve Wenglowsky; Yingqing Ran
View on Scopus
Randomized controlled trial of danoprevir plus peginterferon alfa-2a and ribavirin in treatment-naïve patients with hepatitis c virus genotype 1 infection
Gastroenterology, ISSN: 15280012 00165085
Marcellin; Curtis Cooper; Luis Balart; Dominique Larrey; Terry Box; Eric Yoshida; Eric Lawitz; Peter Buggisch; Peter Ferenci; Martin D. Weltman; Emily Labriola-Tompkins; Sophie Le Pogam; Nájera; Denise Thomas; Gregory J. Hooper; Nancy Shulman; Ying Zhang; Mercidita T. Navarro; Chin Yin Lim; Michael Brunda; Terrault; Ellen S. Yetzer
View on Scopus
Independent radiologic reviewof the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer
Gynecologic Oncology, ISSN: 10956859 00908258
Robert. A. Burger; Mark F. Brady; Joon Rhee; Mika A. Sovak; George Kong; Hoa P. Nguyen; Michael A. Bookman
View on Scopus
An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Patrick Poulin; Donna M. Dambach; Dylan H. Hartley; Kevin A. Ford; Frank-Peter Theil; Eric Harstad; Jason S Halladay; Edna F. Choo; Jason Boggs; Bianca M. Liederer; Brian J. Dean; Dolores Diaz
View on Scopus
Probability of treatment following acute decline in lung function in children with cystic fibrosis is related to baseline pulmonary function
Journal of Pediatrics, ISSN: 10976833 00223476
Morgan; Wagener; Ashley Yegin; David J. Pasta; Stefanie J. Millar; Michael W. Konstan
View on Scopus
Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models
Neoplasia (United States), ISSN: 14765586 15228002
Thomas O'Brien; Jason Oeh; Yang Xiao; Xiaorong Liang; Alexander N. Vanderbilt; Ann R. Qin; Lulu Yang; Leslie Lee; Justin Ly; Ely Cosino; Jennifer A. Lacap; Annie Ogasawara; Simon P. Williams; Michelle Nannini; Bianca M. Liederer; Peter K Jackson; Peter Dragovich; Deepak Sampath
View on Scopus
Assessment of computational methods for predicting the effects of missense mutations in human cancers.
BMC Genomics, ISSN: 14712164
Florian Gnad; Albion Baucom; Kiran Mukhyala; Gerard Manning; Zemin Zhang
View on Scopus
Health-related quality of life in patients with advanced nonsquamous non-small-cell lung cancer receiving bevacizumab or bevacizumab-plus-pemetrexed maintenance therapy in AVAPERL (MO22089)
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Achim Rittmeyer; Vera Gorbunova; Anders Vikström; Arnaud Scherpereel; Joo-Hang Kim; Myung-Ju Ahn; Antonio Chella; Christos Chouaid; Alicyn K. Campbell; Fabrice Barlesi
View on Scopus
CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Kit W. Tam; Wei Zhang; Junichi Soh; Victor Stastny; Min Chen; Han Sun; Kelsie Thu; Jonathan J. Rios; Chenchen Yang; Crystal N. Marconett; Suhaida. A. Selamat; Ite A. Laird-Offringa; Ayumu Taguchi; Samir Hanash; David S. Shames; Xiaotu Ma; Michael Q. Zhang; Wan L. Lam; Adi Gazdar
View on Scopus
The effects of membrane filters used in biopharmaceutical processes on the concentration and composition of polysorbate 20
Biotechnology Progress, ISSN: 15206033 87567938
Ming Lei; Daniel Hewitt; Christopher Cornell; Ken Skidmore; Kao; Jimmy Sugahara; Diane Beane; Junyan A. Ji
View on Scopus
Mapping in vivo tumor oxygenation within viable tumor by 19F-MRI and multispectral analysis
Neoplasia (United States), ISSN: 14765586 15228002
Yunzhou Shi; Jason Oeh; Jeffrey Eastham-Anderson; Sharon Fong Yee; David Finkle; Franklin V. Peale Jr.; Ross; Maj Hedehus; Nicholas Van Bruggen; Rayna Venook; Ross; Deepak Sampath; Richard A. D. Carano
View on Scopus
Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture
Chemical Engineering Research and Design, ISSN: 02638762
Alvin W. Nienow; William H. Scott; Christopher J. Hewitt; Colin R. Thomas; Gareth Lewis; Ashraf Amanullah; Robert Kiss; Steven Meier
View on Scopus
First-line bevacizumab in combination with chemotherapy for HER2-negative metastatic breast cancer: Pooled and subgroup analyses of data from 2447 patients
Annals of Oncology, ISSN: 15698041 09237534
David W. Miles; Diéras; Javier Cortés; Duenne; Joo-Hee Yi; O'Shaughnessy
View on Scopus
