Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7651 - 7700 OF 15487 RESULTS

Sequencing and analysis of a South Asian-Indian personal genome
BMC Genomics, ISSN: 14712164
Ravi Gupta; Aakrosh Ratan; Changanamkandath Rajesh; Rong Chen; Hie Lim Kim; Richard Burhans; Webb Miller; Sam Santhosh; Ramana V. Davuluri; Atul J. Butte; Stephan C. Schuster; Somasekar Seshagiri; George Thomas
View on Scopus
Recurrent R-spondin fusions in colon cancer
Nature, ISSN: 00280836 14764687
Somasekar Seshagiri; Eric Stawiski; Durinck; Zora Modrusan; Elaine E. Storm; Caitlin B. Conboy; Subhra Chaudhuri; Yinghui Guan; Vasantharajan Janakiraman; Bijay S. Jaiswal; Joseph Guillory; Connie Ha; Gerrit J. P. Dijkgraaf; Stinson; Florian Gnad; Melanie A. Huntley; Jeremiah D. Degenhardt; Matthias Peter; Richard Bourgon; Weiru Wang; Koeppen; Robert Gentleman; Timothy Starr; Zemin Zhang; David A. Largaespada; Thomas D Wu; Frederic J. De Sauvage
View on Scopus
Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway
EMBO Journal, ISSN: 02614189 14602075
Guanglei Zhuang; Xiumin Wu; Zhaoshi Jiang; Ian Kasman; Jenny Yao; Yinghui Guan; Jason Oeh; Zora Modrusan; Carlos Bais; Deepak Sampath; Napoleone Ferrara
View on Scopus
Profiling antibody drug conjugate positional isomers: A system-of-equations approach
Analytical Chemistry, ISSN: 15206882 00032700
Lan N. Le; Jamie M. R. Moore; Jun Ouyang; Xiaoying Chen; Mary D. H. Nguyen; William J. Galush
View on Scopus
Transforming quality of care and improving outcomes after acute MI: Lessons from the national registry of myocardial infarction
JAMA - Journal of the American Medical Association, ISSN: 15383598 00987484
William J. French; Vanessa S. Reddy; Hal V. Barron
View on Scopus
Evaluation of an accurate mass approach for the simultaneous detection of drug and metabolite distributions via whole-body mass spectrometric imaging
Analytical Chemistry, ISSN: 00032700 15206882
Sheerin Shahidi-Latham; Sucharita M. Dutta; Maria C. Prieto Conaway; Patrick J. Rudewicz
View on Scopus
Identification and characterization of buried unpaired cysteines in a recombinant monoclonal igg1 antibody
Analytical Chemistry, ISSN: 00032700 15206882
Taylor Zhang; Jennifer Zhang; Daniel Hewitt; Ben Tran; Xiaoying Gao; Zhihua Julia Qiu; Max L. Tejada; Hélène Gazzano-Santoro; Kao
View on Scopus
Step-economic synthesis of (+)-crocacin C: A concise crotylboronation/[3,3] -sigmatropic rearrangement approach
Journal of Organic Chemistry, ISSN: 00223263 15206904
Adele E. Pasqua; Frank D. Ferrari; Chris Hamman; Yanzhou Liu; James J. Crawford; Rodolfo Marquez
View on Scopus
Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Hoanh Tran; Paul G. Polakis
View on Scopus
Balancing continuous and categorical baseline covariates in sequential clinical trials using the area between empirical cumulative distribution functions
Statistics in Medicine, ISSN: 02776715 10970258
Yunzhi Lin; Zheng Su
View on Scopus
Cardiovascular and systemic microvascular-effects of anti-vascular endothelial growth factor therapy for cancer
Journal of the American College of Cardiology, ISSN: 07351097 15583597
J. Todd Belcik; Yue Qi; Beat A. Kaufmann; Aris Xie; Sherron Bullens; Terry K. Morgan; Susan P. Bagby; Ganesh Kolumam; Joe Kowalski; Jon A. Oyer; Bunting; Jonathan R. Lindner
View on Scopus
Pari passu dimers of dimers
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Mark X. Sliwkowski
View on Scopus
Functional significance of isoform diversification in the protocadherin gamma gene cluster
Neuron, ISSN: 08966273 10974199
Weisheng V. Chen; Francisco J. Alvarez; Julie L. Lefebvre; Brad A. Friedman; Chiamaka Nwakeze; Eric Geiman; Courtney Smith; Chan Aye Thu; Juan Carlos Tapia; Bosiljka Tasic; Joshua R. Sanes; Tom Maniatis
