Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7501 - 7550 OF 15394 RESULTS

Improved vision-related function after ranibizumab for macular edema after retinal vein occlusion: Results from the BRAVO and CRUISE trials
Ophthalmology, ISSN: 01616420 15494713
Rohit Varma; Neil M. Bressler; Ivan J. Suñer; Paul P. Lee; Chantal M. Dolan; James Ward; Shoshana Colman; Roman G. Rubio
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Cerebrovascular accidents in patients treated for choroidal neovascularization with ranibizumab in randomized controlled trials
Retina, ISSN: 0275004X 15392864
Neil M. Bressler; David S. Boyer; David F. Williams; Butler; Steve Francom; Benton Brown; Flavia Di Nucci; Timothy Cramm; Lisa Tuomi; Tsontcho Ianchulev; Roman G. Rubio
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Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
Cell, ISSN: 10974172 00928674
Robert M. Samstein; Aaron Arvey; Steven Z. Josefowicz; Xiao Peng; Alex Reynolds; Richard Sandstrom; Shane Neph; Peter Sabo; Kim; Will Liao; Ming Li; Christina Leslie; John A. Stamatoyannopoulos; Alexander Y. Rudensky
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Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT
Blood, ISSN: 15280020 00064971
Raghuveer Singh Mali; Peilin Ma; Li-Fan Zeng; Holly Martin; Baskar Ramdas; Yantao He; Emily Sims; Sarah Nabinger; Joydeep Ghosh; Namit Sharma; Veerendra Munugalavadla; Anindya Chatterjee; Shuo Li; Sandusky; Andrew W. Craig; Kevin D. Bunting; Gen-Sheng Feng; Rebecca J. Chan; Zhong-Yin Zhang; Reuben Kapur
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Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
James F. Blake; Rui Xu; Josef R. Bencsik; Dengming Xiao; Nicholas C. Kallan; Stephen Schlachter; Ian S. Mitchell; Keith L. Spencer; Anna L. Banka; Eli M. Wallace; Susan L. Gloor; Matthew Martinson; Richard D. Woessner; Guy Vigers; Barbara J. Brandhuber; Jun Liang; Brian S. Safina; Jun Li; Birong Zhang; Christine Chabot; Steven Do; Leslie Lee; Jason Oeh; Deepak Sampath; Brian Lee; Kui Lin; Bianca M. Liederer; Nicholas J. Skelton
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Cross-neutralization of influenza A viruses mediated by a single antibody loop
Nature, ISSN: 00280836 14764687
Damian C. Ekiert; Arun K. Kashyap; John Steel; Adam Rubrum; Gira Bhabha; Reza Khayat; Jeong Hyun Lee; Michael Dillon; Ryann E. O'Neil; Aleksandr M. Faynboym; Michael Horowitz; Lawrence Horowitz; Andrew B. Ward; Peter Palese; Richard Webby; Richard A. Lerner; Ramesh R. Bhatt; Ian A. Wilson
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The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Timothy P. Heffron; Laurent Salphati; Bruno Alicke; Jonathan Cheong; Jennafer Dotson; Kyle A. Edgar; Richard Goldsmith; Stephen Gould; Leslie Lee; John Lesnick; Lewis; Chudi O. Ndubaku; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Emile G. Plise; Steve Sideris; Sean Trapp; Jeffery J. Wallin; Lan Wang; Xiaolin Zhang
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Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
James F. Blake; Rui Xu; Josef R. Bencsik; Dengming Xiao; Nicholas C. Kallan; Stephen Schlachter; Ian S. Mitchell; Keith L. Spencer; Anna L. Banka; Eli M. Wallace; Susan L. Gloor; Matthew Martinson; Richard D. Woessner; Guy Vigers; Barbara J. Brandhuber; Jun Liang; Brian S. Safina; Jun Li; Birong Zhang; Christine Chabot; Steven Do; Leslie Lee; Jason Oeh; Deepak Sampath; Brian B. Lee; Kui Lin; Bianca M. Liederer; Nicholas J. Skelton
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Spatially coordinated kinase signaling regulates local axon degeneration
Journal of Neuroscience, ISSN: 02706474 15292401
Mark Chen; Janice Maloney; Dara Y. Kallop; Jasvinder K. Atwal; Stephen Tam; Kristin Baer; Holger Kissel; Joshua S. Kaminker; Joe Lewcock; Robby M. Weimer; Ryan J. Watts
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Loss of the tumor suppressor BAP1 causes myeloid transformation
Science, ISSN: 10959203 00368075