P21-Activated Kinase Inhibitors
Enzymes, ISSN: 18746047
Joachim Rudolph; James J. Crawford; Klaus P. Hoeflich; Jonathan Chernoff
View on Scopus
Anti-vascular endothelial growth factor therapy for diabetic macular edema
Therapeutic Advances in Endocrinology and Metabolism, ISSN: 20420196 20420188
David S. Boyer; J. Jill Hopkins; Jonathan Sorof; Jason S. Ehrlich
View on Scopus
Treatment effect of capecitabine and docetaxel or docetaxel alone byoestrogen receptor status in patients with metastatic breast cancer: Results of an exploratory analysis
Breast, ISSN: 15323080 09609776
Glück; Russell; O'Shaughnessy; Edward McKenna; Hu; Odom; Blum
View on Scopus
Retrospective analysis of first-line anti-vascular endothelial growth factor treatment patterns in wet age-related macular degeneration
Advances in Therapy, ISSN: 18658652 0741238X
Stephen S. Johnston; Kathleen Wilson; Alice Huang; David Smith; Helen Varker; Adam Turpcu
View on Scopus
EGFR mutation testing for squamous cell lung carcinoma (2)
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Larry Leon; Bann-Mo Day; Hu
View on Scopus
The molecular choreography of IRF4 and IRF8 with immune system partners
Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451
Harinder Singh; Elke Glasmacher; Abraham B. Chang; Bryan Vander Lugt
View on Scopus
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice
Journal of Clinical Investigation, ISSN: 15588238 00219738
Tiffany Chang; Kimberly Krisman; Emily Harding Theobald; Jin Xu; Jon Akutagawa; Jennifer O. Lauchle; Scott Kogan; Benjamin S. Braun; Kevin Shannon
View on Scopus
Lupus nephritis: Induction therapy in severe lupus nephritis-should MMF be considered the drug of choice?
Clinical Journal of the American Society of Nephrology, ISSN: 1555905X 15559041
Brad H. Rovin; Samir V. Parikh; Lee A. Hebert; Tak Mao Chan; Chi Chiu Mok; Ginzler; Lai Seong Hooi; Paul Brunetta; Romeo MacIuca; Neil Solomons
View on Scopus
Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator
Journal of Biotechnology, ISSN: 18734863 01681656
Huong Le; Santosh Kabbur; Luciano Pollastrini; Ziran Sun; Mills; Kevin Johnson; George Karypis; Hu
View on Scopus
Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-Bevacizumab or FOLFIRI-bevacizumab: Results from ARIES, a bevacizumab observational cohort study
Oncologist, ISSN: 10837159 1549490X
Bendell; Bekaii-Saab; Cohn; Herbert Hurwitz; Kozloff; Haluk Tezcan; Roach; Yong Mun; Susan Fish; E. Dawn Flick; Darshan Dalal; Grothey
View on Scopus
MTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations
Cancer Letters, ISSN: 03043835 18727980
Ulka Vijapurkar; Liliane Robillard; Siqun Zhou; Michael Degtyarev; Kui Lin; Tom Truong; Jarrod Tremayne; Berry; Zhonghua Pei; Lori S. Friedman; Elizabeth M. Blackwood; Marcia Belvin
View on Scopus
Development of capillary size exclusion chromatography for the analysis of monoclonal antibody fragments extracted from human vitreous humor
Journal of Chromatography A, ISSN: 00219673 18733778
Jennifer C. Rea; Yun Lou; Joel Cuzzi; Yuhua Hu; Isabella de Jong; Yajun Jennifer Wang; Dell Farnan
View on Scopus
TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer
Molecular Cell, ISSN: 10972765 10974164
François Gonzalvez; David Lawrence; Becky Yang; Sharon Fong Yee; Pitti; Scot A. Marsters; Victoria Pham; Jean-Philippe Stephan; Jennie R. Lill; Avi Ashkenazi
View on Scopus
Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Michael F. T. Koehler; Philippe Bergeron; Elizabeth M. Blackwood; Krista K. Bowman; Yunghsiang Chen; Gauri Deshmukh; Xiao Ding; Jennifer A. Epler; Kevin Lau; Leslie Lee; Lichuan Liu; Cuong Q. Ly; Shiva Malek; Jim Nonomiya; Jason Oeh; Daniel F. Ortwine; Deepak Sampath; Steve Sideris; Lan Trinh; Tom Truong; Jiansheng Wu; Zhonghua Pei; Joseph P. Lyssikatos
View on Scopus
LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Bernd Wranik; Erin Christensen; Gabriele Schaefer; Janet Jackman; Andrew C. Vendel; Dan L. Eaton
View on Scopus
The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily
