Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7601 - 7650 OF 15394 RESULTS

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease
Blood, ISSN: 15280020 00064971
Pichika Chantrathammachart; Nigel Mackman; Erica Sparkenbaugh; Jian-Guo Wang; Leslie V. Parise; Daniel Kirchhofer; Nigel S. Key; Rafal Pawlinski
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GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death In Vitro and In Vivo
Clinical Cancer Research, ISSN: 10780432 15573265
Jeffery J. Wallin; Zhengyu Guan; Wei Wei Prior; Leslie Lee; Berry; Lisa D. Belmont; Koeppen; Marcia Belvin; Lori S. Friedman; Deepak Sampath
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Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2
Cancer Research, ISSN: 00085472 15387445
Meilan He; Wei Zhang; Thomas Bakken; Melissa Schutten; Zsolt Toth; Jae U. Jung; Parkash Gill; Mark Cannon; Shou-Jiang Gao
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Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response
Clinical Cancer Research, ISSN: 10780432 15573265
Harvey Wong; Edna F. Choo; Bruno Alicke; Xiao Ding; Hank La; Erin McNamara; Frank-Peter Theil; Jay Tibbitts; Lori S. Friedman; Cornelis E. Hop; Stephen Gould
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The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Youjun Chen; Cecile Chalouni; Christine Tan; Robyn Clark; Rayna Venook; Rachana Ohri; Helga Raab; Ron Firestein; William Mallet; Paul G. Polakis
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Structure and conservation of the periplasmic targeting factor Tic22 protein from plants and cyanobacteria
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Joanna Tripp; Alexander Hahn; Patrick Koenig; Nadine Flinner; Daniela Bublak; Eva M. Brouwer; Franziska Ertel; Oliver Mirus; Irmgard Sinning; Ivo Tews; Enrico Schleiff
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Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Mark Zak; Rohan Mendonca; Mercedesz Balazs; Kathy Barrett; Philippe Bergeron; Wade S. Blair; Christine Chang; Gauri Deshmukh; Jason Devoss; Peter Dragovich; Eigenbrot; Nico Ghilardi; Paul Gibbons; Stefan Gradl; Chris Hamman; Emily J. Hanan; Eric Harstad; Peter R. Hewitt; Christopher A. Hurley; Tian Jin; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Michael F. T. Koehler; Pawan Bir Kohli; Janusz J. Kulagowski; Sharada Labadie; Jiangpeng Liao; Marya Liimatta; Zhonghua Lin; Patrick J. Lupardus; Robert J. Maxey; Jeremy Murray; Rebecca Pulk; Madeleine Rodriguez; Scott Savage; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Ling Xiao; Yisong Xiao
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An effector-reduced anti-β-amyloid (Aβ) antibody with unique Aβ binding properties promotes neuroprotection and glial engulfment of Aβ
Journal of Neuroscience, ISSN: 02706474 15292401
Oskar Adolfsson; Maria Pihlgren; Nicolas Toni; Yvan Varisco; Anna Lucia Buccarello; Katia Antoniello; Sophie Lohmann; Kasia Piorkowska; Valerie Gafner; Jasvinder K. Atwal; Janice Maloney; Mark Chen; Alvin Gogineni; Robby M. Weimer; Deborah L. Mortensen; Michel Friesenhahn; Carole Ho; Robert Paul; Andrea Pfeifer; Andreas Muhs; Ryan J. Watts
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Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth
Cancer Cell, ISSN: 18783686 15356108
Nicholas S. Wilson; Annie Yang; Becky Yang; Suzana Couto; Howard M. Stern; Alvin Gogineni; Pitti; Scot A. Marsters; Robby M. Weimer; Mallika Singh; Avi Ashkenazi
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Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Taejin Yoon; Henriette Macmillan; Sarah E. Mortimer; Wei Jiang; Rinderknecht; Lawrence J. Stern; Mellins
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PiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Cell, ISSN: 10974172 00928674
Alyson Ashe; Alexandra Sapetschnig; Eva-Maria Weick; Jacinth Mitchell; Marloes P. Bagijn; Amy C. Cording; Anna-Lisa Doebley; Leonard D. Goldstein; Nicolas J. Lehrbach; Jérémie Le Pen; Greta Pintacuda; Aisa Sakaguchi; Peter Sarkies; Shawn Ahmed; Eric A. Miska
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A conserved role of IQGAP1 in regulating TOR complex 1
Journal of Cell Science, ISSN: 00219533 14779137
Yemsrach K. Tekletsadik; Robert Sonn; Mahasin A. Osman
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Weak interactions govern the viscosity of concentrated antibody solutions: High-throughput analysis using the diffusion interaction parameter