View on Scopus
Quantification and characterization of micrometer and submicrometer subvisible particles in protein therapeutics by use of a suspended microchannel resonator
Analytical Chemistry, ISSN: 00032700 15206882
Ankit Patel; Doris Lau; Jun Liu
View on Scopus
Patient out-of-pocket payments for oral oncolytics: Results from a 2009 us claims data analysis
American Journal of Managed Care, ISSN: 10880224
Martin L. Raborn; Elise M. Pelletier; Daniel B. Smith; Carolina Reyes
View on Scopus
Function, targets, and evolution of Caenorhabditis elegans piRNAs
Science, ISSN: 10959203 00368075
Marloes P. Bagijn; Leonard D. Goldstein; Alexandra Sapetschnig; Eva-Maria Weick; Samir Bouasker; Nicolas J. Lehrbach; Martin J. Simard; Eric A. Miska
View on Scopus
A mutation in APP protects against Alzheimer‘s disease and age-related cognitive decline
Nature, ISSN: 00280836
Thorlakur Jonsson; Jasvinder K. Atwal; Stacy Steinberg; Jon Snaedal; Palmi V. Jonsson; Sigurbjorn Bjornsson; Hreinn Stefansson; Patrick Sulem; Daniel Gudbjartsson; Janice Maloney; Kwame Hoyte; Amy Gustafson; Yichin Liu; Yanmei Lu; Tushar Bhangale; Robert R. Graham; Johanna Huttenlocher; Gyda Bjornsdottir; Ole A. Andreassen; Erik G. Jönsson; Aarno Palotie; Timothy W. Behrens; Olafur T. Magnusson; Augustine Kong; Unnur Thorsteinsdottir; Ryan J. Watts; Kari Stefansson
View on Scopus
An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan
Aging Cell, ISSN: 14749718 14749726
Kwame Twumasi-Boateng; Tim W. Wang; Linda Tsai; Kuang-Hui Lee; Ali Salehpour; Sudarshan Bhat; Man-Wah Tan; Michael Shapira
View on Scopus
Effect of rifampin and rifabutin on the pharmacokinetics of lersivirine and effect of lersivirine on the pharmacokinetics of rifabutin and 25-O-desacetyl-rifabutin in healthy subjects
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Manoli Vourvahis; John Davis; Rong Wang; Gary Layton; Heng Wee Choo; Chew Lan Chong; Margaret Tawadrous
View on Scopus
The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis
Protein Science, ISSN: 09618368 1469896X
Christian N. Cunningham; Daniel R. Southworth; Kristin A. Krukenberg; David A. Agard
View on Scopus
Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin
Hepatology, ISSN: 02709139 15273350
Stephen A. Harrison; Hamzeh; Jian Han; Prashant K. Pandya; Muhammed Y. Sheikh; John M. Vierling
View on Scopus
Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: An open-label, multiple-dose, randomized, crossover study
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Georgina Cirrincione-Dall; Barbara J. Brennan; Rosa M. Ballester-Sanchis; Mercidita T. Navarro; Brian E. Davies
View on Scopus
Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth
Nature Neuroscience, ISSN: 10976256 15461726
Erik Mire; Cecilia Mezzera; Eduardo Leyva-Diáz; Ana V. Paternain; Paola Squarzoni; Lisa Bluy; Mar Castillo-Paterna; María José López; Sandra Peregrín; Marc Tessier-Lavigne; Sonia Garel; Joan Galcerán; Juan Lerma; Guillermina López-Bendito
View on Scopus
Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors
Journal of Pathology, ISSN: 00223417 10969896
Alicia S Chung; Marcin Kowanetz; Xiumin Wu; Guanglei Zhuang; Hai Ngu; David Finkle; László Kömüves; Franklin V. Peale Jr.; Napoleone Ferrara
View on Scopus
Longitudinal changes in asthma control with omalizumab: 2-year interim data from the EXCELS study
Journal of Asthma, ISSN: 02770903 15324303
Mark D. Eisner; James L. Zazzali; Mary K. Miller; Mary S. Bradley; Michael Schatz
View on Scopus
Stability of GABAB receptor oligomers revealed by dual TR-FRET and drug-induced cell surface targeting
FASEB Journal, ISSN: 08926638 15306860
Laetitia Comps-Agrar; Julie Kniazeff; Arsten Brock; Eric Trinquet; Jean-Philippe Pin