Biochemistry, ISSN: 15204995 00062960
Goetz Parsiegla; Christophe Noguere; Santell; Lazarus; Yves Bourne
View on Scopus
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Michael T. Lipari; Wei Li; Paul Moran; Monica Kong-Beltran; Tao Sai; Joyce Lai; S. Jack Lin; Ganesh Kolumam; Jose Zavala-Solorio; Anita Izrael-Tomasevic; David Arnott; Jianyong Wang; Andrew S. Peterson; Daniel Kirchhofer
View on Scopus
A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments
Statistics in Medicine, ISSN: 02776715 10970258
Kingshuk Roy Choudhury; Finbarr O'Sullivan; Ian Kasman; Greg D. Plowman
View on Scopus
Dynamic randomization and a randomization model for clinical trials data
Statistics in Medicine, ISSN: 02776715 10970258
Lee D. Kaiser
View on Scopus
Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators
PLoS ONE, ISSN: 19326203
Justin M. Scheer; Wendy N. Sandoval; J. Michael Elliott; Lily Shao; Luis; Sock-Cheng Lewin-Koh; Gabriele Schaefer; Richard L. Vandlen
View on Scopus
Multiple secretoglobin 1A1 genes are differentially expressed in horses
BMC Genomics, ISSN: 14712164
Olivier Côté; Brandon N. Lillie; Michael Anthony Hayes; Mary Ellen Clark; Laura van den Bosch; Paula Katavolos; Laurent Viel; Dorothee Bienzle
View on Scopus
Studying dissolution with a model integrating solid-liquid interface kinetics and diffusion kinetics
Analytical Chemistry, ISSN: 00032700 15206882
Jeff Y. Gao
View on Scopus
Mutation Scanning Using MUT-MAP, a High-Throughput, Microfluidic Chip-Based, Multi-Analyte Panel
PLoS ONE, ISSN: 19326203
Rajesh Patel; Alison Tsan; Rachel Tam; Rupal Desai; Nancy Schoenbrunner; Thomas W. Myers; Keith Bauer; Edward Smith; Rajiv Raja
View on Scopus
miR-451 regulates dendritic cell cytokine responses to influenza infection
Journal of Immunology, ISSN: 00221767 15506606
Carrie M. Rosenberger; Rebecca L. Podyminogin; Garnet Navarro; Guo-Wei Zhao; Peter S. Askovich; Mitchell J. Weiss; Alan Aderem
View on Scopus
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Sharada Labadie; Peter Dragovich; Kathy Barrett; Wade S. Blair; Philippe Bergeron; Christine Chang; Gauri Deshmukh; Eigenbrot; Nico Ghilardi; Paul Gibbons; Christopher A. Hurley; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Rohan Mendonca; Jeremy Murray; Rebecca Pulk; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Mark Zak
View on Scopus
Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models
Clinical Cancer Research, ISSN: 10780432 15573265
Jill M. Spoerke; Carol O'Brien; Huw; Koeppen; Jane Fridlyand; Rainer Brachmann; Matthias Peter; Ajay Pandita; Sankar Mohan; Deepak Sampath; Lori S. Friedman; Berry; Garret M. Hampton; Lukas Amler; David S. Shames; Lackner
View on Scopus
The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma
International Journal of Cancer, ISSN: 00207136 10970215
Momen Elshazley; Sato; Tetsunari Hase; Ryo Yamashita; Kenya Yoshida; Shinya Toyokuni; Futoshi Ishiguro; Hirotaka Osada; Yoshitaka Sekido; Kohei Yokoi; Noriyasu Usami; David S. Shames; Masashi Kondo; Adi Gazdar; Minna; Yoshinori Hasegawa
View on Scopus
Molecular pathways: Next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1
Clinical Cancer Research, ISSN: 10780432 15573265
Daniel S. Chen; Bryan Irving; F. Stephen Hodi
View on Scopus
Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria
Immunity, ISSN: 10747613 10974180
Rajatava Basu; Darrell B. O'Quinn; Daniel J. Silberger; Trenton R. Schoeb; Lynette Fouser; Wenjun Ouyang; Robin D. Hatton; Casey T. Weaver
View on Scopus
Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
PLoS ONE, ISSN: 19326203
Christopher E. Heise; Jeremy Murray; Katherine E. Augustyn; Brandon Bravo; Preeti Chugha; Frederick Cohen; Anthony M. Giannetti; Paul Gibbons; Rami N. Hannoush; Brian R. Hearn; Priyadarshini Jaishankar; Cuong Q. Ly; Kinjalkumar Shah; Karen Stanger; Micah Steffek; Yinyan Tang; Xianrui Zhao; Joe Lewcock; Adam R. Renslo; Flygare; Michelle R. Arkin
View on Scopus
© 2025 Genentech, Inc. All rights reserved. This site is intended for US residents only.