Biophysical Journal, ISSN: 00063495 15420086
Brian D. Connolly; Chris Petry; Sandeep Yadav; Barthélemy Demeule; Natalie Ciaccio; Jamie M. R. Moore; Steven J. Shire; Yatin Gokarn
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Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease
Journal of Clinical Investigation, ISSN: 00219738 15588238
Azeb Tadesse Argaw; Linnea Asp; Jingya Zhang; Kristina Navrazhina; Trinh Pham; John N. Mariani; Sean Mahase; Dipankar J. Dutta; Jeremy Seto; Elisabeth G. Kramer; Napoleone Ferrara; Michael V. Sofroniew; Gareth R. John
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Considerations in the development of circulating tumor cell technology for clinical use
Journal of Translational Medicine, ISSN: 14795876
David R. Parkinson; Nicholas Dracopoli; Brenda G. Petty; Carolyn Compton; Massimo Cristofanilli; Albert Deisseroth; Daniel F. Hayes; Gordon Kapke; Prasanna Kumar; Jerry S.H. Lee; Minetta C. Liu; Robert McCormack; Stanislaw Mikulski; Larry Nagahara; Klaus Pantel; Sonia Pearson-White; Elizabeth A. Punnoose; Lori T. Roadcap; Andrew E. Schade; Scher; Caroline C. Sigman; Gary J. Kelloff
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A novel method to calculate mean survival time for time-to-event data
Communications in Statistics: Simulation and Computation, ISSN: 03610918 15324141
Zheng Su; Liang Fang
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Reply to "On the differentiation of mouse IgE + cells"
Nature Immunology, ISSN: 15292908 15292916
Oezcan Talay; Donghong Yan; Hans D. Brightbill; Elizabeth E. M. Straney; Meijuan Zhou; Ena Ladi; Wyne P. Lee; Jackson G. Egen; Cary D. Austin; Min Xu; Lawren C. Wu
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Quantification of antiangiogenic and antivascular drug activity by kinetic analysis of DCE-MRI data
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Gregory Z. Ferl; Ruediger E. Port
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Collective action of hematopoietic cell subsets mediates anti-IL10R1 and CpG tumor immunity
Cancer Immunology, Immunotherapy, ISSN: 03407004 14320851
Meng-Yun Chou; Cary D. Austin; Kim
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Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC
Nature Immunology, ISSN: 15292908 15292916
Jianming Xie; Johannes B. Huppa; Evan W. Newell; Jun Huang; Peter J. R. Ebert; Qi-Jing Li; Mark M. Davis
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Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosis
Journal of Cystic Fibrosis, ISSN: 15691993 18735010
Clement L. Ren; Michael W. Konstan; Ashley Yegin; Lawrence Rasouliyan; Benjamin L. Trzaskoma; Morgan; Warren E. Regelmann
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Antibodies against the gh/gl/UL128/UL130/UL131 complex comprise the majority of the anti-cytomegalovirus (Anti-CMV) neutralizing antibody response in CMV hyperimmune globulin
Journal of Virology, ISSN: 0022538X 10985514
Ashley Fouts; Pamela Chan; Jean-Philippe Stephan; Richard L. Vandlen; Becket Feierbach
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The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell-surface-targeted biological agents in patients
British Journal of Pharmacology, ISSN: 00071188 14765381
Andrew G. Polson; Reina N. Fuji
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Androgen hormone action in prostatic carcinogenesis: Stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis
Carcinogenesis, ISSN: 01433334 14602180
Emily A. Ricke; Karin Williams; Yi-Fen Lee; Suzana Couto; Yuzhuo Wang; Simon W. Hayward; Gerald R. Cunha; William A. Ricke
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Ultrasensitive detection of cellular protein interactions using bioluminescence resonance energy transfer quantum dot-based nanoprobes
Journal of Cellular Biochemistry, ISSN: 07302312 10974644
Gabriel Quinones; Steven C. Miller; Sukanta Bhattacharyya; Daniel Sobek; Jean-Philippe Stephan
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The effect of fellow eye visual acuity on visual acuity of study eyes receiving ranibizumab for age-related macular degeneration
Retina, ISSN: 0275004X 15392864
Sandrine A. Zweifel; Namrata Saroj; Howard Shapiro; K. Bailey Freund
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Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans
mAbs, ISSN: 19420862 19420870