View on Scopus
Validation of a tool to assess medication treatment satisfaction in patients with Type2 diabetes: The Diabetes Medication System Rating Questionnaire (DMSRQ)
Diabetic Medicine, ISSN: 07423071 14645491
Peyrot; Harshaw; Shillington; Yaping Xu; Rubin
View on Scopus
Pcadmix: Principal components-based assignment of ancestry along each chromosome in individuals with admixed ancestry from two or more populations
Human Biology, ISSN: 00187143 15346617
Abra Brisbin; Katarzyna Bryc; Jake Byrnes; Fouad Zakharia; Larsson Omberg; Jeremiah D. Degenhardt; Andy Reynolds; Harry Ostrer; Jason G. Mezey; Carlos D. Bustamante
View on Scopus
DNA methylation alterations in response to pesticide exposure in vitro
Environmental and Molecular Mutagenesis, ISSN: 08936692 10982280
Xiao Zhang; Andrew D. Wallace; Pan Du; Warren A. Kibbe; Nadereh Jafari; Hehuang Xie; Simon Lin; Andrea A. Baccarelli; Marcelo Bento Soares; Lifang Hou
View on Scopus
Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: The phase III FILM trial
Annals of the Rheumatic Diseases, ISSN: 00034967 14682060
Stohl W.; Juan Gomez-Reino; Ewa Olech; Jean Dudler; Roy Fleischmann; Cristiano A. F. Zerbini; Ashrafzadeh; Susanna M. Grzeschik; Rebecca Bieraugel; Jennifer Green; Steve Francom; Wolfgang Dummer
View on Scopus
Overcoming soluble target interference in an anti-therapeutic antibody screening assay for an antibody-drug conjugate therapeutic
Bioanalysis, ISSN: 17576180 17576199
Montserrat Carrasco-Triguero; Connie Mahood; Marija Milojic-Blair; Caroline Amaya; Jane Ruppel; Kyu Hong; Joo-Hee Yi; Surinder Kaur
View on Scopus
Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma
American Journal of Neuroradiology, ISSN: 01956108 1936959X
Jose A. Carrillo; Albert Lai; Phioanh L. Nghiemphu; Kim; Phillips; Samir Kharbanda; Moftakhar; Lalaezari; William H. Yong; Benjamin M. Ellingson; Timothy Cloughesy; Whitney B. Pope
View on Scopus
Protein microarrays, biosensors, and cell-based methods for secretome-wide extracellular protein-protein interaction mapping
Methods, ISSN: 10462023 10959130
Lino C. Gonzalez Jr.
View on Scopus
Drug absorption interactions between oral targeted anticancer agents and PPIs: Is pH-dependent solubility the achilles heel of targeted therapy
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Nageshwar Budha; Adam Frymoyer; Gillian S. Smelick; Jin Y. Jin; Marc R. Yago; Mark J. Dresser; Scott N. Holden; Leslie Z. Benet; Joseph A. Ware
View on Scopus
Nanolitre-scale crystallization using acoustic liquid-transfer technology
Acta Crystallographica Section D: Biological Crystallography, ISSN: 09074449 13990047
Armando G. Villasẽor; April Wong; Ada Shao; Ankur Garg; Timothy J. Donohue; Andreas Kuglstatter; Seth F. Harris
View on Scopus
Identification of Asp isomerization in proteins by 18O labeling and tandem mass spectrometry
Methods in Molecular Biology, ISSN: 10643745
Jennifer Zhang; Viswanatham Katta
View on Scopus
Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function
Methods in Molecular Biology, ISSN: 10643745
Robert F. Kelley; Meng
View on Scopus
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
Nature, ISSN: 00280836 14764687
Wilson; Jane Fridlyand; Yibing Yan; Elicia M. Penuel; Luciana Burton; Emily Chan; Jing Peng; Eva Lin; Wang; Jeffrey A. Sosman; Antoni Ribas; Jiang Li; John Moffat; Daniel P. Sutherlin; Koeppen; Mark Merchant; Richard M. Neve; Jeffrey Settleman
View on Scopus
The development of small-molecule IAP antagonists for the treatment of cancer
Topics in Medicinal Chemistry, ISSN: 18622461 1862247X
Deshayes; Jeremy Murray; Domagoj Vucic
View on Scopus
