Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7701 - 7750 OF 15394 RESULTS

Caspases in synaptic plasticity
Molecular Brain, ISSN: 17566606
Zheng Li; Morgan Sheng
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Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy
Journal of Immunology, ISSN: 00221767 15506606
Maureen A. Su; Dan Davini; Philip Cheng; Karen Giang; Una Fan; Jason Devoss; Kellsey P. A. Johannes; Lorelei Taylor; Anthony K. Shum; Mariella Valenzise; Antonella Meloni; Helene Bour-Jordan; Mark S. Anderson
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Integrating biological knowledge into variable selection: an empirical Bayes approach with an application in cancer biology
BMC Bioinformatics, ISSN: 14712105
Steven M. Hill; Richard M. Neve; Nora Bayani; Wen-Lin Kuo; Safiyyah Ziyad; Paul T. Spellman; Joe W. Gray; Sach Mukherjee
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Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Flygare; Beresini; Nageshwar Budha; Helen Chan; Iris Chan; Sravanthi Cheeti; Frederick Cohen; Deshayes; Karl Doerner; Gail Eckhardt; Linda O. Elliott; Bainian Feng; Matthew C Franklin; Stacy Frankovitz Reisner; Lewis Gazzard; Jason S Halladay; Sarah G. Hymowitz; Hank La; Patricia M. LoRusso; Brigitte Maurer; Lesley J. Murray; Emile G. Plise; Quan; Jean-Philippe Stephan; Young G. Shin; Jeffrey Tom; Vickie Tsui; Joanne Um; Eugene Varfolomeev; Domagoj Vucic; Andrew Wagner; Heidi J. A. Wallweber; Lan Wang; Joseph A. Ware; Zhaoyang Wen; Harvey Wong; Jonathan M. Wong; Melisa Wong; Susan C. Wong; Ron Yu; Zobel; Wayne J. Fairbrother
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Challenges and opportunities in the use of CTCs for companion diagnostic development
Recent Results in Cancer Research, ISSN: 00800015
Elizabeth A. Punnoose; Lackner
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An ATP-site on-off switch that restricts phosphatase accessibility of Akt
Science Signaling, ISSN: 19450877 19379145
Kui Lin; Jie Lin; Wen-I. Wu; Joshua Ballard; Brian Lee; Susan L. Gloor; Guy Vigers; Tony Morales; Lori S. Friedman; Nicholas J. Skelton; Barbara J. Brandhuber
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An ATP-site on-off switch that restricts phosphatase accessibility of Akt
Science Signaling, ISSN: 19450877 19379145
Kui Lin; Jie Lin; Wen-I. Wu; Joshua Ballard; Brian B. Lee; Susan L. Gloor; Guy Vigers; Tony Morales; Lori S. Friedman; Nicholas J. Skelton; Barbara J. Brandhuber
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Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Yonglian Sun; Kate Senger; Tomasz K. Baginski; Anita Mazloom; Yvonne Chinn; Homer Pantua; Kajal Hamidzadeh; Sree R. Ramani; Luis; Irene Tom; Andrew Sebrell; Gabriel Quinones; Ma; Kiran Mukhyala; Tao Sai; Jiabing Ding; Benjamin Haley; Hooman Shadnia; Sharookh B. Kapadia; Lino C. Gonzalez Jr.; Hass; Ali A. Zarrin
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Engineering and structural characterization of a linear polyubiquitin-specific antibody
Journal of Molecular Biology, ISSN: 10898638 00222836
Marissa L. Matsumoto; Ken Dong; Christine Yu; Lilian Phu; Xinxin Gao; Rami N. Hannoush; Sarah G. Hymowitz; Donald S. Kirkpatrick; Vishva M. Dixit; Robert F. Kelley
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Complementary proteomic tools for the dissection of apoptotic proteolysis events
Journal of Proteome Research, ISSN: 15353893 15353907
Victoria Pham; Pitti; Veronica G. Anania; Corey Bakalarski; Daisy J. Bustos; Suchit Jhunjhunwala; Qui Phung; Kebing Yu; William F. Forrest; Donald S. Kirkpatrick; Avi Ashkenazi; Jennie R. Lill
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Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes
PLoS ONE, ISSN: 19326203
Jeffery J. Wallin; Zhengyu Guan; Kyle A. Edgar; Wei Zhou; Ross Francis; Anthony C. Torres; Matthias Peter; Jeffrey Eastham-Anderson; Sabrina Arena; Alberto Bardelli; Sue Griffin; John E. Goodall; Kyla M. Grimshaw; Klaus P. Hoeflich; Christopher Torrance; Marcia Belvin; Lori S. Friedman
