Genentech: Publications

September 26, 2012

Spatially coordinated kinase signaling regulates local axon degeneration

Journal of Neuroscience, ISSN: 02706474 15292401

Mark Chen; Janice Maloney; Dara Y. Kallop; Jasvinder K. Atwal; Stephen Tam; Kristin Baer; Holger Kissel; Joshua S. Kaminker; Joe Lewcock; Robby M. Weimer; Ryan J. Watts

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September 21, 2012

Loss of the tumor suppressor BAP1 causes myeloid transformation

Science, ISSN: 10959203 00368075

Anwesha Dey; Dhaya Seshasayee; Rajkumar Noubade; French; Jinfeng Liu; Mira S. Chaurushiya; Donald S. Kirkpatrick; Victoria Pham; Jennie R. Lill; Corey Bakalarski; Jiansheng Wu; Lilian Phu; Paula Katavolos; Lindsay M. LaFave; Omar Abdel-Wahab; Zora Modrusan; Somasekar Seshagiri; Ken Dong; Zhonghua Lin; Mercedesz Balazs; Rowena Suriben; Kim Newton; Sarah G. Hymowitz; Guillermo Garcia-Manero; Flavius Martin; Ross L. Levine; Vishva M. Dixit

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September 20, 2012

Effectiveness of first-line management strategies for stage I follicular lymphoma: Analysis of the National Lymphocare Study

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Jonathan W. Friedberg; Michelle Byrtek; Brian K. Link; Christopher R. Flowers; Taylor; John Hainsworth; James R. Cerhan; Zelenetz; Jamie Hirata; Thomas P. Miller

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September 19, 2012

Childhood disorders of the synapse: Challenges and opportunities

Science Translational Medicine, ISSN: 19466234 19466242

Virginia Hughes; Morgan Sheng; Huda Y. Zoghbi

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September 18, 2012

Impact of hemodialysis catheter dysfunction on dialysis and other medical services: An observational cohort study

International Journal of Nephrology, ISSN: 2090214X 20902158

Robert I. Griffiths; Britt B. Newsome; Grace Leung; Geoffrey A. Block; Robert J. Herbert; Mark Danese

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September 17, 2012

Validity of cost and utility results?

PharmacoEconomics, ISSN: 11707690 11792027

Alex Diamantopoulos; Laura Sawyer; Sarika Ogale; Fred Dejonckheere

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September 17, 2012

Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging

PLoS ONE, ISSN: 19326203

Amrita Kamath; Simon P. Williams; Sherron Bullens; Kyra J. Cowan; Yvonne Stenberg; Simon R. Cherry; Stephen Rendig; David L. Kukis; Chris Griesemer; Lisa A. Damico; Bunting

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September 15, 2012

Ras inhibition via direct Ras binding - Is there a path forward?

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Weiru Wang; Guowei Fang; Joachim Rudolph

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September 13, 2012

Potent and highly selective benzimidazole inhibitors of PI3-kinase delta

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Jeremy Murray; Zachary K. Sweeney; Bryan K. Chan; Mercedesz Balazs; Erin K. Bradley; Georgette M. Castanedo; Christine Chabot; David Chantry; Michael Flagella; David M. Goldstein; Rama Kondru; John Lesnick; Jun Li; Matthew C. Lucas; Jim Nonomiya; Jodie Pang; Stephen Price; Laurent Salphati; Brian S. Safina; Pascal P. A. Savy; Eileen Seward; Ultsch; Daniel P. Sutherlin

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September 13, 2012

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

Nature, ISSN: 00280836 14764687

David Vilchez; Ianessa Morantte; Zheng Liu; Peter M. Douglas; Carsten Merkwirth; Ana P. C. Rodrigues; Gerard Manning; Andrew Dillin

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September 10, 2012

A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Ian E. Krop; Patricia M. LoRusso; Kathy Miller; Shanu Modi; Denise A. Yardley; Gladys Rodriguez; Ellie Guardino; Michael W. Lu; Maoxia Zheng; Sandhya Girish; Lukas Amler; Eric P. Winer; Hope S. Rugo

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September 6, 2012

High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production

Blood, ISSN: 15280020 00064971

Jonathan N. Thon; Matthew T. Devine; Antonija Jurak Begonja; Jay Tibbitts; Joseph E. Italiano Jr.