Anwesha Dey; Dhaya Seshasayee; Rajkumar Noubade; French; Jinfeng Liu; Mira S. Chaurushiya; Donald S. Kirkpatrick; Victoria Pham; Jennie R. Lill; Corey Bakalarski; Jiansheng Wu; Lilian Phu; Paula Katavolos; Lindsay M. LaFave; Omar Abdel-Wahab; Zora Modrusan; Somasekar Seshagiri; Ken Dong; Zhonghua Lin; Mercedesz Balazs; Rowena Suriben; Kim Newton; Sarah G. Hymowitz; Guillermo Garcia-Manero; Flavius Martin; Ross L. Levine; Vishva M. Dixit
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Effectiveness of first-line management strategies for stage I follicular lymphoma: Analysis of the National Lymphocare Study
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Jonathan W. Friedberg; Michelle Byrtek; Brian K. Link; Christopher R. Flowers; Taylor; John Hainsworth; James R. Cerhan; Zelenetz; Jamie Hirata; Thomas P. Miller
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Childhood disorders of the synapse: Challenges and opportunities
Science Translational Medicine, ISSN: 19466234 19466242
Virginia Hughes; Morgan Sheng; Huda Y. Zoghbi
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Impact of hemodialysis catheter dysfunction on dialysis and other medical services: An observational cohort study
International Journal of Nephrology, ISSN: 2090214X 20902158
Robert I. Griffiths; Britt B. Newsome; Grace Leung; Geoffrey A. Block; Robert J. Herbert; Mark Danese
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Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging
PLoS ONE, ISSN: 19326203
Amrita Kamath; Simon P. Williams; Sherron Bullens; Kyra J. Cowan; Yvonne Stenberg; Simon R. Cherry; Stephen Rendig; David L. Kukis; Chris Griesemer; Lisa A. Damico; Bunting
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Validity of cost and utility results?
PharmacoEconomics, ISSN: 11707690 11792027
Alex Diamantopoulos; Laura Sawyer; Sarika Ogale; Fred Dejonckheere
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Ras inhibition via direct Ras binding - Is there a path forward?
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Weiru Wang; Guowei Fang; Joachim Rudolph
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RPN-6 determines C. elegans longevity under proteotoxic stress conditions
Nature, ISSN: 00280836 14764687
David Vilchez; Ianessa Morantte; Zheng Liu; Peter M. Douglas; Carsten Merkwirth; Ana P. C. Rodrigues; Gerard Manning; Andrew Dillin
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Potent and highly selective benzimidazole inhibitors of PI3-kinase delta
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Jeremy Murray; Zachary K. Sweeney; Bryan K. Chan; Mercedesz Balazs; Erin K. Bradley; Georgette M. Castanedo; Christine Chabot; David Chantry; Michael Flagella; David M. Goldstein; Rama Kondru; John Lesnick; Jun Li; Matthew C. Lucas; Jim Nonomiya; Jodie Pang; Stephen Price; Laurent Salphati; Brian S. Safina; Pascal P. A. Savy; Eileen Seward; Ultsch; Daniel P. Sutherlin
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A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Ian E. Krop; Patricia M. LoRusso; Kathy Miller; Shanu Modi; Denise A. Yardley; Gladys Rodriguez; Ellie Guardino; Michael W. Lu; Maoxia Zheng; Sandhya Girish; Lukas Amler; Eric P. Winer; Hope S. Rugo
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Dr. Sekulic and colleagues reply
New England Journal of Medicine, ISSN: 15334406 00284793
Aleksandar Sekulic; Josina C. Reddy; Axel Hauschild
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Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells
Blood, ISSN: 15280020 00064971
Bithi Chatterjee; Anna Smed-Sörensen; Lillian Cohn; Cecile Chalouni; Richard L. Vandlen; Byoung-Chul Lee; Jenifer Widger; Tibor Keler; Lélia Delamarre; Ira Mellman
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Structural transitions of transmembrane helix 6 in the formation of Metarhodopsin i
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Markus Eilers; Joseph A. Goncalves; Shivani Ahuja; Colleen Kirkup; Amiram Hirshfeld; Carlos Simmerling; Philip J. Reeves; Mordechai Sheves; Steven O. Smith
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High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production
Blood, ISSN: 15280020 00064971
Jonathan N. Thon; Matthew T. Devine; Antonija Jurak Begonja; Jay Tibbitts; Joseph E. Italiano Jr.