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N-Cadherin prodomain processing regulates synaptogenesis
Journal of Neuroscience, ISSN: 02706474 15292401
Analía Reinés; Louis-Philippe Bernier; Robyn McAdam; Wiam Belkaid; Shan; Alexander W. Koch; Philippe Séguéla; David R. Colman; Ajit S. Dhaunchak
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Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: Current recommendations from the Safety Pharmacology Society
Journal of Pharmacological and Toxicological Methods, ISSN: 10568719 1873488X
Leishman; Beck; Noel Dybdal; Gallacher; Guth; Holbrook; Brian Roche; Wallis
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From the editor
BioProcess International, ISSN: 15426319
Siddharth Advant; Hazel Aranha; Milton J. Axley; R. Lee Buckler; Michel Chartrain; Nancy Chew; Laurel Donahue-Hjelle; John Dougherty; Don R. Durham; Jim Faulkner; Pete Gagnon; Hélène Gazzano-Santoro; Rick Hancock; Timothy K. Hayes; Kenneth Hughes; Susan Dana Jones; Alex D. Kanarek; Dennis M. Kraichely; Vadim Klyushnichenko; Fred Mann; Adriana E. Manzi; Otto-Wilhelm Merten; Thomas J. Pritchett; T. Shantha Raju; Nadine Ritter; Sally Seaver; Robert P. Shaw; Abhinav Shukla; Michiel Ultee; Scott M. Wheelwright; William G. Whitford; Shuichi Yamamoto; Jianguo Yang; Xiaoming Yang
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Standardization of single use components' extractable studies for industry
Pharmaceutical Engineering, ISSN: 02738139
Ekta Mahajan; Trishna Ray-Chaudhuri; James Dean Vogel
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Online FDA Resources Versus Data on File: Minimizing Data on File in Standard Medical Response Letters
Drug Information Journal, ISSN: 00928615
Nancy Hwang; Graham; Marbel Catolico
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Proteus: A web-based, context-specific modelling tool for molecular networks
Bioinformatics, ISSN: 13674803 14602059
Florian Gnad; Javier Estrada; Jeremy Gunawardena
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High-throughput methods for miniaturization and automation of monoclonal antibody purification processes
Biotechnology Progress, ISSN: 87567938 15206033
Katrin Treier; Sigrid Hansen; Carolin Richter; Patrick Diederich; Jürgen Hubbuch; Philip M. Lester
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Transcriptional analysis of pluripotency reveals the hippo pathway as a barrier to reprogramming
Human Molecular Genetics, ISSN: 09646906 14602083
Han Qin; Kathryn Blaschke; Grace Wei; Yuki Ohi; Laure Blouin; Zhongxia Qi; Jingwei Yu; Ru-Fang Yeh; Matthias Hebrok; Miguel Ramalho-santos
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Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Edna F. Choo; Marcia Belvin; Jason Boggs; Yuzhong Deng; Klaus P. Hoeflich; Justin Ly; Mark Merchant; Christine Orr; Emile G. Plise; Kirk D. Robarge; Jean-Francois Martini; Robert Kassees; Ron Aoyama; Atulkumar Ramaiya; Stuart H. Johnston
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Gastrointestinal perforation associated with bevacizumab use in metastatic colorectal cancer: Results from a large treatment observational cohort study
European Journal of Cancer, ISSN: 09598049 18790852
Fairooz F. Kabbinavar; Patrick J. Flynn; Kozloff; Ashby; Amy Sing; Charles E. Barr; Grothey
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Introduction for the special issue on glycosylation and immunity
Seminars in Immunopathology, ISSN: 18632297 18632300
John Lowe
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Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice
British Journal of Pharmacology, ISSN: 00071188 14765381
Daniela Bumbaca; Hong Xiang; C. Andrew Boswell; Ruediger E. Port; Shannon Stainton; Eduardo E. Mundo; Sheila Ulufatu; Anil Bagri; Frank-Peter Theil; Fielder; Leslie A. Khawli; Shen