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September 6, 2012

Structural transitions of transmembrane helix 6 in the formation of Metarhodopsin i

Journal of Physical Chemistry B, ISSN: 15205207 15206106

Markus Eilers; Joseph A. Goncalves; Shivani Ahuja; Colleen Kirkup; Amiram Hirshfeld; Carlos Simmerling; Philip J. Reeves; Mordechai Sheves; Steven O. Smith

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September 6, 2012

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

Blood, ISSN: 15280020 00064971

Bithi Chatterjee; Anna Smed-Sörensen; Lillian Cohn; Cecile Chalouni; Richard L. Vandlen; Byoung-Chul Lee; Jenifer Widger; Tibor Keler; Lélia Delamarre; Ira Mellman

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September 6, 2012

Dr. Sekulic and colleagues reply

New England Journal of Medicine, ISSN: 15334406 00284793

Aleksandar Sekulic; Josina C. Reddy; Axel Hauschild

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September 5, 2012

Binding mechanism of metalṡNTP substrates and stringent-response alarmones to bacterial DnaG-type primases

Structure, ISSN: 18784186 09692126

Richard U. Rymer; Francisco A. Solorio; Ashley K. Tehranchi; Clement Chu; Jacob E. Corn; James L. Keck; Jue D. Wang; James M. Berger

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September 4, 2012

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

Journal of Clinical Investigation, ISSN: 00219738 15588238

Yanqiu Liu; Agnes D. Berendsen; Shidong Jia; Sutada Lotinun; Roland Baron; Napoleone Ferrara; Bjorn R. Olsen

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September 4, 2012

Molecular basis for negative regulation of the glucagon receptor

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Christopher M. Koth; Jeremy Murray; Susmith Mukund; Azadeh Madjidi; Alexandra Minn; Holly J. Clarke; Wong; Vicki Chiang; Luis; Alberto Estevez; Jesus Rondon; Yingnan Zhang; Isidro Hötzel; Bernard B. Allan

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September 4, 2012

FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice

Journal of Clinical Investigation, ISSN: 00219738 15588238

Sunyoung Lee; Roland Meier; Saori Furuta; Marc E. Lenburg; Paraic A. Kenny; Ren Xu; Mina J. Bissell

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September 1, 2012

Anti-neuropilin-1 (MNRP1685A): Unexpected pharmacokinetic differences across species, from preclinical models to humans

Pharmaceutical Research, ISSN: 07248741 1573904X

Yan Xin; Shuang Bai; Lisa A. Damico; Denise Jin; Wei-Ching Liang; Yan Wu; Frank-Peter Theil; Amita Joshi; Yanmei Lu; John Lowe; Mauricio Maia; Rainer Brachmann; Hong Xiang

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September 1, 2012

Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): An Emphasis on preclinical and clinical catabolism

Current Drug Metabolism, ISSN: 13892002 18755453

Shen; Daniela Bumbaca; Ola M. Saad; Qin Yue; Cinthia V Pastuskovas; S. Cyrus Khojasteh; Jay Tibbitts; Surinder Kaur; Wang; Yu-Waye Chu; Patricia M. LoRusso; Sandhya Girish

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September 1, 2012

Pharmacokinetic considerations for antibody drug conjugates

Pharmaceutical Research, ISSN: 07248741 1573904X

Kedan Lin; Jay Tibbitts

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September 1, 2012

Psychometric evaluation of the cystic fibrosis questionnaire-revised in a national sample

Quality of Life Research, ISSN: 09629343

Alexandra L. Quittner; Gregory S. Sawicki; Ann McMullen; Lawrence Rasouliyan; David J. Pasta; Ashley Yegin; Michael W. Konstan

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September 1, 2012

A role for Th17 cells in the regulation of tertiary lymphoid follicles

European Journal of Immunology, ISSN: 00142980 15214141

Jane L. Grogan; Wenjun Ouyang

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September 1, 2012

Tissue distribution studies of protein therapeutics using molecular probes: Molecular imaging

AAPS Journal, ISSN: 15507416

Simon P. Williams

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September 1, 2012

Dyslipidemia and changes in lipid profiles associated with rheumatoid arthritis and initiation of anti-tumor necrosis factor therapy