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Binding mechanism of metalṡNTP substrates and stringent-response alarmones to bacterial DnaG-type primases
Structure, ISSN: 18784186 09692126
Richard U. Rymer; Francisco A. Solorio; Ashley K. Tehranchi; Clement Chu; Jacob E. Corn; James L. Keck; Jue D. Wang; James M. Berger
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FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice
Journal of Clinical Investigation, ISSN: 00219738 15588238
Sunyoung Lee; Roland Meier; Saori Furuta; Marc E. Lenburg; Paraic A. Kenny; Ren Xu; Mina J. Bissell
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Molecular basis for negative regulation of the glucagon receptor
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christopher M. Koth; Jeremy Murray; Susmith Mukund; Azadeh Madjidi; Alexandra Minn; Holly J. Clarke; Wong; Vicki Chiang; Luis; Alberto Estevez; Jesus Rondon; Yingnan Zhang; Isidro Hötzel; Bernard B. Allan
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Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
Journal of Clinical Investigation, ISSN: 00219738 15588238
Yanqiu Liu; Agnes D. Berendsen; Shidong Jia; Sutada Lotinun; Roland Baron; Napoleone Ferrara; Bjorn R. Olsen
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Utilizing design of experiments to characterize assay robustness
Bioanalysis, ISSN: 17576180 17576199
Kyra J. Cowan; Erickson; Brian Sue; Reginald Delarosa; Bert Gunter; Daniel A. Coleman; Houston N. Gilbert; An Song; Saloumeh Kadkhodayan Fischer
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A generic HPLC/UV platform method for cleaning verification
American Pharmaceutical Review, ISSN: 10998012
Michael W. Dong; Eileen X. Zhao; Derrick T. Yazzie; Christine Gu; Jackson D. Pellett
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Evaluating the Impact of Patient Recruitment and Retention Practices
Drug Information Journal, ISSN: 00928615
Mary Jo Lamberti; Adam Mathias; Jane E. Myles; Deborah Howe; Ken Getz
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Pre-use/post-sterilization integrity testing of sterilizing grade filters
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124
Karen Bartel; Harold S. Baseman; Gabriele Gori; Richard V. Levy; Hemisha Ly; Maik W. Jornitz; Russell Madsen; Michiel Rook; Sue Schniepp
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QbD for biologics
BioProcess International, ISSN: 15426319
Steven Kozlowski; Wassim Nashabeh; Mark Schenerman; Howard Anderson; Ilse Blumentals; Kowid Ho; Rohin Mahtre; Barbara Rellahan; Victor Vinci; Lorna McLeod
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Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): A phase 3, open-label, multicentre, randomised trial
The Lancet Oncology, ISSN: 14702045 14745488
Gustavo Ismael; Roberto Hegg; Susanne Muehlbauer; Dominik Heinzmann; Bert L. Lum; Sung-Bae Kim; Tadeusz Pienkowski; Mikhail Lichinitser; Vladimir Semiglazov; Melichar; Christian Jackisch
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Safety and biodistribution of an equine infectious anemia virus-based gene therapy, retinostat®, for age-related macular degeneration
Human Gene Therapy, ISSN: 10430342 15577422
Katie Binley; Peter S. Widdowson; Michelle Kelleher; Jackie De Belin; Julie Loader; Georgina Ferrige; Marie Carlucci; Margaret Esapa; Daniel Chipchase; Diana Angell-Manning; Scott Ellis; Kyriacos Mitrophanous; James Miskin; Vlad Bantseev; Michael Nork; Paul Miller; Stuart Naylor
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Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Jun Luo; Jian Zhang; Diya Ren; Wen-Lin Tsai; Feng Li; Ashraf Amanullah; Terry Hudson
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2012 White paper on recent issues in bioanalysis and alignment of multiple guidelines
Bioanalysis, ISSN: 17576180 17576199
Binodh DeSilva; Fabio Garofolo; Mario Rocci; Suzanne Martinez; Isabelle Dumont; France Landry; Catherine Dicaire; Gabriella Szekely-Klepser; Russell Weiner; Mark Arnold; Surendra Bansal; Kevin Bateman; Ronald Bauer; Brian Booth; Scott Davis; Sherri Dudal; Dominique Gouty; John Grundy; Sam Haidar; Roger Hayes; Mohammed Jemal; Surinder Kaur; Marian Kelley; Magnus Knutsson; Olivier Le Blaye; Jean W. Lee; Steve Lowes; Mark Ma; Toshinari Mitsuoka; João Tavares Neto; Robert Nicholson; Eric Ormsby; Jeff M. Sailstad; Lauren Stevenson; Daniel Tang; Jan Welink; Viswanathan; Laixin Wang; Eric Woolf; Eric Yang