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Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors
Xenobiotica, ISSN: 00498254 13665928
Bianca M. Liederer; Xingrong Liu; Leonid M. Berezhkovskiy; Cain; Xiao Ding; John J. Gaudino; Robert Kaus; Emile G. Plise; Daniel P. Sutherlin; Eric Harstad
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Trends in the incidence of noncardiogenic acute respiratory failure: The role of race
Critical Care Medicine, ISSN: 00903493 15300293
Colin R. Cooke; Sara E. Erickson; Mark D. Eisner; Greg S. Martin
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The pharmacokinetics of lersivirine (UK-453,061) and HIV-1 protease inhibitor coadministration in healthy subjects
Journal of Acquired Immune Deficiency Syndromes, ISSN: 15254135 10779450
Manoli Vourvahis; Grant Langdon; Gary Layton; Robert R. LaBadie; Heng Wee Choo; Marie-Noella Ndongo; John Davis
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Mini-scale bioprocessing systems for highly parallel animal cell cultures
Biotechnology Progress, ISSN: 87567938 15206033
Beum Jun Kim; Jinpian Diao; Michael L. Shuler
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Clinical implications of pathophysiological and demographic covariates on the population pharmacokinetics of trastuzumab emtansine, a HER2-targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Manish Gupta; Patricia M. LoRusso; Wang; Joo-Hee Yi; Howard A. Burris; Muralidhar Beeram; Shanu Modi; Yu-Waye Chu; Samuel Agresta; Barbara Klencke; Amita Joshi; Sandhya Girish
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Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Jincai Li; Chun Loong Wong; Natarajan Vijayasankaran; Terry Hudson; Ashraf Amanullah
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Ubiquilins in the crosstalk among proteolytic pathways
Biological Chemistry, ISSN: 14316730 14374315
Dong Yun Lee; Eric J. Brown
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Wnt signaling in cancer
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Paul G. Polakis
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ISCOMATRIX vaccines mediate CD8 T-cell cross-priming by a MyD88-dependent signaling pathway
Immunology and Cell Biology, ISSN: 08189641 14401711
Nicholas S. Wilson; Becky Yang; Adriana Baz Morelli; Sandra Koernig; Annie Yang; Stefanie Loeser; Denise Airey; Larissa Provan; Hass; Hal Braley; Suzana Couto; Debbie Drane; Jeff Boyle; Gabrielle T Belz; Avi Ashkenazi; Eugene Maraskovsky
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Morphological defects in a novel Rdh10 mutant that has reduced retinoic acid biosynthesis and signaling
Genesis, ISSN: 1526954X 1526968X
Amir M. Ashique; Scott R. May; Maureen A. Kane; Alexandra E. Folias; Khanhky Phamluong; Youngshik Choe; Joseph L. Napoli; Andrew S. Peterson
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Tumor angiogenesis mediated by myeloid cells is negatively regulated by CEACAM1
Cancer Research, ISSN: 00085472 15387445
Rongze Lu; Maciej Kujawski; Hao Pan; Shively
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Decision Making for a Companion Diagnostic in an Oncology Clinical Development Program
Drug Information Journal, ISSN: 00928615
Lee D. Kaiser; Claus Becker; Sharad Kukreti; Bernard M. Fine
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Use of the cassette-dosing approach to assess brain penetration in drug discovery
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Xingrong Liu; Xiao Ding; Gauri Deshmukh; Bianca M. Liederer; Cornelis E. Hop
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Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation
Nature Biotechnology, ISSN: 10870156 15461696
Farzaneh Modarresi; Mohammad Ali Faghihi; Miguel A Lopez-Toledano; Roya Pedram Fatemi; Marco Magistri; Shaun P Brothers; Marcel P Van Der Brug; Claes Wahlestedt