Arthritis Care and Research, ISSN: 2151464X 21514658

Jeffrey R. Curtis; Ani John; Onur Baser

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September 1, 2012

Drug interaction potential of trastuzumab emtansine (T-DM1) combined with pertuzumab in patients with HER2-positive metastatic breast cancer

Current Drug Metabolism, ISSN: 13892002 18755453

Dan Lu; Howard A. Burris; Wang; E. Claire Dees; Javier Cortés; Amita Joshi; Manish Gupta; Joo-Hee Yi; Yu-Waye Chu; Ted Shih; Liang Fang; Sandhya Girish

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September 1, 2012

Diagnosis and management of childhood obstructive sleep apnea syndrome

Pediatrics, ISSN: 00314005 10984275

Carole L. Marcus; Lee Jay Brooks; Kari A. Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Michael S. Schechter; Stephen Howard Sheldon; Karen Spruyt; Sally Davidson Ward; Christopher Lehmann; Richard N. Shiffman

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September 1, 2012

Diagnosis and management of childhood obstructive sleep apnea syndrome

Pediatrics, ISSN: 00314005 10984275

Carole L. Marcus; Lee Jay Brooks; Sally Davidson Ward; Kari A. Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Christopher Lehmann; Michael S. Schechter; Stephen Howard Sheldon; Richard N. Shiffman; Karen Spruyt

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September 1, 2012

Compartmental tissue distribution of antibody therapeutics: Experimental approaches and interpretations

AAPS Journal, ISSN: 15507416

C. Andrew Boswell; Daniela Bumbaca; Fielder; Leslie A. Khawli

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September 1, 2012

Differential effects of predosing on tumor and tissue uptake of an 111in-labeled anti-TENB2 antibody-drug conjugate

Journal of Nuclear Medicine, ISSN: 01615505

C. Andrew Boswell; Eduardo E. Mundo; Crystal Zhang; Shannon Stainton; Shang-Fan Yu; Jennifer A. Lacap; Mao; Katherine R. Kozak; Aimee Fourie-O'Donohue; Paul G. Polakis; Leslie A. Khawli; Kedan Lin

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September 1, 2012

The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy

Experimental Oncology, ISSN: 18129269

Maria Cristina De Almagro; Domagoj Vucic

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September 1, 2012

Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex

Nature Protocols, ISSN: 17542189 17502799

Gerard M. J. Beaudoin III; Seung-Hye Lee; Dipika Singh; Yang Yuan; Yu-Gie Ng; Louis F. Reichardt; Jyothi Arikkath

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September 1, 2012

Risk factors for rate of decline in FEV1 in adults with cystic fibrosis

Journal of Cystic Fibrosis, ISSN: 15691993 18735010

Michael W. Konstan; Wagener; Donald R. VanDevanter; David J. Pasta; Ashley Yegin; Lawrence Rasouliyan; Morgan

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September 1, 2012

Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Laurent Salphati; Jodie Pang; Emile G. Plise; Leslie Lee; Alan G. Olivero; Wei Wei Prior; Deepak Sampath; Susan C. Wong; Xiaolin Zhang

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September 1, 2012

Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration

Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783

Kelly M. Loyet; Laura DeForge; Kenneth J. Katschke Jr.; Laurie Diehl; Robert R. Graham; Lily Pao; Lizette Sturgeon; Sock-Cheng Lewin-Koh; Joe G. Hollyfield; Menno Van Lookeren Campagne

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September 1, 2012

Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes

Ophthalmology, ISSN: 01616420 15494713

Lucia Sobrin; Stephan Ripke; Yi Yu; Jesen Fagerness; Tushar Bhangale; Perciliz L. Tan; Eric H. Souied; Gabriëlle H.S. Buitendijk; Joanna E. Merriam; Andrea J. Richardson; Soumya Raychaudhuri; Robyn Reynolds; Kimberly A. Chin; Aaron Y. Lee; Nicolas Leveziel; Donald J. Zack; Peter A. Campochiaro; R. Theodore Smith; Gaetano R. Barile; Ruth E. Hogg; Usha Chakravarthy; Timothy W. Behrens; André G. Uitterlinden; Cornelia M. Van Duijn; Johannes R. Vingerling; Milam A. Brantley Jr.; Paul N. Baird; Caroline C.W. Klaver; Rando Allikmets; Nicholas Katsanis; Robert R. Graham; John P.A. Ioannidis; Mark J. Daly; Johanna M. Seddon