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The assay design used for measurement of therapeutic antibody concentrations can affect pharmacokinetic parameters: Case studies
mAbs, ISSN: 19420862 19420870
Saloumeh Kadkhodayan Fischer; Yang; Banmeet S. Anand; Kyra J. Cowan; Robert Hendricks; Jing Li; Nakamura; An Song
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Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics
AAPS Journal, ISSN: 15507416
Daniela Bumbaca; C. Andrew Boswell; Fielder; Leslie A. Khawli
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Long-term effects of ranibizumab on diabetic retinopathy severity and progression
Archives of Ophthalmology, ISSN: 00039950 15383601
Michael S. Ip; Amitha Domalpally; J. Jill Hopkins; Pamela Wong; Jason S. Ehrlich
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Neuropilin-2 expression in cancer
Histopathology, ISSN: 03090167 13652559
Adrian M. Jubb; Susan Sa; Navneet Ratti; Laura A. Strickland; Maike Schmidt; Christopher Callahan; Koeppen
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Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes
Ophthalmology, ISSN: 01616420 15494713
Lucia Sobrin; Stephan Ripke; Yi Yu; Jesen Fagerness; Tushar Bhangale; Perciliz L. Tan; Eric H. Souied; Gabriëlle H.S. Buitendijk; Joanna E. Merriam; Andrea J. Richardson; Soumya Raychaudhuri; Robyn Reynolds; Kimberly A. Chin; Aaron Y. Lee; Nicolas Leveziel; Donald J. Zack; Peter A. Campochiaro; R. Theodore Smith; Gaetano R. Barile; Ruth E. Hogg; Usha Chakravarthy; Timothy W. Behrens; André G. Uitterlinden; Cornelia M. Van Duijn; Johannes R. Vingerling; Milam A. Brantley Jr.; Paul N. Baird; Caroline C.W. Klaver; Rando Allikmets; Nicholas Katsanis; Robert R. Graham; John P.A. Ioannidis; Mark J. Daly; Johanna M. Seddon
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Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Kelly M. Loyet; Laura DeForge; Kenneth J. Katschke Jr.; Laurie Diehl; Robert R. Graham; Lily Pao; Lizette Sturgeon; Sock-Cheng Lewin-Koh; Joe G. Hollyfield; Menno Van Lookeren Campagne
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Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Laurent Salphati; Jodie Pang; Emile G. Plise; Leslie Lee; Alan G. Olivero; Wei Wei Prior; Deepak Sampath; Susan C. Wong; Xiaolin Zhang
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Risk factors for rate of decline in FEV1 in adults with cystic fibrosis
Journal of Cystic Fibrosis, ISSN: 15691993 18735010
Michael W. Konstan; Wagener; Donald R. VanDevanter; David J. Pasta; Ashley Yegin; Lawrence Rasouliyan; Morgan
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Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex
Nature Protocols, ISSN: 17542189 17502799
Gerard M. J. Beaudoin III; Seung-Hye Lee; Dipika Singh; Yang Yuan; Yu-Gie Ng; Louis F. Reichardt; Jyothi Arikkath
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The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy
Experimental Oncology, ISSN: 18129269
Maria Cristina De Almagro; Domagoj Vucic
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Differential effects of predosing on tumor and tissue uptake of an 111in-labeled anti-TENB2 antibody-drug conjugate
Journal of Nuclear Medicine, ISSN: 01615505
C. Andrew Boswell; Eduardo E. Mundo; Crystal Zhang; Shannon Stainton; Shang-Fan Yu; Jennifer A. Lacap; Mao; Katherine R. Kozak; Aimee Fourie-O'Donohue; Paul G. Polakis; Leslie A. Khawli; Kedan Lin
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Compartmental tissue distribution of antibody therapeutics: Experimental approaches and interpretations
AAPS Journal, ISSN: 15507416
C. Andrew Boswell; Daniela Bumbaca; Fielder; Leslie A. Khawli
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Diagnosis and management of childhood obstructive sleep apnea syndrome
Pediatrics, ISSN: 00314005 10984275
Carole L. Marcus; Lee Jay Brooks; Sally Davidson Ward; Kari A. Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Christopher Lehmann; Michael S. Schechter; Stephen Howard Sheldon; Richard N. Shiffman; Karen Spruyt
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Diagnosis and management of childhood obstructive sleep apnea syndrome
Pediatrics, ISSN: 00314005 10984275
Carole L. Marcus; Lee Jay Brooks; Kari A. Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Michael S. Schechter; Stephen Howard Sheldon; Karen Spruyt; Sally Davidson Ward; Christopher Lehmann; Richard N. Shiffman
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