Marcella Yu; Darren Brown; Chae Reed; Shan Chung; Jeff Lutman; Stefanich; Anne Wong; Jean-Philippe Stephan; Robert Bayer
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Drug-drug interaction potential of marketed oncology drugs: In vitro assessment of time-dependent cytochrome P450 inhibition, reactive metabolite formation and drug-drug interaction prediction
Pharmaceutical Research, ISSN: 07248741 1573904X
Jane R. Kenny; Sophie Mukadam; Chenghong Zhang; Suzanne Tay; Carol Collins; Aleksandra Galetin; S. Cyrus Khojasteh
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Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Daniel P. Sutherlin; Stewart Baker; Angelina Bisconte; Paul M. Blaney; Anthony Brown; Bryan K. Chan; David Chantry; Georgette M. Castanedo; Paul Depledge; Paul Goldsmith; David M. Goldstein; Timothy Hancox; Jasmit Kaur; David Knowles; Rama Kondru; John Lesnick; Matthew C. Lucas; Lewis; Jeremy Murray; Alan J. Nadin; Jim Nonomiya; Jodie Pang; Neil Pegg; Steve Price; Karin Reif; Brian S. Safina; Laurent Salphati; Steven T. Staben; Eileen Seward; Stephen Shuttleworth; Sukhjit Sohal; Zachary K. Sweeney; Ultsch; Bohdan Waszkowycz; Binqing Wei
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Simultaneous, sequential quantitative achiral-chiral analysis by two-dimensional liquid chromatography
Journal of Separation Science, ISSN: 16159306 16159314
Venkatramani; Larry Wigman; Kavita Mistry; Nicholas Chetwyn
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Lack of a meaningful effect of anacetrapib on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
British Journal of Clinical Pharmacology, ISSN: 03065251 13652125
Rajesh Krishna; Daria Stypinski; Melissa Ali; Amit Garg; Josee Cote; Andrea Maes; Bruce Degroot; Yang Liu; Susie Li; Sandra M. Connolly; John A. Wagner; S. Aubrey Stoch
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Generation of a cholesterol-independent, non-GS NS0 cell line through chemical treatment and application for high titer antibody production
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Jincai Li; Wei Gu; Diane G. Edmondson; Connie Lu; Natarajan Vijayasankaran; Bruno Figueroa; Dave Stevenson; Thomas Ryll; Feng Li
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A single-dose study of denosumab in patients with various degrees of renal impairment
Journal of Bone and Mineral Research, ISSN: 08840431 15234681
Geoffrey A. Block; Henry G. Bone; Liang Fang; Edward Lee; Desmond Padhi
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The transcription factor ZNF217 Is a prognostic biomarker and therapeutic target during breast cancer progression
Cancer Discovery, ISSN: 21598274 21598290
Laurie E. Littlepage; Adam S. Adler; Hosein Kouros-Mehr; Guiqing Huang; Jonathan Chou; Sheryl R. Krig; Obi L. Griffith; James E. Korkola; Kun Qu; Devon A. Lawson; Qing Xue; Mark D. Sternlicht; Gerrit J. P. Dijkgraaf; Paul Yaswen; Hope S. Rugo; Colleen A. Sweeney; Colin C. Collins; Joe W. Gray; Howard Y. Chang; Zena Werb
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Regulation of epithelial immunity by IL-17 family cytokines
Trends in Immunology, ISSN: 14714906 14714981
Rajita Pappu; Sascha Rutz; Wenjun Ouyang
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A Randomized, phase II trial of standard triweekly compared with dose-dense biweekly capecitabine plus oxaliplatin plus bevacizumab as first-line treatment for metastatic colorectal cancer: XELOX-A-DVS (dense versus standard)
Oncologist, ISSN: 10837159 1549490X
Herbert Hurwitz; Edith Mitchell; Thomas Cartwright; Ambrose Kwok; Hu; Edward McKenna; Yehuda Z. Patt
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Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
Nature Biotechnology, ISSN: 10870156 15461696
Mallika Singh; Napoleone Ferrara
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Navitoclax (ABT-263) reduces Bcl-x L-mediated chemoresistance in ovarian cancer models
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Maureen Wong; Nguyen Tan; Jiping Zha; Franklin V. Peale Jr.; Peng Yue; Wayne J. Fairbrother; Lisa D. Belmont
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CD28 costimulation regulates genome-wide effects on alternative splicing
PLoS ONE, ISSN: 19326203
Manish J. Butte; Sun Jung Lee; Jonathan Jesneck; Mary E. Keir; W. Nicholas Haining; Arlene H. Sharpe
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Bystanders Not So Innocent after All
Immunity, ISSN: 10747613 10974180