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September 1, 2012

Neuropilin-2 expression in cancer

Histopathology, ISSN: 03090167 13652559

Adrian M. Jubb; Susan Sa; Navneet Ratti; Laura A. Strickland; Maike Schmidt; Christopher Callahan; Koeppen

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September 1, 2012

Long-term effects of ranibizumab on diabetic retinopathy severity and progression

Archives of Ophthalmology, ISSN: 00039950 15383601

Michael S. Ip; Amitha Domalpally; J. Jill Hopkins; Pamela Wong; Jason S. Ehrlich

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September 1, 2012

Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics

AAPS Journal, ISSN: 15507416

Daniela Bumbaca; C. Andrew Boswell; Fielder; Leslie A. Khawli

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September 1, 2012

The assay design used for measurement of therapeutic antibody concentrations can affect pharmacokinetic parameters: Case studies

mAbs, ISSN: 19420862 19420870

Saloumeh Kadkhodayan Fischer; Yang; Banmeet S. Anand; Kyra J. Cowan; Robert Hendricks; Jing Li; Nakamura; An Song

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September 1, 2012

2012 White paper on recent issues in bioanalysis and alignment of multiple guidelines

Bioanalysis, ISSN: 17576180 17576199

Binodh DeSilva; Fabio Garofolo; Mario Rocci; Suzanne Martinez; Isabelle Dumont; France Landry; Catherine Dicaire; Gabriella Szekely-Klepser; Russell Weiner; Mark Arnold; Surendra Bansal; Kevin Bateman; Ronald Bauer; Brian Booth; Scott Davis; Sherri Dudal; Dominique Gouty; John Grundy; Sam Haidar; Roger Hayes; Mohammed Jemal; Surinder Kaur; Marian Kelley; Magnus Knutsson; Olivier Le Blaye; Jean W. Lee; Steve Lowes; Mark Ma; Toshinari Mitsuoka; João Tavares Neto; Robert Nicholson; Eric Ormsby; Jeff M. Sailstad; Lauren Stevenson; Daniel Tang; Jan Welink; Viswanathan; Laixin Wang; Eric Woolf; Eric Yang

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September 1, 2012

Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Jun Luo; Jian Zhang; Diya Ren; Wen-Lin Tsai; Feng Li; Ashraf Amanullah; Terry Hudson

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September 1, 2012

Safety and biodistribution of an equine infectious anemia virus-based gene therapy, retinostat®, for age-related macular degeneration

Human Gene Therapy, ISSN: 10430342 15577422

Katie Binley; Peter S. Widdowson; Michelle Kelleher; Jackie De Belin; Julie Loader; Georgina Ferrige; Marie Carlucci; Margaret Esapa; Daniel Chipchase; Diana Angell-Manning; Scott Ellis; Kyriacos Mitrophanous; James Miskin; Vlad Bantseev; Michael Nork; Paul Miller; Stuart Naylor

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September 1, 2012

Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): A phase 3, open-label, multicentre, randomised trial

The Lancet Oncology, ISSN: 14702045 14745488

Gustavo Ismael; Roberto Hegg; Susanne Muehlbauer; Dominik Heinzmann; Bert L. Lum; Sung-Bae Kim; Tadeusz Pienkowski; Mikhail Lichinitser; Vladimir Semiglazov; Melichar; Christian Jackisch

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September 1, 2012

QbD for biologics

BioProcess International, ISSN: 15426319

Steven Kozlowski; Wassim Nashabeh; Mark Schenerman; Howard Anderson; Ilse Blumentals; Kowid Ho; Rohin Mahtre; Barbara Rellahan; Victor Vinci; Lorna McLeod

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September 1, 2012

Pre-use/post-sterilization integrity testing of sterilizing grade filters

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124

Karen Bartel; Harold S. Baseman; Gabriele Gori; Richard V. Levy; Hemisha Ly; Maik W. Jornitz; Russell Madsen; Michiel Rook; Sue Schniepp

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September 1, 2012

Evaluating the Impact of Patient Recruitment and Retention Practices

Drug Information Journal, ISSN: 00928615

Mary Jo Lamberti; Adam Mathias; Jane E. Myles; Deborah Howe; Ken Getz

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September 1, 2012