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Structure of human ADAM-8 catalytic domain complexed with batimastat
Acta Crystallographica Section F: Structural Biology and Crystallization Communications, ISSN: 17443091
Troii Hall; Huey-Sheng Shieh; Jacqueline E. Day; Nicole Caspers; Jill E. Chrencik; Jennifer M. Williams; Lyle E. Pegg; Adele M. Pauley; Andrea F. Moon; Joseph M. Krahn; David H. Fischer; James R. Kiefer; Alfredo G. Tomasselli; Marc D. Zack
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Clinical pharmacology of trastuzumab emtansine (T-DM1): An antibody-drug conjugate in development for the treatment of HER2-positive cancer
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Sandhya Girish; Manish Gupta; Wang; Dan Lu; Ian E. Krop; Charles L. Vogel; Howard A. Burris; Patricia M. LoRusso; Joo-Hee Yi; Ola M. Saad; Barbara Tong; Yu-Waye Chu; Scott N. Holden; Amita Joshi
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Quantitative evaluation of fucose reducing effects in a humanized antibody on Fcγ receptor binding and antibody-dependent cell-mediated cytotoxicity activities
mAbs, ISSN: 19420862 19420870
Shan Chung; Quarmby; Xiaoying Gao; Yong Ying; Yuwen L. Lin; Chae Reed; Chris Fong; Wendy Lau; Zhihua Julia Qiu; Amy Shen; Vanderlaan; An Song
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Translation levels control multi-spanning membrane protein expression
PLoS ONE, ISSN: 19326203
Hok Seon Kim; James A. Ernst; Cecilia Brown; Jenny Bostrom; Fuh; Chingwei V. Lee; Arthur Huang; Richard L. Vandlen; Yansura
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Cilia - the prodigal organelle
Cilia, ISSN: 20462530
Phil Beales; Peter K Jackson
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Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Carla M. Lema Tome; Enzo Palma; Sara Ferluga; W. Todd Lowther; Roy Hantgan; Jill Wykosky; Waldemar Debinski
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FGF19 and cancer
Advances in Experimental Medicine and Biology, ISSN: 00652598
Benjamin C. Lin; Luc Desnoyers
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Formal synthesis of (+)-crocacin C
Tetrahedron Letters, ISSN: 00404039 18733581
Adele E. Pasqua; Frank D. Ferrari; James J. Crawford; Rodolfo Marquez
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Genetic and Epigenetic Determinants of Neurogenesis and Myogenesis
Developmental Cell, ISSN: 15345807 18781551
Abraham P. Fong; Zizhen Yao; Jun Wen Zhong; Yi Cao; Walter L. Ruzzo; Robert Gentleman; Stephen J. Tapscott
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Application of genetic algorithms and response surface analysis for the optimization of batch chromatographic systems
Biochemical Engineering Journal, ISSN: 1369703X 1873295X
Katrin Treier; Philip M. Lester; Jürgen Hubbuch
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Rapamycin with antiretroviral therapy in AIDS-associated kaposi sarcoma: An AIDS malignancy consortium study
Journal of Acquired Immune Deficiency Syndromes, ISSN: 15254135 10779450
Susan E. Krown; Debasmita Roy; Jeannette Y. Lee; Bruce J. Dezube; Erin G. Reid; Raman Venkataramanan; Kelong Han; Ethel Cesarman; Dirk P. Dittmer
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Evaluation of circulating tumor cells and circulating tumor DNA in non-small cell lung cancer: Association with clinical endpoints in a phase II clinical trial of pertuzumab and erlotinib
Clinical Cancer Research, ISSN: 10780432 15573265
Elizabeth A. Punnoose; Siminder Atwal; Weiqun Liu; Rajiv Raja; Bernard M. Fine; Brett Hughes; Rodney Hicks; Garret M. Hampton; Lukas Amler; Andrea Pirzkall; Lackner
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CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency
Cancer Research, ISSN: 00085472 15387445
Adam S. Adler; Mark L. McCleland; Tom Truong; Shari Lau; Zora Modrusan; Tim M. Soukup; Merone Roose-Girma; Elizabeth M. Blackwood; Ron Firestein
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