Marcel Batten; Nico Ghilardi
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ERK inhibition overcomes acquired resistance to MEK Inhibitors
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Georgia Hatzivassiliou; Bonnie Liu; Carol O'Brien; Jill M. Spoerke; Klaus P. Hoeflich; Matthias Peter; Robert Soriano; William F. Forrest; Sherry Heldens; Huifen Chen; Toy; Connie Ha; Wei Zhou; Kyung Song; Lori S. Friedman; Lukas Amler; Garret M. Hampton; John Moffat; Marcia Belvin; Lackner
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The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Hans Erickson; Gail L. Phillips; Douglas Leipold; Carmela A. Provenzano; Elaine Mai; Holly A. Johnson; Bert Gunter; Charlene A. Audette; Manish Gupta; Jan Pinkas; Jay Tibbitts
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Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Janusz J. Kulagowski; Wade S. Blair; Richard J. Bull; Christine Chang; Gauri Deshmukh; Hazel J. Dyke; Eigenbrot; Nico Ghilardi; Paul Gibbons; Trevor K. Harrison; Peter R. Hewitt; Marya Liimatta; Christopher A. Hurley; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Pawan Bir Kohli; Robert J. Maxey; Rohan Mendonca; Kyle Mortara; Jeremy Murray; Raman Narukulla; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Bohdan Waszkowycz; Mark Zak
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Discovery of novel PI3-Kinase δ specific inhibitors for the treatment of rheumatoid arthritis: Taming CYP3A4 time-dependent inhibition
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Brian S. Safina; Stewart Baker; Matthew Baumgardner; Paul M. Blaney; Bryan K. Chan; Yunghsiang Chen; Matthew W. Cartwright; Georgette M. Castanedo; Christine Chabot; Arnaud J. Cheguillaume; Paul Goldsmith; David M. Goldstein; Bindu Goyal; Timothy Hancox; Raj K. Handa; Pravin S Iyer; Jasmit Kaur; Rama Kondru; Jane R. Kenny; Sussie L. Krintel; Jun Li; John Lesnick; Matthew C. Lucas; Lewis; Sophie Mukadam; Jeremy Murray; Alan J. Nadin; Jim Nonomiya; Fernando Padilla; Wylie S. Palmer; Jodie Pang; Neil Pegg; Steve Price; Karin Reif; Laurent Salphati; Pascal P. A. Savy; Eileen Seward; Stephen Shuttleworth; Sukhjit Sohal; Zachary K. Sweeney; Suzanne Tay; Parcharee Tivitmahaisoon; Bohdan Waszkowycz; Binqing Wei; Qin Yue; Chenghong Zhang; Daniel P. Sutherlin
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Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib
Biochemistry, ISSN: 00062960 15204995
Youngjoo Kim; Zhimin Li; Mihaela Apetri; Beibei Luo; Jeffrey Settleman; Karen S. Anderson
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DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina
Cell, ISSN: 10974172 00928674
Joseph M. Zullo; Ignacio A. Demarco; Roger Piqué-Regi; Daniel J. Gaffney; Charles B. Epstein; Chauncey J. Spooner; Teresa R. Luperchio; Bradley E. Bernstein; Jonathan K. Pritchard; Karen L. Reddy; Harinder Singh
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Clinical trial considerations on male contraception and collection of pregnancy information from female partners
Journal of Translational Medicine, ISSN: 14795876
Maria L. Banholzer; Heinrich Buergin; Christoph Wandel; Georg Schmitt; Elmar Gocke; Richard Peck; Thomas Singer; Theresa Reynolds; Marie Mannino; Jonathan Deutsch; Lucette Doessegger
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Pharmacokinetic models for FcRn-mediated IgG disposition
Journal of Biomedicine and Biotechnology, ISSN: 11107243 11107251
Jim J. Xiao
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Charge heterogeneity of monoclonal antibodies by multiplexed imaged capillary isoelectric focusing immunoassay with chemiluminescence detection
Analytical Chemistry, ISSN: 00032700
David A. Michels; Andrea W. Tu; Will McElroy; David Voehringer; Oscar Salas-Solano
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Analysis of Fcγ receptor IIIa and IIa polymorphisms: Lack of correlation with outcome in trastuzumab-treated breast cancer patients
Clinical Cancer Research, ISSN: 10780432 15573265
Sara A. Hurvitz; David J. Betting; Howard M. Stern; Emmanuel Quinaux; Stinson; Somasekar Seshagiri; Ying Zhao; Marc Buyse; John Mackey; Adrian Driga; Sambasivarao Damaraju; Mark X. Sliwkowski; Nicholas J. Robert; Vicente Valero; John Crown; Carla Falkson; Adam Brufsky; Tadeusz Pienkowski; Wolfgang Eiermann; Miguel Martín; Valerie Bée; Omkar Marathe; Dennis J. Slamon; John M. Timmerman
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