Inefficiency of randomization methods that balance on stratum margins and improvements with permuted blocks and a sequential method
Statistics in Medicine, ISSN: 02776715 10970258
Lee D. Kaiser
View on Scopus
Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease
Blood, ISSN: 15280020 00064971
Pichika Chantrathammachart; Nigel Mackman; Erica Sparkenbaugh; Jian-Guo Wang; Leslie V. Parise; Daniel Kirchhofer; Nigel S. Key; Rafal Pawlinski
View on Scopus
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Blood, ISSN: 15280020 00064971
Sebastian Willenborg; Tina Lucas; Geert Van Loo; Johanna A. Knipper; Thomas Krieg; Ingo Haase; Bent Brachvogel; Matthias Hammerschmidt; Andras Nagy; Napoleone Ferrara; Manolis Pasparakis; Sabine A. Eming
View on Scopus
Coarse-grained modeling of the self-association of therapeutic monoclonal antibodies
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Anuj Chaudhri; Isidro E. Zarraga; Tim J. Kamerzell; J. Paul Brandt; Thomas W. Patapoff; Steven J. Shire; Gregory A. Voth
View on Scopus
Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response
Clinical Cancer Research, ISSN: 10780432 15573265
Harvey Wong; Edna F. Choo; Bruno Alicke; Xiao Ding; Hank La; Erin McNamara; Frank-Peter Theil; Jay Tibbitts; Lori S. Friedman; Cornelis E. Hop; Stephen Gould
View on Scopus
Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2
Cancer Research, ISSN: 00085472 15387445
Meilan He; Wei Zhang; Thomas Bakken; Melissa Schutten; Zsolt Toth; Jae U. Jung; Parkash Gill; Mark Cannon; Shou-Jiang Gao
View on Scopus
GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death In Vitro and In Vivo
Clinical Cancer Research, ISSN: 10780432 15573265
Jeffery J. Wallin; Zhengyu Guan; Wei Wei Prior; Leslie Lee; Berry; Lisa D. Belmont; Koeppen; Marcia Belvin; Lori S. Friedman; Deepak Sampath
View on Scopus
Structure and conservation of the periplasmic targeting factor Tic22 protein from plants and cyanobacteria
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Joanna Tripp; Alexander Hahn; Patrick Koenig; Nadine Flinner; Daniela Bublak; Eva M. Brouwer; Franziska Ertel; Oliver Mirus; Irmgard Sinning; Ivo Tews; Enrico Schleiff
View on Scopus
The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Youjun Chen; Cecile Chalouni; Christine Tan; Robyn Clark; Rayna Venook; Rachana Ohri; Helga Raab; Ron Firestein; William Mallet; Paul G. Polakis
View on Scopus
Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Mark Zak; Rohan Mendonca; Mercedesz Balazs; Kathy Barrett; Philippe Bergeron; Wade S. Blair; Christine Chang; Gauri Deshmukh; Jason Devoss; Peter Dragovich; Eigenbrot; Nico Ghilardi; Paul Gibbons; Stefan Gradl; Chris Hamman; Emily J. Hanan; Eric Harstad; Peter R. Hewitt; Christopher A. Hurley; Tian Jin; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Michael F. T. Koehler; Pawan Bir Kohli; Janusz J. Kulagowski; Sharada Labadie; Jiangpeng Liao; Marya Liimatta; Zhonghua Lin; Patrick J. Lupardus; Robert J. Maxey; Jeremy Murray; Rebecca Pulk; Madeleine Rodriguez; Scott Savage; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Ling Xiao; Yisong Xiao
View on Scopus
An effector-reduced anti-β-amyloid (Aβ) antibody with unique Aβ binding properties promotes neuroprotection and glial engulfment of Aβ
Journal of Neuroscience, ISSN: 02706474 15292401
Oskar Adolfsson; Maria Pihlgren; Nicolas Toni; Yvan Varisco; Anna Lucia Buccarello; Katia Antoniello; Sophie Lohmann; Kasia Piorkowska; Valerie Gafner; Jasvinder K. Atwal; Janice Maloney; Mark Chen; Alvin Gogineni; Robby M. Weimer; Deborah L. Mortensen; Michel Friesenhahn; Carole Ho; Robert Paul; Andrea Pfeifer; Andreas Muhs; Ryan J. Watts
View on Scopus
© 2025 Genentech, Inc. All rights reserved. This site is intended for US residents only.